[go: up one dir, main page]

WO2006034369A3 - Parapluies moleculaires sulfates en tant qu'agents anti-vih et anti-vhs - Google Patents

Parapluies moleculaires sulfates en tant qu'agents anti-vih et anti-vhs Download PDF

Info

Publication number
WO2006034369A3
WO2006034369A3 PCT/US2005/033880 US2005033880W WO2006034369A3 WO 2006034369 A3 WO2006034369 A3 WO 2006034369A3 US 2005033880 W US2005033880 W US 2005033880W WO 2006034369 A3 WO2006034369 A3 WO 2006034369A3
Authority
WO
WIPO (PCT)
Prior art keywords
hiv
derivative
units
sulfated
residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/033880
Other languages
English (en)
Other versions
WO2006034369A2 (fr
Inventor
Steven Regen
Betsy C Herold
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lehigh University
Icahn School of Medicine at Mount Sinai
Original Assignee
Lehigh University
Mount Sinai School of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lehigh University, Mount Sinai School of Medicine filed Critical Lehigh University
Priority to EP05800868A priority Critical patent/EP1817325B1/fr
Priority to DE602005012538T priority patent/DE602005012538D1/de
Publication of WO2006034369A2 publication Critical patent/WO2006034369A2/fr
Publication of WO2006034369A3 publication Critical patent/WO2006034369A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un genre chimique de cholestanes sulfatés attachés à un oligomère par l'intermédiaire de liaisons amide ou ester. Ces composés sont indiqués en tant qu'agents anti-viraux contre le virus de l'immunodéficience humaine (HIV) et contre le virus de l'herpès simplex (VHS). Ces composés présentent la formule générale n, ( formule n) dans laquelle CPS (la structure entre crochets) représente un dérivé d'acide cholanique. R1 à R16 sont choisis indépendamment les uns des autres parmi H, OH et OSO3-A+. W représente une liaison directe ou un résidu déshydrogène d'un diol ou d'un triol C3-C6. A est choisi parmi H+, une espèce ammonium quaternaire, et le cation d'un métal alcalin ou alcalino-terreux. Z représente une liaison directe ou un résidu d'un acide aminé, d'un peptide, ou d'un acide aminosulfonique. O représente une fraction possédant au moins n groupes -NH et -OH séparés par un maximum de 6 atomes de carbone, et n représente un nombre entier valant de 6 à 200.
PCT/US2005/033880 2004-09-21 2005-09-20 Parapluies moleculaires sulfates en tant qu'agents anti-vih et anti-vhs Ceased WO2006034369A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05800868A EP1817325B1 (fr) 2004-09-21 2005-09-20 Parapluies moleculaires sulfates contenant 6-200 acides cholariques (derives) en tant qu' agents anti-vih et anti-vhs
DE602005012538T DE602005012538D1 (de) 2004-09-21 2005-09-20 6-200 cholansäure(derivat)-einheiten enthaltende sulfatierte molekulare schirme als anti-hiv- und anti-hsv-mittel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61130604P 2004-09-21 2004-09-21
US60/611,306 2004-09-21

Publications (2)

Publication Number Publication Date
WO2006034369A2 WO2006034369A2 (fr) 2006-03-30
WO2006034369A3 true WO2006034369A3 (fr) 2006-06-01

Family

ID=35811741

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/033880 Ceased WO2006034369A2 (fr) 2004-09-21 2005-09-20 Parapluies moleculaires sulfates en tant qu'agents anti-vih et anti-vhs

Country Status (5)

Country Link
US (1) US20070232576A1 (fr)
EP (1) EP1817325B1 (fr)
AT (1) ATE421522T1 (fr)
DE (1) DE602005012538D1 (fr)
WO (1) WO2006034369A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7960439B1 (en) 2006-06-12 2011-06-14 Iowa State University Research Foundation, Inc. Environmentally sensitive foldable oligomers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6190650B1 (en) * 1994-06-15 2001-02-20 Biomolecular Research Institute Ltd. Antiviral dendrimers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583239A (en) * 1995-05-30 1996-12-10 Lehigh University Antimicrobial sterol conjugates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6190650B1 (en) * 1994-06-15 2001-02-20 Biomolecular Research Institute Ltd. Antiviral dendrimers

