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WO2006065671A2 - Dispositif de traitement medical a ultrasons comprenant une zone focale variable - Google Patents

Dispositif de traitement medical a ultrasons comprenant une zone focale variable Download PDF

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Publication number
WO2006065671A2
WO2006065671A2 PCT/US2005/044732 US2005044732W WO2006065671A2 WO 2006065671 A2 WO2006065671 A2 WO 2006065671A2 US 2005044732 W US2005044732 W US 2005044732W WO 2006065671 A2 WO2006065671 A2 WO 2006065671A2
Authority
WO
WIPO (PCT)
Prior art keywords
segments
medical treatment
treatment device
device defined
probe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/044732
Other languages
English (en)
Other versions
WO2006065671A3 (fr
Inventor
Ronald R. Manna
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Misonix LLC
Original Assignee
Misonix LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Misonix LLC filed Critical Misonix LLC
Priority to EP05853614A priority Critical patent/EP1833449A2/fr
Priority to JP2007546784A priority patent/JP2008522783A/ja
Priority to CA002590057A priority patent/CA2590057A1/fr
Publication of WO2006065671A2 publication Critical patent/WO2006065671A2/fr
Publication of WO2006065671A3 publication Critical patent/WO2006065671A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0056—Beam shaping elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0056—Beam shaping elements
    • A61N2007/006—Lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0056—Beam shaping elements
    • A61N2007/0065—Concave transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A61N2007/027—Localised ultrasound hyperthermia with multiple foci created simultaneously

