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WO2006079797A3 - Apparatus for measurement of analyte concentration - Google Patents

Apparatus for measurement of analyte concentration Download PDF

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Publication number
WO2006079797A3
WO2006079797A3 PCT/GB2006/000243 GB2006000243W WO2006079797A3 WO 2006079797 A3 WO2006079797 A3 WO 2006079797A3 GB 2006000243 W GB2006000243 W GB 2006000243W WO 2006079797 A3 WO2006079797 A3 WO 2006079797A3
Authority
WO
WIPO (PCT)
Prior art keywords
measurement
waveguide
outputting
analyte
body region
Prior art date
Application number
PCT/GB2006/000243
Other languages
French (fr)
Other versions
WO2006079797A2 (en
Inventor
Dawood Parker
John Edwin Enderby
Original Assignee
Melys Diagnostics Ltd
Dawood Parker
John Edwin Enderby
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melys Diagnostics Ltd, Dawood Parker, John Edwin Enderby filed Critical Melys Diagnostics Ltd
Publication of WO2006079797A2 publication Critical patent/WO2006079797A2/en
Publication of WO2006079797A3 publication Critical patent/WO2006079797A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Apparatus for measuring an analyte such as glucose comprises heated ribbon as an IR source (1) outputting IR light in two opposed directions, an ATR waveguide (4) , having a surface for forming an interface with a body region such as skin, hollow waveguide collimators (2) and (5) , and detectors (3) and (6) for each for measurement and reference wavelength bands outputting an optical absorbance d for the measurement band and an optical absorbance c for the reference band, and producing a time dependant output of the concentration g of said analyte calculated as where A and b/a are constants for a given set of conditions of use, and b and a corresponding to measures d and c respectively, but are determined with water rather than said body region in contact with said optical waveguide surface. Collimator (5) and detector (6) view the waveguide (4) at an adjustable angle α. The effect of temperature on the measurement is compensated for by a reading obtained from a temperature sensor (8) . A final value for g is obtained by applying a predictive algorithm to measurements taken at time intervals .
PCT/GB2006/000243 2005-01-28 2006-01-25 Apparatus for measurement of analyte concentration WO2006079797A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0501826.2A GB0501826D0 (en) 2005-01-28 2005-01-28 Apparatus for measurement of analyte concentration
GB0501826.2 2005-01-28

Publications (2)

Publication Number Publication Date
WO2006079797A2 WO2006079797A2 (en) 2006-08-03
WO2006079797A3 true WO2006079797A3 (en) 2006-10-05

Family

ID=34307635

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/000243 WO2006079797A2 (en) 2005-01-28 2006-01-25 Apparatus for measurement of analyte concentration

Country Status (2)

Country Link
GB (1) GB0501826D0 (en)
WO (1) WO2006079797A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8647489B2 (en) 2005-09-30 2014-02-11 Bayer Healthcare Llc Gated voltammetry devices
US8877035B2 (en) 2005-07-20 2014-11-04 Bayer Healthcare Llc Gated amperometry methods
US9005527B2 (en) 2006-10-24 2015-04-14 Bayer Healthcare Llc Transient decay amperometry biosensors
US9410917B2 (en) 2004-02-06 2016-08-09 Ascensia Diabetes Care Holdings Ag Method of using a biosensor

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5039062B2 (en) 2006-02-27 2012-10-03 バイエル・ヘルスケア・エルエルシー Temperature-corrected analyte determination in a biosensor system
US7966859B2 (en) 2006-05-03 2011-06-28 Bayer Healthcare Llc Underfill detection system for a biosensor
WO2009076302A1 (en) 2007-12-10 2009-06-18 Bayer Healthcare Llc Control markers for auto-detection of control solution and methods of use
EP3438661B1 (en) 2007-12-10 2022-08-03 Ascensia Diabetes Care Holdings AG Slope-based compensation
JP5738770B2 (en) 2008-12-08 2015-06-24 バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅＬＬＣ Biosensor system with signal conditioning
EP2259048A1 (en) 2009-06-03 2010-12-08 Koninklijke Philips Electronics N.V. Measuring reflectance using waveguide for coupling light to larger volume of sample
IN2012DN02872A (en) 2009-11-10 2015-07-24 Bayer Healthcare Llc
MX2012010860A (en) 2010-03-22 2013-03-05 Bayer Healthcare Llc Residual compensation for a biosensor.
US9222910B2 (en) 2010-06-07 2015-12-29 Bayer Healthcare Llc Underfill management system for a biosensor
SG10201507109TA (en) 2010-06-07 2015-10-29 Bayer Healthcare Llc Slope-based compensation including secondary output signals
CN106645002B (en) 2011-06-07 2020-07-21 精量电子(美国)有限公司 System for determining the concentration of a first fluid in a second fluid in a sample
ES2757909T3 (en) 2011-09-21 2020-04-30 Ascensia Diabetes Care Holdings Ag Compensation analysis including segmented signals
WO2015030832A1 (en) * 2013-08-31 2015-03-05 Pandata Research Llc Integrated optoelectronic module for physiological measurements and methods of use of the module
WO2015167417A1 (en) * 2014-04-08 2015-11-05 Pandata Research Llc Optical measurement system having an integrated internal reflection element and array detector
WO2015156777A1 (en) * 2014-04-08 2015-10-15 Pandata Research Llc Optical measurement system having an integrated internal reflection element and array detector
WO2015156778A1 (en) * 2014-04-08 2015-10-15 Pandata Research Llc Optical measurement system having an integrated internal reflection element and a plurality of array detectors
US10806385B2 (en) 2015-01-21 2020-10-20 National Institutes For Quantum And Radiological Science And Technology Device for measuring concentration of substance in blood, and method for measuring concentration of substance in blood
KR102115105B1 (en) * 2015-11-23 2020-05-26 에프. 호프만-라 로슈 아게 Method and apparatus for determining the concentration of analyte in body fluids
WO2018122319A1 (en) * 2016-12-30 2018-07-05 Swiss Spectral Ag Device and method for the non-invasive determination of analytes
ES2774983B2 (en) 2019-01-22 2021-06-10 Univ Sevilla PORTABLE DEVICE AND METHOD FOR NON-INVASIVE ESTIMATION OF GLUCOSE LEVEL IN BLOOD
JP7438774B2 (en) * 2020-02-05 2024-02-27 アズビル株式会社 measuring device
CN116075709A (en) * 2020-07-30 2023-05-05 株式会社理光 measuring equipment
WO2023060953A1 (en) * 2021-10-12 2023-04-20 深圳硅基传感科技有限公司 Sensor and method for obtaining analyte concentration while taking into consideration temperature compensation
CN114878492B (en) * 2022-06-02 2024-06-21 西北核技术研究所 Hyperspectral light source scanning interval selection method based on temperature sensitive factors

