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WO2006010494A3 - Diagnostics and therapeutics for diseases associated with methionine aminopeptidase 1 (metapi) - Google Patents

Diagnostics and therapeutics for diseases associated with methionine aminopeptidase 1 (metapi) Download PDF

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Publication number
WO2006010494A3
WO2006010494A3 PCT/EP2005/007703 EP2005007703W WO2006010494A3 WO 2006010494 A3 WO2006010494 A3 WO 2006010494A3 EP 2005007703 W EP2005007703 W EP 2005007703W WO 2006010494 A3 WO2006010494 A3 WO 2006010494A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
metapi
therapeutics
diagnostics
diseases associated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/007703
Other languages
French (fr)
Other versions
WO2006010494A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of WO2006010494A2 publication Critical patent/WO2006010494A2/en
Publication of WO2006010494A3 publication Critical patent/WO2006010494A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G01N33/5758—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a human MetAP1 which is associated with the cardiovascular diseases, infections, respiratory diseases, gastroenterological diseases, cancer, hematological diseases, muscle skeleton diseases, metabolic diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, respiratory diseases, gastroenterological diseases, cancer, hematological diseases, muscle skeleton diseases, metabolic diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of MetAP1 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2005/007703 2004-07-28 2005-07-15 Diagnostics and therapeutics for diseases associated with methionine aminopeptidase 1 (metapi) Ceased WO2006010494A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04017832.9 2004-07-28
EP04017832 2004-07-28

Publications (2)

Publication Number Publication Date
WO2006010494A2 WO2006010494A2 (en) 2006-02-02
WO2006010494A3 true WO2006010494A3 (en) 2006-03-23

Family

ID=35045325

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/007703 Ceased WO2006010494A2 (en) 2004-07-28 2005-07-15 Diagnostics and therapeutics for diseases associated with methionine aminopeptidase 1 (metapi)

Country Status (1)

Country Link
WO (1) WO2006010494A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004048938A2 (en) * 2002-11-26 2004-06-10 Protein Design Labs, Inc. Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004048938A2 (en) * 2002-11-26 2004-06-10 Protein Design Labs, Inc. Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BERNIER SYLVIE G ET AL: "Methionine aminopeptidases type I and type II are essential to control cell proliferation.", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 95, no. 6, 15 August 2005 (2005-08-15), pages 1191 - 1203, XP002349197 *

Also Published As

Publication number Publication date
WO2006010494A2 (en) 2006-02-02

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