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WO2006031683A3 - Compositions containing uridine, and methods utilizing same - Google Patents

Compositions containing uridine, and methods utilizing same

Info

Publication number
WO2006031683A3
WO2006031683A3 PCT/US2005/032312 US2005032312W WO2006031683A3 WO 2006031683 A3 WO2006031683 A3 WO 2006031683A3 US 2005032312 W US2005032312 W US 2005032312W WO 2006031683 A3 WO2006031683 A3 WO 2006031683A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions containing
methods utilizing
utilizing same
containing uridine
uridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/032312
Other languages
French (fr)
Other versions
WO2006031683A2 (en
Inventor
Richard J Wurtman
Carol Watkins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/941,025 external-priority patent/US20050203053A1/en
Priority claimed from US10/944,269 external-priority patent/US8143234B2/en
Priority claimed from US10/972,777 external-priority patent/US8314064B2/en
Priority to AU2005285090A priority Critical patent/AU2005285090A1/en
Priority to EP05796529A priority patent/EP1802314A4/en
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Priority to JP2007532388A priority patent/JP2008513453A/en
Priority to CA2579851A priority patent/CA2579851C/en
Publication of WO2006031683A2 publication Critical patent/WO2006031683A2/en
Publication of WO2006031683A3 publication Critical patent/WO2006031683A3/en
Priority to IL181810A priority patent/IL181810A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

The present invention is directed to methods of improving cognitive and neurological functions and increasing synthesis and release of neurotransmitters and membrane synthesis by neural cells and brain cells, comprising administering a composition comprising a uridine.
PCT/US2005/032312 2004-09-15 2005-09-13 Compositions containing uridine, and methods utilizing same Ceased WO2006031683A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2579851A CA2579851C (en) 2004-09-15 2005-09-13 Use of uridine for improving cognitive and neurological functions
JP2007532388A JP2008513453A (en) 2004-09-15 2005-09-13 Compositions containing uridine and methods of use thereof
AU2005285090A AU2005285090A1 (en) 2004-09-15 2005-09-13 Compositions containing uridine, and methods utilizing same
EP05796529A EP1802314A4 (en) 2004-09-15 2005-09-13 COMPOSITIONS CONTAINING URIDINE AND METHODS OF USE
IL181810A IL181810A0 (en) 2004-09-15 2007-03-08 Compositions containing uridine, and methods utilizing same

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10/941,025 2004-09-15
US10/941,025 US20050203053A1 (en) 1999-07-30 2004-09-15 Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function
US10/944,269 US8143234B2 (en) 1998-07-31 2004-09-20 Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function
US10/944,269 2004-09-20
US10/972,777 US8314064B2 (en) 1998-07-31 2004-10-26 Uridine administration stimulates membrane production
US10/972,777 2004-10-26

Publications (2)

Publication Number Publication Date
WO2006031683A2 WO2006031683A2 (en) 2006-03-23
WO2006031683A3 true WO2006031683A3 (en) 2006-12-21

Family

ID=36060581

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/032312 Ceased WO2006031683A2 (en) 2004-09-15 2005-09-13 Compositions containing uridine, and methods utilizing same

Country Status (6)

