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WO2006010040A3 - Agents antibacteriens - Google Patents

Agents antibacteriens Download PDF

Info

Publication number
WO2006010040A3
WO2006010040A3 PCT/US2005/024350 US2005024350W WO2006010040A3 WO 2006010040 A3 WO2006010040 A3 WO 2006010040A3 US 2005024350 W US2005024350 W US 2005024350W WO 2006010040 A3 WO2006010040 A3 WO 2006010040A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibacterial agents
quinoxaline
quinoline
mammals
naphthalene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/024350
Other languages
English (en)
Other versions
WO2006010040A2 (fr
Inventor
William Henry Miller
Meagan B Rouse
Mark Andrew Seefeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Priority to EP05764670A priority Critical patent/EP1773847A2/fr
Priority to US11/570,443 priority patent/US20080194547A1/en
Priority to JP2007520555A priority patent/JP2008505926A/ja
Publication of WO2006010040A2 publication Critical patent/WO2006010040A2/fr
Publication of WO2006010040A3 publication Critical patent/WO2006010040A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention a trait à des dérivés de naphtalène, de quinoline, de quinoxaline et de naphtyridine, utiles pour traiter des infections bactériennes chez des mammifères, en particulier chez des êtres humains.
PCT/US2005/024350 2004-07-09 2005-07-08 Agents antibacteriens Ceased WO2006010040A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP05764670A EP1773847A2 (fr) 2004-07-09 2005-07-08 Agents antibacteriens
US11/570,443 US20080194547A1 (en) 2004-07-09 2005-07-08 Antibacterial Agents
JP2007520555A JP2008505926A (ja) 2004-07-09 2005-07-08 抗細菌剤

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58658004P 2004-07-09 2004-07-09
US60/586,580 2004-07-09
US58727204P 2004-07-12 2004-07-12
US60/587,272 2004-07-12

Publications (2)

Publication Number Publication Date
WO2006010040A2 WO2006010040A2 (fr) 2006-01-26
WO2006010040A3 true WO2006010040A3 (fr) 2006-05-04

Family

ID=35785761

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/024350 Ceased WO2006010040A2 (fr) 2004-07-09 2005-07-08 Agents antibacteriens

Country Status (4)

Country Link
US (1) US20080194547A1 (fr)
EP (1) EP1773847A2 (fr)
JP (1) JP2008505926A (fr)
WO (1) WO2006010040A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1846416A4 (fr) 2005-01-25 2009-07-01 Glaxo Group Ltd Agents antibacteriens
WO2007115947A1 (fr) 2006-04-06 2007-10-18 Glaxo Group Limited Derives de pyrrolo-quinoxalinone en tant qu'agents antibacteriens
JP2009532504A (ja) 2006-04-06 2009-09-10 グラクソ グループ リミテッド 抗菌薬
EP1992628A1 (fr) 2007-05-18 2008-11-19 Glaxo Group Limited Dérivés et analogues de N-éthylquinolones et N-éthylazaquinolones
TW200819457A (en) * 2006-08-30 2008-05-01 Actelion Pharmaceuticals Ltd Spiro antibiotic derivatives
MY149347A (en) * 2007-04-20 2013-08-30 Glaxo Group Ltd Tricyclic nitrogen containing compounds as antibacterial agents
EP2080761A1 (fr) 2008-01-18 2009-07-22 Glaxo Group Limited Composés
JP2011518149A (ja) 2008-04-15 2011-06-23 アクテリオン ファーマシューティカルズ リミテッド 三環式抗菌剤
WO2010043714A1 (fr) 2008-10-17 2010-04-22 Glaxo Group Limited Composés azotés tricycliques utilisés comme agents antibactériens
US8318940B2 (en) 2009-01-15 2012-11-27 Glaxo Group Limited Naphthyridin-2 (1 H)-one compounds useful as antibacterials
TWI675836B (zh) 2014-03-25 2019-11-01 美商伊格尼塔公司 非典型蛋白質激酶ｃ之氮雜喹唑啉抑制劑
SG11201700566SA (en) 2014-08-22 2017-03-30 Glaxosmithkline Ip Dev Ltd Tricyclic nitrogen containing compounds for treating neisseria gonorrhoea infection
TW201722965A (zh) * 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
EP3927703B1 (fr) * 2019-02-19 2023-04-05 Univerza V Ljubljani Antibactériens à base de fragments monocycliques couplés à un échafaudage de naphtyridine aminopipéridine
WO2021076886A1 (fr) 2019-10-18 2021-04-22 The Regents Of The University Of California Dérivés de 3-phénylsulfonyl-quinoléine en tant qu'agents pour le traitement de troubles des vaisseaux sanguins pathogènes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010339A1 (fr) * 1997-08-27 1999-03-04 Pfizer Products Inc. 2-aminopyridines contenant des substituants a noyau condense en tant qu'inhibiteurs des nos
WO2004014361A1 (fr) * 2002-07-25 2004-02-19 Glaxo Group Limited Medicaments
WO2004058144A2 (fr) * 2002-12-18 2004-07-15 Glaxo Group Limited Agents antibacteriens

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010339A1 (fr) * 1997-08-27 1999-03-04 Pfizer Products Inc. 2-aminopyridines contenant des substituants a noyau condense en tant qu'inhibiteurs des nos
WO2004014361A1 (fr) * 2002-07-25 2004-02-19 Glaxo Group Limited Medicaments
WO2004058144A2 (fr) * 2002-12-18 2004-07-15 Glaxo Group Limited Agents antibacteriens

Also Published As

Publication number Publication date
JP2008505926A (ja) 2008-02-28
WO2006010040A2 (fr) 2006-01-26
EP1773847A2 (fr) 2007-04-18
US20080194547A1 (en) 2008-08-14

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