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WO2006008660A3 - Nouveaux polypeptides purifies derives de streptococcus pneumoniae - Google Patents

Nouveaux polypeptides purifies derives de streptococcus pneumoniae Download PDF

Info

Publication number
WO2006008660A3
WO2006008660A3 PCT/IB2005/003287 IB2005003287W WO2006008660A3 WO 2006008660 A3 WO2006008660 A3 WO 2006008660A3 IB 2005003287 W IB2005003287 W IB 2005003287W WO 2006008660 A3 WO2006008660 A3 WO 2006008660A3
Authority
WO
WIPO (PCT)
Prior art keywords
fabk
reductase
acyl
protein
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2005/003287
Other languages
English (en)
Other versions
WO2006008660A2 (fr
Inventor
Akil Dharamsi
Aled Edwards
Simon Houston
Dhushy Kanagarajah
Vladimir Romanov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affinium Pharmaceuticals Inc
Original Assignee
Affinium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affinium Pharmaceuticals Inc filed Critical Affinium Pharmaceuticals Inc
Publication of WO2006008660A2 publication Critical patent/WO2006008660A2/fr
Publication of WO2006008660A3 publication Critical patent/WO2006008660A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention a trait à des cibles polypeptidiques pour bactéries pathogènes. L'invention a également trait à des propriétés biochimiques et biophysiques des polypeptides de l'invention.
PCT/IB2005/003287 2004-07-20 2005-07-20 Nouveaux polypeptides purifies derives de streptococcus pneumoniae Ceased WO2006008660A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58951004P 2004-07-20 2004-07-20
US60/589,510 2004-07-20

Publications (2)

Publication Number Publication Date
WO2006008660A2 WO2006008660A2 (fr) 2006-01-26
WO2006008660A3 true WO2006008660A3 (fr) 2006-10-26

Family

ID=35785598

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/003287 Ceased WO2006008660A2 (fr) 2004-07-20 2005-07-20 Nouveaux polypeptides purifies derives de streptococcus pneumoniae

Country Status (1)

Country Link
WO (1) WO2006008660A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005005469A2 (fr) 2003-07-11 2005-01-20 Affinium Pharmaceuticals, Inc. Nouveaux polypeptides purifies provenant du staphylocoque dore
KR101831674B1 (ko) 2007-08-06 2018-02-23 밀레니엄 파머슈티컬스 인코퍼레이티드 프로테아좀 억제제
US7797112B2 (en) * 2007-12-28 2010-09-14 Korea Institute Of Science And Technology Method of identifying a FabK protein inhibitor using a three-dimensional structure of FabK protein
CN102066386A (zh) 2008-06-17 2011-05-18 米伦纽姆医药公司 硼酸酯化合物及其医药组合物
CN102946879B (zh) 2010-04-19 2015-04-22 尼基制药公司 一种蛋白酶体抑制剂和镓络合物在制备治疗增殖性疾病的药物中的应用
MA41505A (fr) 2015-02-11 2017-12-19 Millennium Pharm Inc Nouvelle forme cristalline d'un inhibiteur de protéasome

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002031128A1 (fr) * 2000-10-06 2002-04-18 Smithkline Beecham Corporation Procedes d'utilisation d'agonistes et d'antagonistesdes polypeptides fabk
US6613553B1 (en) * 2000-02-04 2003-09-02 St. Jude Children's Research Hospital Enoyl reductases and methods of use thereof
WO2003102190A2 (fr) * 2002-05-31 2003-12-11 Affinium Pharmaceuticals, Inc. Nouveaux polypeptides purifies responsables de la viabilite bacterienne

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613553B1 (en) * 2000-02-04 2003-09-02 St. Jude Children's Research Hospital Enoyl reductases and methods of use thereof
WO2002031128A1 (fr) * 2000-10-06 2002-04-18 Smithkline Beecham Corporation Procedes d'utilisation d'agonistes et d'antagonistesdes polypeptides fabk
WO2003102190A2 (fr) * 2002-05-31 2003-12-11 Affinium Pharmaceuticals, Inc. Nouveaux polypeptides purifies responsables de la viabilite bacterienne

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
COURCHESNE P L ET AL: "Identification of Proteins by Matrix-Assisted Laser Desorption/Ionization Mass Spectroscopy Using Peptide and Fragment Ion Masses (from 2-D Proteome Analysis Protocols, Ed. A. J. Link)", METHODS IN MOLECULAR BIOLOGY, HUMANA PRESS INC., CLIFTON, NJ, US, vol. 112, 1999, pages 487 - 511, XP002103063 *
DATABASE EMBL [online] 10 August 2000 (2000-08-10), "Streptococcus pneumoniae fab gene cluster, complete sequence", XP002387418, Database accession no. AF197933 *
HEATH R J ET AL: "A triclosan-resistant bacterial enzyme", NATURE, NATURE PUBLISHING GROUP, LONDON, GB, vol. 406, 13 July 2000 (2000-07-13), pages 145 - 146, XP000993256, ISSN: 0028-0836 *
KAY L E: "Nuclear Magnetic Resonance Methods for High Molecular Weight Proteins: A Study Involving a Complex of Maltose Binding Protein and Beta-Cyclodextrin", METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC, SAN DIEGO, CA, US, vol. 339, 2001, pages 174 - 203, XP001152928, ISSN: 0076-6879 *
MARRAKCHI HEDIA ET AL: "Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK).", BIOCHEMICAL JOURNAL, vol. 370, no. 3, 15 March 2003 (2003-03-15), pages 1055 - 1062, XP002387412, ISSN: 0264-6021 *
QUI X ET AL: "Molecular basis for triclosan activity involves a flipping loop in the active site", PROTEIN SCIENCE, CAMBRIDGE UNIVERSITY PRESS, CAMBRIDGE, GB, vol. 8, no. 11, November 1999 (1999-11-01), pages 2529 - 2532, XP001205990, ISSN: 0961-8368 *
RODGERS D W: "Cryocrystallography.", STRUCTURE (LONDON, ENGLAND) 15 DEC 1994, vol. 2, no. 12, 15 December 1994 (1994-12-15), pages 1135 - 1140, XP002387413, ISSN: 0969-2126 *

Also Published As

Publication number Publication date
WO2006008660A2 (fr) 2006-01-26

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