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WO2006020509A1 - Container system - Google Patents

Container system Download PDF

Info

Publication number
WO2006020509A1
WO2006020509A1 PCT/US2005/027872 US2005027872W WO2006020509A1 WO 2006020509 A1 WO2006020509 A1 WO 2006020509A1 US 2005027872 W US2005027872 W US 2005027872W WO 2006020509 A1 WO2006020509 A1 WO 2006020509A1
Authority
WO
WIPO (PCT)
Prior art keywords
bottle
tip
container system
neck
nozzle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/027872
Other languages
French (fr)
Inventor
Scott J. Gerondale
Lon T. Spada
Paul T. Butorac
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Priority to JP2007525678A priority Critical patent/JP2008509852A/en
Priority to BRPI0514302-0A priority patent/BRPI0514302A/en
Priority to EP05779592A priority patent/EP1776279A1/en
Priority to CA002576457A priority patent/CA2576457A1/en
Priority to AU2005273992A priority patent/AU2005273992A1/en
Publication of WO2006020509A1 publication Critical patent/WO2006020509A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Rigid or semi-rigid containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material or by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
    • B65D1/023—Neck construction
    • B65D1/0246—Closure retaining means, e.g. beads, screw-threads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers

Definitions

  • the present invention generally relates to dropper bottles for dispensing of medicaments in droplet form and is more particularly directed to a container system for dispensing medicaments in less than 100 ml volumes with precise and uniform droplets.
  • dropwise container systems have typically included nozzles that are press fitted or otherwise inserted into a neck portion of a squeeze bottle.
  • squeeze bottle In operation, squeeze bottle is inverted and manually squeezed by a user to dispense one or more drops through the nozzle.
  • the container system When medicament delivery when the medicament is fully dispensed, the container system is typically discarded.
  • resilient squeeze bottles often have substantial drop-to-drop volume variation when dispensing one or more drops in volumes of less than 100 ml, particularly in the 10 to 50 ml range.
  • This variation may be due to a bubble formation on interior surfaces of the bottle when the bottle is inverted so that drops, particularly eye drop medication, are dispensed unevenly. Such adhered bubbles may be prevalent in square shoulder bottles and nozzles having areas which promote such bubble formation. In addition, in view of the popularity of tamper proof bottles, it is desirable to facilitate the installation of such tamper proof systems.
  • a container system in accordance with the present invention generally includes a squeeze bottle of a specific volume having a neck with an open end and a medicament disposed within the bottle.
  • a tip fixable to the open end and includes internal tapered nozzle with the nozzle having increased diameter toward a tip opening.
  • a cap is provided for removably sealing the tip opening by attachment to the bottleneck.
  • the container system in accordance with the present invention may include a tip face surrounding the tip opening with a face width to control the uniformity and size of the droplets formed at the tip opening by squeezing of the bottle.
  • the face width may be between about 0.015 inches and about 0.060 inches with the specific volume of the bottle of between about 5 ml and about 15 ml.
  • the container system in accordance with the present invention provides droplet sizes between about 10 ml and about 50 ml.
  • Figure 1 is a side view of a 5 ml bottle in accordance with the present invention generally showing a neck with an open end and a shoulder formed into the bottle proximate the neck having an angle of between about 45° and 50° to a bottle centerline;
  • Figure 2 is a top view of the bottle shown in Figure 1;
  • Figure 3 is a cross sectional view of the bottle shown in Figure 2 taken along the line 3-3;
  • Figure 4 is an enlarged view of the bottleneck shown in Figures 1 and 3;
  • Figure 5 is a side view of a 10 ml bottle in accordance with the present invention.
  • Figure 6 is a top view of the bottle shown in Figure 5;
  • Figure 7 is a cross sectional view of the bottle shown in Figure 6 taken along the line 7-7;
  • Figure 8 is a side view of a 15 ml bottle in accordance with the present invention.
  • Figure 9 is a top view of the bottle shown in Figure 8.
  • Figure 10 is a cross sectional view taken along the line 10-10 of Figure 9;
  • Figure 11 is a side view of a tip in accordance with the present invention for insertion into the neck of the bottle of the present invention
  • Figure 12 is a top view of the tip shown in Figure 11;
