[go: up one dir, main page]

WO2006078320A3 - Methods for manufacturing delivery devices and devices thereof - Google Patents

Methods for manufacturing delivery devices and devices thereof Download PDF

Info

Publication number
WO2006078320A3
WO2006078320A3 PCT/US2005/027477 US2005027477W WO2006078320A3 WO 2006078320 A3 WO2006078320 A3 WO 2006078320A3 US 2005027477 W US2005027477 W US 2005027477W WO 2006078320 A3 WO2006078320 A3 WO 2006078320A3
Authority
WO
WIPO (PCT)
Prior art keywords
devices
methods
manufacturing delivery
manufacturing
delivery devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/027477
Other languages
French (fr)
Other versions
WO2006078320A2 (en
Inventor
Jay K Staas
Thomas R Tice
Bruce W Hudson
Arthur J Tipton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Surmodics SMP Inc
Original Assignee
Brookwood Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brookwood Pharmaceuticals Inc filed Critical Brookwood Pharmaceuticals Inc
Priority to HK07111739.6A priority Critical patent/HK1103362B/en
Priority to AU2005325213A priority patent/AU2005325213B2/en
Priority to ES05856905T priority patent/ES2432556T3/en
Priority to EP05856905.4A priority patent/EP1781264B1/en
Priority to CA2575988A priority patent/CA2575988C/en
Publication of WO2006078320A2 publication Critical patent/WO2006078320A2/en
Publication of WO2006078320A3 publication Critical patent/WO2006078320A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Described herein are methodes for reducing and achieving the desired release of an agent from a delivery system. The desired release kinetics are achieved by exposing the surface of the delivery system with a fluid for a desired period of time.
PCT/US2005/027477 2004-08-04 2005-08-03 Methods for manufacturing delivery devices and devices thereof Ceased WO2006078320A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
HK07111739.6A HK1103362B (en) 2004-08-04 2005-08-03 Methods for manufacturing delivery devices and devices thereof
AU2005325213A AU2005325213B2 (en) 2004-08-04 2005-08-03 Methods for manufacturing delivery devices and devices thereof
ES05856905T ES2432556T3 (en) 2004-08-04 2005-08-03 Methods for manufacturing supply devices and their devices
EP05856905.4A EP1781264B1 (en) 2004-08-04 2005-08-03 Methods for manufacturing delivery devices and devices thereof
CA2575988A CA2575988C (en) 2004-08-04 2005-08-03 Methods for manufacturing delivery devices and devices thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59917404P 2004-08-04 2004-08-04
US60/599,174 2004-08-04

Publications (2)

Publication Number Publication Date
WO2006078320A2 WO2006078320A2 (en) 2006-07-27
WO2006078320A3 true WO2006078320A3 (en) 2006-10-19

Family

ID=36660844

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/027477 Ceased WO2006078320A2 (en) 2004-08-04 2005-08-03 Methods for manufacturing delivery devices and devices thereof

Country Status (7)

Country Link
US (2) US8541028B2 (en)
EP (2) EP2594259A1 (en)
AU (1) AU2005325213B2 (en)
CA (1) CA2575988C (en)
ES (1) ES2432556T3 (en)
PT (1) PT1781264E (en)
WO (1) WO2006078320A2 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7989018B2 (en) * 2001-09-17 2011-08-02 Advanced Cardiovascular Systems, Inc. Fluid treatment of a polymeric coating on an implantable medical device
US7285304B1 (en) * 2003-06-25 2007-10-23 Advanced Cardiovascular Systems, Inc. Fluid treatment of a polymeric coating on an implantable medical device
US7858110B2 (en) 2003-08-11 2010-12-28 Endo Pharmaceuticals Solutions, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
CA2437639C (en) 2003-08-11 2016-07-05 Valera Pharmaceuticals, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
EP2594259A1 (en) 2004-08-04 2013-05-22 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
JP5405825B2 (en) * 2005-07-18 2014-02-05 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Drug-containing implant and method of using the same
US20100273667A1 (en) * 2006-02-10 2010-10-28 The Regents Of The University Of Michigan Cell culture well-plates having inverted colloidal crystal scaffolds
US20090041825A1 (en) * 2006-02-10 2009-02-12 Kotov Nicholas A Cell culture well-plates having inverted colloidal crystal scaffolds
US8685421B2 (en) * 2006-07-07 2014-04-01 Surmodics, Inc. Beaded wound spacer device
US7794495B2 (en) * 2006-07-17 2010-09-14 Advanced Cardiovascular Systems, Inc. Controlled degradation of stents
EP1917971A1 (en) * 2006-10-27 2008-05-07 Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) Substained release formulations comprising very low molecular weight polymers
US20080233199A1 (en) * 2007-03-22 2008-09-25 Alkermes, Inc. Coacervation Process
WO2008153997A1 (en) * 2007-06-07 2008-12-18 Brookwood Pharmaceuticals, Inc. Reduced-mass, long-acting dosage forms
US20080317865A1 (en) * 2007-06-20 2008-12-25 Alkermes, Inc. Quench liquids and washing systems for production of microparticles
US20090110713A1 (en) * 2007-10-31 2009-04-30 Florencia Lim Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices
US8124601B2 (en) * 2007-11-21 2012-02-28 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
US8728528B2 (en) 2007-12-20 2014-05-20 Evonik Corporation Process for preparing microparticles having a low residual solvent volume
US20090202609A1 (en) * 2008-01-06 2009-08-13 Keough Steven J Medical device with coating composition
SI2957292T1 (en) * 2008-03-27 2018-04-30 Clinuvel Pharmaceuticals Limited Therapy for vitiligo
UA105502C2 (en) * 2008-09-30 2014-05-26 Ендо Фармас'Ютікалз Солюшнз Інк. Implantable device for the delivery of octreotide and methods of use thereof
CA2739181C (en) 2008-09-30 2017-03-14 Endo Pharmaceuticals Solutions Inc. Implantable device for the delivery of risperidone and methods of use thereof
CA2739179A1 (en) * 2008-09-30 2010-04-08 Endo Pharmaceuticals Solutions Inc. Implantable device for the delivery of histrelin and methods of use thereof
US8822546B2 (en) 2008-12-01 2014-09-02 Medtronic, Inc. Flowable pharmaceutical depot
EP2246063A1 (en) * 2009-04-29 2010-11-03 Ipsen Pharma S.A.S. Sustained release formulations comprising GnRH analogues
BR112012006103B8 (en) 2009-09-17 2021-05-25 Evonik Corp implant device and kit
JP2013505113A (en) * 2009-09-22 2013-02-14 エボニック デグサ コーポレイション Implant device for regulating bioactive agent release profile
EP2590628A1 (en) 2010-06-30 2013-05-15 Evonik Corporation Implant processing methods for thermally labile and other bioactive agents and implants prepared from same
US8486435B2 (en) 2010-06-30 2013-07-16 Evonik Corporation Core-sheath implant device having an inner core lobe
EP2790637A4 (en) * 2011-12-16 2015-04-29 Combinent Biomedical Systems Inc Vaginal drug delivery devices and manufacturing methods
DK2793962T3 (en) * 2011-12-23 2016-08-15 Dang Quang Svend Le PROCEDURE FOR MODIFYING THE SURFACE MORPHOLOGY OF A MEDICAL DEVICE
EP2908870B1 (en) 2012-10-16 2018-05-23 SurModics, Inc. Wound packing device and methods
US10201457B2 (en) 2014-08-01 2019-02-12 Surmodics, Inc. Wound packing device with nanotextured surface
CN108042855A (en) * 2017-12-20 2018-05-18 江苏省健尔康医用敷料有限公司 The preparation method of polylactic acid anti-adhesion film
US11690807B2 (en) 2018-05-24 2023-07-04 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
EP3803866A4 (en) 2018-05-24 2022-03-16 Nureva Inc. METHOD, DEVICE AND COMPUTER-READABLE MEDIA FOR MANAGING SEMI-CONSTANT (PERSISTENT) SOUND SOURCES IN MICROPHONE RECORDING/FOCUS ZONES
AU2019275409B2 (en) 2018-05-24 2024-08-15 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
EP4329734A4 (en) 2021-04-26 2025-04-02 Celanese EVA Performance Polymers LLC IMPLANTABLE DEVICE FOR THE SUSTAINED RELEASE OF A MACROMOLECULAR DRUG COMPOUND

