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WO2005118014A3 - Procedes d'elimination de cellules et de debris de cellules de tissus et de cultures de tissus, utilises pour des transplantation et la reconstitution de tissus - Google Patents

Procedes d'elimination de cellules et de debris de cellules de tissus et de cultures de tissus, utilises pour des transplantation et la reconstitution de tissus Download PDF

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Publication number
WO2005118014A3
WO2005118014A3 PCT/US2005/018578 US2005018578W WO2005118014A3 WO 2005118014 A3 WO2005118014 A3 WO 2005118014A3 US 2005018578 W US2005018578 W US 2005018578W WO 2005118014 A3 WO2005118014 A3 WO 2005118014A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
ionic
detergent
ionic detergent
transplantation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/018578
Other languages
English (en)
Other versions
WO2005118014A2 (fr
Inventor
Yuichiro Ueda
Mark W Torrianni
F M Everaerts
Paul V Trescony
F J L Everaerts
Hartog Wifred Den
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/858,174 external-priority patent/US20050266390A1/en
Application filed by Medtronic Inc filed Critical Medtronic Inc
Publication of WO2005118014A2 publication Critical patent/WO2005118014A2/fr
Publication of WO2005118014A3 publication Critical patent/WO2005118014A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3625—Vascular tissue, e.g. heart valves

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention porte sur des procédés de décellularisation de tissus de mammifères utilisés pour des transplantations ou la culture de tissus un vitro consistant: à soumettre simultanément les tissus à un détergent ionique, et à un détergent non ionique pendant une longue période pouvant excéder cinq jours (on utilise dans l'un des procédés le SDS comme détergent ionique, et le Triton-X 100 comme détergent non ionique); puis à les soumettre à un long rinçage pouvant aussi durer plus de cinq jours. Ce traitement de longue durée donne des tissus dont les courbes contrainte/déformation et les données DSC sont similaires à celles des tissus frais non traités. Les tissus traités, qui sont quasiment exempts de cellules et dont la structure sous-jacente est essentiellement intacte, présentent une réponse inflammatoire notablement accrue par rapport aux tissus frais, même sans fixation par le glutaraldéhyde. On a constaté une calcification in situ sensiblement réduite par rapport aux tissus fixés par le glutaraldéhyde. Les déposants pensent que le détergent ionique et le détergent non ionique agissent en synergie pour fixer les protéines au détergent ionique, et que détergent non ionique élimine du tissu le complexe détergent ionique/protéine. Lesdits procédés peuvent par exemple servir à décellulariser les valvules cardiaques porcines et les tissus pariétaux, utilisés pour les transplantations.
PCT/US2005/018578 2004-06-01 2005-05-26 Procedes d'elimination de cellules et de debris de cellules de tissus et de cultures de tissus, utilises pour des transplantation et la reconstitution de tissus Ceased WO2005118014A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/858,174 US20050266390A1 (en) 2004-06-01 2004-06-01 Processes for removing cells and cell debris from tissue and tissue constructs used in transplantation and tissue reconstruction
US10/858,174 2004-06-01
US65776405P 2005-03-01 2005-03-01
US60/657,764 2005-03-01

Publications (2)

Publication Number Publication Date
WO2005118014A2 WO2005118014A2 (fr) 2005-12-15
WO2005118014A3 true WO2005118014A3 (fr) 2006-06-22

Family

ID=35115755

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/018578 Ceased WO2005118014A2 (fr) 2004-06-01 2005-05-26 Procedes d'elimination de cellules et de debris de cellules de tissus et de cultures de tissus, utilises pour des transplantation et la reconstitution de tissus

Country Status (1)

Country Link
WO (1) WO2005118014A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009505752A (ja) * 2005-08-26 2009-02-12 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 臓器および組織の脱細胞化および再細胞化
US9682173B2 (en) * 2008-06-11 2017-06-20 The Children's Mercy Hospital Solutions for tissue engineering and methods of use
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
CN103458935B (zh) 2010-09-01 2016-08-03 明尼苏达大学董事会 使组织或器官再细胞化以提高其可移植性的方法
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
SG10201906304TA (en) 2013-03-15 2019-08-27 Miromatrix Medical Inc Use of perfusion decellularized liver for islet cell recellularization
EP2832379B1 (fr) 2013-07-31 2015-07-22 Biotronik AG Procédé de préparation de tissus biologiques
US10537662B2 (en) 2013-07-31 2020-01-21 Biotronik Ag Method for preparing biological tissue
US10293082B2 (en) * 2014-07-23 2019-05-21 Clemson University Research Foundation Decellularization method and system and decellularized tissue formed thereby
EP3509651B1 (fr) 2016-09-06 2022-12-28 Miromatrix Medical Inc. Utilisation de sérum de foie réséqué pour ingénierie du foie entier
CN107233622B (zh) * 2017-06-20 2020-05-15 爱美客技术发展股份有限公司 一种脱细胞组织膜的制备方法
US12263275B2 (en) 2018-06-13 2025-04-01 Miromatrix Medical Inc. Fistula filler and deployment system
US11998662B1 (en) 2021-06-09 2024-06-04 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods
US12383657B1 (en) 2021-06-09 2025-08-12 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4553974A (en) * 1984-08-14 1985-11-19 Mayo Foundation Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor
US4801299A (en) * 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
WO1995024873A1 (fr) * 1994-03-14 1995-09-21 Cryolife, Inc. Tissu traite pour une implantation et procedes pour sa preparation
US20020115208A1 (en) * 2000-08-16 2002-08-22 Shannon Mitchell Decellularized tissue engineered constructs and tissues

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801299A (en) * 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US4553974A (en) * 1984-08-14 1985-11-19 Mayo Foundation Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor
WO1995024873A1 (fr) * 1994-03-14 1995-09-21 Cryolife, Inc. Tissu traite pour une implantation et procedes pour sa preparation
US20020115208A1 (en) * 2000-08-16 2002-08-22 Shannon Mitchell Decellularized tissue engineered constructs and tissues

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JONES M ET AL: "Anticalcification treatments of bioprosthetic heart valves: in vivo studies in sheep.", JOURNAL OF CARDIAC SURGERY. MAR 1989, vol. 4, no. 1, March 1989 (1989-03-01), pages 69 - 73, XP009055892, ISSN: 0886-0440 *
JONES M ET AL: "The effects of anticalcification treatments on bioprosthetic heart valves implanted in sheep.", ASAIO TRANSACTIONS / AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS. 1988 OCT-DEC, vol. 34, no. 4, October 1988 (1988-10-01), pages 1027 - 1030, XP009055891, ISSN: 0889-7190 *
KASIMIR M -T ET AL: "Comparison of different decellularization procedures of porcine heart valves.", INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, vol. 26, no. 5, May 2003 (2003-05-01), pages 421 - 427, XP009055893, ISSN: 0391-3988 *

Also Published As

Publication number Publication date
WO2005118014A2 (fr) 2005-12-15

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