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WO2006003293A3 - Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique - Google Patents

Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique Download PDF

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Publication number
WO2006003293A3
WO2006003293A3 PCT/FR2005/001385 FR2005001385W WO2006003293A3 WO 2006003293 A3 WO2006003293 A3 WO 2006003293A3 FR 2005001385 W FR2005001385 W FR 2005001385W WO 2006003293 A3 WO2006003293 A3 WO 2006003293A3
Authority
WO
WIPO (PCT)
Prior art keywords
analysis
producing
mask
relates
microfludic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR2005/001385
Other languages
English (en)
Other versions
WO2006003293A2 (fr
Inventor
Jean-Christophe Fourrier
Francois Caron
Pierre Tabourier
Christian Druon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite Lille 1 Sciences et Technologies
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite Lille 1 Sciences et Technologies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite Lille 1 Sciences et Technologies filed Critical Centre National de la Recherche Scientifique CNRS
Priority to EP05775767A priority Critical patent/EP1781409B1/fr
Priority to CN2005800240790A priority patent/CN101031362B/zh
Priority to US11/628,416 priority patent/US20080110753A1/en
Priority to KR1020067025513A priority patent/KR101179411B1/ko
Priority to CA2568805A priority patent/CA2568805C/fr
Priority to AT05775767T priority patent/ATE540756T1/de
Priority to JP2007514033A priority patent/JP4763690B2/ja
Publication of WO2006003293A2 publication Critical patent/WO2006003293A2/fr
Publication of WO2006003293A3 publication Critical patent/WO2006003293A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/088—Passive control of flow resistance by specific surface properties
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F05—INDEXING SCHEMES RELATING TO ENGINES OR PUMPS IN VARIOUS SUBCLASSES OF CLASSES F01-F04
    • F05C—INDEXING SCHEME RELATING TO MATERIALS, MATERIAL PROPERTIES OR MATERIAL CHARACTERISTICS FOR MACHINES, ENGINES OR PUMPS OTHER THAN NON-POSITIVE-DISPLACEMENT MACHINES OR ENGINES
    • F05C2225/00—Synthetic polymers, e.g. plastics; Rubber
    • F05C2225/04—PTFE [PolyTetraFluorEthylene]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Micromachines (AREA)

Abstract

L'invention a pour premier objet un dispositif de manipulation de gouttes sur un plan de déplacement par électromouillage, comprenant au moins une piste de déplacement. La piste comprend un substrat électriquement isolant à la surface duquel reposent deux ou plusieurs électrodes conductrices interdigitées. Ces électrodes sont recouvertes d'une couche diélectrique isolante, elles-mêmes recouvertes d'une couche partiellement mouillante. L'invention se rapporte également à un procédé de fabrication du dispositif précité dans lequel la création de la couche partiellement mouillante comprend la création d'un masque en matériau photosensible par dépôt de ce matériau sur un substrat, une étape photolithographique, la révélation du matériau photosensible, le dépôt d'un matériau non mouillant sur le masque, au moins un recuit en dissolution, dissolution du masque, et au moins un recuit après dissolution. L'invention se rapporte enfin à un système d'analyse microfluidique d'un échantillon de liquide, qui comprend au moins un moyen de préparation de l'échantillon de liquide couplé à au moins un dispositif de manipulation de gouttes selon l'invention, lui-même couplé à au moins un moyen d'analyse de l'échantillon.
PCT/FR2005/001385 2004-06-04 2005-06-06 Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique Ceased WO2006003293A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP05775767A EP1781409B1 (fr) 2004-06-04 2005-06-06 Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique
CN2005800240790A CN101031362B (zh) 2004-06-04 2005-06-06 用于生物化学分析的液滴操纵装置，制造所述装置的方法与微流体分析系统
US11/628,416 US20080110753A1 (en) 2004-06-04 2005-06-06 Device For Handling Drops For Biochemical Analysis, Method For Producing Said Device And A System For Microfluidic Analysis
KR1020067025513A KR101179411B1 (ko) 2004-06-04 2005-06-06 생화학적 분석을 위한 점적 조작용 장치, 상기 장치의 제조방법 및 마이크로 흐름 분석용 시스템
CA2568805A CA2568805C (fr) 2004-06-04 2005-06-06 Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique
AT05775767T ATE540756T1 (de) 2004-06-04 2005-06-06 Vorrichtung zur handhabung von tropfen zur biochemischen analyse, verfahren zur herstellung einer derartigen vorrichtung und system zur mikrofluidischen analyse
JP2007514033A JP4763690B2 (ja) 2004-06-04 2005-06-06 生化学的分析のために液滴を扱う装置、前記装置を製造する方法及びマイクロ流体分析