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450150A (en) * 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
US4612009A (en) * 1984-06-19 1986-09-16 Ceskoslovenska Akademie Ved Biodegradable implant and a method for preparation thereof
US5153002A (en) * 1991-03-04 1992-10-06 University Of Montreal Biocompatible gradient controlled release implant
WO1993017662A1 (en) * 1992-03-02 1993-09-16 Daratech Pty. Ltd. Improved implants
US20030161881A1 (en) * 2001-12-18 2003-08-28 Hansen Henrik Egesborg Solid dose micro implant

Family Cites Families (409)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2648609A (en) 1949-01-21 1953-08-11 Wisconsin Alumni Res Found Method of applying coatings to edible tablets or the like
BE590276A (en) 1959-04-30
US3117027A (en) 1960-01-08 1964-01-07 Wisconsin Alumni Res Found Apparatus for coating particles in a fluidized bed
US3207824A (en) 1962-06-22 1965-09-21 Wisconsin Alumni Res Found Process for preparing agglomerates
US3196827A (en) 1962-11-19 1965-07-27 Wisconsin Alumni Res Found Apparatus for the encapsulation of discrete particles
US3253944A (en) 1964-01-13 1966-05-31 Wisconsin Alumni Res Found Particle coating process
US3241520A (en) 1964-10-19 1966-03-22 Wisconsin Alumni Res Found Particle coating apparatus
US4344431A (en) 1969-03-24 1982-08-17 University Of Delaware Polymeric article for dispensing drugs
US4419340A (en) 1969-03-24 1983-12-06 University Of Delaware Controlled release of anticancer agents from biodegradable polymers
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4069307A (en) 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US4351337A (en) 1973-05-17 1982-09-28 Arthur D. Little, Inc. Biodegradable, implantable drug delivery device, and process for preparing and using the same
US3978203A (en) 1974-07-12 1976-08-31 Dynatech Corporation Sustained release of pharmaceuticals from polyester matrices
US4093709A (en) 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4134742A (en) 1977-06-06 1979-01-16 Envirogenic Systems Company Gas separation membranes
US4186189A (en) 1977-09-28 1980-01-29 Ethicon, Inc. Absorbable pharmaceutical compositions based on poly(alkylene oxalates)
US4249531A (en) 1979-07-05 1981-02-10 Alza Corporation Bioerodible system for delivering drug manufactured from poly(carboxylic acid)
US4346709A (en) 1980-11-10 1982-08-31 Alza Corporation Drug delivery devices comprising erodible polymer and erosion rate modifier
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
IN156886B (en) 1981-08-22 1985-11-30 Council Scient Ind Res
US5310559A (en) 1982-09-01 1994-05-10 Hercon Laboratories Corporation Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer
CH661206A5 (en) 1983-09-23 1987-07-15 Debiopharm Sa PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF HORMONDEPENDENT DISEASES.
US4568559A (en) 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
US4623588A (en) 1984-02-06 1986-11-18 Biotek, Inc. Controlled release composite core coated microparticles
US6410056B1 (en) 1984-03-16 2002-06-25 The United States Of America As Represented By The Secretary Of The Army Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix
US6309669B1 (en) 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US6217911B1 (en) 1995-05-22 2001-04-17 The United States Of America As Represented By The Secretary Of The Army sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres
US4657543A (en) 1984-07-23 1987-04-14 Massachusetts Institute Of Technology Ultrasonically modulated polymeric devices for delivering compositions
US4650665A (en) 1985-02-08 1987-03-17 Ethicon, Inc. Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4863735A (en) 1985-02-19 1989-09-05 Massachusetts Institute Of Technology Biodegradable polymeric drug delivery system with adjuvant activity
US4720384A (en) 1985-05-03 1988-01-19 E. I. Du Pont De Nemours And Company Manufacture of hollow fine tubular drug delivery systems
DE3521684A1 (en) 1985-06-18 1986-12-18 Dr. Müller-Lierheim KG, Biologische Laboratorien, 8033 Planegg METHOD FOR COATING POLYMERS
US4976949A (en) 1985-10-25 1990-12-11 The University Of Michigan Controlled release dosage form
DE3542972A1 (en) 1985-12-05 1987-06-11 Merck Patent Gmbh PHARMACADEPOT
US4794001A (en) 1986-03-04 1988-12-27 American Home Products Corporation Formulations providing three distinct releases
IT1204294B (en) * 1986-03-11 1989-03-01 Gentili Ist Spa METHOD OF MANUFACTURE OF GRANULARS SUITABLE FOR THE PRODUCTION OF COATED TABLETS, FOR ORAL USE, WITH CONTROLLED RELEASE
EP0246795A3 (en) 1986-05-20 1990-04-04 Advanced Peptide Development Limited Synthetic natriuretic peptides
CA1257199A (en) 1986-05-20 1989-07-11 Paul Y. Wang Preparation containing bioactive macromolecular substance for multi-months release in vivo
US4832686A (en) 1986-06-24 1989-05-23 Anderson Mark E Method for administering interleukin-2
US4839130A (en) 1986-07-17 1989-06-13 United States Surgical Corporation Process of making an absorbable surgical device
US5322691A (en) 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US4981696A (en) 1986-12-22 1991-01-01 E. I. Du Pont De Nemours And Company Polylactide compositions
CH668553A5 (en) 1987-02-02 1989-01-13 Mepha Ag MEDICINAL PRODUCTS WITH DELAYED RELEASE OF THE ACTIVE SUBSTANCE.
US4883666A (en) 1987-04-29 1989-11-28 Massachusetts Institute Of Technology Controlled drug delivery system for treatment of neural disorders
US5114719A (en) 1987-04-29 1992-05-19 Sabel Bernhard A Extended drug delivery of small, water-soluble molecules
US4792448A (en) 1987-06-11 1988-12-20 Pfizer Inc. Generic zero order controlled drug delivery system
US4952403A (en) 1987-06-19 1990-08-28 President And Fellows Of Harvard College Implants for the promotion of healing of meniscal tissue
US5013553A (en) 1987-06-30 1991-05-07 Vipont Pharmaceutical, Inc. Drug delivery devices
US4894231A (en) 1987-07-28 1990-01-16 Biomeasure, Inc. Therapeutic agent delivery system
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
DE19975054I2 (en) 1987-08-08 2000-04-13 Akzo Nobel Nv Contraceptive implant
GB2209937B (en) 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US5035891A (en) 1987-10-05 1991-07-30 Syntex (U.S.A.) Inc. Controlled release subcutaneous implant
US5187150A (en) 1987-10-14 1993-02-16 Debiopharm S.A. Polyester-based composition for the controlled release of polypeptide medicinal substances
US5152781A (en) 1987-12-17 1992-10-06 Allied-Signal Inc. Medical devices fabricated from homopolymers and copolymers having recurring carbonate units
US5120802A (en) 1987-12-17 1992-06-09 Allied-Signal Inc. Polycarbonate-based block copolymers and devices
US4898734A (en) 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
US4902515A (en) 1988-04-28 1990-02-20 E. I. Dupont De Nemours And Company Polylactide compositions
US5702716A (en) 1988-10-03 1997-12-30 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5633002A (en) 1988-10-04 1997-05-27 Boehringer Ingelheim Gmbh Implantable, biodegradable system for releasing active substance
US5034229A (en) 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US4975280A (en) 1989-01-23 1990-12-04 Ethyl Corporation Bioerodable sustained release implants
US5141748A (en) 1989-02-17 1992-08-25 Hoffmann-La Roche, Inc. Implant drug delivery device
US6419655B1 (en) 1998-07-16 2002-07-16 Gonex, Inc. Method for controlling animal populations utilizing a sterilant projectile
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
DE69024953T3 (en) 1989-05-04 2005-01-27 Southern Research Institute, Birmingham encapsulation
US5178874A (en) 1989-06-30 1993-01-12 Smithkline Beechman Corporation Intermittent release dosage form
US5273752A (en) 1989-07-18 1993-12-28 Alza Corporation Controlled release dispenser comprising beneficial agent
US5439688A (en) 1989-07-28 1995-08-08 Debio Recherche Pharmaceutique S.A. Process for preparing a pharmaceutical composition