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BANDYOPADHYAY, JANOUT, ZHANG, REGEN: "Ion conductors derived from cholic acid and spermine: importance of facial hydrophilicity on Na+ transport and membrane selectivity", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 123, 2001, pages 7691 - 7696, XP002369338 *
JANOUT, STAINA, BANDYOPADHYAY, REGEN: "Evidence of an umbrella mechanism of bilayer transport", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 123, 2001, pages 9926 - 9927, XP002369339 *
JING, JANOUT, HEROLD, KLOTMAN HEALD, REGEN: "Persulfated molecular umbrellas as anti-HIV and anti-HSV agents", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, 18 November 2004 (2004-11-18), pages 15930 - 15931, XP002369337 *
REISING, BOURNE, EL-AWAR, STANBERRY: "Selective activity of cholic acid and related compounds against herpes simplex virus type 2.", 9TH INTERNATIONAL CONFERENCE ON ANTIVIRAL RESEARCH. ANTIVIRAL RESEARCH, 1996, pages A46, XP002369343 *

Also Published As

Publication number Publication date
EP1817325B1 (fr) 2009-01-21
US20070232576A1 (en) 2007-10-04
DE602005012538D1 (de) 2009-03-12
ATE421522T1 (de) 2009-02-15
EP1817325A2 (fr) 2007-08-15
WO2006034369A2 (fr) 2006-03-30

Similar Documents

Publication Publication Date Title
CA2175375A1 (fr) Disaccharides de glucosamine, leur procede de preparation, composition pharmaceutique les contenant, et leurs utilisations
DE69905181T2 (de) Antivirale purin-derivate
CA2227004A1 (fr) Compositions d'ecran solaire
DE59300819D1 (de) Aminoacrylate, ein Verfahren zu ihrer Herstellung und ihre Verwendung.
CA2371894A1 (fr) Recipient avec panneau reagissant a la pression
CA2417825A1 (fr) 6.alpha., 9.alpha.-difluoro-17.alpha.-`(2-furanylcarboxyle) oxy!-11.beta.-hydroxy-16.alpha.-methyle-3-oxo-androst-1,4,-diene-17-acide carbothioique s-fluoromethyle ester utilise comme agent anti inflammatoire
MX9701229A (es) Antifungicos de tetrahidrofurano.
AU693140B2 (en) Thickener for aqueous compositions
JP2016515099A5 (fr)
AU1428588A (en) Aqueous lamellar silicate dispersions, their use as lacquer auxiliaries, and water-dilutable coating compositions containing lamellar silicates
EP2863925B1 (fr) Dérivé d'acide sialique
HU229865B1 (en) Acyclic nucleoside derivatives
KR940004008A (ko) 광학재료용 조성물
WO2006034369A3 (fr) Parapluies moleculaires sulfates en tant qu'agents anti-vih et anti-vhs
IL41234A (en) Sterol sulfates are soluble in water
WO2003064548A3 (fr) Diluants reactifs et revetements comprenant ces diluants
WO2005059042A3 (fr) Tensioactif
TW200738832A (en) Radiation curable compositions
CA2028094A1 (fr) Copolymeres carbohydrateacryl- et methacryliques; procede de fabrication
WO2005092305A3 (fr) Ameliorations apportees a des composes destines a etre utilises dans le traitement du sida ou d'autres maladies virales et infections associees au vih et compositions contenant ces composes, methodes de traitement de ces maladies et de ces infections et methodes de fabrication de ces composes et de ces compositions
Oka et al. Sialyl α (2→ 3) lactose clusters using carbosilane dendrimer core scaffolds as influenza hemagglutinin blockers
CA2075288A1 (fr) Conjuguees d'anthracycline
WO2007110526A3 (fr) Nouveau procédé d'amélioration de la tolérance oculaire de compositions moussantes et/ou détergentes à usage cutané
EP0837124A3 (fr) Formulation d'agent de blanchiment fluorescent
Ouchi et al. Synthesis of acryloyl‐type polymer fixing 5‐fluorouracil residues through D‐glucofuranoses and its antitumor activity

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2005800868

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2005800868

Country of ref document: EP