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WO2006018682A3 - Oxazolidinone derivatives as antimicrobials - Google Patents

Oxazolidinone derivatives as antimicrobials Download PDF

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Publication number
WO2006018682A3
WO2006018682A3 PCT/IB2005/002226 IB2005002226W WO2006018682A3 WO 2006018682 A3 WO2006018682 A3 WO 2006018682A3 IB 2005002226 W IB2005002226 W IB 2005002226W WO 2006018682 A3 WO2006018682 A3 WO 2006018682A3
Authority
WO
WIPO (PCT)
Prior art keywords
spp
antimicrobials
mycobacterium
compounds
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2005/002226
Other languages
French (fr)
Other versions
WO2006018682A2 (en
Inventor
Biswajit Das
Shahadat Ahmed
Ajay Singh Yadav
Soma Ghosh
Ashok Rattan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ranbaxy Laboratories Ltd
Original Assignee
Ranbaxy Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Laboratories Ltd filed Critical Ranbaxy Laboratories Ltd
Publication of WO2006018682A2 publication Critical patent/WO2006018682A2/en
Publication of WO2006018682A3 publication Critical patent/WO2006018682A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to certain substituted phenyl oxazolidinones and to process for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
PCT/IB2005/002226 2004-08-11 2005-07-27 Oxazolidinone derivatives as antimicrobials Ceased WO2006018682A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60049504P 2004-08-11 2004-08-11
US60/600,495 2004-08-11

Publications (2)

Publication Number Publication Date
WO2006018682A2 WO2006018682A2 (en) 2006-02-23
WO2006018682A3 true WO2006018682A3 (en) 2006-07-06

Family

ID=35478326

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/002226 Ceased WO2006018682A2 (en) 2004-08-11 2005-07-27 Oxazolidinone derivatives as antimicrobials

Country Status (1)

Country Link
WO (1) WO2006018682A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008108988A1 (en) * 2007-03-02 2008-09-12 Micurx Pharmaceuticals, Inc. Antimicrobial heterocyclic compounds for treatment of bacterial infections
CN102276595A (en) * 2010-04-16 2011-12-14 山东轩竹医药科技有限公司 Oxazolidinone antibiotic containing five-membered heterocycles

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654435A (en) * 1991-11-01 1997-08-05 Pharmacia & Upjohn Company Substituted arylphenyloxazolindinones
WO2001094342A1 (en) * 2000-06-05 2001-12-13 Dong A Pharm. Co., Ltd. Novel oxazolidinone derivatives and a process for the preparation thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654435A (en) * 1991-11-01 1997-08-05 Pharmacia & Upjohn Company Substituted arylphenyloxazolindinones
WO2001094342A1 (en) * 2000-06-05 2001-12-13 Dong A Pharm. Co., Ltd. Novel oxazolidinone derivatives and a process for the preparation thereof

Also Published As

Publication number Publication date
WO2006018682A2 (en) 2006-02-23

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