US5225205A (en) 1989-07-28 1993-07-06 Debiopharm S.A. Pharmaceutical composition in the form of microparticles
CH679207A5 (en) 1989-07-28 1992-01-15 Debiopharm Sa
MY107937A (en) 1990-02-13 1996-06-29 Takeda Chemical Industries Ltd Prolonged release microcapsules.
US5290494A (en) 1990-03-05 1994-03-01 Board Of Regents, The University Of Texas System Process of making a resorbable implantation device
US5872100A (en) 1990-05-11 1999-02-16 Deghenghi; Romano Peptides containing D-2-Alkyl-Tryptophan
US5668254A (en) 1990-05-11 1997-09-16 Romano Deghenghi D-2-alkyl-tryptophan and peptides containing same
GB9011767D0 (en) 1990-05-25 1990-07-18 Britannia Pharmaceuticals Ltd Pharmaceutical compositions
US5234693A (en) 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
NZ239370A (en) 1990-08-22 1994-04-27 Merck & Co Inc Bioerodible implantable controlled release dosage form comprising a poly(ortho ester) or a polyacetal with an active agent incorporated into the chain backbone
US5164190A (en) 1990-12-11 1992-11-17 Theratech, Inc. Subsaturated transdermal drug delivery device exhibiting enhanced drug flux
WO1992011843A1 (en) 1991-01-09 1992-07-23 Alza Corporation Bioerodible devices and compositions for diffusional release of agents
US5340586A (en) 1991-04-12 1994-08-23 University Of Southern California Methods and formulations for use in treating oophorectomized women
US5800829A (en) 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
EP0585368B1 (en) 1991-04-25 1997-08-06 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
US5403595A (en) 1991-05-07 1995-04-04 Dynagen, Inc. Controlled, sustained release delivery system for smoking cessation
US5486362A (en) 1991-05-07 1996-01-23 Dynagen, Inc. Controlled, sustained release delivery system for treating drug dependency
HU222501B1 (en) 1991-06-28 2003-07-28 Endorecherche Inc. For the preparation of a sustained release pharmaceutical composition and method comprising MPA or MGA
CH683149A5 (en) 1991-07-22 1994-01-31 Debio Rech Pharma Sa Process for the preparation of microspheres of a biodegradable polymeric material.
AU2605592A (en) 1991-10-15 1993-04-22 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
ATE133331T1 (en) 1991-11-13 1996-02-15 Glaxo Canada DEVICE FOR CONTROLLED RELEASE OF ACTIVE INGREDIENTS
DE69212497T2 (en) 1991-12-05 1996-12-12 Mallinckrodt Veterinary, Inc., Mundelein, Ill. GLASS-LIKE CARBOHYDRATE MATRICE FOR THE ADMINISTRATION OF MEDICINES WITH DELAYED DELIVERY OF ACTIVE SUBSTANCES
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US6013853A (en) 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5456679A (en) 1992-02-18 1995-10-10 Alza Corporation Delivery devices with pulsatile effect
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5656297A (en) 1992-03-12 1997-08-12 Alkermes Controlled Therapeutics, Incorporated Modulated release from biocompatible polymers
US5912015A (en) 1992-03-12 1999-06-15 Alkermes Controlled Therapeutics, Inc. Modulated release from biocompatible polymers
US5429822A (en) 1992-03-13 1995-07-04 Cambridge Scientific, Inc. Biodegradable bursting release system
GB9206504D0 (en) 1992-03-25 1992-05-06 Jevco Ltd Heteromorphic sponges as wound implants
EP0633907A1 (en) 1992-03-30 1995-01-18 Alza Corporation Additives for bioerodible polymers to regulate degradation
US5756117A (en) 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
US5461140A (en) 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
US5518730A (en) 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
US5711968A (en) 1994-07-25 1998-01-27 Alkermes Controlled Therapeutics, Inc. Composition and method for the controlled release of metal cation-stabilized interferon
US6514533B1 (en) 1992-06-11 2003-02-04 Alkermas Controlled Therapeutics, Inc. Device for the sustained release of aggregation-stabilized, biologically active agent
US5716644A (en) 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
FR2695826B1 (en) 1992-09-21 1995-01-06 Theramex New pharmaceutical compositions based on nomegestrol derivatives and methods for obtaining them.
GB9223144D0 (en) 1992-11-05 1992-12-16 Scherer Corp R P Controlled release device
EP1013270A3 (en) 1992-12-02 2001-03-28 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
GB2273874A (en) 1992-12-31 1994-07-06 Pertti Olavi Toermaelae Preparation of pharmaceuticals in a polymer matrix
US5429634A (en) 1993-09-09 1995-07-04 Pdt Systems Biogenic implant for drug delivery and method
US6096331A (en) 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5478355A (en) 1993-03-18 1995-12-26 United States Surgical Corporation Method for improving the in vivo strength retention of a bioabsorbable implantable medical device and resulting medical device
US5382435A (en) 1993-03-24 1995-01-17 Southwest Research Institute Microparticulate pharmaceutical delivery system
US5456917A (en) 1993-04-12 1995-10-10 Cambridge Scientific, Inc. Method for making a bioerodible material for the sustained release of a medicament and the material made from the method
US5906817A (en) 1993-04-21 1999-05-25 Institut Pasteur Biocompatible implant for the expression and in vivo secretion of a therapeutic substance
JPH07112940A (en) 1993-08-26 1995-05-02 Takeda Chem Ind Ltd Sustained-release parenteral preparation and its production
IL110787A0 (en) 1993-08-27 1994-11-11 Sandoz Ag Biodegradable polymer, its preparation and pharmaceutical composition containing it
EP0677297B1 (en) 1993-09-24 2000-12-13 Takiron Co. Ltd. Implantation material
US5681873A (en) 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
US6913767B1 (en) 1993-10-25 2005-07-05 Genentech, Inc. Compositions for microencapsulation of antigens for use as vaccines
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
JP3720386B2 (en) 1993-12-27 2005-11-24 住友製薬株式会社 Drug release controlled formulation
US5554147A (en) 1994-02-01 1996-09-10 Caphco, Inc. Compositions and devices for controlled release of active ingredients
US5626611A (en) 1994-02-10 1997-05-06 United States Surgical Corporation Composite bioabsorbable materials and surgical articles made therefrom
CA2190121A1 (en) 1994-03-15 1995-09-21 Edith Mathiowitz Polymeric gene delivery system
ATE317690T1 (en) 1994-04-08 2006-03-15 Qlt Usa Inc LIQUID COMPOSITIONS FOR DRUG DELIVERY
US6855331B2 (en) 1994-05-16 2005-02-15 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US6447796B1 (en) 1994-05-16 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Sustained release hydrophobic bioactive PLGA microspheres
US5958458A (en) 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
US5633000A (en) 1994-06-23 1997-05-27 Axxia Technologies Subcutaneous implant
US5817327A (en) 1994-07-27 1998-10-06 The Trustees Of The University Of Pennsylvania Incorporation of biologically active molecules into bioactive glasses
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5681568A (en) 1994-08-19 1997-10-28 Cambridge Neuroscience, Inc. Device for delivery of substances and methods of use thereof
ES2186730T3 (en) 1994-09-27 2003-05-16 Ardana Bioscience Ltd OLIGOPPEPTIDIC COMPOUNDS CONTAINING A D-2-ALKYL TRIPTOPHAN AMINO ACID AND THAT ARE ABLE TO RELEASE GROWTH HORMONE.
AUPM897594A0 (en) 1994-10-25 1994-11-17 Daratech Pty Ltd Controlled release container
US6395303B1 (en) 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
EP0808153B1 (en) 1995-02-10 1999-08-04 Medtronic, Inc. Method and device for administering analgesics
US5900425A (en) 1995-05-02 1999-05-04 Bayer Aktiengesellschaft Pharmaceutical preparations having controlled release of active compound and processes for their preparation
US5922253A (en) 1995-05-18 1999-07-13 Alkermes Controlled Therapeutics, Inc. Production scale method of forming microparticles
US6902743B1 (en) 1995-05-22 2005-06-07 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
HUP9700322A3 (en) 1995-06-09 2001-03-28 Euro Celtique Sa Formulations and methods for providing prolonged local anesthesia