  • Figure 13 is a bottom view of the tip shown in Figure 11;
  • Figure 14 is a cross sectional view of the tip shown in Figure 13 taken along the line 14-14 and showing an internal nozzle and a face surrounding a tip opening;
  • FIG. 15 is a side view of another tip in accordance with the present invention.
  • Figure 16 is a top view of the tip shown in Figure 15;
  • Figure 17 is a bottom view of the tip shown in Figure 15;
  • Figure 18 is a cross sectional view taken along the line 18-18 of Figure 17 showing a larger face surrounding a tip opening and an internal nozzle;
  • Figure 19 is a side view of a cap suitable for closure of the tips and bottles of the present invention.
  • Figure 20 is a top view of the cap shown in Figure 19;
  • Figure 21 is a bottom view of the cap shown in Figure 19;
  • Figure 22 is a cross sectional view of the cap taken along the line 20-22 of Figure 21;
  • Figure 23 is a side view of an assembled bottle and cap along with a taper proof seal .
  • FIG. 1-3 there is shown a squeeze bottle 10 in accordance with the present invention having a neck 14 with an open end 16, see also Figure 4, which is an enlarged view of the neck 14 of the bottle 10 in accordance with the present invention.
  • the bottle 10 may be formed from a suitable material, such as, for example, low-density polyethylene.
  • the bottle 10 has a specific volume of 5 ml for containing a medicament 20 suitable for installation into an eye, not shown, by droplet formation, as will be hereinafter discussed in greater detail.
  • FIGS 5-7 illustrate a bottle 24 in accordance with the present invention similar to that shown in Figures 1-3 with the bottle 24 having a specific volume of 10 ml and a neck 26 with an opening 28 therein.
  • Figures 8-10 illustrate a bottle 32 in accordance with the present invention which has a specific volume of 15 ml along with a neck 34, an opening 36.
  • a tip 40 in accordance with the present invention includes a base 42 sized for insertion into the bottleneck opening 16 and includes an internal tapered nozzle 46 having increased diameter toward a tip opening 50.
  • each of the bottles 10, 24, 32 include shoulders 50, 52, 54 proximate necks 14, 26, 34 and disposed at an angle of between about 45° and about 50° to bottle centerlines 58, 60, 62, with an angle of 47° in 30 seconds being shown as a specific example.
  • This shoulder angle enhances bubbless flow of medicament 20 to the nozzle 46.
  • Figures 15-18 illustrate another nozzle 66 in accordance with the present invention including a base 68 sized for insertion into openings 16, 28, 34 and including an internal nozzle 70 similar to the nozzle 46 of the tip 40.
  • each include tip faces 72, 74 respectively surrounding openings 50, 80 respectively and having different surface areas, or face widths.
  • the face width is about 0.015 inches while with the tip 66 the face width is about 0.060 inches. While only two tips 40, 66 being shown, it should be appreciated that similar tips having different tip face width dimensions are to be considered within the scope of the present invention and taken in combination with various bottle sizes, such as, for example, 5 ml, 10 ml, and 15 ml illustrated by the bottles 10, 24, 32 enable the control dropwise dispensing of medicament 20 with droplet sizes between less than 10 ⁇ l and about 50 ⁇ l, preferably between about 8-12 ⁇ l . A greater face area provides for a larger droplet size.
  • a cap 80 formed from a suitable material having internal threads 82 for engaging a neck threads 84, see Figures 1 and 3 for example, and sealing the tip opening 50 with a convex surface 88.
  • FIG. 23 An assembled container system 92 is shown in Figure 23 along with a tamper proof seal 96.
  • the sloped shoulder 50 facilitates the application of the seal 96 and enables a larger surface of the bottle 10 upper surface 100 to be sealed along with the cap 80 in order to provide a more secure tamper proof seal 96.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Ceramic Engineering (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

A container system includes a squeeze bottle (10) of a specific volume having a neck (14) with an open end (16) and a medicament disposed within the bottle. A tip (40) is provided which is insertable into the open end of the squeezable bottle and includes an internal tapered nozzle with the nozzle (46) having increased diameter toward a tip opening (50). A cap (80) is provided for removable attachment to the bottleneck for sealing the tip opening and a shoulder (50) formed in the bottle proximate the neck and disposed at an angle is provided in order to enhance bubbless flow of the medicament to the nozzle and facilitate tamper proof sealing of the cap.

