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WO2006001848A3 - Quantum dots as high-sensitivity optical sensors and biocompatible imaging probes, compositions thereof, and related methods - Google Patents

Quantum dots as high-sensitivity optical sensors and biocompatible imaging probes, compositions thereof, and related methods Download PDF

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Publication number
WO2006001848A3
WO2006001848A3 PCT/US2005/004310 US2005004310W WO2006001848A3 WO 2006001848 A3 WO2006001848 A3 WO 2006001848A3 US 2005004310 W US2005004310 W US 2005004310W WO 2006001848 A3 WO2006001848 A3 WO 2006001848A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
quantum dots
optical sensors
related methods
imaging probes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/004310
Other languages
French (fr)
Other versions
WO2006001848A2 (en
Inventor
Christoph A Naumann
Bruce A Young
Eric C Long
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indiana University Research and Technology Corp
Original Assignee
Indiana University Research and Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indiana University Research and Technology Corp filed Critical Indiana University Research and Technology Corp
Publication of WO2006001848A2 publication Critical patent/WO2006001848A2/en
Anticipated expiration legal-status Critical
Publication of WO2006001848A3 publication Critical patent/WO2006001848A3/en
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0065—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
    • A61K49/0067—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle quantum dots, fluorescent nanocrystals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Ceramic Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Luminescent Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention provides a semiconductor nanoparticle with improved stability and biocompatibility properties. Accordingly, the present invention provides a nanoparticle that is capped with two separate protective layers: an inner inert layer and an outer inert layer and related in vitro and in vivo methods of use.
PCT/US2005/004310 2004-02-12 2005-02-11 Quantum dots as high-sensitivity optical sensors and biocompatible imaging probes, compositions thereof, and related methods Ceased WO2006001848A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54396504P 2004-02-12 2004-02-12
US60/543,965 2004-02-12

Publications (2)

Publication Number Publication Date
WO2006001848A2 WO2006001848A2 (en) 2006-01-05
WO2006001848A3 true WO2006001848A3 (en) 2007-01-25

Family

ID=35782210

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/004310 Ceased WO2006001848A2 (en) 2004-02-12 2005-02-11 Quantum dots as high-sensitivity optical sensors and biocompatible imaging probes, compositions thereof, and related methods

Country Status (1)

Country Link
WO (1) WO2006001848A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103554477A (en) * 2008-02-25 2014-02-05 纳米技术有限公司 Semicondcutor nanoparticle capping agents
US8766315B2 (en) 2010-03-22 2014-07-01 Samsung Display Co., Ltd. Quantum dot-block copolymer hybrid, methods of fabricating and dispersing the same, light emitting device including the same, and fabrication method thereof
US8847197B2 (en) 2009-09-23 2014-09-30 Nanoco Technologies Ltd. Semiconductor nanoparticle-based materials
US8957401B2 (en) 2009-09-23 2015-02-17 Nanoco Technologies, Ltd Semiconductor nanoparticle-based materials
US9159590B2 (en) 2010-04-01 2015-10-13 Nanoco Technologies, Ltd. Encapsulated nanoparticles

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0409877D0 (en) 2004-04-30 2004-06-09 Univ Manchester Preparation of nanoparticle materials
GB2472542B (en) 2005-08-12 2011-03-23 Nanoco Technologies Ltd Nanoparticles
US8563348B2 (en) 2007-04-18 2013-10-22 Nanoco Technologies Ltd. Fabrication of electrically active films based on multiple layers
US20080264479A1 (en) 2007-04-25 2008-10-30 Nanoco Technologies Limited Hybrid Photovoltaic Cells and Related Methods
US8784701B2 (en) 2007-11-30 2014-07-22 Nanoco Technologies Ltd. Preparation of nanoparticle material
GB0814458D0 (en) 2008-08-07 2008-09-10 Nanoco Technologies Ltd Surface functionalised nanoparticles
GB0820101D0 (en) 2008-11-04 2008-12-10 Nanoco Technologies Ltd Surface functionalised nanoparticles
GB0821122D0 (en) 2008-11-19 2008-12-24 Nanoco Technologies Ltd Semiconductor nanoparticle - based light emitting devices and associated materials and methods
WO2021041874A1 (en) 2019-08-29 2021-03-04 Martin David C Biofunctional thiophene monomers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NIEMEYER: "Nanoparticles, Proteins And Nucleic Acids: Biotechnology Meets Materials Science", ANGEWANDTE CHEMIE (INTERNATIONAL EDITION), vol. 40, 2001, pages 4128 - 4158, XP003003923 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103554477A (en) * 2008-02-25 2014-02-05 纳米技术有限公司 Semicondcutor nanoparticle capping agents
US8847197B2 (en) 2009-09-23 2014-09-30 Nanoco Technologies Ltd. Semiconductor nanoparticle-based materials
US8957401B2 (en) 2009-09-23 2015-02-17 Nanoco Technologies, Ltd Semiconductor nanoparticle-based materials
US9543481B2 (en) 2009-09-23 2017-01-10 Nanoco Technologies Ltd. Semiconductor nanoparticle-based materials
US8766315B2 (en) 2010-03-22 2014-07-01 Samsung Display Co., Ltd. Quantum dot-block copolymer hybrid, methods of fabricating and dispersing the same, light emitting device including the same, and fabrication method thereof
US9159590B2 (en) 2010-04-01 2015-10-13 Nanoco Technologies, Ltd. Encapsulated nanoparticles

Also Published As

Publication number Publication date
WO2006001848A2 (en) 2006-01-05

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