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WO2005113419A3 - Electrokinetic delivery systems, devices and methods - Google Patents

Electrokinetic delivery systems, devices and methods Download PDF

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Publication number
WO2005113419A3
WO2005113419A3 PCT/US2005/013728 US2005013728W WO2005113419A3 WO 2005113419 A3 WO2005113419 A3 WO 2005113419A3 US 2005013728 W US2005013728 W US 2005013728W WO 2005113419 A3 WO2005113419 A3 WO 2005113419A3
Authority
WO
WIPO (PCT)
Prior art keywords
reservoir
fluid
fluid reservoir
devices
systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2005/013728
Other languages
French (fr)
Other versions
WO2005113419A2 (en
Inventor
Deon S Anex
Phillip H Paul
David W Neyer
Edwin K Hlavka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eksigent Technologies LLC
Original Assignee
Eksigent Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eksigent Technologies LLC filed Critical Eksigent Technologies LLC
Priority to CN2005800186796A priority Critical patent/CN101365885B/en
Priority to AU2005245347A priority patent/AU2005245347A1/en
Priority to CA2564800A priority patent/CA2564800C/en
Priority to EP05779953.8A priority patent/EP1740497A4/en
Priority to JP2007509658A priority patent/JP4646976B2/en
Publication of WO2005113419A2 publication Critical patent/WO2005113419A2/en
Anticipated expiration legal-status Critical
Publication of WO2005113419A3 publication Critical patent/WO2005113419A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/1483—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B19/00—Machines or pumps having pertinent characteristics not provided for in, or of interest apart from, groups F04B1/00 - F04B17/00
    • F04B19/006—Micropumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/04—Pumps having electric drive
    • F04B43/043—Micropumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/201—Glucose concentration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Dermatology (AREA)
  • External Artificial Organs (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Micromachines (AREA)
  • Electrotherapy Devices (AREA)

Abstract

Devices, systems and methods according to the present invention utilize electrokinetic pumps capable of generating high and low pressures flow for various medical applications, including drug delivery and analyte sampling. The EK pumps and systems are configured and constructed to be low cost, compact and precise. In one embodiment, the EK pump comprises a first fluid reservoir 102 and a second fluid reservoir 104. First fluid reservoir 102 is coupled to second fluid reservoir 104 by through- vias 106, 110 and porous dielectric material 108. Through-vias 106 and 110, along with porous dielectric material 108 proivde a fluidic path between first reservoir 102 and second reservoir 104. Each fluid rservoir further comprises a fluid port 118, which can be an inlet or outlet, and capacitive electrode 120a and 120b.
PCT/US2005/013728 2004-04-21 2005-04-21 Electrokinetic delivery systems, devices and methods Ceased WO2005113419A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN2005800186796A CN101365885B (en) 2004-04-21 2005-04-21 Electric conveying systems, devices and methods
AU2005245347A AU2005245347A1 (en) 2004-04-21 2005-04-21 Electrokinetic delivery systems, devices and methods
CA2564800A CA2564800C (en) 2004-04-21 2005-04-21 Electrokinetic delivery systems, devices and methods
EP05779953.8A EP1740497A4 (en) 2004-04-21 2005-04-21 Electrokinetic delivery systems, devices and methods
JP2007509658A JP4646976B2 (en) 2004-04-21 2005-04-21 Electrokinetic delivery system, apparatus and method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56449704P 2004-04-21 2004-04-21
US60/564,497 2004-04-21

Publications (2)

Publication Number Publication Date
WO2005113419A2 WO2005113419A2 (en) 2005-12-01
WO2005113419A3 true WO2005113419A3 (en) 2007-12-27

Family

ID=35428903

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/013728 Ceased WO2005113419A2 (en) 2004-04-21 2005-04-21 Electrokinetic delivery systems, devices and methods

Country Status (6)

Country Link
EP (1) EP1740497A4 (en)
JP (1) JP4646976B2 (en)
CN (1) CN101365885B (en)
AU (1) AU2005245347A1 (en)
CA (1) CA2564800C (en)
WO (1) WO2005113419A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9416777B2 (en) 2014-09-26 2016-08-16 Becton, Dickinson And Company Control circuits for electrochemical pump with E-valves