Definitions

  • This invention relates to a medical device and more specifically to an ultrasonic minimally or non-invasive tissue ablation instrument. Even more specifically, this invention relates to an ultrasonic medical treatment device with a variable and shaped focal zone. This invention also relates to an associated medical treatment method.
  • Radio-frequency electric current, microwave energy and cryogenically chilled probes are all used to ablate diseased tissue, such as cancer lesions in the body. These devices have significantly improved the treatment results over using scalpel and sutures alone.
  • ultrasound waves or ultrasonic acoustic energy Another form of energy that has come under consideration for use as a therapeutic agent is ultrasound waves or ultrasonic acoustic energy.
  • Ultrasound has long been used for diagnostic procedures where the waves are generated and collected much the same way that sonar wave are. These ultrasound waves are of an energy level that has no therapeutic effects, meaning that the ultrasound waves do not change the tissue structure in any way.
  • the frequency of such waves is generally in the 5 to 30 MHz range.
  • ultrasonic diathermy instrument Another ultrasound device that has been employed for decades is the ultrasonic diathermy instrument.
  • This instrument uses an ultrasonic transducer to generate ultrasound waves at a higher intensity level than the diagnostic units.
  • the acoustic waves are transmitted into the body where they are attenuated and absorbed. This absorption of energy causes the tissue temperature to rise, thereby causing deep heating of tissue. This heating is not sufficient to cause cell death, but promotes healing by increasing blood flow to the region, the same as if heating compresses were used.
  • the acoustic waves in both the diagnostic and diathermy machines are collimated or non-focused.
  • acoustic waves are focused to a point within a patient's tissues. By concentrating this energy at a specific location, the energy density increases to the point that ablation or necrosis of the tissue occurs.
  • Such therapy has been given the designation "High Intensity Focused Ultrasound" or "HIFU.”
  • HIFU generators or transducers have been proposed over the years. All of these devices take the energy output of an entire crystal face and through either curvature of the crystal itself or by focusing acoustic lenses concentrate the energy at a single point.
  • An ordinary magnifying glass is a simple analogy where light energy is focused to a point in space. The concentrated energy can then easily raise the temperature of paper to greater than the fiammability point.
  • the circumference of the crystal is shaped as part of a concave surface. Since the acoustic waves propagate in a direction perpendicular to the face of the vibrating crystal, the waves will propagate in a manner such that they will converge at the focal point of the concave surface, Fig. 1, assuming that the crystal is in contact with a medium which will allow acoustic wave transmission, such as water or body tissues.
  • the acoustic energy density watts/cm 2
  • the acoustic energy density increases to a point at which the temperature of the tissue rises above the ablation point.
  • cavitation and micro streaming of the liquids surrounding the cells has been identified as mechanisms of cell destruction. In any event, the cells are rendered unviable. The body will then remove the necrotic tissue with its normal cleansing mechanism.
  • the focal zone is theoretically a point in space, but in actuality it will be a small three-dimensional volume. It has been described as having the shape of a rice kernel. In order to treat a larger volume, the transducer head must be manipulated by the physician to treat another location, move it again and so on until the operation is completed.
  • the focal point is quite small in volume. In some cases, this is desirable since only a discrete volume of tissue needs to be treated or the treatment area is close to or contiguous with healthy or important structures such as bile ducts. However, in some cases, a much larger volume of tissue must be ablated, such an entire kidney lobe. When such a large volume needs to be ablated, the only possibility has been to treat a volume, then physically move transducer head to a different location and treat that volume, move the head and so on. This has increased the operation time and operator fatigue factor considerably. Conversely, if a transducer were constructed that provided a very large focal zone, the transducer would not be able to be used for smaller lesions or for discrete points around viable tissue or structures.
  • the present invention aims to provide an improved ultrasonic ablation device and more particularly an ultrasonic ablation device with a HIFU transducer assembly or probe that provides not only a large focal zone or treatment volume but also allows the operator to significantly expand or contract that volume at will.
  • the present invention also aims to provide an ultrasonic ablation device with a HIFU transducer that projects acoustic waves into the body so that the waves converge to a focal point that is adjustable in size and intensity by the operator.
  • An ultrasonic medical treatment device in accordance with the present invention comprises an elongate probe having an elongate wave-generating concave surface with a longitudinal axis and ultrasonic electromechanical transducer elements for vibrating said concave surface to generate ultrasonic pressure waves focused along a linear locus extending parallel to said longitudinal axis.
  • the probe includes a unitary or monolithic element typically made of a piezoelectric crystal material.
  • the concave surface is a surface of the crystal element.
  • the transducer elements may include electrode pairs provided along the unitary or monolithic element in a spaced array.
  • the probe includes a plurality of separate piezoelectric crystal elements disposed in a predetermined array. The separate crystal elements are typically provided with respective pairs of electrodes for vibrating the crystals to generate the ultrasonic pressure waves focused along the linear locus.
  • An ultrasonic medical treatment device in accordance with the present invention comprises a probe having a plurality of wave-generating elements each for focusing ultrasonic pressure waves at a respective locus of focal points extending in at least one dimension, the loci of focal points being different and spaced from each other.
  • the wave- generating elements include ultrasonic electromechanical transducer elements for vibrating at least one surface to generate ultrasonic pressure waves focused along the respective loci.
  • the transducer elements are independently energizable to focus ultrasonic waveform energy selectively along the different loci.
  • the probe is elongate and has a longitudinal axis, while the loci of focal points are linear and extend parallel to the longitudinal axis. More particularly, the probe has an elongate wave-generating concave surface formed along the longitudinal axis.
  • the probe includes a plurality of segments each having a respective wave-generating concave surface, the ultrasonic electromechanical transducer elements vibrating the respective wave-generating concave surfaces to generate ultrasonic pressure waves focused along respective linear loci extending parallel to the longitudinal axis.
  • the loci are parallel to and spaced from one another, while the probe segments are spaced from one another in a direction transverse to the longitudinal axis.
