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WO2006031371A3 - A method for producing non-human transgenic primates - Google Patents

A method for producing non-human transgenic primates Download PDF

Info

Publication number
WO2006031371A3
WO2006031371A3 PCT/US2005/029532 US2005029532W WO2006031371A3 WO 2006031371 A3 WO2006031371 A3 WO 2006031371A3 US 2005029532 W US2005029532 W US 2005029532W WO 2006031371 A3 WO2006031371 A3 WO 2006031371A3
Authority
WO
WIPO (PCT)
Prior art keywords
human transgenic
producing non
primates
transgenic primates
human primates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/029532
Other languages
French (fr)
Other versions
WO2006031371A2 (en
Inventor
William W Hauswirth
Jorg Bungert
Kenneth Berns
Don P Wolf
Martha Neuringer
Shoukhrat Mitalipov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Florida
Original Assignee
University of Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Florida filed Critical University of Florida
Publication of WO2006031371A2 publication Critical patent/WO2006031371A2/en
Anticipated expiration legal-status Critical
Publication of WO2006031371A3 publication Critical patent/WO2006031371A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/106—Primate
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to transgenic non-human primates. The invention further relates to methods of making chromosomally targeted transgenic non-human primates.
PCT/US2005/029532 2004-08-19 2005-08-18 A method for producing non-human transgenic primates Ceased WO2006031371A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60281204P 2004-08-19 2004-08-19
US60/602,812 2004-08-19

Publications (2)

Publication Number Publication Date
WO2006031371A2 WO2006031371A2 (en) 2006-03-23
WO2006031371A3 true WO2006031371A3 (en) 2007-04-19

Family

ID=36060491

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/029532 Ceased WO2006031371A2 (en) 2004-08-19 2005-08-18 A method for producing non-human transgenic primates

Country Status (1)

Country Link
WO (1) WO2006031371A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113881708B (en) * 2021-01-05 2024-08-06 清华大学 Method for electrically transfecting gene editing of animal fertilized egg and application thereof
CA3209115A1 (en) * 2021-01-25 2022-07-28 Prevail Therapeutics, Inc. Modulation of aav-based gene expression

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D. KIRIK ET AL: "Nigrostriatal Alpha-Synucleinopathy induced by viral Vector-Mediated overexpression of human Alpha-Synuclein: A new primate model of Parkinson's disease", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (USA), vol. 100, no. 5, 4 March 2003 (2003-03-04), pages 2884 - 2889, XP003010908 *
HUTTNER ET AL: "Analysis of site-specific transgene integration following cotransduction with recombinant adeno-associated virus and a Rep encoding plasmid", THE JOURNAL OF GENE MEDICINE, vol. 5, 2003, pages 120 - 129, XP003010910 *
T. OKADA ET AL: "Adeno-Associated Virus Vectors for Gene Transfer to the Brain", METHODES, vol. 28, 2000, pages 237 - 247, XP003010909 *

Also Published As

Publication number Publication date
WO2006031371A2 (en) 2006-03-23

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