US6245347B1 (en) 1995-07-28 2001-06-12 Zars, Inc. Methods and apparatus for improved administration of pharmaceutically active compounds
US5705191A (en) 1995-08-18 1998-01-06 The United States Of America As Represented By The Secretary Of The Navy Sustained delivery of active compounds from tubules, with rational control
WO1997007788A2 (en) 1995-08-31 1997-03-06 Alkermes Controlled Therapeutics, Inc. Composition for sustained release of an agent
US6265389B1 (en) 1995-08-31 2001-07-24 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of oligonucleotides
TW448055B (en) 1995-09-04 2001-08-01 Takeda Chemical Industries Ltd Method of production of sustained-release preparation
FI954565A0 (en) 1995-09-27 1995-09-27 Biocon Oy Biologically applied polymeric material to the implant and foil preparation
AUPN605795A0 (en) 1995-10-19 1995-11-09 F.H. Faulding & Co. Limited Analgesic pharmaceutical composition
US6419920B1 (en) 1995-10-25 2002-07-16 Trans Karyotic Therapies, Inc. Hybrid matrix implants and explants
US5965125A (en) 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
EP0877599B1 (en) 1996-02-02 2003-03-26 Alza Corporation Sustained delivery of leuprolide using an implantable system
US6395292B2 (en) 1996-02-02 2002-05-28 Alza Corporation Sustained delivery of an active agent using an implantable system
US6261584B1 (en) 1996-02-02 2001-07-17 Alza Corporation Sustained delivery of an active agent using an implantable system
US6156331A (en) 1996-02-02 2000-12-05 Alza Corporation Sustained delivery of an active agent using an implantable system
DE19608423A1 (en) 1996-03-05 1997-09-11 Merck Patent Gmbh Phased drug delivery implants
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
US5747060A (en) 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
FR2748205A1 (en) 1996-05-06 1997-11-07 Debio Rech Pharma Sa PHARMACEUTICAL COMPOSITIONS FOR THE CONTROLLED RELEASE OF INSOLUBLE ACTIVE SUBSTANCES
US5817343A (en) 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
DE19622355A1 (en) 1996-06-04 1997-12-11 Bayer Ag Molded bodies that release agrochemicals
US5807985A (en) 1996-06-11 1998-09-15 Deghenghi; Romano Oligopeptide compounds containing D-2-alkyltryptophan capable of promoting the release of growth hormone
US6066325A (en) 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US5945128A (en) 1996-09-04 1999-08-31 Romano Deghenghi Process to manufacture implants containing bioactive peptides
DE19701912C1 (en) 1997-01-10 1998-05-14 Jenapharm Gmbh Implant for controlled drug release
US6203813B1 (en) 1997-01-13 2001-03-20 Lance L. Gooberman Pharmaceutical delivery device and method of preparation therefor
FR2762318B1 (en) 1997-04-18 1999-09-17 Pharma Biotech COMPOSITIONS HAVING SUSTAINED RELEASE AND A PROCESS FOR THEIR PREPARATION
DK0981381T3 (en) 1997-05-12 2007-06-04 Metabolix Inc Polyhydroxyalkanoates ten applications in vivo
US5945284A (en) 1997-05-27 1999-08-31 The Perkin-Elmer Corporation Length determination of nucleic acid repeat sequences by discontinuous primer extension
US5874098A (en) 1997-05-28 1999-02-23 Ivy Laboratories, Inc. Pellet implant system
JP2002511075A (en) 1997-06-04 2002-04-09 デビオ ルシェルシュ ファルマスティク ソシエテ アノニム Implant for controlled release of pharmaceutically active ingredient and method for producing the same
SI9700186B (en) 1997-07-14 2006-10-31 Lek, Tovarna Farmacevtskih In Kemicnih Izdelkov, D.D. Novel pharmaceutical preparation with controlled release of active healing substances
IL134084A0 (en) 1997-07-18 2001-04-30 Infimed Inc Biodegradable macromers for the controlled release of biologically active substances
US6828357B1 (en) 1997-07-31 2004-12-07 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
AU9062998A (en) 1997-09-11 1999-03-29 Nycomed Danmark A/S Modified release multiple-units compositions of non-steroid anti-inflammatory drug substances (nsaids)
US6120788A (en) 1997-10-16 2000-09-19 Bioamide, Inc. Bioabsorbable triglycolic acid poly(ester-amide)s
CA2221195A1 (en) 1997-11-14 1999-05-14 Chantal E. Holy Biodegradable polymer matrix
US6472210B1 (en) 1997-11-14 2002-10-29 Bonetec Corporation Polymer scaffold having microporous polymer struts defining interconnected macropores
US6187329B1 (en) 1997-12-23 2001-02-13 Board Of Regents Of The University Of Texas System Variable permeability bone implants, methods for their preparation and use
KR20010041528A (en) 1998-03-02 2001-05-25 어플라이드 백신 테크놀로지스 코포레이션 Methods and devices for modulating the immune response
ES2359973T3 (en) 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. LIQUID POLYMER COMPOSITIONS FOR THE CONTROLLED RELEASE OF BIOACTIVE SUBSTANCES.
US6296831B1 (en) 1998-04-10 2001-10-02 Battelle Memorial Institute Stimulus sensitive gel with radioisotope and methods of making
US6406719B1 (en) 1998-05-13 2002-06-18 Microbiological Research Authority Encapsulation of bioactive agents
US6129757A (en) 1998-05-18 2000-10-10 Scimed Life Systems Implantable members for receiving therapeutically useful compositions
TW586944B (en) 1998-05-29 2004-05-11 Sumitomo Pharma Controlled release agent having a multi-layer structure
US6117441A (en) 1998-07-02 2000-09-12 The Population Council, Inc. Silicone core long term androgen delivery implant
NZ509186A (en) 1998-07-17 2005-01-28 Skyepharma Inc Biodegradable compositions for the controlled release of encapsulated substances
EP1100479B2 (en) 1998-08-06 2016-12-07 Jörg Dr.Dr. Schierholz Medicinal products with retarded pharmacological activity and method for the production thereof
US20040126404A1 (en) 1998-08-21 2004-07-01 University Of Queensland Of St. Lucia Implant material
US6335029B1 (en) 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
JP2003524444A (en) 1998-09-10 2003-08-19 パーカーディア，インコーポレイティド TMR shunt
US6565874B1 (en) 1998-10-28 2003-05-20 Atrix Laboratories Polymeric delivery formulations of leuprolide with improved efficacy
US6143314A (en) 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
US6063395A (en) 1998-11-12 2000-05-16 Leiras Oy Drug delivery device especially for the delivery of progestins and estrogens
US6117442A (en) 1998-11-12 2000-09-12 Leiras Oy Drug delivery device, especially for the delivery of androgens
US6165486A (en) 1998-11-19 2000-12-26 Carnegie Mellon University Biocompatible compositions and methods of using same
IT1304152B1 (en) 1998-12-10 2001-03-08 Mediolanum Farmaceutici Srl COMPOSITIONS INCLUDING A PEPTIDE AND POLYLACTIC-GLYCOLIC ACID FOR THE PREPARATION OF SUBCUTANEOUS IMPLANTS HAVING A PROLONGED
US6692520B1 (en) 1998-12-15 2004-02-17 C. R. Bard, Inc. Systems and methods for imbedded intramuscular implants
US6455526B1 (en) 1998-12-16 2002-09-24 Aventis Pharmaceuticals, Inc. Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same
US6696073B2 (en) 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6835194B2 (en) 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
DE60026513T2 (en) 1999-05-27 2006-10-05 Biocompatibles Uk Ltd., Farnham LOCAL DRUG DELIVERY
US6541020B1 (en) 1999-07-09 2003-04-01 Trimeris, Inc. Methods and compositions for administration of therapeutic reagents
US6309660B1 (en) 1999-07-28 2001-10-30 Edwards Lifesciences Corp. Universal biocompatible coating platform for medical devices
US6855160B1 (en) 1999-08-04 2005-02-15 C. R. Bard, Inc. Implant and agent delivery device
AU6526100A (en) 1999-08-06 2001-03-05 Board Of Regents, The University Of Texas System Drug releasing biodegradable fiber implant
FI19991852A7 (en) 1999-09-01 2001-03-02 Yli Urpo Antti Novel multilayer material comprising an active ingredient and its preparation
JP4172883B2 (en) 1999-09-08 2008-10-29 Ｈｏｙａ株式会社 Drug sustained release carrier and method for producing drug sustained release carrier
US6573311B1 (en) 1999-09-22 2003-06-03 Atrium Medical Corporation Method for treating polymer materials and products produced therefrom
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