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0160768A1 (en) * 1984-05-04 1985-11-13 Kurabo Industries Ltd. Spectrophotometric apparatus for the non-invasive determination of glucose in body tissues
WO1992017765A1 (en) * 1991-03-28 1992-10-15 Johnson & Johnson Professional Products Limited Method and apparatus for glucose concentration monitoring
US5553613A (en) * 1994-08-17 1996-09-10 Pfizer Inc. Non invasive blood analyte sensor
WO2001079818A2 (en) * 2000-04-12 2001-10-25 Medoptix, Inc. Infrared atr glucose measurement system
US20030023152A1 (en) * 2001-04-11 2003-01-30 Abbink Russell E. System for non-invasive measurement of glucose in humans
US20030031597A1 (en) * 2001-08-03 2003-02-13 Waseda University Apparatus for measuring glucose concentration
WO2004091403A1 (en) * 2003-04-15 2004-10-28 Optiscan Biomedical Corporation Sample element with barrier material

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0160768A1 (en) * 1984-05-04 1985-11-13 Kurabo Industries Ltd. Spectrophotometric apparatus for the non-invasive determination of glucose in body tissues
WO1992017765A1 (en) * 1991-03-28 1992-10-15 Johnson & Johnson Professional Products Limited Method and apparatus for glucose concentration monitoring
US5553613A (en) * 1994-08-17 1996-09-10 Pfizer Inc. Non invasive blood analyte sensor
WO2001079818A2 (en) * 2000-04-12 2001-10-25 Medoptix, Inc. Infrared atr glucose measurement system
US20030023152A1 (en) * 2001-04-11 2003-01-30 Abbink Russell E. System for non-invasive measurement of glucose in humans
US20030031597A1 (en) * 2001-08-03 2003-02-13 Waseda University Apparatus for measuring glucose concentration
WO2004091403A1 (en) * 2003-04-15 2004-10-28 Optiscan Biomedical Corporation Sample element with barrier material

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KEN-ICHIRO KAJIWARA: "SPECTROSCOPIC QUANTITATIVE ANALYSIS OF BLOOD GLUCOSE BY FOURIER TRANSFORM INFRARED SPECTROSCOPY WITH AN ATTENUATED TOTAL REFLECTIONPRISM", MEDICAL PROGRESS THROUGH TECHNOLOGY, SPRINGER VERLAG. BERLIN, DE, vol. 18, no. 3, January 1992 (1992-01-01), pages 181 - 189, XP000331119, ISSN: 0047-6552 *
SIMHI R ET AL: "Blood diagnostics using fiberoptic evanescent wave spectroscopy and neural networks analysis", SENSORS AND ACTUATORS B, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 42, no. 3, August 1997 (1997-08-01), pages 157 - 161, XP004100260, ISSN: 0925-4005 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9410917B2 (en) 2004-02-06 2016-08-09 Ascensia Diabetes Care Holdings Ag Method of using a biosensor
US8877035B2 (en) 2005-07-20 2014-11-04 Bayer Healthcare Llc Gated amperometry methods
US8647489B2 (en) 2005-09-30 2014-02-11 Bayer Healthcare Llc Gated voltammetry devices
US9110013B2 (en) 2005-09-30 2015-08-18 Bayer Healthcare Llc Gated voltammetry methods
US9005527B2 (en) 2006-10-24 2015-04-14 Bayer Healthcare Llc Transient decay amperometry biosensors

Also Published As

Publication number Publication date
GB0501826D0 (en) 2005-03-09
WO2006079797A2 (en) 2006-08-03

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