Description

CONTAINER SYSTEM
The present invention generally relates to dropper bottles for dispensing of medicaments in droplet form and is more particularly directed to a container system for dispensing medicaments in less than 100 ml volumes with precise and uniform droplets.
Heretofore, dropwise container systems have typically included nozzles that are press fitted or otherwise inserted into a neck portion of a squeeze bottle.
In operation, squeeze bottle is inverted and manually squeezed by a user to dispense one or more drops through the nozzle. When medicament delivery when the medicament is fully dispensed, the container system is typically discarded.
Heretofore, resilient squeeze bottles often have substantial drop-to-drop volume variation when dispensing one or more drops in volumes of less than 100 ml, particularly in the 10 to 50 ml range.
This variation may be due to a bubble formation on interior surfaces of the bottle when the bottle is inverted so that drops, particularly eye drop medication, are dispensed unevenly. Such adhered bubbles may be prevalent in square shoulder bottles and nozzles having areas which promote such bubble formation. In addition, in view of the popularity of tamper proof bottles, it is desirable to facilitate the installation of such tamper proof systems.
Accordingly, there is a need for an improved container system for providing a uniform dropwise dispensing of medication.
SUMMARY OF THE INVENTION
A container system in accordance with the present invention generally includes a squeeze bottle of a specific volume having a neck with an open end and a medicament disposed within the bottle.
A tip fixable to the open end and includes internal tapered nozzle with the nozzle having increased diameter toward a tip opening.
A cap is provided for removably sealing the tip opening by attachment to the bottleneck.
A shoulder formed into the bottle proximate the neck and disposed at an angle of between about 45° and about 50° to a bottle centerline, is provided in order to both enhance bubbless flow of medicament to the nozzle and facilitate tamper proof sealing of the cap. More particularly, the container system in accordance with the present invention may include a tip face surrounding the tip opening with a face width to control the uniformity and size of the droplets formed at the tip opening by squeezing of the bottle. In that regard, the face width may be between about 0.015 inches and about 0.060 inches with the specific volume of the bottle of between about 5 ml and about 15 ml.
Preferably, the container system in accordance with the present invention provides droplet sizes between about 10 ml and about 50 ml.
BRIEF DESCRIPTION OF THE DRAWINGS
The advantages and features of the present invention will be better understood by the following description when considered in conjunction with the accompanying drawings in which:
Figure 1 is a side view of a 5 ml bottle in accordance with the present invention generally showing a neck with an open end and a shoulder formed into the bottle proximate the neck having an angle of between about 45° and 50° to a bottle centerline;
Figure 2 is a top view of the bottle shown in Figure 1; Figure 3 is a cross sectional view of the bottle shown in Figure 2 taken along the line 3-3;
Figure 4 is an enlarged view of the bottleneck shown in Figures 1 and 3;
Figure 5 is a side view of a 10 ml bottle in accordance with the present invention;
Figure 6 is a top view of the bottle shown in Figure 5;
Figure 7 is a cross sectional view of the bottle shown in Figure 6 taken along the line 7-7;
Figure 8 is a side view of a 15 ml bottle in accordance with the present invention;
Figure 9 is a top view of the bottle shown in Figure 8;
Figure 10 is a cross sectional view taken along the line 10-10 of Figure 9;
Figure 11 is a side view of a tip in accordance with the present invention for insertion into the neck of the bottle of the present invention;
Figure 12 is a top view of the tip shown in Figure 11;
Figure 13 is a bottom view of the tip shown in Figure 11; Figure 14 is a cross sectional view of the tip shown in Figure 13 taken along the line 14-14 and showing an internal nozzle and a face surrounding a tip opening;
Figure 15 is a side view of another tip in accordance with the present invention;
Figure 16 is a top view of the tip shown in Figure 15;
Figure 17 is a bottom view of the tip shown in Figure 15;
Figure 18 is a cross sectional view taken along the line 18-18 of Figure 17 showing a larger face surrounding a tip opening and an internal nozzle;
Figure 19 is a side view of a cap suitable for closure of the tips and bottles of the present invention;
Figure 20 is a top view of the cap shown in Figure 19;
Figure 21 is a bottom view of the cap shown in Figure 19;
Figure 22 is a cross sectional view of the cap taken along the line 20-22 of Figure 21; and
Figure 23 is a side view of an assembled bottle and cap along with a taper proof seal . DETAILED DESCRIPTION
With reference to Figures 1-3, there is shown a squeeze bottle 10 in accordance with the present invention having a neck 14 with an open end 16, see also Figure 4, which is an enlarged view of the neck 14 of the bottle 10 in accordance with the present invention.
The bottle 10 may be formed from a suitable material, such as, for example, low-density polyethylene. The bottle 10 has a specific volume of 5 ml for containing a medicament 20 suitable for installation into an eye, not shown, by droplet formation, as will be hereinafter discussed in greater detail.
Figures 5-7 illustrate a bottle 24 in accordance with the present invention similar to that shown in Figures 1-3 with the bottle 24 having a specific volume of 10 ml and a neck 26 with an opening 28 therein.
Figures 8-10 illustrate a bottle 32 in accordance with the present invention which has a specific volume of 15 ml along with a neck 34, an opening 36.
As illustrated in Figures 12-14, a tip 40 in accordance with the present invention includes a base 42 sized for insertion into the bottleneck opening 16 and includes an internal tapered nozzle 46 having increased diameter toward a tip opening 50. With reference again to Figures 1, 3, 5, 7, 8, and 10 each of the bottles 10, 24, 32 include shoulders 50, 52, 54 proximate necks 14, 26, 34 and disposed at an angle of between about 45° and about 50° to bottle centerlines 58, 60, 62, with an angle of 47° in 30 seconds being shown as a specific example.
This shoulder angle enhances bubbless flow of medicament 20 to the nozzle 46.
Figures 15-18 illustrate another nozzle 66 in accordance with the present invention including a base 68 sized for insertion into openings 16, 28, 34 and including an internal nozzle 70 similar to the nozzle 46 of the tip 40.
In comparing the tip 46 and 68, it can be seen that each include tip faces 72, 74 respectively surrounding openings 50, 80 respectively and having different surface areas, or face widths.
In the case of tip 40, the face width is about 0.015 inches while with the tip 66 the face width is about 0.060 inches. While only two tips 40, 66 being shown, it should be appreciated that similar tips having different tip face width dimensions are to be considered within the scope of the present invention and taken in combination with various bottle sizes, such as, for example, 5 ml, 10 ml, and 15 ml illustrated by the bottles 10, 24, 32 enable the control dropwise dispensing of medicament 20 with droplet sizes between less than 10μl and about 50μl, preferably between about 8-12 μl . A greater face area provides for a larger droplet size.
With reference to Figures 19-22, there is shown a cap 80, formed from a suitable material having internal threads 82 for engaging a neck threads 84, see Figures 1 and 3 for example, and sealing the tip opening 50 with a convex surface 88.
An assembled container system 92 is shown in Figure 23 along with a tamper proof seal 96. Importantly, the sloped shoulder 50 facilitates the application of the seal 96 and enables a larger surface of the bottle 10 upper surface 100 to be sealed along with the cap 80 in order to provide a more secure tamper proof seal 96.
Although there has been hereinabove described a specific container system in accordance with the present invention for the purpose of illustrating the manner in which the invention may be used to advantage, it should be appreciated that the invention is not limited thereto. That is, the present invention may suitably comprise, consist of, or consist essentially of the recited elements. Further, the invention illustratively disclosed herein suitably may be practiced in the absence of any element which is not specifically disclosed herein. Accordingly, any and all modifications, variations or equivalent arrangements which may occur to those skilled in the art, should be considered to be within the scope of the present invention as defined in the appended claims.