US6461631B1 (en) 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
US20040009228A1 (en) 1999-11-30 2004-01-15 Pertti Tormala Bioabsorbable drug delivery system for local treatment and prevention of infections
US6579533B1 (en) 1999-11-30 2003-06-17 Bioasborbable Concepts, Ltd. Bioabsorbable drug delivery system for local treatment and prevention of infections
US20020131988A1 (en) 1999-12-16 2002-09-19 Foster Todd P. Pharmaceutical implant containing immediate-release and sustained-release components and method of administration
CA2395974A1 (en) 2000-01-20 2001-07-26 Suggy S. Chrai Multi-step drug dosage forms
TW200800298A (en) 2000-01-27 2008-01-01 Zentaris Ag Compressed microparticles for dry injection
CA2398668C (en) 2000-02-17 2010-06-15 3M Innovative Properties Company Delivery systems using preformed biodegradable polymer compositions and methods
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US20040175410A1 (en) 2000-04-26 2004-09-09 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors
US20040208910A1 (en) 2000-04-26 2004-10-21 Control Delivery Systems, Inc. Sustained release device and method for ocular delivery of adrenergic agents
US7300662B2 (en) 2000-05-12 2007-11-27 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
US20040243097A1 (en) 2000-05-12 2004-12-02 Robert Falotico Antiproliferative drug and delivery device
US20050002986A1 (en) 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US6419954B1 (en) 2000-05-19 2002-07-16 Yamanouchi Pharmaceutical Co., Ltd. Tablets and methods for modified release of hydrophilic and other active agents
US6306423B1 (en) 2000-06-02 2001-10-23 Allergan Sales, Inc. Neurotoxin implant
KR100392501B1 (en) 2000-06-28 2003-07-22 동국제약 주식회사 Preparation Method for Sustained Release Microparticles by Multiple Emulsion Method and Micropartic les Thereof
US6767550B1 (en) 2000-06-30 2004-07-27 Berkeley Advanced Biomaterials, Inc. Hydroxyapatite based drug delivery implant for cancer treatment
US8158143B2 (en) 2000-07-14 2012-04-17 Helmholtz-Zentrum Geesthacht Zentrum Fuer Material- Und Kuestenforschung Gmbh Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect
US6669959B1 (en) 2000-07-18 2003-12-30 Aeropharm Technology Incorporated Modulated release particles for lung delivery
US6479065B2 (en) 2000-08-10 2002-11-12 Alkermes Controlled Therapeutics, Inc. Process for the preparation of polymer-based sustained release compositions
US6296842B1 (en) 2000-08-10 2001-10-02 Alkermes Controlled Therapeutics, Inc. Process for the preparation of polymer-based sustained release compositions
DE10044545A1 (en) 2000-09-05 2002-04-04 Roland Bodmeier Retardpartikeldispersion
US6953560B1 (en) 2000-09-28 2005-10-11 Advanced Cardiovascular Systems, Inc. Barriers for polymer-coated implantable medical devices and methods for making the same
US20040115236A1 (en) 2000-10-06 2004-06-17 Chan Tai Wah Devices and methods for management of inflammation
US6783793B1 (en) 2000-10-26 2004-08-31 Advanced Cardiovascular Systems, Inc. Selective coating of medical devices
US6746661B2 (en) 2000-11-16 2004-06-08 Microspherix Llc Brachytherapy seed
US6545097B2 (en) 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
US20030049320A1 (en) 2000-12-18 2003-03-13 Wockhardt Limited Novel in-situ forming controlled release microcarrier delivery system
US7192604B2 (en) 2000-12-22 2007-03-20 Ethicon, Inc. Implantable biodegradable devices for musculoskeletal repair or regeneration
US20020119179A1 (en) 2000-12-22 2002-08-29 Alireza Rezania Implantable biodegradable devices for musculoskeletal repair or regeneration
US6939375B2 (en) 2000-12-22 2005-09-06 Avantac Vascular Corporation Apparatus and methods for controlled substance delivery from implanted prostheses
EP1345588A2 (en) 2000-12-29 2003-09-24 Bausch & Lomb Incorporated Sustained release drug delivery devices
US6756058B2 (en) 2001-01-03 2004-06-29 Bausch & Lomb Incorporated Sustained release drug delivery devices with multiple agents
US6719935B2 (en) 2001-01-05 2004-04-13 Howmedica Osteonics Corp. Process for forming bioabsorbable implants
US6524615B2 (en) 2001-02-21 2003-02-25 Kos Pharmaceuticals, Incorporated Controlled release pharmaceutical composition
US20020131953A1 (en) 2001-03-14 2002-09-19 Ut Southwestern Medical Center In situ langerhans cell vaccine
DE10114244A1 (en) 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Antibiotic / antibiotic preparation with active ingredient release
DE10114247A1 (en) 2001-03-22 2002-10-10 Heraeus Kulzer Gmbh & Co Kg Antibiotic / antibiotics-polymer combination
EP1247537A1 (en) 2001-04-04 2002-10-09 Isotis B.V. Coating for medical devices
US6913762B2 (en) 2001-04-25 2005-07-05 Mayo Foundation For Medical Education And Research Stent having non-woven framework containing cells
US20020168393A1 (en) 2001-05-08 2002-11-14 Ryota Sugimoto Implantable medical material and implantable medical device
AU2002324447B2 (en) 2001-06-22 2006-06-29 Durect Corporation Zero-order prolonged release coaxial implants
US6648849B2 (en) 2001-06-27 2003-11-18 Ethicon, Inc. Medicinal implant and device and method for loading and delivering implants containing drugs and cells
AUPR602501A0 (en) 2001-06-29 2001-07-26 Smart Drug Systems Inc Sustained release pharmaceutical composition
AUPR602401A0 (en) 2001-06-29 2001-07-26 Smart Drug Systems Inc Sustained release delivery system
JP4490095B2 (en) 2001-06-29 2010-06-23 メドグラフト マイクロテック インコーポレイテッド Biodegradable injectable implants and related methods of manufacture and use
US6921390B2 (en) 2001-07-23 2005-07-26 Boston Scientific Scimed, Inc. Long-term indwelling medical devices containing slow-releasing antimicrobial agents and having a surfactant surface
US6913760B2 (en) 2001-08-06 2005-07-05 New England Medical Hospitals, Inc. Drug delivery composition
US7056338B2 (en) 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US6669955B2 (en) 2001-08-28 2003-12-30 Longwood Pharmaceutical Research, Inc. Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin
GB0122113D0 (en) 2001-09-11 2001-10-31 Astrazeneca Ab Composition
GB2404865B (en) 2001-09-11 2005-09-28 Caretek Medical Ltd Novel drug delivery technology
CA2452194A1 (en) 2001-09-11 2003-03-20 Smart Drug Systems Inc Sustained release pharmaceutical compositions comprising a silicone support material
US20050129728A1 (en) 2001-09-11 2005-06-16 Martinod Serge R. Sustained release pharmaceutical composition
US20030158598A1 (en) 2001-09-17 2003-08-21 Control Delivery Systems, Inc. System for sustained-release delivery of anti-inflammatory agents from a coated medical device
IN2014DN10834A (en) 2001-09-17 2015-09-04 Psivida Inc
US20030229390A1 (en) 2001-09-17 2003-12-11 Control Delivery Systems, Inc. On-stent delivery of pyrimidines and purine analogs
US7285304B1 (en) * 2003-06-25 2007-10-23 Advanced Cardiovascular Systems, Inc. Fluid treatment of a polymeric coating on an implantable medical device
US6827737B2 (en) 2001-09-25 2004-12-07 Scimed Life Systems, Inc. EPTFE covering for endovascular prostheses and method of manufacture
US7163691B2 (en) 2001-10-12 2007-01-16 Osteotech, Inc. Bone graft
US6926903B2 (en) 2001-12-04 2005-08-09 Inion Ltd. Resorbable polymer composition, implant and method of making implant
CA2822457C (en) 2001-12-14 2016-03-08 The University Of Wyoming Methods and compositions for controlled resease of drugs
GB2399753B (en) 2002-01-18 2006-04-19 Michael E Snyder Method of making a sustained release ophthalmological device
JP2005522418A (en) 2002-01-24 2005-07-28 スマート ドラッグ システムズ インコーポレイティド Sustained release pharmaceutical composition
US8133501B2 (en) 2002-02-08 2012-03-13 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled drug delivery
US6887270B2 (en) 2002-02-08 2005-05-03 Boston Scientific Scimed, Inc. Implantable or insertable medical device resistant to microbial growth and biofilm formation
