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WO2005123131A3 - High pressure spray-dry of bioactive materials - Google Patents

High pressure spray-dry of bioactive materials Download PDF

Info

Publication number
WO2005123131A3
WO2005123131A3 PCT/US2005/020792 US2005020792W WO2005123131A3 WO 2005123131 A3 WO2005123131 A3 WO 2005123131A3 US 2005020792 W US2005020792 W US 2005020792W WO 2005123131 A3 WO2005123131 A3 WO 2005123131A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioactive materials
high pressure
dry
pressure spray
powder particles
Prior art date
Application number
PCT/US2005/020792
Other languages
French (fr)
Other versions
WO2005123131A2 (en
Inventor
Vu Truong-Le
Tom Scherer
Original Assignee
Medimmune Vaccines Inc
Vu Truong-Le
Tom Scherer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Vaccines Inc, Vu Truong-Le, Tom Scherer filed Critical Medimmune Vaccines Inc
Priority to AU2005254062A priority Critical patent/AU2005254062B2/en
Priority to CA002564791A priority patent/CA2564791A1/en
Priority to EP05770439A priority patent/EP1755677A4/en
Priority to JP2007527797A priority patent/JP2008505192A/en
Publication of WO2005123131A2 publication Critical patent/WO2005123131A2/en
Publication of WO2005123131A3 publication Critical patent/WO2005123131A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

This invention provides compositions and methods providing, e.g., stable powder particles containing bioactive materials. The methods include, e.g., high pressure spraying of the bioactive materials in solution or suspension, with viscosity enhancing agents, organic solvents, and/or surfactants. Formulations are provided for spraying therapeutic bioactive materials into powder particles containing amino acids and sugars. Compositions of the invention provide, e.g., high initial purity, high stability in storage, and reconstitution at high concentrations.
PCT/US2005/020792 2002-04-11 2005-06-13 High pressure spray-dry of bioactive materials WO2005123131A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2005254062A AU2005254062B2 (en) 2002-04-11 2005-06-13 High pressure spray-dry of bioactive materials
CA002564791A CA2564791A1 (en) 2004-06-14 2005-06-13 High pressure spray-dry of bioactive materials
EP05770439A EP1755677A4 (en) 2004-06-14 2005-06-13 High pressure spray-dry of bioactive materials
JP2007527797A JP2008505192A (en) 2004-06-14 2005-06-13 High pressure spray drying of bioactive materials

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57985004P 2004-06-14 2004-06-14
US60/579,850 2004-06-14

Publications (2)

Publication Number Publication Date
WO2005123131A2 WO2005123131A2 (en) 2005-12-29
WO2005123131A3 true WO2005123131A3 (en) 2008-01-03

Family

ID=35510270

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/020792 WO2005123131A2 (en) 2002-04-11 2005-06-13 High pressure spray-dry of bioactive materials

Country Status (5)

Country Link
EP (1) EP1755677A4 (en)
JP (1) JP2008505192A (en)
AU (1) AU2005254062B2 (en)
CA (1) CA2564791A1 (en)
WO (1) WO2005123131A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9115357B2 (en) 2004-05-12 2015-08-25 Baxter International Inc. Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes
US9339465B2 (en) 2004-05-12 2016-05-17 Baxter International, Inc. Nucleic acid microspheres, production and delivery thereof
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
CN105555376B (en) * 2013-03-28 2017-05-17 英斯迪罗有限公司 Apparatus and method for producing dispersions and solids

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1834651A1 (en) * 2006-03-15 2007-09-19 Universiteit Gent Compositions and methods for veterinary vaccination
US8268354B2 (en) * 2007-11-07 2012-09-18 Aridis Pharmaceuticals Sonic low pressure spray drying
EP2344188B1 (en) 2008-10-02 2017-02-15 Pharmathene Inc. Anthrax vaccine formulation and uses thereof
EP2432502B1 (en) * 2009-05-20 2018-01-03 Aeras Stable, spray dried, immunogenic, viral compositions
KR20120130757A (en) 2010-02-26 2012-12-03 노보 노르디스크 에이/에스 Stable antibody containing compositions
SG183443A1 (en) 2010-03-01 2012-09-27 Bayer Healthcare Llc Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
BR112012030139A2 (en) 2010-05-28 2017-06-13 Novo Nordisk As stable multiple dose antibody compositions comprising an antibody and a preservative
DK2691415T3 (en) * 2011-03-28 2018-10-29 Ablynx Nv PROCEDURE FOR PREPARING SOLID FORMULATIONS CONTAINING VARIABLE SINGLE DOMAINS OF IMMUNOGLOBULIN
ITMI20112042A1 (en) * 2011-11-10 2013-05-11 Eratech S R L POWDER TO RECONSTITUTE BEFORE INCLUDING MELATONIN AND INJECTABLE PREPARATION OBTAINABLE FROM SUCH POWDER.
EP3532500A1 (en) * 2016-10-31 2019-09-04 Vectura Limited Inhalable powder composition comprising il-13 antibody
EP3459529A1 (en) * 2017-09-20 2019-03-27 Tillotts Pharma Ag Preparation of sustained release solid dosage forms comprising antibodies by spray drying
GB201718888D0 (en) * 2017-11-15 2017-12-27 Ucb Biopharma Sprl Method
KR20220088752A (en) * 2019-10-28 2022-06-28 메드임뮨 리미티드 Dry powder formulations of thymic matrix lymphopoietin (TSLP)-binding antibodies and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040042971A1 (en) * 2002-04-11 2004-03-04 Medimmune Vaccines, Inc. Spray freeze dry of compositions for pulmonary administration
US20040042972A1 (en) * 2002-04-11 2004-03-04 Medimmune Vaccines, Inc. Spray freeze dry of compositions for intranasal administration

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0913177A1 (en) * 1997-11-03 1999-05-06 Roche Diagnostics GmbH Process for producing dry, amorphous products comprising biological active materials by means of convection drying technique, especially spray drying
US6531580B1 (en) * 1999-06-24 2003-03-11 Ixsys, Inc. Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same
US6855493B2 (en) * 2000-11-28 2005-02-15 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
KR20100112206A (en) * 2002-04-11 2010-10-18 메디뮨 엘엘씨 Preservation of bioactive materials by spray drying
US7378110B2 (en) * 2002-12-17 2008-05-27 Med Immune Vaccines, Inc. High pressure spray-dry of bioactive materials

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040042971A1 (en) * 2002-04-11 2004-03-04 Medimmune Vaccines, Inc. Spray freeze dry of compositions for pulmonary administration
US20040042972A1 (en) * 2002-04-11 2004-03-04 Medimmune Vaccines, Inc. Spray freeze dry of compositions for intranasal administration

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1755677A4 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9115357B2 (en) 2004-05-12 2015-08-25 Baxter International Inc. Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes
US9339465B2 (en) 2004-05-12 2016-05-17 Baxter International, Inc. Nucleic acid microspheres, production and delivery thereof
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
CN105555376B (en) * 2013-03-28 2017-05-17 英斯迪罗有限公司 Apparatus and method for producing dispersions and solids

Also Published As

Publication number Publication date
JP2008505192A (en) 2008-02-21
CA2564791A1 (en) 2005-12-29
AU2005254062A1 (en) 2005-12-29
AU2005254062B2 (en) 2011-02-17
EP1755677A2 (en) 2007-02-28
EP1755677A4 (en) 2009-11-25
WO2005123131A2 (en) 2005-12-29

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