Claims

WHAT IS CLAIMED IS:
1. A container system comprising: a squeeze bottle of a specific volume having a neck with an open end; a medicament disposed in the bottle; a tip insertable into said open end and having an internal tapered nozzle, the nozzle having increased diameter toward a tip opening; a cap for removable attachment to the bottle neck for sealing said tip opening; a shoulder formed into the bottle proximate said neck and disposed at an angle of between about 45° and about
50° to a bottle centerline in order to enhance bubbless flow of medicament to the nozzle and facilitate tamper proof sealing of said cap.
2. The container system according to claim 1 further comprises a tip face surrounding said tip opening with a face width to control uniformity and size of medicament droplets formed at said tip opening by squeezing of the bottle.
3. The container system according to claim 2 wherein said face width is between about 0.015 inches and about 0.060 inches and the specific volume is between about 5 ml and about 15 ml.
4. The container system according to claim 3 wherein the droplet size is between about lOμl and about 50μl.
5. A container system comprising: a squeeze bottle of a specific volume having a neck with an open end; a medicament disposed in the bottle; a tip insertable into said open end and having an internal tapered nozzle, the nozzle having increased diameter toward a tip opening, said tip including a face surrounding said tip opening with a face width to control uniformity and size of medicament droplets formed at said tip opening by- squeezing of the bottle; and a threaded cap for removable attachment to the bottleneck for sealing said tip opening.
6. The container system according to claim 5 wherein said face width is between about 0.015 inches and about 0.060 inches and the specific volume is between about 5 ml about 15 ml.
7. The container system according to claim 6 wherein the droplet size is between about lOμl and about 50μl.
8. The container system according to claim 5 further comprising a shoulder formed into the bottle proximate said neck and disposed at an angle of between about 45° and about 50° to a bottle centerline in order to enhance bubbless flow of medicament to the nozzle and facilitate tamper proof sealing of said cap to said neck.
PCT/US2005/027872 2004-08-11 2005-08-05 Container system Ceased WO2006020509A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2007525678A JP2008509852A (en) 2004-08-11 2005-08-05 Container device
BRPI0514302-0A BRPI0514302A (en) 2004-08-11 2005-08-05 container system
EP05779592A EP1776279A1 (en) 2004-08-11 2005-08-05 Container system
CA002576457A CA2576457A1 (en) 2004-08-11 2005-08-05 Container system
AU2005273992A AU2005273992A1 (en) 2004-08-11 2005-08-05 Container system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/916,067 2004-08-11
US10/916,067 US20060032873A1 (en) 2004-08-11 2004-08-11 Container system