DE10208335A1 (en) 2002-02-27 2003-09-04 Roehm Gmbh Pharmaceutical form and process for its preparation
US7074426B2 (en) 2002-03-27 2006-07-11 Frank Kochinke Methods and drug delivery systems for the treatment of orofacial diseases
US7101394B2 (en) 2002-05-02 2006-09-05 Boston Scientific Scimed, Inc. Energetically-controlled delivery of biologically active material from an implanted medical device
NZ536965A (en) 2002-05-31 2007-02-23 Titan Pharmaceuticals Inc Nonerodible polymeric matrix with buprenorphine encapsulated for the treatment of opiate addiction and pain
NZ519363A (en) 2002-06-05 2004-02-27 Agres Ltd A novel drug dosing regimen
US7097850B2 (en) 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
US7105175B2 (en) 2002-06-19 2006-09-12 Boston Scientific Scimed, Inc. Implantable or insertable medical devices for controlled delivery of a therapeutic agent
US7101566B2 (en) 2002-06-28 2006-09-05 Ethicon, Inc. Polymer coated microparticles for sustained release
US7049348B2 (en) 2002-07-06 2006-05-23 Kensey Nash Corporation Resorbable structure for treating and healing of tissue defects
US20040006146A1 (en) 2002-07-06 2004-01-08 Evans Douglas G. Resorbable structure for treating and healing of tissue defects
US6916483B2 (en) 2002-07-22 2005-07-12 Biodynamics, Llc Bioabsorbable plugs containing drugs
US7767222B2 (en) 2002-07-31 2010-08-03 Mast Biosurgery Ag Apparatus and method for preventing adhesions between an implant and surrounding tissues
JP2006502135A (en) 2002-08-13 2006-01-19 メドトロニック・インコーポレーテッド Active drug delivery system, medical device and method
US7951392B2 (en) 2002-08-16 2011-05-31 Boston Scientific Scimed, Inc. Microarray drug delivery coatings
US7438925B2 (en) 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
WO2004021861A2 (en) 2002-09-03 2004-03-18 Vit Lauermann Targeted release
DE10242476B4 (en) 2002-09-11 2006-10-26 Heraeus Kulzer Gmbh Antibiotic / antibiotics-polymer combination
US7459169B2 (en) 2002-10-21 2008-12-02 Allvivo, Inc. Surface coating comprising bioactive compound
JP2006508127A (en) 2002-11-06 2006-03-09 アルザ・コーポレーション Controlled release depot formulation
US20050070989A1 (en) 2002-11-13 2005-03-31 Whye-Kei Lye Medical devices having porous layers and methods for making the same
US20060121080A1 (en) 2002-11-13 2006-06-08 Lye Whye K Medical devices having nanoporous layers and methods for making the same
US7758881B2 (en) 2004-06-30 2010-07-20 Advanced Cardiovascular Systems, Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US20040143221A1 (en) 2002-12-27 2004-07-22 Shadduck John H. Biomedical implant for sustained agent release
KR20050091040A (en) * 2002-12-30 2005-09-14 안지오테크 인터내셔날 아게 Silk-containing stent graft
US7985414B2 (en) 2003-02-04 2011-07-26 Warsaw Orthopedic, Inc. Polyurethanes for osteoimplants
US20050079199A1 (en) 2003-02-18 2005-04-14 Medtronic, Inc. Porous coatings for drug release from medical devices
US20080051866A1 (en) 2003-02-26 2008-02-28 Chao Chin Chen Drug delivery devices and methods
US20060083767A1 (en) 2003-02-27 2006-04-20 Kai Deusch Surgical prosthesis having biodegradable and nonbiodegradable regions
GB0304726D0 (en) 2003-03-01 2003-04-02 Ardana Bioscience Ltd New Process
US8313759B2 (en) 2003-03-06 2012-11-20 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing miscible polymer blends for controlled delivery of a therapeutic agent
EP1603532B1 (en) 2003-03-14 2008-08-13 Debio Recherche Pharmaceutique S.A. Subcutaneous delivery system, process for the preparation of the same and use of the same for the treatment of cholinergic deficient disorders
ES2359977T3 (en) 2003-03-31 2011-05-30 Titan Pharmaceuticals, Inc. IMPLANTABLE POLYMER DEVICE FOR SUSTAINED RELEASE OF DOPAMINE AGONIST.
US8007823B2 (en) 2003-04-03 2011-08-30 Corporation De L'ecole Polytechnique De Montreal Microporous articles comprising biodegradable medical polymers, method of preparation thereof and method of use thereof
US7241455B2 (en) 2003-04-08 2007-07-10 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing radiation-crosslinked polymer for controlled delivery of a therapeutic agent
US20060105018A1 (en) 2004-11-17 2006-05-18 Epstein Samuel J Therapeutic driving layer for a medical device
JP4824549B2 (en) 2003-05-02 2011-11-30 サーモディクス，インコーポレイティド Controlled release bioactive substance delivery device
US20040224000A1 (en) 2003-05-05 2004-11-11 Romano Deghenghi Implants for non-radioactive brachytherapy of hormonal-insensitive cancers
ES2819189T3 (en) 2003-05-08 2021-04-15 Tepha Inc Polyhydroxyalkanoate Medical Fibers and Fabrics
WO2004101017A2 (en) 2003-05-16 2004-11-25 Blue Membranes Gmbh Medical implants comprising biocompatible coatings
US20050031668A1 (en) 2003-05-30 2005-02-10 Patel Rajesh A. Implantable polymeric device for sustained release of nalmefene
WO2004108180A1 (en) 2003-06-04 2004-12-16 Inion Ltd Biodegradable implant and method for manufacturing one
US20040253293A1 (en) 2003-06-16 2004-12-16 Afshin Shafiee Rate controlled release of a pharmaceutical agent in a biodegradable device
ITMI20031302A1 (en) 2003-06-26 2004-12-27 Mediolanum Pharmaceuticals Ltd USE OF ETHANOL AS A PLASTICIZER TO PREPARE SUBCUTANEOUS IMPLANTS CONTAINING THERMALABLE ACTIVE PRINCIPLES DISPERSED IN A PLGA MATRIX.
CN100592904C (en) 2003-06-26 2010-03-03 梅迪奥拉努姆制药有限公司 Subcutaneous implants with limited initial release and subsequent linear-change extended release of active principle
US7220433B2 (en) 2003-06-27 2007-05-22 Ethicon, Inc. Compositions for parenteral administration and sustained-release of therapeutic agents
FI20045223A7 (en) 2004-06-15 2005-12-16 Bioretec Oy Multifunctional biodegradable composite and surgical implant comprising said composite
US20060240071A1 (en) 2003-07-31 2006-10-26 Sidney Lerner Non-hormonal vaginal contraceptive
US8870814B2 (en) 2003-07-31 2014-10-28 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing silicone copolymer for controlled delivery of therapeutic agent
US9114199B2 (en) 2003-07-31 2015-08-25 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing acrylic copolymer for controlled delivery of therapeutic agent
US7357940B2 (en) 2003-07-31 2008-04-15 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents
US7914805B2 (en) 2003-07-31 2011-03-29 Boston Scientific Scimed, Inc. Implantable or insertable medical devices containing radiation-treated polymer for improved delivery of therapeutic agent
US7169405B2 (en) 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
US20050037047A1 (en) 2003-08-11 2005-02-17 Young-Ho Song Medical devices comprising spray dried microparticles
US8529625B2 (en) 2003-08-22 2013-09-10 Smith & Nephew, Inc. Tissue repair and replacement
EP2462958A3 (en) 2003-09-23 2012-09-19 Orthocon Inc. Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects
US20050118229A1 (en) 2003-10-21 2005-06-02 Imedd, Inc. Implantable drug delivery device for sustained release of therapeutic agent
US7435256B2 (en) 2003-11-06 2008-10-14 Boston Scientific Scimed, Inc. Method and apparatus for controlled delivery of active substance
US20050208095A1 (en) 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
AU2004293075A1 (en) 2003-11-20 2005-06-09 Angiotech International Ag Soft tissue implants and anti-scarring agents
US20050249776A1 (en) 2003-12-19 2005-11-10 Chen Chao C Coated aneurysmal repair device
US8747881B2 (en) 2003-12-19 2014-06-10 Cordis Corporation Intraluminal medical devices in combination with therapeutic agents
JP2007517042A (en) 2003-12-30 2007-06-28 デュレクト コーポレーション Polymer implant for the controlled release of an active substance, preferably GNRH, preferably containing a mixture of PEG and PLG
US8329203B2 (en) 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US7303758B2 (en) 2004-01-20 2007-12-04 Cordis Corporation Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis following vascular injury
US20050181015A1 (en) 2004-02-12 2005-08-18 Sheng-Ping (Samuel) Zhong Layered silicate nanoparticles for controlled delivery of therapeutic agents from medical articles
