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WO2006010096A3 - Genetic manipulation of condensed tannins - Google Patents

Genetic manipulation of condensed tannins Download PDF

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Publication number
WO2006010096A3
WO2006010096A3 PCT/US2005/024470 US2005024470W WO2006010096A3 WO 2006010096 A3 WO2006010096 A3 WO 2006010096A3 US 2005024470 W US2005024470 W US 2005024470W WO 2006010096 A3 WO2006010096 A3 WO 2006010096A3
Authority
WO
WIPO (PCT)
Prior art keywords
plants
condensed
condensed tannin
condensed tannins
genetic manipulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/024470
Other languages
French (fr)
Other versions
WO2006010096A2 (en
WO2006010096A8 (en
Inventor
Richard A Dixon
Shashi B Sharma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roberts Samuels Noble Foundation Inc
Original Assignee
Roberts Samuels Noble Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roberts Samuels Noble Foundation Inc filed Critical Roberts Samuels Noble Foundation Inc
Priority to EP05773590A priority Critical patent/EP1766031A2/en
Priority to AU2005265356A priority patent/AU2005265356B2/en
Priority to NZ552453A priority patent/NZ552453A/en
Publication of WO2006010096A2 publication Critical patent/WO2006010096A2/en
Publication of WO2006010096A3 publication Critical patent/WO2006010096A3/en
Publication of WO2006010096A8 publication Critical patent/WO2006010096A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8222—Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
    • C12N15/8223—Vegetative tissue-specific promoters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8222—Developmentally regulated expression systems, tissue, organ specific, temporal or spatial regulation
    • C12N15/823—Reproductive tissue-specific promoters
    • C12N15/8234—Seed-specific, e.g. embryo, endosperm
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/825—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving pigment biosynthesis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0093—Oxidoreductases (1.) acting on CH or CH2 groups (1.17)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Fodder In General (AREA)

Abstract

The invention provides method and compositions for the modulation of condensed tannin production in plants. The methods of the invention allow creation of plants having novel phenotypes. Increased expression of condensed tannins in plants may be used to increase the nutritional value of food plants for both human and animal consumption. Increased condensed tannin content also reduces the potential for bloat in animals fed certain forage plants low in condensed tannin content. The invention may also be used to modify plant pigmentation.
PCT/US2005/024470 2004-07-09 2005-07-11 Genetic manipulation of condensed tannins Ceased WO2006010096A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP05773590A EP1766031A2 (en) 2004-07-09 2005-07-11 Genetic manipulation of condensed tannins
AU2005265356A AU2005265356B2 (en) 2004-07-09 2005-07-11 Genetic manipulation of condensed tannins
NZ552453A NZ552453A (en) 2004-07-09 2005-07-11 Genetic manipulation of condensed tannins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58702004P 2004-07-09 2004-07-09
US60/587,020 2004-07-09

Publications (3)

Publication Number Publication Date
WO2006010096A2 WO2006010096A2 (en) 2006-01-26
WO2006010096A3 true WO2006010096A3 (en) 2006-10-12
WO2006010096A8 WO2006010096A8 (en) 2006-12-07

Family

ID=35456999

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/024470 Ceased WO2006010096A2 (en) 2004-07-09 2005-07-11 Genetic manipulation of condensed tannins

Country Status (5)

Country Link
US (1) US7709701B2 (en)
EP (1) EP1766031A2 (en)
AU (1) AU2005265356B2 (en)
NZ (1) NZ552453A (en)
WO (1) WO2006010096A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1546335B1 (en) * 2002-06-28 2008-08-06 The Samuel Roberts Noble Foundation, Inc. Genetic manipulation of condensed tannins
WO2004024079A2 (en) * 2002-09-10 2004-03-25 The Samuel Roberts Noble Foundation, Inc. Methods and compositions for production of flavonoid and isoflavonoid nutraceuticals
US7442851B2 (en) * 2003-10-29 2008-10-28 The Samuel Roberts Noble Foundation Plant isoflavonoid hydroxylases and methods of use thereof
CA2626920C (en) 2005-10-26 2018-09-18 Aidyn Mouradov Modification of flavonoid biosynthesis in plants
AU2007213711B2 (en) * 2006-02-09 2012-08-30 The Samuel Roberts Noble Foundation, Inc. Methods and compositions for modifying plant biosynthetic pathways
JP2009296886A (en) * 2006-10-03 2009-12-24 Japan Science & Technology Agency Tool for screening plant having useful trait and use thereof
US7880059B2 (en) * 2007-04-26 2011-02-01 The Samuel Roberts Noble Foundation Production of proanthocyanidins to improve forage quality
US8420889B2 (en) 2008-08-29 2013-04-16 The Samuel Roberts Noble Foundation Epicatechin glucosyltransferase
US9121031B2 (en) 2011-04-11 2015-09-01 The Samuel Roberts Noble Foundation, Inc. Methods and compositions for regulating production of proanthocyanidins
WO2018136476A1 (en) * 2017-01-18 2018-07-26 University Of North Texas Methods for engineering proanthocyanidins (pas) in plants by affecting myb transcription factors
HUE072810T2 (en) 2017-09-15 2025-12-28 Covercress Inc Low fiber pennycress meal and methods of making
CN113604478B (en) * 2021-08-31 2023-05-23 中国农业科学院北京畜牧兽医研究所 Baimaigen LcMYB5 gene and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004002215A2 (en) * 2002-06-28 2004-01-08 The Samuel Roberts Noble Foundation, Inc. Genetic manipulation of condensed tannins
US20040045049A1 (en) * 1998-09-22 2004-03-04 James Zhang Polynucleotides and polypeptides in plants