  • the segments include pairs of segments, each such pair including members disposed on opposite sides of the plane.
  • the transducer elements may be disposed in a stepped array.
  • the loci are collinear and the probe segments are disposed in a linear array extending parallel to the longitudinal axis. Adjacent segments are preferably joined to one another by resilient spacer elements, with different segments being independently energizable.
  • the energization of different groups of transducers results in the focusing of ultrasound waveform energy along different focal loci.
  • the probe includes a plurality of segments disposed in an arc relative to one another, each of the segments having a respective wave- generating surface.
  • the ultrasonic electromechanical transducer elements serve to vibrate the respective wave-generating surfaces to generate ultrasonic pressure waves focused along respective linear loci extending parallel to the longitudinal axis of the probe and transversely spaced from one another.
  • the segments including pairs of segments, each such pair including members disposed on opposite sides of the plane.
  • the probe includes an epoxy lens along an inner side and a backing along an outer side, the transducer elements being disposed between the epoxy lens and the backing.
  • the present invention further contemplates an ultrasonic medical treatment device comprising (a) an elongate probe having an elongate wave-generating concave surface with a longitudinal axis and (b) ultrasonic electromechanical transducer elements the serve to vibrate the concave surface to generate ultrasonic pressure waves focused along a linear locus extending parallel to the longitudinal axis.
  • the surface has a transverse cross-sectional shape preferably taken from the group consisting of circular, parabolic, and conical, the cross-sectional shape being taken in a plane oriented substantially perpendicularly to the locus and the longitudinal axis.
  • the probe may include a plurality of segments each having a respective wave- generating concave surface, the ultrasonic electromechanical transducer elements vibrating the respective wave-generating concave surfaces to generate ultrasonic pressure waves focused along respective linear loci extending parallel to the longitudinal axis.
  • the segments may be spaced from one another in a direction transverse to the longitudinal axis or may be disposed in a linear array extending parallel to the longitudinal axis.
  • the individual loci are collinear, while in the former case the different loci may be spaced from one another in the transverse direction. Adjacent segments may be joined to one another by resilient spacer elements, the transducer elements of different segments being independently energizable.
  • a medical treatment method in accordance with the present invention utilizes an ultrasonic medical probe having a plurality of wave-generating elements each for focusing ultrasonic pressure waves at a respective locus of focal points extending in at least one dimension, the loci of focal points being different and spaced from each other.
  • the method comprises (1) placing the probe into effective wave-transmitting contact with one patient, (2) thereafter energizing a first set of the wave-generating elements on the probe to generate ultrasonic pressure waves focused along a preselected first locus extending along at least one dimension inside the patient, (3) subsequently placing the probe into effective wave- transmitting contact with another patient, and (4) thereafter energizing a second set of wave- generating elements on the probe to generate ultrasonic pressure waves focused along a second preselected locus extending along at least one dimension inside the other patient, the second locus being in a different location than the first locus with respect to the probe.
  • FIG. 1 is a schematic cross-sectional view of a conventional high-intensity focused ultrasound probe.
  • Fig. 2 is a schematic perspective view of a high-intensity focused ultrasound probe in accordance with the present invention.
  • Fig. 3 is a schematic perspective view of another high-intensity focused ultrasound probe in accordance with the present invention.
  • Fig. 4A is a schematic perspective view of a high-intensity focused ultrasound probe in accordance with the present invention, showing a first mode of operation of the probe.
  • Fig. 4B is a schematic perspective view similar to Fig. 4A, showing a second mode of operation of the probe of Fig. 4 A.
  • Fig. 4C is a schematic perspective view similar to Figs. 4A and 4B, showing a third mode of operation of the probe of Fig. 4A.
  • Fig. 5 is a schematic cross-sectional view of a high-intensity focused ultrasound probe in accordance with the present invention.
  • Fig. 6 is a schematic perspective view of a further high-intensity focused ultrasound probe in accordance with the present invention.
  • Fig. 7 is a schematic transverse cross-sectional view of the probe of Fig. 6.
  • Fig. 8 is a schematic perspective view of a probe similar to that shown in Figs. 6 and 7, in accordance with the present invention, having the cross-sectional configuration depicted in Fig. 7.
  • Fig. 9 is a schematic cross-sectional view of yet another high-intensity focused ultrasound probe in accordance with the present invention, representing a modification of the probes shown in Figs. 6-8.
  • Fig. 10 is a schematic cross-sectional view of a high-intensity focused ultrasound probe such as that of Figs. 6-9, showing structural details in accordance with the present invention.
  • locus is used herein to denote a set of spatial points, preferably located in a continuous array such as a line.
  • a longitudinal axis of a cylinder may be the axis of symmetry of the cylinder or any line parallel thereto, the cylinder being mathematically generated by translating a circle or a circular segment parallel to the longitudinal axes.
  • a preferred form of an ultrasonic treatment device as described herein includes a wave-generating surface defined by moving a parabola parallel to a longitudinal axis.
  • wave-generating surface designates a surface that is in effective engagement with an electromechanical or electro-acoustic transducer element such as a piezoelectric crystal, whereby an excitation of the transducer element at an ultrasonic frequency causes the surface to vibrate at the same frequency.
  • an electromechanical or electro-acoustic transducer element such as a piezoelectric crystal
  • the ultrasonic vibrations of the surface induce the formation of ultrasonic waves of the same frequency in the patient's tissues.
  • transverse refers to a plane that is perpendicular to, or substantially perpendicular to, a longitudinal axis of an ultrasonic probe.
  • a “transverse cross- sectional shape” is taken in such a plane.
  • a “transverse direction” is a vector in such plane.
  • transducer element is used herein to denote a vibrating portion of an ultrasonic probe.
  • a transducer element typically includes a piezoelectric crystal section and at least one pair of electrodes on opposite sides of the crystal section.
  • a transducer element may be a single monolithic crystal with a predetermined shape and provided with a plurality of electrode pairs in a spaced array.
  • the electrode elements by themselves may be viewed as transducer elements disposed along the larger body of the monolithic crystal.
  • an ultrasonic probe as described herein comprises a plurality of individual crystals, either contiguous with one another or separated by spacer elements
