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WO2006000143A1 - Microcapsule metallique pour la transplantation de cellules et de tissus - Google Patents

Microcapsule metallique pour la transplantation de cellules et de tissus Download PDF

Info

Publication number
WO2006000143A1
WO2006000143A1 PCT/CN2005/000804 CN2005000804W WO2006000143A1 WO 2006000143 A1 WO2006000143 A1 WO 2006000143A1 CN 2005000804 W CN2005000804 W CN 2005000804W WO 2006000143 A1 WO2006000143 A1 WO 2006000143A1
Authority
WO
WIPO (PCT)
Prior art keywords
microcapsule
metal
titanium
microcapsules
base material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2005/000804
Other languages
English (en)
Chinese (zh)
Inventor
Gang Li
Minjing Zhan
Ling Lin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tianjin University
Original Assignee
Tianjin University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tianjin University filed Critical Tianjin University
Publication of WO2006000143A1 publication Critical patent/WO2006000143A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/501—Inorganic compounds

Definitions

  • the molecular mass, strength, chemical composition of the polymer material, and the thickness or number of layers of the encapsulating film change the permeability of the film.
  • the micro-package is prepared.
  • the concentration of the polymer solution used in the capsule, the time of the gelation reaction, the pH of the system, and the type and amount of the additive all have a significant effect on the permeability and biocompatibility of the membrane, allowing the cells to be embedded. Loss of apoptosis or function.
  • microencapsulation of such materials often finds problems of excessive volume during the transplantation process.
  • the present invention has the following technical effects: (1) using the metal microcapsules to embed biological cells, which can reduce the volume of the transplanted microcapsules, and enable the microcapsules to be transplanted into the human body. It does not cause water swelling in a physiological environment, so that the implanted cells can function normally and have long-term stability in the body; (2)
  • the metal microcapsules are harmless to the human body and have good biocompatibility. Made of metal or alloy material, such as titanium metal, due to its light weight, good biocompatibility, non-toxicity, good corrosion resistance, good stability in the body, small thermal expansion coefficient, high melting point, etc., thus avoiding the use of polymer materials. Disadvantages: low mechanical strength, unclear degradation, short service life, exposure of xenogeneic cells to the human body may lead to problems such as unidentified viruses entering the human body and gene transfer. detailed description
  • the base material is used as the base material; the base material is used as the base material in the diameter of the base material of the base material;
  • the surface is plated with titanium coating, and then cut to obtain a bowl-shaped hemisphere. After cleaning and surface treatment on the hemisphere, the living cells are placed into the titanium hemisphere and assembled into microcapsules. The two hemispheres are spot welded at the seam. Welding is performed. .

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne un type de microcapsules métalliques qui sont destinées à la transplantation de cellules et de tissus vivants. La microcapsule de l'invention est basée sur un alliage ou un métal biocompatible tel que le titane, l'argent, le fer, etc. Les matières de base de la microcapsule sont enrobées ou recouvertes avec une couche de titane ou d'alliage de titane. Les microcapsules métalliques sont creuses et représentent des microsphères, des cellules ou des tissus actifs destinés à la transplantation étant placés à l'intérieur des microsphères. Le rayon externe de la microsphère est généralement compris entre 0,05 et 5 mm. L'épaisseur de la paroi de membrane de la microsphère est généralement comprise entre 0,001 et 0,5 mm. Les parois de membrane comportent des pores sensiblement ronds, le rayon de chaque pore étant compris entre 0,00005 et 0,01 mm. Le volume de la microcapsule de transplantation est réduit, et les microcapsules métalliques ne vont pas gonfler dans des conditions physiologiques après leur transplantation dans le corps humain, alors que les microcapsules métalliques sont utilisées pour encapsuler des cellules biologiques. Par conséquent, les microcapsules métalliques peuvent maintenir une stabilité à long terme in vivo et prolonger la survie des tissus ou des cellules fonctionnelles.
PCT/CN2005/000804 2004-06-29 2005-06-08 Microcapsule metallique pour la transplantation de cellules et de tissus Ceased WO2006000143A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB2004100198199A CN100457900C (zh) 2004-06-29 2004-06-29 细胞和组织移植用金属微囊
CN200410019819.9 2004-06-29

Publications (1)

Publication Number Publication Date
WO2006000143A1 true WO2006000143A1 (fr) 2006-01-05

Family

ID=34663084

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2005/000804 Ceased WO2006000143A1 (fr) 2004-06-29 2005-06-08 Microcapsule metallique pour la transplantation de cellules et de tissus

Country Status (2)

Country Link
CN (1) CN100457900C (fr)
WO (1) WO2006000143A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2356227B1 (fr) * 2008-11-14 2018-03-28 Viacyte, Inc. Encapsulation de cellules pancréatiques dérivées de cellules souches pluripotentes humaines

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070028A1 (fr) * 2001-03-05 2002-09-12 Bio-Smart, Ltd. Composition d'element poreux pour une biomatiere
WO2003013396A1 (fr) * 2001-08-11 2003-02-20 Stanmore Implants Worldwide Ltd. Implant chirurgical
US20040167633A1 (en) * 2003-02-24 2004-08-26 Depuy Products, Inc. Metallic implants having roughened surfaces and methods for producing the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070028A1 (fr) * 2001-03-05 2002-09-12 Bio-Smart, Ltd. Composition d'element poreux pour une biomatiere
WO2003013396A1 (fr) * 2001-08-11 2003-02-20 Stanmore Implants Worldwide Ltd. Implant chirurgical
US20040167633A1 (en) * 2003-02-24 2004-08-26 Depuy Products, Inc. Metallic implants having roughened surfaces and methods for producing the same

Also Published As

Publication number Publication date
CN1594561A (zh) 2005-03-16
CN100457900C (zh) 2009-02-04

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