US20050181047A1 (en) 2004-02-18 2005-08-18 Jaime Romero Compositions and methods for timed release of water-soluble nutritional supplements
US7806924B2 (en) 2004-02-18 2010-10-05 Cordis Corporation Implantable structures for local vascular delivery of cladribine in combination with rapamycin for restenosis
US8828416B2 (en) 2004-03-09 2014-09-09 Cordis Corporation Local vascular delivery of topotecan in combination with rapamycin to prevent restenosis following vascular injury
US7695731B2 (en) 2004-03-22 2010-04-13 Cordis Corporation Local vascular delivery of etoposide in combination with rapamycin to prevent restenosis following vascular injury
US7034050B2 (en) 2004-04-28 2006-04-25 Romano Deghenghi Pseudopeptides growth hormone secretagogues
US20050244461A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Controlled release drug delivery systems and methods for treatment of an eye
US8685435B2 (en) 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US20070059336A1 (en) 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
US8425929B2 (en) 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US8119154B2 (en) 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20050244465A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Drug delivery systems and methods for treatment of an eye
WO2006002399A2 (en) 2004-06-24 2006-01-05 Surmodics, Inc. Biodegradable implantable medical devices, methods and systems
DK1809349T3 (en) 2004-07-05 2009-12-07 Ziscoat N V Biocompatible coating for medical devices comprising molecular sieves
PL1629844T5 (en) 2004-07-13 2012-10-31 Bayer Schering Pharma Oy A longterm delivery system with controlled initial burst
US7771740B2 (en) 2004-07-19 2010-08-10 Boston Scientific Scimed, Inc. Medical devices containing copolymers with graft copolymer endblocks for drug delivery
US7713539B2 (en) 2004-07-19 2010-05-11 Boston Scientific Scimed, Inc. Medical devices containing radiation resistant block copolymer
EP2594259A1 (en) 2004-08-04 2013-05-22 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
KR100895135B1 (en) 2004-08-13 2009-05-04 마스트 바이오서저리 아게 Surgical prosthesis having biodegradable and nonbiodegradable regions
US20060039946A1 (en) 2004-08-20 2006-02-23 Medtronic Inc. Drug eluting medical device
US20060051390A1 (en) 2004-09-03 2006-03-09 Schwarz Marlene C Medical devices having self-forming rate-controlling barrier for drug release
AU2005292145C1 (en) 2004-10-01 2011-07-21 Ramscor, Inc. Conveniently implantable sustained release drug compositions
US20060210604A1 (en) 2004-10-04 2006-09-21 Eric Dadey Ocular delivery of polymeric delivery formulations
US20060093643A1 (en) 2004-11-04 2006-05-04 Stenzel Eric B Medical device for delivering therapeutic agents over different time periods
WO2006063021A2 (en) 2004-12-07 2006-06-15 Surmodics, Inc. Coatngs with crystallized active agents (s)
EP1835885A1 (en) 2004-12-23 2007-09-26 Durect Corporation Polymeric implants, preferably containing a mixture of peg and plg, for controlled release of a gnrh
US20060198868A1 (en) 2005-01-05 2006-09-07 Dewitt David M Biodegradable coating compositions comprising blends
US20060147491A1 (en) 2005-01-05 2006-07-06 Dewitt David M Biodegradable coating compositions including multiple layers
US7988987B2 (en) 2005-01-25 2011-08-02 Boston Scientific Scimed, Inc. Medical devices containing crazed polymeric release regions for drug delivery
US20060171980A1 (en) 2005-02-01 2006-08-03 Helmus Michael N Implantable or insertable medical devices having optimal surface energy
US8075906B2 (en) 2005-02-01 2011-12-13 Boston Scientific Scimed, Inc. Medical devices having polymeric regions with copolymers containing hydrocarbon and heteroatom-containing monomeric species
US8663639B2 (en) * 2005-02-09 2014-03-04 Santen Pharmaceutical Co., Ltd. Formulations for treating ocular diseases and conditions
US20060177480A1 (en) 2005-02-10 2006-08-10 Hsing-Wen Sung Drug-eluting biodegradable stent
US20060204548A1 (en) 2005-03-01 2006-09-14 Allergan, Inc. Microimplants for ocular administration
EP1879552B1 (en) 2005-03-14 2016-02-17 Biotegra, Inc. Drug delivery compositions comprising a polyelectrolyte complex within a polymeric matrix
US7857856B2 (en) 2005-03-15 2010-12-28 Warsaw Ortho Pedic, Inc. Composite spinal nucleus implant with water absorption and swelling capabilities
US7517914B2 (en) 2005-04-04 2009-04-14 Boston Scientificscimed, Inc. Controlled degradation materials for therapeutic agent delivery
CA2601864A1 (en) 2005-04-08 2006-10-19 Surmodics, Inc. Sustained release implants and methods for subretinal delivery of bioactive agents to treat or prevent retinal disease
US20060257448A1 (en) 2005-05-10 2006-11-16 The University Of Zurich Resorbable polymer composition, implant and method of making implant
US20070009564A1 (en) 2005-06-22 2007-01-11 Mcclain James B Drug/polymer composite materials and methods of making the same
WO2007001624A2 (en) 2005-06-28 2007-01-04 Microchips, Inc. Medical and dental implant devices for controlled drug delivery
US8722074B2 (en) 2005-07-19 2014-05-13 Boston Scientific Scimed, Inc. Medical devices containing radiation resistant polymers
US20070048350A1 (en) 2005-08-31 2007-03-01 Robert Falotico Antithrombotic coating for drug eluting medical devices
US20070053952A1 (en) 2005-09-07 2007-03-08 Medtronic Vascular, Inc. Nitric oxide-releasing polymers derived from modified polymers
US8652504B2 (en) 2005-09-22 2014-02-18 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
US8784860B2 (en) 2005-10-27 2014-07-22 Cordis Corporation Local administration of a combination of rapamycin and cilostazol for the treatment of vascular disease
US20070196423A1 (en) 2005-11-21 2007-08-23 Med Institute, Inc. Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent
US20070116736A1 (en) 2005-11-23 2007-05-24 Argentieri Dennis C Local vascular delivery of PI3 kinase inhibitors alone or in combination with sirolimus to prevent restinosis following vascular injury
CA2635534C (en) 2005-12-30 2014-07-29 Neurotech Usa Inc. Micronized device for the delivery of biologically active molecules and methods of use thereof
US7910152B2 (en) 2006-02-28 2011-03-22 Advanced Cardiovascular Systems, Inc. Poly(ester amide)-based drug delivery systems with controlled release rate and morphology
US20070212393A1 (en) 2006-03-08 2007-09-13 Sahajanand Medical Technologies Pvt. Ltd. Compositions and coatings for implantable medical devices
US20070224239A1 (en) 2006-03-27 2007-09-27 Niall Behan Method of making a coated medical device
WO2007115259A2 (en) 2006-03-31 2007-10-11 Qlt Plug Delivery, Inc. Nasolacrimal drainage system implants for drug therapy
CN105327393A (en) 2006-06-22 2016-02-17 南佛罗里达大学 Collagen scaffolds, medical implants with same and methods of use
US20070298073A1 (en) 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8802128B2 (en) 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
CA2656191C (en) 2006-06-28 2015-12-08 Surmodics, Inc. Hydrophilic active agent eluting polymeric matrices with microparticles
US7731987B2 (en) 2006-07-13 2010-06-08 Advanced Cardiovascular Systems, Inc. Implantable medical device comprising a pro-healing poly(ester-amide)
US8506984B2 (en) 2006-07-26 2013-08-13 Cordis Corporation Therapeutic agent elution control process
US9248121B2 (en) 2006-08-21 2016-02-02 Abbott Laboratories Medical devices for controlled drug release
US20080075753A1 (en) 2006-09-25 2008-03-27 Chappa Ralph A Multi-layered coatings and methods for controlling elution of active agents
BR112012006103B8 (en) 2009-09-17 2021-05-25 Evonik Corp implant device and kit
JP2013505113A (en) 2009-09-22 2013-02-14 エボニック デグサ コーポレイション Implant device for regulating bioactive agent release profile
EP2480200A2 (en) 2009-09-22 2012-08-01 Evonik Degussa Corporation Implant devices having varying bioactive agent loading configurations