  • a transducer element may take the form of a single crystal which is typically, but not necessarily, provided with a single pair of energizing electrodes.
  • an ultrasonic medical treatment device has an electromechanical or electro-acoustic transducer element 10 generally in the form of a hemispherical, conical, or parabolic segment, as illustrated in Fig. 1.
  • Energization of the transducer element 10 at ultrasonic frequencies vibrates a hemispherical, conical, or parabolic wave-generating surface 14 to thereby generate ultrasonic waves 16 in a patient's tissues.
  • the waves 16 converge at a focal region 18 as discussed above.
  • the transducer active elements are not segments of a sphere, cone, or paraboloid of revolution 14, or disposed along a spherical, conical, or parabolic section, as in Fig. 1.
  • a probe 22 is in the form of a cylindrical section.
  • the cylindrical section 22 may include a unitary or monolithic element such as a single piezoelectric crystal provided with an array of spaced electrode pairs 20 (Fig. 2).
  • One member of each electrode pair 20 is typically placed along an inner surface of the crystal while the other member is placed along an outer surface of the crystal.
  • the electrode pairs 20 effectively divide the monolithic piezoelectric crystal into a plurality of separate transducer segments.
  • the cylindrical section 22 may contain a plurality of individual electro-acoustic transducers (not separately shown in Fig. 2) in the form of separate piezoelectric crystals provided with respective electrode pairs 20.
  • Probe 22 including the crystalline portions thereof and electrodes 20 may be embedded in or in contact with an epoxy lens, as discussed below with reference to Fig. 10.
  • a focal zone 24 generated by probe 22 is an elongated locus of points having a longer extent in the X dimension than in the Y dimension.
  • Focal zone 24 extends parallel to a longitudinal axis 26 of a generally cylindrical wave-generating surface 28.
  • Focal zone 24 extends along a line or linear locus in space, rather than being confined to a small sphere or rice grain such as focal region 18
  • the focal line or locus can be of any desired length.
  • a probe 30 comprises a plurality of substantially cylindrical segments 32, as illustrated in Fig 3, each of which may be energized independently of the other probe segments, to focus ultrasonic waveform energy along respective focal loci 38.
  • Probe segments 32 may be shaped piezoelectric transducer crystals.
  • probe segments 32 may take the form of polymeric bodies that contain or incorporate transducer elements 34. In either case, the respective probe segments 32 may be alternately energized and de-energized by methods known to the art. In this way, focal lines of various lengths (up to the maximum length of probe 30) may be created (Fig 4A, 4B and
  • Probe segments 32 Adjacent probe segments 32 are separated or vibrationally insulated from one another via resilient spacer elements 36. Probe segments 32 have respective concave wave- generating surfaces 38 that are generally contiguous with one another to effectively form a single cylindrical, conical or parabolic wave generating surface when all of the transducer elements 34 are activated.
  • Figs. 4A, 4B and 4C show a probe 40 having a plurality of substantially cylindrical wave-generating segments 42 disposed in a linear array.
  • Segments 42 are, or are provided with, piezoelectric ultrasonic transducer elements (not separately illustrated). Segments 42 are preferably spaced by resilient spacer elements (not shown; see spacer elements 36 of Fig. 3) so that the segments 42 are independently activatable to generate focal lines 44, 45, 46 of different lengths.
  • Fig. 4A two adjacent probe segments 42a are activated to generate two collinear focal loci 44a together forming focal line 44. The remaining segments 42a' are deactivated.
  • Fig. 4AB four adjacent probe segments 42b are activated to generate four collinear focal loci 45a together forming focal line 45. The remaining segments 42b' are not activated.
  • the concave wave-generating surfaces 50 of the probes 52 are shaped to project all of the acoustic energy 54 to the radial centers 56 of the curves. This focusing provides the acoustic energy increase in the tissue volume which then allows for tissue temperature rise. It also causes the focal zone 58 to be a small line in space.
  • an ultrasonic probe 60 may have a transducer face 62 that is segmented in the Y direction. Segments 64 have wave-generating surfaces 65 that are stepped and angled relative to one another, as depicted in Fig. 7, so that the focal zone 66 for each segment 64 is displaced in the Z direction, transversely to a longitudinal axis 66 of the probe 60, relative to the segments on either side.
  • the stepped and mutually angled configuration of surfaces 65 causes the focal point or zone 66 of any given element or segment 64 to be above or below the adjacent segments.
  • a composite focal zone 68 with significant dimension or extent in the X and Z planes may be created.
  • FIG. 8 more particularly shows a probe 70 including a linear array of wave- generating segments 72 contiguous with and connected to each other.
  • Each segment 72 in turn comprises a plurality of stepped and angled wave-generating surfaces 65 as described above with reference to Figs. 6 and 7.
  • segments 72 may be separated by resilient spacer elements 74 to enable a selective energization of the segments 72.
  • selected segments 72' may be energized while segments 72" are de-energized, thereby generating several discontinuous focal zones 76. If the activating energy is maintained for a sufficient period of time, the volume of each zone 16 will expand until the zones connect into a solid oblong cross section.
  • the electronics for turning these segments on and off, as well as the electronics for creating the ultrasonic acoustic energy are well known and are outside the scope of the present disclosure.
  • the wave-generating function of the probes discussed hereinabove is attained by transducer elements in the form of piezoelectric crystals. Such crystals are commonly used in the industry since they are efficient transformers of electrical into mechanical energy. These crystals are molded into the shapes desired and segmented as known in the prior art. The back sides of the crystals have electrodes (not shown) placed above the areas which are desired to be active.
  • the wave-generating surface 78 of a probe segment 80 as discussed above may be formed by an acoustic lens 82, usually made from poured epoxy resin.
  • the shape and thickness of the lens may be varied to achieve a desired performance.
  • the backing 84 of the probe or transducer segment 80 is a metal stamping or shaping which will give the elements of the transducer segment the desired focal direction(s).
  • This backing 84 can be made of a heavy metal such as tungsten, or an epoxy pouring.
  • a casing (not shown) is placed over the entire assembly to protect the assembly and to provide a hand hold for the operator.
  • a cable bundle 86 is attached to an electronic generator, the system may be turned on and used in much the same way as conventional ultrasonic systems.
  • Fig. 10 depicts transducer elements 88 in the form of separate piezoelectric crystals embedded in backing 84. As discussed above, individual probe segments may be molded or shaped piezoelectric crystals that are provided with electrodes connected to cable bundle 86.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Transducers For Ultrasonic Waves (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)

