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WO2006021399A3 - Azabicyclononene derivatives as renin inhibitors - Google Patents

Azabicyclononene derivatives as renin inhibitors Download PDF

Info

Publication number
WO2006021399A3
WO2006021399A3 PCT/EP2005/009045 EP2005009045W WO2006021399A3 WO 2006021399 A3 WO2006021399 A3 WO 2006021399A3 EP 2005009045 W EP2005009045 W EP 2005009045W WO 2006021399 A3 WO2006021399 A3 WO 2006021399A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
azabicyclononene
renin inhibitors
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/009045
Other languages
French (fr)
Other versions
WO2006021399A2 (en
Inventor
Olivier Bezencon
Christoph Boss
Daniel Bur
Olivier Corminboeuf
Walter Fischli
Corinna Grisostomi
Lubos Remen
Sylvia Richard
Thierry Sifferlen
Thomas Weller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Actelion Pharmaceuticals Ltd
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of WO2006021399A2 publication Critical patent/WO2006021399A2/en
Publication of WO2006021399A3 publication Critical patent/WO2006021399A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to novel bicyclononene derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
PCT/EP2005/009045 2004-08-25 2005-08-22 Azabicyclononene derivatives as renin inhibitors Ceased WO2006021399A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2004009475 2004-08-25
EPPCT/EP2004/009475 2004-08-25

Publications (2)

Publication Number Publication Date
WO2006021399A2 WO2006021399A2 (en) 2006-03-02
WO2006021399A3 true WO2006021399A3 (en) 2006-10-26

Family

ID=35967900

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/009045 Ceased WO2006021399A2 (en) 2004-08-25 2005-08-22 Azabicyclononene derivatives as renin inhibitors

Country Status (1)

Country Link
WO (1) WO2006021399A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1908763A1 (en) * 2006-10-04 2008-04-09 Speedel Experimenta AG Bicyclic compounds
JP2010527942A (en) 2007-05-24 2010-08-19 メルク フロスト カナダ リミテツド A new class of renin inhibitors
US8334308B2 (en) 2007-08-20 2012-12-18 Merck Sharp & Dohme Corp. Renin inhibitors
MY152042A (en) 2008-05-05 2014-08-15 Actelion Pharmaceuticals Ltd 3,4- substituted piperidine derivatives as renin inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003093267A1 (en) * 2002-04-29 2003-11-13 Actelion Pharmaceuticals Ltd 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases
WO2004105762A1 (en) * 2003-05-30 2004-12-09 Actelion Pharmaceuticals Ltd Medical use of diazabicyclononene derivatives as inhibitors of parasite aspartic proteases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003093267A1 (en) * 2002-04-29 2003-11-13 Actelion Pharmaceuticals Ltd 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardiovascular or renal diseases
WO2004105762A1 (en) * 2003-05-30 2004-12-09 Actelion Pharmaceuticals Ltd Medical use of diazabicyclononene derivatives as inhibitors of parasite aspartic proteases

Also Published As

Publication number Publication date
WO2006021399A2 (en) 2006-03-02

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