Publications (1)

Publication Number Publication Date
WO2006020509A1 true WO2006020509A1 (en) 2006-02-23

Family

ID=35447809

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/027872 Ceased WO2006020509A1 (en) 2004-08-11 2005-08-05 Container system

Country Status (7)

Country Link
US (1) US20060032873A1 (en)
EP (1) EP1776279A1 (en)
JP (1) JP2008509852A (en)
AU (1) AU2005273992A1 (en)
BR (1) BRPI0514302A (en)
CA (1) CA2576457A1 (en)
WO (1) WO2006020509A1 (en)

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Publication number Priority date Publication date Assignee Title
TWI765049B (en) * 2017-05-30 2022-05-21 日商夏普股份有限公司 Semiconductor device and method for manufacturing the same

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US8485378B2 (en) * 2009-04-08 2013-07-16 General Mills, Inc. Multi-container packages for dispensing liquid and dry food
WO2011143093A2 (en) * 2010-05-10 2011-11-17 Dr. Reddy's Laboratories Ltd. Ophthalmic dispensing device
EP3105138B1 (en) * 2014-02-13 2019-12-25 Obrist Closures Switzerland GmbH A tamper-evident closure
JP6305911B2 (en) * 2014-12-12 2018-04-04 株式会社無有 Perfume container
PE20160759A1 (en) * 2015-06-09 2016-07-28 Gonzalez Sierra Andres Fernando IMPROVED DOSING SYSTEM
US10723526B1 (en) * 2019-03-29 2020-07-28 Chubby Gorilla, Inc. Bottle and cap arrangement
EP4190303A1 (en) * 2021-12-01 2023-06-07 Wirthwein Medical GmbH & Co. KG Medication container
USD1073472S1 (en) * 2022-04-13 2025-05-06 Chubby Gorilla, Inc. Bottle

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EP0431885A1 (en) * 1989-12-08 1991-06-12 LABORATOIRES MERCK, SHARP & DOHME-CHIBRET A dropper tip for dispensing a liquid, in particular eye drops
US20040140319A1 (en) * 2003-01-22 2004-07-22 Allergan, Inc. Controlled drop dispensing container

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DE2355057A1 (en) * 1973-11-03 1975-05-07 Pfizer Gmbh Bottle dropper insert - has passage tapering outwards towards outlet for drop dispension of e.g. therapeutic fluids
FR2622795A1 (en) * 1987-11-05 1989-05-12 Kerplas Snc Drip dispenser
EP0431885A1 (en) * 1989-12-08 1991-06-12 LABORATOIRES MERCK, SHARP & DOHME-CHIBRET A dropper tip for dispensing a liquid, in particular eye drops
US20040140319A1 (en) * 2003-01-22 2004-07-22 Allergan, Inc. Controlled drop dispensing container

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI765049B (en) * 2017-05-30 2022-05-21 日商夏普股份有限公司 Semiconductor device and method for manufacturing the same

Also Published As

Publication number Publication date
EP1776279A1 (en) 2007-04-25
CA2576457A1 (en) 2006-02-23
AU2005273992A1 (en) 2006-02-23
JP2008509852A (en) 2008-04-03
US20060032873A1 (en) 2006-02-16
BRPI0514302A (en) 2008-06-10

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