[go: up one dir, main page]

WO2006037105A3 - Polymeres diazeniumdiolates a base d'acrylonitrile liberant du monoxyde d'azote et compositions, dispositifs medicaux et utilisations correspondantes - Google Patents

Polymeres diazeniumdiolates a base d'acrylonitrile liberant du monoxyde d'azote et compositions, dispositifs medicaux et utilisations correspondantes Download PDF

Info

Publication number
WO2006037105A3
WO2006037105A3 PCT/US2005/035065 US2005035065W WO2006037105A3 WO 2006037105 A3 WO2006037105 A3 WO 2006037105A3 US 2005035065 W US2005035065 W US 2005035065W WO 2006037105 A3 WO2006037105 A3 WO 2006037105A3
Authority
WO
WIPO (PCT)
Prior art keywords
nitric oxide
releasing
acrylonitrile
medical devices
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/035065
Other languages
English (en)
Other versions
WO2006037105A2 (fr
Inventor
Joseph A Hrabie
Michael L Citro
Frank Derosa
Larry K Keefer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Priority to AU2005289414A priority Critical patent/AU2005289414B2/en
Priority to US11/576,012 priority patent/US7968664B2/en
Priority to EP05802080.1A priority patent/EP1794195B1/fr
Priority to CA2581939A priority patent/CA2581939C/fr
Publication of WO2006037105A2 publication Critical patent/WO2006037105A2/fr
Anticipated expiration legal-status Critical
Publication of WO2006037105A3 publication Critical patent/WO2006037105A3/fr
Priority to AU2011200972A priority patent/AU2011200972C1/en
Priority to US13/111,613 priority patent/US8093343B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux polymères libérant du monoxyde d'azote qui comprennent au moins deux unités adjacentes dérivées d'unités de monomères à base d'acrylonitrile et contenant au moins un diazéniumdiolate lié au carbone. Les polymères diazéniumdiolatés dérivés d'acrylonitrile peuvent être utilisés dans des dispositifs médicaux à des fins thérapeutiques. Par conséquent, l'invention concerne également une méthode de traitement d'un trouble biologique et une méthode de stimulation de l'angiogenèse qui consiste à administrer un dispositif médical comprenant un polymère libérant du monoxyde d'azote comprenant au moins deux unités adjacentes d'acrylonitrile avant une exposition au monoxyde d'azote et au moins un groupe N2O2- libérant du monoxyde d'azote, le groupe N2O2- étant directement lié au squelette du polyacrylonitrile, à un endroit spécifique situé sur ou dans un mammifère, en quantité efficace pour traiter le trouble biologique ou stimuler l'angiogenèse.
PCT/US2005/035065 2004-09-27 2005-09-27 Polymeres diazeniumdiolates a base d'acrylonitrile liberant du monoxyde d'azote et compositions, dispositifs medicaux et utilisations correspondantes Ceased WO2006037105A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2005289414A AU2005289414B2 (en) 2004-09-27 2005-09-27 Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof
US11/576,012 US7968664B2 (en) 2004-09-27 2005-09-27 Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof
EP05802080.1A EP1794195B1 (fr) 2004-09-27 2005-09-27 Polymeres diazeniumdiolates a base d'acrylonitrile liberant du monoxyde d'azote et compositions, dispositifs medicaux et utilisations correspondantes
CA2581939A CA2581939C (fr) 2004-09-27 2005-09-27 Polymeres diazeniumdiolates a base d'acrylonitrile liberant du monoxyde d'azote et compositions, dispositifs medicaux et utilisations correspondantes
AU2011200972A AU2011200972C1 (en) 2004-09-27 2011-03-04 Nitric oxide-releasing compounds and uses thereof
US13/111,613 US8093343B2 (en) 2004-09-27 2011-05-19 Nitric oxide-releasing diazeniumdiolated compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61325704P 2004-09-27 2004-09-27
US60/613,257 2004-09-27

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/576,012 A-371-Of-International US7968664B2 (en) 2004-09-27 2005-09-27 Nitric oxide-releasing diazeniumdiolated acrylonitrile-based polymers, and compositions, medical devices, and uses thereof
US13/111,613 Division US8093343B2 (en) 2004-09-27 2011-05-19 Nitric oxide-releasing diazeniumdiolated compounds

Publications (2)

Publication Number Publication Date
WO2006037105A2 WO2006037105A2 (fr) 2006-04-06
WO2006037105A3 true WO2006037105A3 (fr) 2007-10-04

Family

ID=35954003

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/035065 Ceased WO2006037105A2 (fr) 2004-09-27 2005-09-27 Polymeres diazeniumdiolates a base d'acrylonitrile liberant du monoxyde d'azote et compositions, dispositifs medicaux et utilisations correspondantes