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPR324101A0 (en) 2001-02-21 2001-03-15 Commonwealth Scientific And Industrial Research Organisation Novel gene and uses therefor to modify pasture qualities of crops
FR2828210B1 (en) * 2001-08-01 2004-08-06 Agronomique Inst Nat Rech REGULATING NUCLEIC ACID FOR THE EXPRESSION OF A POLYNUCLEOTIDE OF INTEREST SPECIFICALLY IN THE ENDOTHELIUM OF A PLANT SEED, AND ITS APPLICATIONS
AUPR811301A0 (en) 2001-10-05 2001-10-25 Agresearch Limited Manipulation of flavonoid biosynthesis
US7154027B2 (en) 2001-11-07 2006-12-26 Jeroen Demmer Compositions isolated from forage grasses and methods for their use
US20030237108A1 (en) 2002-05-06 2003-12-25 Genesis Corporation Research & Development Corporation Limited Compositions isolated from forage grasses and methods for their use
US20040103458A1 (en) * 2002-11-01 2004-05-27 Johnson Lauren D. Alfalfa plants with detectable tannin levels and methods for producing same
CN1836045B (en) * 2003-03-28 2012-05-09 孟山都技术有限公司 Novel plant promoter for early seed development
AU2003901797A0 (en) 2003-04-14 2003-05-01 Agresearch Limited Manipulation of condensed tannin biosynthesis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040045049A1 (en) * 1998-09-22 2004-03-04 James Zhang Polynucleotides and polypeptides in plants
WO2004002215A2 (en) * 2002-06-28 2004-01-08 The Samuel Roberts Noble Foundation, Inc. Genetic manipulation of condensed tannins

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BAUDRY A ET AL: "TT2, TT8, and TTG1 synergistically specify the expression of BANYULS and proanthocyanidin biosynthesis in Arabidopsis thaliana", 15 June 2004, PLANT JOURNAL, BLACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, GB, PAGES 366-380, ISSN: 0960-7412, XP002982940 *
DATABASE EMBL [online] 30 May 2001 (2001-05-30), "Arabidopsis thaliana TT2 gene for transparent testa 2 protein, exons 1-3", XP002363655, retrieved from EBI accession no. EM_PRO:ATH299452 Database accession no. AJ299452 *
DATABASE Geneseq [online] 1 July 2004 (2004-07-01), "Thalecress transcription factor cDNA #223.", XP002363656, retrieved from EBI accession no. GSN:ADO02032 Database accession no. ADO02032 *
MARLES M A S ET AL: "New perspectives on proanthocyanidin biochemistry and molecular regulation", January 2004, PHYTOCHEMISTRY, PERGAMON PRESS, GB, PAGES 367-383, ISSN: 0031-9422, XP004448652 *
NESI N ET AL: "The Arabidopsis TT2 gene encodes an R2R3 MYB domain protein that acts as a key determinant for proanthocyanidin accumulation in developing seed", September 2001, PLANT CELL, AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MD, US, PAGES 2099-2114, ISSN: 1040-4651, XP002982938 *
SHARMA SHASHI B ET AL: "Metabolic engineering of proanthocyanidins by ectopic expression of transcription factors in Arabidopsis thaliana", 16 August 2005, PLANT JOURNAL, VOL. 44, NR. 1, PAGES 62-75, ISSN: 0960-7412, XP002363652 *

Also Published As

Publication number Publication date
EP1766031A2 (en) 2007-03-28
US20060123508A1 (en) 2006-06-08
AU2005265356B2 (en) 2010-10-07
NZ552453A (en) 2009-09-25
WO2006010096A2 (en) 2006-01-26
WO2006010096A8 (en) 2006-12-07
AU2005265356A1 (en) 2006-01-26
US7709701B2 (en) 2010-05-04

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