[go: up one dir, main page]

WO2006128120A3 - Nouveaux composes de lapachone et methodes d'utilisation - Google Patents

Nouveaux composes de lapachone et methodes d'utilisation Download PDF

Info

Publication number
WO2006128120A3
WO2006128120A3 PCT/US2006/020780 US2006020780W WO2006128120A3 WO 2006128120 A3 WO2006128120 A3 WO 2006128120A3 US 2006020780 W US2006020780 W US 2006020780W WO 2006128120 A3 WO2006128120 A3 WO 2006128120A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compounds
lapachone compounds
novel
novel lapachone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/020780
Other languages
English (en)
Other versions
WO2006128120A2 (fr
Inventor
Mark Ashwell
Manish Tandon
Jean-Marc Lapierre
Syed Ali
Yanbin Liu
Chiang J Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arqule Inc
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of WO2006128120A2 publication Critical patent/WO2006128120A2/fr
Publication of WO2006128120A3 publication Critical patent/WO2006128120A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des analogues et des dérivés de lapachone ainsi que leurs méthodes d'utilisation. Ces composés peuvent s'utiliser dans des compositions pharmaceutiques pour le traitement ou la prévention du cancer ou d'états précancéreux.
PCT/US2006/020780 2005-05-26 2006-05-26 Nouveaux composes de lapachone et methodes d'utilisation Ceased WO2006128120A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68504505P 2005-05-26 2005-05-26
US60/685,045 2005-05-26

Publications (2)

Publication Number Publication Date
WO2006128120A2 WO2006128120A2 (fr) 2006-11-30
WO2006128120A3 true WO2006128120A3 (fr) 2007-01-18

Family

ID=37076320

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/020780 Ceased WO2006128120A2 (fr) 2005-05-26 2006-05-26 Nouveaux composes de lapachone et methodes d'utilisation

Country Status (1)

Country Link
WO (1) WO2006128120A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1877097B1 (fr) 2004-08-11 2012-06-20 Arqule, Inc. Conjugués d'acides aminés et de bêta-lapachone pour le ciblage de tumeurs
US8614228B2 (en) 2004-08-11 2013-12-24 Arqule, Inc. Quinone prodrug compositions and methods of use
WO2007139569A1 (fr) * 2006-05-26 2007-12-06 Arqule, Inc. Nouveaux composés de lapachone et leurs procédés d'utilisation
JP2010526072A (ja) 2007-04-30 2010-07-29 アークル インコーポレイテッド キノン化合物のヒドロキシスルホナートおよびその使用
US10829427B2 (en) 2015-12-18 2020-11-10 The Board Of Regents Of The University Of Texas System Naphthoquinones, pro-drugs, and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045557A2 (fr) * 2002-11-18 2004-06-03 Arqule, Inc. Nouveaux composes de lapachone et procedes d'utilisation correspondants

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045557A2 (fr) * 2002-11-18 2004-06-03 Arqule, Inc. Nouveaux composes de lapachone et procedes d'utilisation correspondants

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SUGIYAMA K ET AL: "ALDOSE REDUCTASE CATALYZES THE OXIDATION OF NAPHTHALENE-1,2- DIHYDRODIOL FOR THE FORMATION OF ORTHO-NAPHTHOQUINONE", DRUG METABOLISM AND DISPOSITION, WILLIAMS AND WILKINS., BALTIMORE, MD, US, vol. 27, no. 1, 1999, pages 60 - 67, XP002948478, ISSN: 0090-9556 *

Also Published As

Publication number Publication date
WO2006128120A2 (fr) 2006-11-30

Similar Documents

Publication Publication Date Title
WO2006107451A3 (fr) Derives d'honokiol pour traiter les maladies proliferantes
WO2004045557A3 (fr) Nouveaux composes de lapachone et procedes d'utilisation correspondants
WO2006124748A3 (fr) Composes polycycliques et procedes pour les utiliser
WO2007095124A3 (fr) Derives, compositions de benzazole et procedes d'utilisation en tant qu'inhibiteurs de la kinase aurora
WO2007064797A3 (fr) Inhibiteurs de c-met et leurs utilisations
WO2010078421A8 (fr) Composés de 5,6-dihydro-6-phénylbenzo[f]isoquinoléine-2-amines substituées
WO2006123113A3 (fr) Composes chimiques
WO2007044084A3 (fr) Inhibiteurs heterocycliques de mek et leurs procedes d'utilisation
WO2008064351A3 (fr) (r)-n-stéréoisomères d'analogues 4,5-époxy-morphinanium saturé en position 7 et 8
WO2007109279A3 (fr) Composes de tetrahydropyridothienopyrimidine et leurs procedes d'utilisation
WO2006086562A3 (fr) Derives de phenylazetidinone
EA025871B9 (ru) Ингибиторы mek и способы их применения
IL184898A0 (en) Pyrrolopyrimidine derivatives and pharmaceutical compositions containing the same
WO2007075895A3 (fr) Derives heterocycliques utilises comme modulateurs de canaux ioniques
EP1951729A4 (fr) Derives de pyrimidine a liaison oxygene
WO2006071960A3 (fr) Compositions et procedes de traitement de troubles de la proliferation cellulaire
WO2006034154A3 (fr) Sels de 5-azacytidine
WO2007087250A3 (fr) Inhibiteurs tricycliques de la 5-lipoxygenase
AU2005339139A8 (en) Pharmaceutical compositions and methods for treating or preventing oxalate-related disease
WO2008021038A3 (fr) Pyridobenzazépines et méthodes d'inhibition de la progression mitotique
PL2083809T3 (pl) Kompozycja dietetyczna lub farmaceutyczna zawierająca tricykliczne diterpeny do leczenia depresji
WO2010014253A3 (fr) Composés inhibiteurs d’ant4 et leurs procédés d’utilisation
WO2005086656A3 (fr) Derives d'heteroarylaminopyrazole utilises pour traiter le diabete
WO2008054808A3 (fr) Compositions pharmaceutiques d'elvucitabine
WO2004026253A3 (fr) Nouveaux composes de lapacho et procedes d'utilisation associes

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: RU

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC SENT ON 11-04-2008

122 Ep: pct application non-entry in european phase

Ref document number: 06771500

Country of ref document: EP

Kind code of ref document: A2