Country Status (5)

Country Link
US (2) US7968664B2 (fr)
EP (1) EP1794195B1 (fr)
AU (2) AU2005289414B2 (fr)
CA (1) CA2581939C (fr)
WO (1) WO2006037105A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8282967B2 (en) 2005-05-27 2012-10-09 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
US8981139B2 (en) 2011-02-28 2015-03-17 The University Of North Carolina At Chapel Hill Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same
US9526738B2 (en) 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same
US9919072B2 (en) 2009-08-21 2018-03-20 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2555552A1 (fr) 2004-02-09 2005-09-09 Noxilizer, Inc. Molecules liberant du monoxyde d'azote
US7569559B2 (en) * 2004-02-09 2009-08-04 Noxilizer, Inc. Nitric oxide-releasing molecules
EP1896091B1 (fr) 2005-06-30 2011-06-22 Accord Biomaterials, Inc. Revetements d'oxyde nitrique pour dispositifs medicaux
US20080241208A1 (en) * 2005-06-30 2008-10-02 Charles Shanley Methods, Compositions and Devices For Promoting Anglogenesis
JP2009505727A (ja) 2005-08-25 2009-02-12 メドトロニック ヴァスキュラー インコーポレイテッド 医療機器及びそのコーティングとして有益な一酸化窒素放出生分解性ポリマー
US20070053952A1 (en) * 2005-09-07 2007-03-08 Medtronic Vascular, Inc. Nitric oxide-releasing polymers derived from modified polymers
WO2007126344A1 (fr) * 2006-04-27 2007-11-08 St. Jude Medical Ab Dispositif médical implantable à composition de libération
US8241619B2 (en) 2006-05-15 2012-08-14 Medtronic Vascular, Inc. Hindered amine nitric oxide donating polymers for coating medical devices
US7811600B2 (en) 2007-03-08 2010-10-12 Medtronic Vascular, Inc. Nitric oxide donating medical devices and methods of making same
US8273828B2 (en) 2007-07-24 2012-09-25 Medtronic Vascular, Inc. Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation
US8852640B2 (en) * 2008-07-03 2014-10-07 Ecole Polytechnique Federale De Lausanne (Epfl) Micelles for delivery of nitric oxide
US8158187B2 (en) 2008-12-19 2012-04-17 Medtronic Vascular, Inc. Dry diazeniumdiolation methods for producing nitric oxide releasing medical devices
US8709465B2 (en) 2009-04-13 2014-04-29 Medtronic Vascular, Inc. Diazeniumdiolated phosphorylcholine polymers for nitric oxide release
CA2835320A1 (fr) 2011-05-09 2012-11-15 Topical Therapeutic Agent (Tta) Ltd. Formulations topiques capturant l'oxyde nitrique
US20150174158A1 (en) 2012-03-07 2015-06-25 Advanced Inhalation Therapies (Ait) Ltd. Inhalation of nitric oxide for treating respiratory diseases
US9017653B2 (en) 2012-06-14 2015-04-28 The Board Of Regents Of The University Of Texas System Nitric oxide-releasing compositions and methods
AU2013292695B2 (en) * 2012-07-17 2017-04-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Nitric oxide-releasing diazeniumdiolated polyvinylpyrrolidone-based polymers, and compositions, medical devices, and uses thereof
CN106574005B (zh) * 2014-08-14 2020-07-21 罗门哈斯公司 具有可释放气体的聚合物
US20180243526A1 (en) 2015-09-09 2018-08-30 Advanced Inhalation Therapies (AIT), Ltd. Nitric oxide inhalation therapy for infants with bronchiolitis
CN107446096B (zh) * 2017-09-01 2020-08-04 中车唐山机车车辆有限公司 重金属离子多孔吸附剂及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991005551A1 (fr) * 1989-10-18 1991-05-02 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce Compositions anti-hypertensives et leur emploi
US5721365A (en) * 1989-09-15 1998-02-24 Us Health N-substituted piperazine NONOates
EP1300424A1 (fr) * 2001-10-04 2003-04-09 Medtronic AVE Inc. Polymères hautement réticulés et extrêmement hydrophobes libérant de l'oxyde nitrique, leurs procédés de préparation et leur utilisation
EP1308179A1 (fr) * 2001-10-30 2003-05-07 Boehringer Ingelheim Pharma GmbH & Co.KG Dispositif endoprothétique amélioré
WO2004012874A1 (fr) * 2002-08-02 2004-02-12 The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services Substrats reticules enduits de polyamine a liberation d'oxyde nitrique, compositions contenant ces substance s et methode de production associee