Country Link
EP (1) EP1802314A4 (en)
JP (2) JP2008513453A (en)
CN (1) CN102600199A (en)
AU (1) AU2005285090A1 (en)
CA (1) CA2579851C (en)
WO (1) WO2006031683A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8143234B2 (en) 1998-07-31 2012-03-27 Massachusetts Institute Of Technology Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function
US8314064B2 (en) 1998-07-31 2012-11-20 Massachusetts Institute Of Technology Uridine administration stimulates membrane production
US8518882B2 (en) 1998-07-31 2013-08-27 Massachusetts Institute Of Technology Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same
WO2006031683A2 (en) * 2004-09-15 2006-03-23 Massachusetts Institute Of Technology Compositions containing uridine, and methods utilizing same
EP2689782B1 (en) * 2007-06-26 2020-05-13 N.V. Nutricia Improving memory in subjects with mini-mental state examination of 24-26
WO2009002145A1 (en) 2007-06-26 2008-12-31 N.V. Nutricia Lipid composition for improving function of brain functioning
WO2009002146A1 (en) 2007-06-26 2008-12-31 N.V. Nutricia Supporting activities of daily living
WO2009002148A1 (en) 2007-06-27 2008-12-31 N.V. Nutricia Food composition for prodromal dementia patients
WO2009057994A1 (en) 2007-11-02 2009-05-07 N.V. Nutricia Unit dosage for brain health
RU2446807C2 (en) * 2007-12-20 2012-04-10 Н.В. Нютрисиа Liquid product containing nucleotides/nucleosides
WO2012125020A1 (en) 2011-03-14 2012-09-20 N.V. Nutricia Method for treating neurotrauma
TWI640533B (en) * 2013-03-13 2018-11-11 美國金繐大學 Uridine nucleoside derivatives, compositions and methods of use
CN106822393A (en) * 2017-02-17 2017-06-13 福建康是美生物科技有限公司 A kind of health-caring capsule for strengthening memory
WO2019152776A1 (en) * 2018-02-01 2019-08-08 Wellstat Therapeutics Corporation Compositions and devices for systemic delivery of uridine
CN115120607A (en) * 2022-06-07 2022-09-30 珍奥集团股份有限公司 Application of nucleotide mixture in preparation for preventing and treating Alzheimer's disease
CN120225075A (en) * 2022-09-16 2025-06-27 雅玛山酱油株式会社 Agent and method for improving comprehensive memory of healthy people
CN115737666B (en) * 2022-11-24 2024-03-26 暨南大学 Application of uridine diphosphate glucose in preparation of anti-aging products

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010005719A1 (en) * 1998-08-31 2001-06-28 Von Borstel Reid W. Compositions and methods for treatment of mitochondrial diseases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3011A (en) * 1843-03-21 Improvement in water-wheels
CA2255748C (en) * 1996-05-28 2002-12-03 Polifarma S.P.A. Uridine-comprising therapeutic active agent for treatment of neurodegenerative disorders
IT1290781B1 (en) * 1996-05-28 1998-12-10 Polifarma Spa ACTIVE THERAPEUTIC AGENT FOR THE TREATMENT OF NEURONAL DEGENERATIVE DISEASES.
ES2294850T3 (en) * 1998-07-31 2008-04-01 Massachusetts Institute Of Technology TREATMENT OF ALZHEIMER'S DISEASE THROUGH THE INCREASE OF THE LEVELS OF IN VIVO.
JP2001233776A (en) * 2000-02-25 2001-08-28 Yamasa Shoyu Co Ltd Agent for improving lowering of learning and memorizing ability and its use
US20030114415A1 (en) * 2001-12-14 2003-06-19 Wurtman Richard J. Compositions and methods for treating and preventing memory impairment using citicoline
US7829332B2 (en) * 2004-02-13 2010-11-09 Cornell Research Foundation, Inc. Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom
BRPI0510857A (en) * 2004-05-13 2007-12-26 Massachusetts Inst Technology effects of uridine on dopamine release
WO2006031683A2 (en) * 2004-09-15 2006-03-23 Massachusetts Institute Of Technology Compositions containing uridine, and methods utilizing same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010005719A1 (en) * 1998-08-31 2001-06-28 Von Borstel Reid W. Compositions and methods for treatment of mitochondrial diseases

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Chapter 63 Goodman & gilmans's The Pharmacological Basis of Therapeutics", vol. 8TH ED., 1990, PERGAMON PRESS, ELMSFORD, NY, article MARCUS ET AL.: "Water Soluble Vitamins", pages: 1530, XP008074108 *
See also references of EP1802314A4 *
SITARAM ET AL.: "Human Serial Learning: Enhancement with Arecholine and Choline and Impairment with Scopolamine", SCIENCE, vol. 201, 21 July 1978 (1978-07-21), pages 274 - 276, XP003004900 *

Also Published As

Publication number Publication date
JP6141643B2 (en) 2017-06-07
CN102600199A (en) 2012-07-25
WO2006031683A2 (en) 2006-03-23
CA2579851A1 (en) 2006-03-23
EP1802314A2 (en) 2007-07-04
JP2013064026A (en) 2013-04-11
EP1802314A4 (en) 2011-02-23
JP2008513453A (en) 2008-05-01
CA2579851C (en) 2018-09-04
AU2005285090A1 (en) 2006-03-23

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