Abstract

L'invention concerne un dispositif de traitement médical à ultrasons qui se présente sous la forme d'une sonde allongée pourvue d'une surface concave allongée génératrice d'ondes présentant un axe longitudinal et des éléments de transduction ultrasonore électromécanique destinés à faire vibrer cette surface concave afin de générer des ondes ultrasonores de pression focalisées le long d'un lieu linéaire s'étendant parallèlement à l'axe longitudinal. La sonde peut comprendre un élément cristallin piézoélectrique monolithique et des paires d'électrodes disposées le long de l'élément unitaire ou monolithique dans un réseau espacé.
PCT/US2005/044732 2004-12-13 2005-12-09 Dispositif de traitement medical a ultrasons comprenant une zone focale variable Ceased WO2006065671A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP05853614A EP1833449A2 (fr) 2004-12-13 2005-12-09 Dispositif de traitement medical a ultrasons comprenant une zone focale variable
JP2007546784A JP2008522783A (ja) 2004-12-13 2005-12-09 可変な焦点領域を有する超音波医療機器
CA002590057A CA2590057A1 (fr) 2004-12-13 2005-12-09 Dispositif de traitement medical a ultrasons comprenant une zone focale variable

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US63553004P 2004-12-13 2004-12-13
US60/635,530 2004-12-13
US11/296,554 US8162858B2 (en) 2004-12-13 2005-12-07 Ultrasonic medical treatment device with variable focal zone
US11/296,554 2005-12-07

Publications (2)

Publication Number Publication Date
WO2006065671A2 true WO2006065671A2 (fr) 2006-06-22
WO2006065671A3 WO2006065671A3 (fr) 2006-12-21

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US (1) US8162858B2 (fr)
EP (1) EP1833449A2 (fr)
JP (1) JP2008522783A (fr)
CA (1) CA2590057A1 (fr)
WO (1) WO2006065671A2 (fr)