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1567710A (fr) 1967-06-07 1969-05-16
FR2073796A5 (fr) 1969-12-25 1971-10-01 Toray Industries
US4954526A (en) 1989-02-28 1990-09-04 The United States Of America As Represented By The Department Of Health And Human Services Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents
US5366997A (en) 1991-09-24 1994-11-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs
US5039705A (en) 1989-09-15 1991-08-13 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5208233A (en) 1989-09-15 1993-05-04 The United States Of America As Represented By The Department Of Health And Human Services Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof
US5155137A (en) 1990-09-20 1992-10-13 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Complexes of nitric oxide with polyamines
US5683668A (en) 1990-09-20 1997-11-04 The United States Of America As Represented By The Department Of Health And Human Services Method of generating nitric oxide gas using nitric oxide complexes
US5185376A (en) 1991-09-24 1993-02-09 The United States Of America As Represented By The Department Of Health And Human Services Therapeutic inhibition of platelet aggregation by nucleophile-nitric oxide complexes and derivatives thereof
US5389675A (en) 1992-03-27 1995-02-14 The United States Of America As Represented By The Department Of Health And Human Services Mixed ligand metal complexes of nitric oxide-nucleophile adducts useful as cardiovascular agents
US5814666A (en) 1992-04-13 1998-09-29 The United States As Represented By The Department Of Health And Human Services Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
US5272231A (en) * 1992-07-28 1993-12-21 General Electric Company Nitric oxide for vapor phase elimination of styrene and acrylonitrile popcorn polymer in bulk SAN production
US5525357A (en) * 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5632981A (en) 1992-08-24 1997-05-27 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US6200558B1 (en) 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5650447A (en) 1992-08-24 1997-07-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitric oxide-releasing polymers to treat restenosis and related disorders
US5691423A (en) * 1992-08-24 1997-11-25 The United States Of America As Represented By The Department Of Health And Human Services Polysaccharide-bound nitric oxide-nucleophile adducts
US5910316A (en) 1992-08-24 1999-06-08 The United States Of America, As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents to treat impotency
US5700830A (en) 1994-11-22 1997-12-23 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents for reducing metastasis risk
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US5674894A (en) * 1995-05-15 1997-10-07 G.D. Searle & Co. Amidine derivatives useful as platelet aggregation inhibitors and vasodilators
US5714511A (en) 1995-07-31 1998-02-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
CA2705474C (fr) 1996-09-27 2013-07-16 The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services Diazen-1-ium-1,2-diolates substitues en position 1 et glycosyles en position 02
DE69842142D1 (de) * 1997-07-03 2011-04-07 Us Gov Health & Human Serv Stickoxid freistetzende amidin- und enaminverwandte diazeniumdiolate, zubereitungen und verwendungen davon und verfahren zu ihrer herstellung
US6270779B1 (en) * 2000-05-10 2001-08-07 United States Of America Nitric oxide-releasing metallic medical devices
US6673338B1 (en) 2001-09-10 2004-01-06 The United States Of America As Represented By The Department Of Health And Human Services Nitric oxide-releasing imidate and thioimidate diazeniumdiolates, compositions, uses thereof and method of making same
EP1436018A1 (fr) 2001-09-26 2004-07-14 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Dispositifs medicaux revetus a liberation d'oxyde nitrique et leur procede de preparation
US6949530B2 (en) * 2002-07-18 2005-09-27 The United States Of America As Represented By The Department Of Health And Human Services Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same
US20050043585A1 (en) * 2003-01-03 2005-02-24 Arindam Datta Reticulated elastomeric matrices, their manufacture and use in implantable devices
CN101193623A (zh) * 2003-05-15 2008-06-04 柏尔迈瑞克斯公司 可植入的网状弹性基质的制造和应用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721365A (en) * 1989-09-15 1998-02-24 Us Health N-substituted piperazine NONOates
WO1991005551A1 (fr) * 1989-10-18 1991-05-02 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce Compositions anti-hypertensives et leur emploi
EP1300424A1 (fr) * 2001-10-04 2003-04-09 Medtronic AVE Inc. Polymères hautement réticulés et extrêmement hydrophobes libérant de l'oxyde nitrique, leurs procédés de préparation et leur utilisation
EP1308179A1 (fr) * 2001-10-30 2003-05-07 Boehringer Ingelheim Pharma GmbH & Co.KG Dispositif endoprothétique amélioré
WO2004012874A1 (fr) * 2002-08-02 2004-02-12 The Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services Substrats reticules enduits de polyamine a liberation d'oxyde nitrique, compositions contenant ces substance s et methode de production associee