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0406080 2004-06-04
FR0406080A FR2871150B1 (fr) 2004-06-04 2004-06-04 Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique

Publications (2)

Publication Number Publication Date
WO2006003293A2 WO2006003293A2 (fr) 2006-01-12
WO2006003293A3 true WO2006003293A3 (fr) 2006-09-21

Family

ID=34946857

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2005/001385 Ceased WO2006003293A2 (fr) 2004-06-04 2005-06-06 Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique

Country Status (9)

Country Link
US (1) US20080110753A1 (fr)
EP (1) EP1781409B1 (fr)
JP (1) JP4763690B2 (fr)
KR (1) KR101179411B1 (fr)
CN (1) CN101031362B (fr)
AT (1) ATE540756T1 (fr)
CA (1) CA2568805C (fr)
FR (1) FR2871150B1 (fr)
WO (1) WO2006003293A2 (fr)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2871076A1 (fr) * 2004-06-04 2005-12-09 Univ Lille Sciences Tech Dispositif pour desorption par rayonnement laser incorporant une manipulation de l'echantillon liquide sous forme de gouttes individuelles permettant leur traitement chimique et biochimique
JP4632300B2 (ja) * 2005-02-14 2011-02-16 国立大学法人 筑波大学 送液装置
JP4893197B2 (ja) * 2006-09-28 2012-03-07 ブラザー工業株式会社 液体移送装置
US8702938B2 (en) * 2007-09-04 2014-04-22 Advanced Liquid Logic, Inc. Droplet actuator with improved top substrate
EP3756767B1 (fr) 2007-10-02 2024-05-01 Labrador Diagnostics LLC Dispositifs modulaires a utiliser sur place et leurs utilisations
JP5383138B2 (ja) * 2008-10-01 2014-01-08 シャープ株式会社 エレクトロウエッティングバルブ付き送液構造体、これを用いたマイクロ分析チップ及び分析装置
US8877512B2 (en) * 2009-01-23 2014-11-04 Advanced Liquid Logic, Inc. Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
US8734628B2 (en) * 2010-03-10 2014-05-27 Empire Technology Development, Llc Microfluidic channel device with array of drive electrodes
WO2011137533A1 (fr) 2010-05-05 2011-11-10 The Governing Council Of The University Of Toronto Procédé de traitement d'échantillons séchés utilisant un dispositif microfluidique numérique
CN101865928B (zh) * 2010-05-06 2012-07-18 大连理工大学 一种基于电场作用的超疏水表面微液滴操控方法
JP4949506B2 (ja) * 2010-07-16 2012-06-13 シャープ株式会社 流路構造体及びその製造方法、並びに、分析チップ及び分析装置
CA2813090C (fr) * 2010-10-01 2019-11-12 The Governing Council Of The University Of Toronto Dispositifs microfluidiques numeriques et procedes d'incorporation d'une phase solide
JP2012150098A (ja) * 2010-12-28 2012-08-09 Sharp Corp 検体検出用チップ、それを用いたセンサ、及び検体検出方法
RU2620922C2 (ru) 2011-01-21 2017-05-30 Теранос, Инк. Системы и методы оптимизации использования образца
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
BR112014007073A2 (pt) * 2011-09-25 2017-04-11 Theranos Inc sistemas e métodos para multi-análise
