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WO2005113598A3 - Membres de la superfamille des tnf avec immunogenicite modifiee - Google Patents

Membres de la superfamille des tnf avec immunogenicite modifiee Download PDF

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Publication number
WO2005113598A3
WO2005113598A3 PCT/US2005/018130 US2005018130W WO2005113598A3 WO 2005113598 A3 WO2005113598 A3 WO 2005113598A3 US 2005018130 W US2005018130 W US 2005018130W WO 2005113598 A3 WO2005113598 A3 WO 2005113598A3
Authority
WO
WIPO (PCT)
Prior art keywords
super family
family members
altered immunogenicity
tnf super
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/018130
Other languages
English (en)
Other versions
WO2005113598A2 (fr
Inventor
Shannon Alicia Marshall
Gregory L Moore
Arthur J Chirino
John R Desjarlais
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xencor Inc
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc filed Critical Xencor Inc
Publication of WO2005113598A2 publication Critical patent/WO2005113598A2/fr
Publication of WO2005113598A3 publication Critical patent/WO2005113598A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Cette invention concerne des protéines variantes existant à l'état naturel membres de la superfamille des facteurs de nécrose tumorale avec immunogénicité réduite. Cette invention concerne plus spécifiquement les protéines variantes BAFF, RANKL, TRAIL, CD40L et APRIL avec immunogénicité réduite.
PCT/US2005/018130 2004-05-21 2005-05-23 Membres de la superfamille des tnf avec immunogenicite modifiee Ceased WO2005113598A2 (fr)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US57339504P 2004-05-21 2004-05-21
US57320604P 2004-05-21 2004-05-21
US57330104P 2004-05-21 2004-05-21
US60/573,301 2004-05-21
US60/573,395 2004-05-21
US60/573,206 2004-05-21
US58831404P 2004-07-14 2004-07-14
US60/588,314 2004-07-14
US60739704P 2004-09-02 2004-09-02
US60739604P 2004-09-02 2004-09-02
US60/607,397 2004-09-02
US60/607,396 2004-09-02

Publications (2)

Publication Number Publication Date
WO2005113598A2 WO2005113598A2 (fr) 2005-12-01
WO2005113598A3 true WO2005113598A3 (fr) 2006-06-01

Family

ID=35428917

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/018130 Ceased WO2005113598A2 (fr) 2004-05-21 2005-05-23 Membres de la superfamille des tnf avec immunogenicite modifiee

Country Status (1)

Country Link
WO (1) WO2005113598A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5905184B2 (ja) 2005-10-13 2016-04-20 ヒューマン ジノーム サイエンシーズ， インコーポレイテッドＨｕｍａｎ Ｇｅｎｏｍｅ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 自己抗体陽性疾患を有する患者の処置に使用するための方法および組成物
EP2066339B1 (fr) 2006-09-18 2014-08-13 The Board Of Trustees Of The University Of Arkansas Compositions et procédés pour améliorer des réponses immunes
US9125854B2 (en) 2007-10-30 2015-09-08 The Board Of Trustees Of The University Of Arkansas Compositions and methods of enhancing immune responses to flagellated bacterium
HUE047164T2 (hu) 2007-11-01 2020-04-28 Univ Arkansas Kompozíciók és eljárások eimeria elleni immunválasz fokozására
WO2011091255A1 (fr) 2010-01-21 2011-07-28 The Board Of Trustees Of The University Of Arkansas Vecteurs de vaccin et procédés d'amplification de réponses immunitaires
EP3556397A1 (fr) 2010-06-09 2019-10-23 The Board of Trustees of the University of Arkansas Vaccin et procédés pour réduire une infection à campylobacter
NZ711019A (en) 2013-02-14 2019-07-26 Univ Arkansas Compositions and methods of enhancing immune responses to eimeria or limiting eimeria infection
CN105142653B (zh) 2013-03-15 2019-11-15 阿肯色大学评议会 增强对肠病原体免疫应答的组合物和方法
TWI843057B (zh) 2016-05-03 2024-05-21 阿肯色州大學董事會 包含免疫刺激性及抗原性多肽的酵母菌疫苗載體以及其使用方法
AU2021412369A1 (en) * 2020-12-29 2023-07-13 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Anti-april antibodies and uses thereof

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999012965A2 (fr) * 1997-09-12 1999-03-18 Biogen, Inc. Nouveaux ligands de la famille des tnf
WO2000067034A1 (fr) * 1999-04-30 2000-11-09 Immunex Corporation Methodes d'utilisation de l'interaction taci/taci-l
WO2002018445A2 (fr) * 2000-09-01 2002-03-07 Biogen, Inc. Structure co-cristalline de l'anticorps monoclonal 5c8 et cd154, et utilisation de cette structure dans la mise au point de medicaments
WO2002036141A2 (fr) * 2000-11-02 2002-05-10 Immunex Corporation Methode permettant d'ameliorer des reponses immunitaires induites par des lymphocytes
US20020061525A1 (en) * 2000-05-16 2002-05-23 Rodrigo Yelin Sequences of trail variants
WO2003006154A2 (fr) * 2001-07-10 2003-01-23 Xencor, Inc. Automatisation de conception de proteines pour la conception de bibliotheques de proteines a antigenicite modifiee
WO2003029420A2 (fr) * 2001-10-02 2003-04-10 Genentech, Inc. Variants de ligands apo-2 et leurs utilisations
WO2003059281A2 (fr) * 2002-01-04 2003-07-24 Xencor Nouveaux variants de proteines rankl
WO2004081043A2 (fr) * 2003-01-06 2004-09-23 Xencor, Inc. Variants de baff et leurs methodes d'utilisation
WO2004089982A2 (fr) * 2003-01-06 2004-10-21 Xencor Variantes april et leurs procedes
WO2005035570A2 (fr) * 2003-10-10 2005-04-21 Xencor, Inc. Nouveaux variants de la proteine cd40l

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999012965A2 (fr) * 1997-09-12 1999-03-18 Biogen, Inc. Nouveaux ligands de la famille des tnf
WO2000067034A1 (fr) * 1999-04-30 2000-11-09 Immunex Corporation Methodes d'utilisation de l'interaction taci/taci-l
US20020061525A1 (en) * 2000-05-16 2002-05-23 Rodrigo Yelin Sequences of trail variants
WO2002018445A2 (fr) * 2000-09-01 2002-03-07 Biogen, Inc. Structure co-cristalline de l'anticorps monoclonal 5c8 et cd154, et utilisation de cette structure dans la mise au point de medicaments
WO2002036141A2 (fr) * 2000-11-02 2002-05-10 Immunex Corporation Methode permettant d'ameliorer des reponses immunitaires induites par des lymphocytes
WO2003006154A2 (fr) * 2001-07-10 2003-01-23 Xencor, Inc. Automatisation de conception de proteines pour la conception de bibliotheques de proteines a antigenicite modifiee
WO2003029420A2 (fr) * 2001-10-02 2003-04-10 Genentech, Inc. Variants de ligands apo-2 et leurs utilisations
WO2003059281A2 (fr) * 2002-01-04 2003-07-24 Xencor Nouveaux variants de proteines rankl
WO2004081043A2 (fr) * 2003-01-06 2004-09-23 Xencor, Inc. Variants de baff et leurs methodes d'utilisation
WO2004089982A2 (fr) * 2003-01-06 2004-10-21 Xencor Variantes april et leurs procedes
WO2005035570A2 (fr) * 2003-10-10 2005-04-21 Xencor, Inc. Nouveaux variants de la proteine cd40l

Also Published As

Publication number Publication date
WO2005113598A2 (fr) 2005-12-01

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