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010094349A1 (fr) * 2009-02-18 2010-08-26 Eye Tech Care Dispositif ultrasonore comprenant un moyen de génération d'un faisceau d'ultrasons présentant une forme de segment concave ayant une courbure unique
CN102316834A (zh) * 2008-02-19 2012-01-11 护眼科技公司 包括产生具有单一曲率的凹进的节段形状的超声波束的装置的超声波设备
FR2973250A1 (fr) * 2011-03-29 2012-10-05 Edap Tms France Sonde de therapie pour le traitement de tissus par l'intermediaire d'ondes ultrasonores focalisees croisees
US9039619B2 (en) 2004-10-06 2015-05-26 Guided Therapy Systems, L.L.C. Methods for treating skin laxity
US9517359B2 (en) 2009-02-18 2016-12-13 Eye Tech Care High intensity focused ultrasound device with a concave segment shaped transducer for eye treatment
US9694212B2 (en) 2004-10-06 2017-07-04 Guided Therapy Systems, Llc Method and system for ultrasound treatment of skin
US9700340B2 (en) 2004-10-06 2017-07-11 Guided Therapy Systems, Llc System and method for ultra-high frequency ultrasound treatment
US9707412B2 (en) 2004-10-06 2017-07-18 Guided Therapy Systems, Llc System and method for fat and cellulite reduction
US9713731B2 (en) 2004-10-06 2017-07-25 Guided Therapy Systems, Llc Energy based fat reduction
US9802063B2 (en) 2012-09-21 2017-10-31 Guided Therapy Systems, Llc Reflective ultrasound technology for dermatological treatments
US9827449B2 (en) 2004-10-06 2017-11-28 Guided Therapy Systems, L.L.C. Systems for treating skin laxity
US9895560B2 (en) 2004-09-24 2018-02-20 Guided Therapy Systems, Llc Methods for rejuvenating skin by heating tissue for cosmetic treatment of the face and body
US9907535B2 (en) 2000-12-28 2018-03-06 Ardent Sound, Inc. Visual imaging system for ultrasonic probe
US9974982B2 (en) 2004-10-06 2018-05-22 Guided Therapy Systems, Llc System and method for noninvasive skin tightening
EP2152367B1 (fr) * 2007-05-07 2018-07-11 Guided Therapy Systems, L.L.C. Système permettant un profil combiné de thérapie énergétique
US10039938B2 (en) 2004-09-16 2018-08-07 Guided Therapy Systems, Llc System and method for variable depth ultrasound treatment
US10046181B2 (en) 2004-10-06 2018-08-14 Guided Therapy Systems, Llc Energy based hyperhidrosis treatment
US10183182B2 (en) 2010-08-02 2019-01-22 Guided Therapy Systems, Llc Methods and systems for treating plantar fascia
US10420960B2 (en) 2013-03-08 2019-09-24 Ulthera, Inc. Devices and methods for multi-focus ultrasound therapy
US10537304B2 (en) 2008-06-06 2020-01-21 Ulthera, Inc. Hand wand for ultrasonic cosmetic treatment and imaging
US10561862B2 (en) 2013-03-15 2020-02-18 Guided Therapy Systems, Llc Ultrasound treatment device and methods of use
US10603521B2 (en) 2014-04-18 2020-03-31 Ulthera, Inc. Band transducer ultrasound therapy
US10864385B2 (en) 2004-09-24 2020-12-15 Guided Therapy Systems, Llc Rejuvenating skin by heating tissue for cosmetic treatment of the face and body
US11207548B2 (en) 2004-10-07 2021-12-28 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US11224895B2 (en) 2016-01-18 2022-01-18 Ulthera, Inc. Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board and method of assembly thereof
US11235179B2 (en) 2004-10-06 2022-02-01 Guided Therapy Systems, Llc Energy based skin gland treatment
US11241218B2 (en) 2016-08-16 2022-02-08 Ulthera, Inc. Systems and methods for cosmetic ultrasound treatment of skin
US11338156B2 (en) 2004-10-06 2022-05-24 Guided Therapy Systems, Llc Noninvasive tissue tightening system
US11717661B2 (en) 2007-05-07 2023-08-08 Guided Therapy Systems, Llc Methods and systems for ultrasound assisted delivery of a medicant to tissue
US11724133B2 (en) 2004-10-07 2023-08-15 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US11883688B2 (en) 2004-10-06 2024-01-30 Guided Therapy Systems, Llc Energy based fat reduction
US11944849B2 (en) 2018-02-20 2024-04-02 Ulthera, Inc. Systems and methods for combined cosmetic treatment of cellulite with ultrasound
US12076591B2 (en) 2018-01-26 2024-09-03 Ulthera, Inc. Systems and methods for simultaneous multi-focus ultrasound therapy in multiple dimensions
US12102473B2 (en) 2008-06-06 2024-10-01 Ulthera, Inc. Systems for ultrasound treatment
WO2025001201A1 (fr) * 2023-06-25 2025-01-02 深圳半岛医疗集团股份有限公司 Instrument de thérapie par ultrasons à grande région focale
US12377293B2 (en) 2019-07-15 2025-08-05 Ulthera, Inc. Systems and methods for measuring elasticity with imaging of ultrasound multi-focus shearwaves in multiple dimensions