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450150A (en) * 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
US4612009A (en) * 1984-06-19 1986-09-16 Ceskoslovenska Akademie Ved Biodegradable implant and a method for preparation thereof
US5153002A (en) * 1991-03-04 1992-10-06 University Of Montreal Biocompatible gradient controlled release implant
WO1993017662A1 (en) * 1992-03-02 1993-09-16 Daratech Pty. Ltd. Improved implants
US20030161881A1 (en) * 2001-12-18 2003-08-28 Hansen Henrik Egesborg Solid dose micro implant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ICHIRO YAMAKAWA ET AL: "SUSTAINED RELEASE OF INSULIN BY DOUBLE-LAYERED IMPLANT USING POLY(D,L-LACTIC ACID)", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 79, no. 6, 1 June 1990 (1990-06-01), pages 505 - 509, XP000132665, ISSN: 0022-3549 *

Also Published As

Publication number Publication date
EP1781264B1 (en) 2013-07-24
US20140037707A1 (en) 2014-02-06
EP1781264A2 (en) 2007-05-09
US8541028B2 (en) 2013-09-24
AU2005325213A1 (en) 2006-07-27
CA2575988C (en) 2014-02-18
CA2575988A1 (en) 2006-07-27
HK1103362A1 (en) 2007-12-21
EP2594259A1 (en) 2013-05-22
WO2006078320A2 (en) 2006-07-27
ES2432556T3 (en) 2013-12-04
US20060029637A1 (en) 2006-02-09
AU2005325213B2 (en) 2010-10-07
PT1781264E (en) 2013-10-16

Similar Documents

Publication Publication Date Title
WO2006078320A3 (en) Methods for manufacturing delivery devices and devices thereof
WO2005018683A3 (en) Anastomotic connector devices
WO2008076731A3 (en) A coating of fast absorption or dissolution
WO2009152276A3 (en) Photoacid generators and lithographic resists comprising the same
WO2006049942A3 (en) Drug coated medical device with nucleating agents
WO2007145961A3 (en) Microporous coating on medical devices
EP1784267A4 (en) Stent and method for manufacturing the stent
EP1948267A4 (en) Fluid delivery devices, systems and methods
WO2008064111A3 (en) Radiopaque medical devices
WO2009059129A3 (en) Endoprosthesis with porous reservoir and non-polymer diffusion layer
WO2007067488A3 (en) Method and system for double-sided patterning of substrates
EP2034929A4 (en) Prosthetic heart valves, support structures and systems and methods for implanting the same
WO2008070269A3 (en) Methods, software and systems for imaging
WO2006074406A3 (en) Biodegradable coating compositions including multiple layers
WO2005046745A3 (en) Method and device for controlled delivery of active substance
WO2005048923A3 (en) Extended release venlafaxine formulation
EP2079410A4 (en) Devices, systems and methods having mobile ferromagnetic structures
PT1779375E (en) Method, device and system for altering the reverberation time of a room
WO2007067469A3 (en) Method for expelling gas positioned between a substrate and a mold
IL181243A0 (en) Method for controlling exposure system, exposure method and system using same, and method for manufacturing device
EG25586A (en) Coated fertiliser with a controlled release of active ingredients, and method for the production thereof
EP2063807A4 (en) Prosthetic heart valves, support structures and systems and methods for implanting the same
WO2006121669A3 (en) Coating of medical devices with solids
NL1028255A1 (en) Polymer for upper anti-reflective coating, method of preparing it, and composition of an upper anti-reflective coating comprising the polymer.
WO2006121908A3 (en) Impregnated polymer compositions and devices using them

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2575988

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2005325213

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2005856905

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2005325213

Country of ref document: AU

Date of ref document: 20050803

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2005325213

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2005856905

Country of ref document: EP