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
CN102824933B (zh) * 2012-09-20 2014-09-03 复旦大学 一种单向液滴输运的数字微流芯片电极配置方法
US9366647B2 (en) * 2013-03-14 2016-06-14 Taiwan Semiconductor Manufacturing Company, Ltd. Optical detection for bio-entities
US10422806B1 (en) 2013-07-25 2019-09-24 Theranos Ip Company, Llc Methods for improving assays of biological samples
TWI507690B (zh) * 2014-09-02 2015-11-11 Silicon Optronics Inc 生物晶片構裝
US20200390811A1 (en) * 2015-04-23 2020-12-17 The Trustees Of The University Of Pennsylvania Compositions to disrupt protein kinase a anchoring and uses thereof
US10695762B2 (en) 2015-06-05 2020-06-30 Miroculus Inc. Evaporation management in digital microfluidic devices
EP3303547A4 (fr) 2015-06-05 2018-12-19 Miroculus Inc. Appareils et procédés microfluidiques numériques à matrice d'air destinés à limiter l'évaporation et l'encrassement de surface
US11148138B2 (en) * 2015-09-02 2021-10-19 Tecan Trading Ag Magnetic conduits in microfluidics
WO2018039281A1 (fr) 2016-08-22 2018-03-01 Miroculus Inc. Système de rétroaction permettant la maîtrise des gouttelettes en parallèle dans un dispositif microfluidique numérique
CA3049416A1 (fr) 2016-12-28 2018-07-05 Miroculus Inc. Dispositifs microfluidiques numeriques et procedes
WO2018187476A1 (fr) 2017-04-04 2018-10-11 Miroculus Inc. Appareils microfluidiques numériques et procédés de manipulation et de traitement de gouttelettes encapsulées
EP3658908B1 (fr) 2017-07-24 2025-11-12 Integra Biosciences AG Systèmes microfluidiques numériques et procédés à dispositif de collecte de plasma intégré
CN115582155B (zh) 2017-09-01 2025-08-26 因特格拉生物科学股份公司 数字微流控设备及其使用方法
US20190262829A1 (en) * 2018-02-28 2019-08-29 Volta Labs, Inc. Directing Motion of Droplets Using Differential Wetting
EP3796999A4 (fr) 2018-05-23 2022-03-09 Miroculus Inc. Contrôle de l'évaporation dans la microfluidique numérique
EP3917670A4 (fr) 2019-01-31 2022-11-02 Miroculus Inc. Compositions anti-encrassement et procédés de manipulation et de traitement de gouttelettes encapsulées
EP3932537A4 (fr) * 2019-02-25 2023-01-04 National Institute Of Advanced Industrial Science And Technology Dispositif de manipulation de liquide de type à espace ouvert
CN119158636A (zh) 2019-04-08 2024-12-20 米罗库鲁斯公司 多盒式数字微流控装置和使用方法
WO2021016614A1 (fr) 2019-07-25 2021-01-28 Miroculus Inc. Dispositifs microfluidiques numériques et leurs procédés d'utilisation
CN111804354B (zh) * 2020-04-07 2021-09-21 苏州大学 液滴无损转移装置及方法、液滴微反应方法
US11772093B2 (en) 2022-01-12 2023-10-03 Miroculus Inc. Methods of mechanical microfluidic manipulation