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6050943A (en) 1997-10-14 2000-04-18 Guided Therapy Systems, Inc. Imaging, therapy, and temperature monitoring ultrasonic system
US8974446B2 (en) * 2001-10-11 2015-03-10 St. Jude Medical, Inc. Ultrasound ablation apparatus with discrete staggered ablation zones
US20040082859A1 (en) 2002-07-01 2004-04-29 Alan Schaer Method and apparatus employing ultrasound energy to treat body sphincters
AU2003904061A0 (en) * 2003-08-01 2003-08-14 Sonartech Atlas Pty Ltd A sonar antenna
US9011336B2 (en) 2004-09-16 2015-04-21 Guided Therapy Systems, Llc Method and system for combined energy therapy profile
US7393325B2 (en) 2004-09-16 2008-07-01 Guided Therapy Systems, L.L.C. Method and system for ultrasound treatment with a multi-directional transducer
US20130046209A1 (en) 2011-07-10 2013-02-21 Guided Therapy Systems, Llc Systems and methods for improving an outside appearance of skin using ultrasound as an energy source
EP2279699B1 (fr) 2004-10-06 2019-07-24 Guided Therapy Systems, L.L.C. Procédé pour l'amélioration cosmétique non invasive de la cellulite
EP2533130A1 (fr) 2005-04-25 2012-12-12 Ardent Sound, Inc. Procédé et système pour améliorer la sécurité de périphérique d'ordinateur
US9566454B2 (en) 2006-09-18 2017-02-14 Guided Therapy Systems, Llc Method and sysem for non-ablative acne treatment and prevention
TWI526233B (zh) 2007-05-07 2016-03-21 指導治療系統股份有限公司 利用聲波能量調製藥劑輸送及效能之系統
DK2152167T3 (en) 2007-05-07 2018-12-10 Guided Therapy Systems Llc Methods and systems for coupling and focusing acoustic energy using a coupling element
US20100063422A1 (en) * 2008-09-08 2010-03-11 Sunnybrook Health Sciences Center Ultrasound therapy transducer head and ultrasound therapy system incorporating the same
WO2010029555A1 (fr) * 2008-09-12 2010-03-18 Slender Medical, Ltd. Ciseaux virtuels à ultrasons
EP2467108B1 (fr) * 2009-08-18 2020-01-08 Eye Tech Care Paramètres pour un dispositif à ultrasons comprenant des moyens pour produire un faisceau d ultrasons de haute intensité
DE102009049487B4 (de) * 2009-10-15 2015-05-13 Richard Wolf Gmbh Elektroakustischer Wandler
EP2995350B1 (fr) 2009-10-30 2016-08-03 ReCor Medical, Inc. Appareil pour le traitement de l'hypertension par dénervation rénale à ultrasons percutanée
US20130178765A1 (en) * 2011-11-29 2013-07-11 David J. Mishelevich Ultrasound neuromodulation of spinal cord
US8715186B2 (en) 2009-11-24 2014-05-06 Guided Therapy Systems, Llc Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
US20110144544A1 (en) * 2009-12-15 2011-06-16 General Electric Company Ultrasound transducer assembly and methods of using
KR101214458B1 (ko) * 2010-01-18 2012-12-21 주식회사 휴먼스캔 초음파 프로브
US20110184322A1 (en) * 2010-01-22 2011-07-28 Slender Medical Ltd. Method and device for treatment of keloids and hypertrophic scars using focused ultrasound
US9504446B2 (en) 2010-08-02 2016-11-29 Guided Therapy Systems, Llc Systems and methods for coupling an ultrasound source to tissue
US8857438B2 (en) 2010-11-08 2014-10-14 Ulthera, Inc. Devices and methods for acoustic shielding
EP2675525A1 (fr) * 2011-02-18 2013-12-25 ReCor Medical, Inc. Appareil destiné à réaliser une dénervation rénale au moyen d'ultrasons
US20120302927A1 (en) * 2011-05-23 2012-11-29 University Of Washington Methods for characterizing nonlinear fields of a high-intensity focused ultrasound source and associated systems and devices
KR20190080967A (ko) 2011-07-11 2019-07-08 가이디드 테라피 시스템스, 엘.엘.씨. 조직에 초음파원을 연결하는 시스템 및 방법
WO2013139872A1 (fr) * 2012-03-20 2013-09-26 Intelligendt Systems & Services Gmbh Palpeur à ultrasons
US9263663B2 (en) 2012-04-13 2016-02-16 Ardent Sound, Inc. Method of making thick film transducer arrays
KR101335476B1 (ko) 2013-02-25 2013-12-11 주식회사 코러스트 선집속 초음파 변환기 및 이를 포함하는 고강도 선집속 초음파 발생 장치
WO2014159273A1 (fr) 2013-03-14 2014-10-02 Recor Medical, Inc. Procédés de placage ou de revêtement de capteurs ultrasonores
JP6322696B2 (ja) 2013-03-14 2018-05-09 リコール メディカル インコーポレイテッドＲｅＣｏｒ Ｍｅｄｉｃａｌ， Ｉｎｃ． 超音波による神経調節システム
US9786266B2 (en) * 2013-12-10 2017-10-10 Covaris, Inc. Method and system for acoustically treating material
JP6463374B2 (ja) * 2014-11-28 2019-01-30 キヤノン株式会社 超音波プローブ、及びそれを備えた情報取得装置
US9974983B2 (en) 2015-11-12 2018-05-22 SonaCare Medical, LLC Tissue stabilization for therapeutic ultrasound
WO2018057580A1 (fr) 2016-09-23 2018-03-29 SonaCare Medical, LLC Système, appareil et procédé de distribution d'ultrasons focalisés de haute intensité (hifu) et/ou d'ultrasons tout en protégeant des structures critiques
US11260249B2 (en) 2018-07-19 2022-03-01 Sonablate Corp. System, apparatus and method for high intensity focused ultrasound and tissue healing activation
KR102321645B1 (ko) * 2019-12-11 2021-11-04 주식회사 리메드 체외 충격파 치료기
KR102360057B1 (ko) * 2019-12-17 2022-02-08 주식회사 리메드 체외 충격파 치료기
IL308265A (en) * 2021-05-06 2024-01-01 Viol Co Ltd Ultrasound examination and device for skin care based on high intensity focused ultrasound
KR102646675B1 (ko) * 2021-11-17 2024-03-12 (주)비올 피부 처치를 위한 고강도 집속 초음파 프로브의 제조 방법
CN115137449A (zh) * 2022-07-01 2022-10-04 上海沈德医疗器械科技有限公司 一种用于磁波刀的超声探头装置
CN117653939A (zh) * 2023-12-29 2024-03-08 广东医希斯医疗科技有限公司 一种私密超声系统