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9403852B2 (en) 2005-05-27 2016-08-02 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8282967B2 (en) 2005-05-27 2012-10-09 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8956658B2 (en) 2005-05-27 2015-02-17 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US8962029B2 (en) 2005-05-27 2015-02-24 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US11691995B2 (en) 2005-05-27 2023-07-04 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US9403851B2 (en) 2005-05-27 2016-08-02 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
US9919072B2 (en) 2009-08-21 2018-03-20 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same
US11583608B2 (en) 2009-08-21 2023-02-21 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same
US9737561B2 (en) 2009-08-21 2017-08-22 Novan, Inc. Topical gels and methods of using the same
US10376538B2 (en) 2009-08-21 2019-08-13 Novan, Inc. Topical gels and methods of using the same
US9526738B2 (en) 2009-08-21 2016-12-27 Novan, Inc. Topical gels and methods of using the same
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
US9713652B2 (en) 2011-02-28 2017-07-25 The University Of North Carolina At Chapel Hill Nitric oxide-releasing S-nitrosothiol-modified silica particles and methods of making the same
US8981139B2 (en) 2011-02-28 2015-03-17 The University Of North Carolina At Chapel Hill Tertiary S-nitrosothiol-modified nitric—oxide-releasing xerogels and methods of using the same

Also Published As

Publication number Publication date
AU2011200972A1 (en) 2011-03-24
US20110282060A1 (en) 2011-11-17
EP1794195A2 (fr) 2007-06-13
AU2011200972C1 (en) 2012-05-24
US8093343B2 (en) 2012-01-10
AU2011200972B2 (en) 2012-01-12
US20070292471A1 (en) 2007-12-20
US7968664B2 (en) 2011-06-28
EP1794195B1 (fr) 2014-12-17
AU2005289414B2 (en) 2010-12-09
AU2005289414A1 (en) 2006-04-06
CA2581939C (fr) 2013-01-08
CA2581939A1 (fr) 2006-04-06
WO2006037105A2 (fr) 2006-04-06

Similar Documents

Publication Publication Date Title
WO2006037105A3 (fr) Polymeres diazeniumdiolates a base d'acrylonitrile liberant du monoxyde d'azote et compositions, dispositifs medicaux et utilisations correspondantes
ATE474563T1 (de) Hydrogelzusammensetzung zur transdermalen arzneistoffabgabe
WO2005081752A3 (fr) Polymeres liberant du monoxyde d'azote
ATE380553T1 (de) Aminpolymere zur behandlung von gicht und zur senkung des harnsäuregehaltes
ATE457166T1 (de) Orale zusammensetzungen zur behandlung von diabetes
CY1119486T1 (el) Χρηση πολυμερους αμινης για μειωση της γλυκοζης στον ορο
WO2006014607A3 (fr) Dispositifs medicaux contenant des copolymeres blocs resistant aux rayonnements
MD20020072A (en) Combination of antibiotic(s) - polymer and utilization there of
WO2005070008A3 (fr) Revetement en nanofibres de promedicament donneur de non polymerique pour des dispositifs medicaux et therapie associee
WO2008154482A3 (fr) Compositions d'arnsi et procédés d'utilisation dans le traitement de maladies oculaires
WO2007089435A3 (fr) Dispositifs médicaux destinés à l'administration d'agent thérapeutique et dotés de zones polymères qui contiennent des copolymères présentant à la fois des segments souples et des segments durs de même longueur
JP2007509902A5 (fr)
JP2007197470A5 (fr)
BR0307974A (pt) Composição anti-parasita
EP1753777A4 (fr) METHODES ET COMPOSITIONS POUR LE TRAITEMENT ET LA PREVENTION D'UNE INFECTION PAR LE VIH AU MOYEN DE TRIM5a
RU2003133217A (ru) Чрескожная терапевтическая система для лечения болезни паркинсона, индуцирующая высокие уровни ротиготина в плазме
PL2347723T3 (pl) Urządzenie do anastomozy
WO2007012012A3 (fr) Dispositifs medicaux contenant des polymeres resistants aux rayonnements
EP2076284A4 (fr) Procédés de traitement, de prévention et de diagnostic de l'infection à ttv chez le porc
CA2635603A1 (fr) Traitement de la xerostomie
NO20064050L (no) Anvendelse av agomelatin for a oppna medikamenter tiltenkt for behandlingen av sovnforstyrrelser i den deprimerte pasient
EE200200556A (et) Midodriini ja/või desglümidodriini sisaldav kontrollitud vabanemisega farmatseutiline kompositsioon
MX2023005154A (es) Nanopartículas codificadas de adn y método de uso de las mismas como una vacuna contra la enfermedad corona virus (covid-19).
DE60213669D1 (de) Bioabbaubares polymermaterial für biomedizinische anwendungen
BR0306960A (pt) Uso de composição polimérica no tratamento de doença gastrintestinal

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2581939

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2005802080

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2005289414

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2005289414

Country of ref document: AU

Date of ref document: 20050927

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2005289414

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 11576012

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2005802080

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 11576012

Country of ref document: US