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0815940A2 (fr) * 1996-06-28 1998-01-07 Caliper Technologies Corporation Pipette électrocinétique, et moyens de compensation d'effets électrophorétiques
US6183970B1 (en) * 1998-08-27 2001-02-06 Hitachi, Ltd. Polynucleotide probe chip and polynucleotide detection method
US6565727B1 (en) * 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
WO2003045556A2 (fr) * 2001-11-26 2003-06-05 Keck Graduate Institute Procede, appareil et article de regulation microfluidique par electromouillage destines a des analyses chimiques, biochimiques, biologiques et analogues
EP1364702A2 (fr) * 2002-05-15 2003-11-26 Samsung Electronics Co., Ltd. Procédé de fabrication d'une plaque matrice de biomolecules avec des zones hydrophiles et hydrophobes
US20040055891A1 (en) * 2002-09-24 2004-03-25 Pamula Vamsee K. Methods and apparatus for manipulating droplets by electrowetting-based techniques
US20040055536A1 (en) * 2002-09-24 2004-03-25 Pramod Kolar Method and apparatus for non-contact electrostatic actuation of droplets

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3791999B2 (ja) * 1997-03-24 2006-06-28 株式会社アドバンス 液体微粒子ハンドリング装置
JP2002031638A (ja) * 2000-07-17 2002-01-31 Mitsubishi Chemicals Corp 生体試料検出用チップ及び生体試料検出方法
JP2002027984A (ja) * 2000-07-17 2002-01-29 Mitsubishi Chemicals Corp マイクロリアクタチップ，化学反応試験方法及びマイクロリアクタチップ用薄膜部材
US6773566B2 (en) * 2000-08-31 2004-08-10 Nanolytics, Inc. Electrostatic actuators for microfluidics and methods for using same
JP2003222611A (ja) * 2001-11-20 2003-08-08 Nec Corp 分離装置、分離方法および分離装置の製造方法
JP2003230829A (ja) * 2001-12-06 2003-08-19 Hitachi Ltd 平面マイクロファクトリー
US7459127B2 (en) * 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
JP2003294733A (ja) * 2002-03-29 2003-10-15 Sumitomo Bakelite Co Ltd 細胞内蛋白量の同定方法及び基板
JP3914806B2 (ja) * 2002-04-09 2007-05-16 三菱化学株式会社 分析用チップ
JPWO2004008132A1 (ja) * 2002-07-11 2005-11-10 三菱電機株式会社 生体分子分離セル及びその製造方法並びにｄｎａ分取装置
JP2004061229A (ja) * 2002-07-26 2004-02-26 Hitachi Ltd 感染症検査装置、検査方法、及び感染検査用マイクロファブリケーション
US7329545B2 (en) * 2002-09-24 2008-02-12 Duke University Methods for sampling a liquid flow
JP4590542B2 (ja) * 2003-06-10 2010-12-01 国立大学法人九州工業大学 マイクロ液滴輸送デバイス
JP4385124B2 (ja) * 2004-03-12 2009-12-16 国立大学法人九州工業大学 電気的制御可能な微量液滴輸送デバイス
FR2871076A1 (fr) * 2004-06-04 2005-12-09 Univ Lille Sciences Tech Dispositif pour desorption par rayonnement laser incorporant une manipulation de l'echantillon liquide sous forme de gouttes individuelles permettant leur traitement chimique et biochimique
US20060266700A1 (en) * 2005-05-31 2006-11-30 General Electric Company Porous structures with engineered wettability properties and methods of making them

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0815940A2 (fr) * 1996-06-28 1998-01-07 Caliper Technologies Corporation Pipette électrocinétique, et moyens de compensation d'effets électrophorétiques
US6183970B1 (en) * 1998-08-27 2001-02-06 Hitachi, Ltd. Polynucleotide probe chip and polynucleotide detection method
US6565727B1 (en) * 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
WO2003045556A2 (fr) * 2001-11-26 2003-06-05 Keck Graduate Institute Procede, appareil et article de regulation microfluidique par electromouillage destines a des analyses chimiques, biochimiques, biologiques et analogues
EP1364702A2 (fr) * 2002-05-15 2003-11-26 Samsung Electronics Co., Ltd. Procédé de fabrication d'une plaque matrice de biomolecules avec des zones hydrophiles et hydrophobes
US20040055891A1 (en) * 2002-09-24 2004-03-25 Pamula Vamsee K. Methods and apparatus for manipulating droplets by electrowetting-based techniques
US20040055536A1 (en) * 2002-09-24 2004-03-25 Pramod Kolar Method and apparatus for non-contact electrostatic actuation of droplets

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
POLLACK M G ET AL: "ELECTROWETTING-BASED ACTUATION OF DROPLETS FOR INTEGRATED MICROFLUIDICS", LAB ON A CHIP, ROYAL SOCIETY OF CHEMISTRY, CAMBRIDGE, GB, vol. 2, no. 2, 11 March 2002 (2002-03-11), pages 96 - 101, XP008038786, ISSN: 1473-0197 *
SUNG KWON CHO ET AL: "Particle separation and concentration control for digital microfluidic systems", PROCEEDINGS OF THE IEEE 16TH. ANNUAL INTERNATIONAL CONFERENCE ON MICROELECTRO MECHANICAL SYSTEMS. MEMS 2003. KYOTO, JAPAN, AN. 19 - 23, 2003, IEEE INTERNATIONAL MICRO ELECTRO MECHANICAL SYSTEMS CONFERENCE, NEW YORK, NY : IEEE, US, vol. CONF. 16, 19 January 2003 (2003-01-19), pages 686 - 689, XP010637065, ISBN: 0-7803-7744-3 *

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CA2568805A1 (fr) 2006-01-12
CN101031362A (zh) 2007-09-05
EP1781409B1 (fr) 2012-01-11
CN101031362B (zh) 2012-01-11
JP2008502882A (ja) 2008-01-31
FR2871150A1 (fr) 2005-12-09
US20080110753A1 (en) 2008-05-15
WO2006003293A2 (fr) 2006-01-12
ATE540756T1 (de) 2012-01-15
EP1781409A2 (fr) 2007-05-09
JP4763690B2 (ja) 2011-08-31
FR2871150B1 (fr) 2006-09-22
CA2568805C (fr) 2012-08-28
KR101179411B1 (ko) 2012-09-07

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