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276779A (en) * 1979-03-29 1981-07-07 Raytheon Company Dynamically focussed array
US4957099A (en) 1988-02-10 1990-09-18 Siemens Aktiengesellschaft Shock wave source for extracorporeal lithotripsy
US5207226A (en) * 1991-01-25 1993-05-04 Regents Of The University Of Minnesota Device and method for measurement of blood flow
EP1241994A4 (fr) 1999-12-23 2005-12-14 Therus Corp Transducteurs a ultrasons utilises en imagerie et en therapie
US6546803B1 (en) * 1999-12-23 2003-04-15 Daimlerchrysler Corporation Ultrasonic array transducer
US6613005B1 (en) * 2000-11-28 2003-09-02 Insightec-Txsonics, Ltd. Systems and methods for steering a focused ultrasound array

Cited By (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9907535B2 (en) 2000-12-28 2018-03-06 Ardent Sound, Inc. Visual imaging system for ultrasonic probe
US10039938B2 (en) 2004-09-16 2018-08-07 Guided Therapy Systems, Llc System and method for variable depth ultrasound treatment
US9895560B2 (en) 2004-09-24 2018-02-20 Guided Therapy Systems, Llc Methods for rejuvenating skin by heating tissue for cosmetic treatment of the face and body
US10864385B2 (en) 2004-09-24 2020-12-15 Guided Therapy Systems, Llc Rejuvenating skin by heating tissue for cosmetic treatment of the face and body
US10328289B2 (en) 2004-09-24 2019-06-25 Guided Therapy Systems, Llc Rejuvenating skin by heating tissue for cosmetic treatment of the face and body
US10532230B2 (en) 2004-10-06 2020-01-14 Guided Therapy Systems, Llc Methods for face and neck lifts
US9827450B2 (en) 2004-10-06 2017-11-28 Guided Therapy Systems, L.L.C. System and method for fat and cellulite reduction
US9694211B2 (en) 2004-10-06 2017-07-04 Guided Therapy Systems, L.L.C. Systems for treating skin laxity
US9694212B2 (en) 2004-10-06 2017-07-04 Guided Therapy Systems, Llc Method and system for ultrasound treatment of skin
US9700340B2 (en) 2004-10-06 2017-07-11 Guided Therapy Systems, Llc System and method for ultra-high frequency ultrasound treatment
US9707412B2 (en) 2004-10-06 2017-07-18 Guided Therapy Systems, Llc System and method for fat and cellulite reduction
US11883688B2 (en) 2004-10-06 2024-01-30 Guided Therapy Systems, Llc Energy based fat reduction
US11717707B2 (en) 2004-10-06 2023-08-08 Guided Therapy Systems, Llc System and method for noninvasive skin tightening
US9827449B2 (en) 2004-10-06 2017-11-28 Guided Therapy Systems, L.L.C. Systems for treating skin laxity
US10603519B2 (en) 2004-10-06 2020-03-31 Guided Therapy Systems, Llc Energy based fat reduction
US9833639B2 (en) 2004-10-06 2017-12-05 Guided Therapy Systems, L.L.C. Energy based fat reduction
US9833640B2 (en) 2004-10-06 2017-12-05 Guided Therapy Systems, L.L.C. Method and system for ultrasound treatment of skin
US11697033B2 (en) 2004-10-06 2023-07-11 Guided Therapy Systems, Llc Methods for lifting skin tissue
US9039619B2 (en) 2004-10-06 2015-05-26 Guided Therapy Systems, L.L.C. Methods for treating skin laxity
US11400319B2 (en) 2004-10-06 2022-08-02 Guided Therapy Systems, Llc Methods for lifting skin tissue
US9974982B2 (en) 2004-10-06 2018-05-22 Guided Therapy Systems, Llc System and method for noninvasive skin tightening
US10010726B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US10010721B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, L.L.C. Energy based fat reduction
US10010725B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, Llc Ultrasound probe for fat and cellulite reduction
US10010724B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US11338156B2 (en) 2004-10-06 2022-05-24 Guided Therapy Systems, Llc Noninvasive tissue tightening system
US11235179B2 (en) 2004-10-06 2022-02-01 Guided Therapy Systems, Llc Energy based skin gland treatment
US10046182B2 (en) 2004-10-06 2018-08-14 Guided Therapy Systems, Llc Methods for face and neck lifts
US10046181B2 (en) 2004-10-06 2018-08-14 Guided Therapy Systems, Llc Energy based hyperhidrosis treatment
US11235180B2 (en) 2004-10-06 2022-02-01 Guided Therapy Systems, Llc System and method for noninvasive skin tightening
US10238894B2 (en) 2004-10-06 2019-03-26 Guided Therapy Systems, L.L.C. Energy based fat reduction
US10245450B2 (en) 2004-10-06 2019-04-02 Guided Therapy Systems, Llc Ultrasound probe for fat and cellulite reduction
US10252086B2 (en) 2004-10-06 2019-04-09 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US10265550B2 (en) 2004-10-06 2019-04-23 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US11207547B2 (en) 2004-10-06 2021-12-28 Guided Therapy Systems, Llc Probe for ultrasound tissue treatment
US11179580B2 (en) 2004-10-06 2021-11-23 Guided Therapy Systems, Llc Energy based fat reduction
US10525288B2 (en) 2004-10-06 2020-01-07 Guided Therapy Systems, Llc System and method for noninvasive skin tightening
US11167155B2 (en) 2004-10-06 2021-11-09 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US10960236B2 (en) 2004-10-06 2021-03-30 Guided Therapy Systems, Llc System and method for noninvasive skin tightening
US9713731B2 (en) 2004-10-06 2017-07-25 Guided Therapy Systems, Llc Energy based fat reduction
US10888717B2 (en) 2004-10-06 2021-01-12 Guided Therapy Systems, Llc Probe for ultrasound tissue treatment
US10888718B2 (en) 2004-10-06 2021-01-12 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US10888716B2 (en) 2004-10-06 2021-01-12 Guided Therapy Systems, Llc Energy based fat reduction
US10610705B2 (en) 2004-10-06 2020-04-07 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US10610706B2 (en) 2004-10-06 2020-04-07 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US10603523B2 (en) 2004-10-06 2020-03-31 Guided Therapy Systems, Llc Ultrasound probe for tissue treatment
US11724133B2 (en) 2004-10-07 2023-08-15 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US11207548B2 (en) 2004-10-07 2021-12-28 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
EP2152367B1 (fr) * 2007-05-07 2018-07-11 Guided Therapy Systems, L.L.C. Système permettant un profil combiné de thérapie énergétique
US11717661B2 (en) 2007-05-07 2023-08-08 Guided Therapy Systems, Llc Methods and systems for ultrasound assisted delivery of a medicant to tissue
US9259597B2 (en) 2008-02-19 2016-02-16 Eye Tech Care Method of treating an ocular pathology by applying ultrasound to the trabecular meshwork and device thereof
CN102316834A (zh) * 2008-02-19 2012-01-11 护眼科技公司 包括产生具有单一曲率的凹进的节段形状的超声波束的装置的超声波设备
US9931245B2 (en) 2008-02-19 2018-04-03 Eye Tech Care High intensity focused ultrasound device with a concave segment shaped transducers for treatment of ocular pathology
US10537304B2 (en) 2008-06-06 2020-01-21 Ulthera, Inc. Hand wand for ultrasonic cosmetic treatment and imaging
US12102473B2 (en) 2008-06-06 2024-10-01 Ulthera, Inc. Systems for ultrasound treatment
US11123039B2 (en) 2008-06-06 2021-09-21 Ulthera, Inc. System and method for ultrasound treatment
US11723622B2 (en) 2008-06-06 2023-08-15 Ulthera, Inc. Systems for ultrasound treatment
WO2010094349A1 (fr) * 2009-02-18 2010-08-26 Eye Tech Care Dispositif ultrasonore comprenant un moyen de génération d'un faisceau d'ultrasons présentant une forme de segment concave ayant une courbure unique
AU2009340220B2 (en) * 2009-02-18 2013-07-18 Eye Tech Care Ultrasound device comprising means to generate ultrasound beam presenting a concave segment shape having a single curvature
US9517359B2 (en) 2009-02-18 2016-12-13 Eye Tech Care High intensity focused ultrasound device with a concave segment shaped transducer for eye treatment
US10183182B2 (en) 2010-08-02 2019-01-22 Guided Therapy Systems, Llc Methods and systems for treating plantar fascia
FR2973250A1 (fr) * 2011-03-29 2012-10-05 Edap Tms France Sonde de therapie pour le traitement de tissus par l'intermediaire d'ondes ultrasonores focalisees croisees
US9802063B2 (en) 2012-09-21 2017-10-31 Guided Therapy Systems, Llc Reflective ultrasound technology for dermatological treatments
US10420960B2 (en) 2013-03-08 2019-09-24 Ulthera, Inc. Devices and methods for multi-focus ultrasound therapy
US11517772B2 (en) 2013-03-08 2022-12-06 Ulthera, Inc. Devices and methods for multi-focus ultrasound therapy
US11969609B2 (en) 2013-03-08 2024-04-30 Ulthera, Inc. Devices and methods for multi-focus ultrasound therapy
US10561862B2 (en) 2013-03-15 2020-02-18 Guided Therapy Systems, Llc Ultrasound treatment device and methods of use
US11351401B2 (en) 2014-04-18 2022-06-07 Ulthera, Inc. Band transducer ultrasound therapy
US10603521B2 (en) 2014-04-18 2020-03-31 Ulthera, Inc. Band transducer ultrasound therapy
US11224895B2 (en) 2016-01-18 2022-01-18 Ulthera, Inc. Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board and method of assembly thereof
US11241218B2 (en) 2016-08-16 2022-02-08 Ulthera, Inc. Systems and methods for cosmetic ultrasound treatment of skin
US12076591B2 (en) 2018-01-26 2024-09-03 Ulthera, Inc. Systems and methods for simultaneous multi-focus ultrasound therapy in multiple dimensions
US11944849B2 (en) 2018-02-20 2024-04-02 Ulthera, Inc. Systems and methods for combined cosmetic treatment of cellulite with ultrasound
US12377293B2 (en) 2019-07-15 2025-08-05 Ulthera, Inc. Systems and methods for measuring elasticity with imaging of ultrasound multi-focus shearwaves in multiple dimensions
WO2025001201A1 (fr) * 2023-06-25 2025-01-02 深圳半岛医疗集团股份有限公司 Instrument de thérapie par ultrasons à grande région focale

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US20060184072A1 (en) 2006-08-17
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CA2590057A1 (fr) 2006-06-22
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