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WO2006067224A3 - Spiro-benzodioxole and spiro-benzodioxane compounds as orexin receptor antagonists - Google Patents

Spiro-benzodioxole and spiro-benzodioxane compounds as orexin receptor antagonists Download PDF

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Publication number
WO2006067224A3
WO2006067224A3 PCT/EP2005/057132 EP2005057132W WO2006067224A3 WO 2006067224 A3 WO2006067224 A3 WO 2006067224A3 EP 2005057132 W EP2005057132 W EP 2005057132W WO 2006067224 A3 WO2006067224 A3 WO 2006067224A3
Authority
WO
WIPO (PCT)
Prior art keywords
spiro
compounds
benzodioxole
receptor antagonists
disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/057132
Other languages
French (fr)
Other versions
WO2006067224A2 (en
Inventor
Emma Barker
Jensen Annika Jenmalm
Erik Nordling
Andrew Proud
Martin Slater
Mikael Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Swedish Orphan Biovitrum AB
Original Assignee
Biovitrum AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0403160A external-priority patent/SE0403160D0/en
Application filed by Biovitrum AB filed Critical Biovitrum AB
Publication of WO2006067224A2 publication Critical patent/WO2006067224A2/en
Publication of WO2006067224A3 publication Critical patent/WO2006067224A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to compounds of Formula (I): wherein R1, A, Y, n and m are as described herein, processes for preparing the compounds, pharmaceutical compositions comprising the compounds, and use of the compounds and compositions in the prophylaxis or treatment of orexin-1 receptor- related disorders and orexin-2 receptor-related disorders. Examples of such disorders are obesity and related disorders such as diabetes type II, dyslipidemia and the metabolic syndrome, cardiovascular diseases such as atherosclerotic vascular disease, angina pectoris, myocardial infarction and stroke, drug addiction, and sleeping disorders.
PCT/EP2005/057132 2004-12-23 2005-12-22 Spiro-benzodioxole and spiro-benzodioxane compounds as orexin receptor antagonists Ceased WO2006067224A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0403160A SE0403160D0 (en) 2004-12-23 2004-12-23 New compounds
SE0403160-5 2004-12-23
US65380305P 2005-02-17 2005-02-17
US60/653,803 2005-02-17

Publications (2)

Publication Number Publication Date
WO2006067224A2 WO2006067224A2 (en) 2006-06-29
WO2006067224A3 true WO2006067224A3 (en) 2006-11-02

Family

ID=36602122

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/057132 Ceased WO2006067224A2 (en) 2004-12-23 2005-12-22 Spiro-benzodioxole and spiro-benzodioxane compounds as orexin receptor antagonists

Country Status (1)

Country Link
WO (1) WO2006067224A2 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009543785A (en) 2006-07-14 2009-12-10 メルク エンド カムパニー インコーポレーテッド Cross-linked diazepan orexin receptor antagonist
KR20090047458A (en) 2006-08-08 2009-05-12 사노피-아벤티스 Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, methods of preparation thereof, medicaments comprising these compounds and uses thereof
PE20081229A1 (en) 2006-12-01 2008-08-28 Merck & Co Inc DIAZEPAM OREXIN RECEPTOR ANTAGONISTS REPLACED
EP2150115B1 (en) 2007-05-23 2013-09-18 Merck Sharp & Dohme Corp. Cyclopropyl pyrrolidine orexin receptor antagonists
JP4881476B2 (en) 2007-05-23 2012-02-22 メルク・シャープ・エンド・ドーム・コーポレイション Pyridylpiperidine orexin receptor antagonist
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
UY31968A (en) 2008-07-09 2010-01-29 Sanofi Aventis NEW HETEROCYCLIC DERIVATIVES, THEIR PROCESSES FOR THEIR PREPARATION, AND THEIR THERAPEUTIC USES
WO2010043592A1 (en) * 2008-10-15 2010-04-22 Revotar Biopharmaceuticals Ag Lipase inhibitors for use for the treatment of obesity
US8957219B2 (en) 2008-10-17 2015-02-17 Shionogi & Co., Ltd. Acetic acid amide derivative having inhibitory activity on endothelial lipase
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
CA2771278A1 (en) 2009-08-26 2011-03-03 Sanofi Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
GB201021104D0 (en) * 2010-12-13 2011-01-26 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683703B1 (en) 2011-03-08 2015-05-27 Sanofi Novel substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120054A1 (en) 2011-03-08 2012-09-13 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120056A1 (en) 2011-03-08 2012-09-13 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8809325B2 (en) 2011-03-08 2014-08-19 Sanofi Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof
WO2012120050A1 (en) 2011-03-08 2012-09-13 Sanofi Novel substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120058A1 (en) 2011-03-08 2012-09-13 Sanofi Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
AR088352A1 (en) 2011-10-19 2014-05-28 Merck Sharp & Dohme ANTAGONISTS OF THE RECEIVER OF 2-PIRIDILOXI-4-NITRILE OREXINE
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
KR20140124398A (en) 2012-02-07 2014-10-24 이올라스 테라퓨틱스, 인코포레이티드 Substituted Prolines / Piperidines as Orexin Receptor Antagonists
UY36272A (en) 2014-08-13 2016-02-29 Eolas Therapeutics Inc DIFLUOROPIRROLIDINS AS MODULATORS OF OREXIN RECEPTORS
CN109219606B (en) 2016-02-12 2021-10-01 阿斯利康(瑞典)有限公司 Halogen-substituted piperidines of orexin receptor modulators
WO2017194548A1 (en) 2016-05-10 2017-11-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052876A1 (en) * 2002-12-12 2004-06-24 Janssen Pharmaceutica, N.V. Substituted 4-phenyl-[1,3]-dioxanes
WO2004111056A2 (en) * 2003-06-13 2004-12-23 Biofocus Plc Compound libraries of spiro-benzodioxine-piperidines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052876A1 (en) * 2002-12-12 2004-06-24 Janssen Pharmaceutica, N.V. Substituted 4-phenyl-[1,3]-dioxanes
WO2004111056A2 (en) * 2003-06-13 2004-12-23 Biofocus Plc Compound libraries of spiro-benzodioxine-piperidines

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
PORTER R A ET AL: "1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 11, 2001, pages 1907 - 1910, XP002269254, ISSN: 0960-894X *
PUJOL MD ROSELL G GUILLAUMET G: "Novel tricyclic spiropiperidines. Synthesis and adrenergic activity of spiro[1,3-benzodioxolopiperidines] and spiro[1,3-benzodioxanepiperidines", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 31, no. 11, 1996, pages 889 - 894, XP004063481, ISSN: 0223-5234 *
SAKURAI T ET AL: "OREXINS AND OREXIN RECEPTORS: A FAMILY OF HYPOTHALAMIC NEUROPEPTIDES AND G PROTEIN-COUPLED RECEPTORS THAT REGULATE FEEDINGBEHAVIOR", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 92, 20 February 1998 (1998-02-20), pages 573 - 585, XP002943277, ISSN: 0092-8674 *
SANCHEZ I ET AL: "SYNTHESIS OF NEW PIPERIDINE AND CYCLOHEXYLAMINO-SPIRO DERIVATIVES AS POTENTIAL ANTICALCIUM AGENTS", SCIENTIA PHARMACEUTICA, OESTERREICHISCHE APOTHEKER VERLAGSGESELLSCHAFT,, AT, vol. 70, no. 2, 2002, pages 177 - 187, XP009035726, ISSN: 0036-8709 *

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Publication number Publication date
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