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2316505B1 (en) * 2006-03-14 2017-01-18 University Of Southern California Mems device for delivery of therapeutic agents
JP2009535552A (en) * 2006-04-28 2009-10-01 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Osmotic pump having at least one chargeable material
WO2008070262A2 (en) 2006-10-06 2008-06-12 The Cleveland Clinic Foundation Apparatus and method for targeting a body tissue
US8694077B2 (en) 2006-10-06 2014-04-08 The Cleveland Clinic Foundation Apparatus and method for targeting a body tissue
GB2448493B (en) * 2007-04-16 2009-10-14 Dewan Fazlul Hoque Chowdhury Microneedle transdermal delivery device
CN103813814A (en) * 2011-05-05 2014-05-21 艾克西根特技术有限公司 Gel coupling for electrokinetic delivery system
JP2014523499A (en) * 2011-05-05 2014-09-11 エクシジェント テクノロジーズ， エルエルシー System and method for differential pressure control of a reciprocating electrokinetic pump
US9956338B2 (en) 2012-07-06 2018-05-01 Sanofi-Aventis Deutschland Gmbh Drug delivery device
ES2691478T3 (en) 2012-10-22 2018-11-27 The Cleveland Clinic Foundation Apparatus for acting on a body tissue
JP6038194B2 (en) * 2013-02-18 2016-12-07 テルモ株式会社 Drug administration device, drug administration system, and operation method thereof
WO2015199981A1 (en) * 2014-06-25 2015-12-30 Min Wei Medication infusion device
JP2018501071A (en) * 2014-12-30 2018-01-18 ミニパンプス・リミテッド・ライアビリティ・カンパニーＭｉｎｉｐｕｍｐｓ，Ｌｌｃ Implantable electrolytic diaphragm pump
KR101910932B1 (en) * 2016-08-31 2018-10-23 이오플로우(주) Electoosmotic pump
KR101928297B1 (en) * 2016-09-08 2018-12-12 이오플로우(주) Medical fluid delivery device
US20210330751A1 (en) * 2016-11-09 2021-10-28 PhysioLogic Devices, Inc. Insulins Compatible with New Generation Implantable Pumps
EP3338832A1 (en) * 2016-12-23 2018-06-27 Sanofi-Aventis Deutschland GmbH Medicament delivery device
WO2018194041A1 (en) * 2017-04-21 2018-10-25 ヨダカ技研株式会社 Portable compact infusion device
GB201714645D0 (en) 2017-09-12 2017-10-25 Osmotex Ag Method
US10809139B2 (en) * 2018-02-14 2020-10-20 Carefusion 303, Inc. Integrated sensor to monitor fluid delivery
JP6744527B1 (en) 2020-04-01 2020-08-19 アットドウス株式会社 Chemical liquid administration unit, chemical liquid administration module, chemical liquid administration device, and medication management system
TWI806182B (en) * 2020-11-18 2023-06-21 潔霺生醫科技股份有限公司 Multi-stage gas actuated medicine supply device and method
WO2025262746A1 (en) * 2024-06-17 2025-12-26 Ｎｔｔ株式会社 Drug liquid transport device
EP4684817A1 (en) * 2024-07-23 2026-01-28 Manta MedTech LLC Implantable device having piston displacement monitoring

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US4140122A (en) * 1976-06-11 1979-02-20 Siemens Aktiengesellschaft Implantable dosing device
US4886514A (en) * 1985-05-02 1989-12-12 Ivac Corporation Electrochemically driven drug dispenser
US6409698B1 (en) * 2000-11-27 2002-06-25 John N. Robinson Perforate electrodiffusion pump
US6495015B1 (en) * 1999-06-18 2002-12-17 Sandia National Corporation Electrokinetically pumped high pressure sprays
US20030232203A1 (en) * 2002-01-18 2003-12-18 The Regents Of The University Of Michigan Porous polymers: compositions and uses thereof
US6719535B2 (en) * 2002-01-31 2004-04-13 Eksigent Technologies, Llc Variable potential electrokinetic device

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Publication number Priority date Publication date Assignee Title
US3923426A (en) * 1974-08-15 1975-12-02 Alza Corp Electroosmotic pump and fluid dispenser including same
US4140122A (en) * 1976-06-11 1979-02-20 Siemens Aktiengesellschaft Implantable dosing device
US4886514A (en) * 1985-05-02 1989-12-12 Ivac Corporation Electrochemically driven drug dispenser
US6495015B1 (en) * 1999-06-18 2002-12-17 Sandia National Corporation Electrokinetically pumped high pressure sprays
US6409698B1 (en) * 2000-11-27 2002-06-25 John N. Robinson Perforate electrodiffusion pump
US20030232203A1 (en) * 2002-01-18 2003-12-18 The Regents Of The University Of Michigan Porous polymers: compositions and uses thereof
US6719535B2 (en) * 2002-01-31 2004-04-13 Eksigent Technologies, Llc Variable potential electrokinetic device

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Title
See also references of EP1740497A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9416777B2 (en) 2014-09-26 2016-08-16 Becton, Dickinson And Company Control circuits for electrochemical pump with E-valves

Also Published As

Publication number Publication date
CN101365885A (en) 2009-02-11
CA2564800C (en) 2014-04-15
JP2008504794A (en) 2008-02-14
WO2005113419A2 (en) 2005-12-01
CN101365885B (en) 2011-08-03
JP4646976B2 (en) 2011-03-09
EP1740497A4 (en) 2015-11-11
CA2564800A1 (en) 2005-12-01
AU2005245347A1 (en) 2005-12-01
EP1740497A2 (en) 2007-01-10

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