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WO2005009039A3 - System and method for isotopic signature and mass analysis - Google Patents

System and method for isotopic signature and mass analysis Download PDF

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Publication number
WO2005009039A3
WO2005009039A3 PCT/US2004/021248 US2004021248W WO2005009039A3 WO 2005009039 A3 WO2005009039 A3 WO 2005009039A3 US 2004021248 W US2004021248 W US 2004021248W WO 2005009039 A3 WO2005009039 A3 WO 2005009039A3
Authority
WO
WIPO (PCT)
Prior art keywords
interest
masses
intensity values
mass intensity
criteria
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/021248
Other languages
French (fr)
Other versions
WO2005009039A2 (en
Inventor
Jose Castro-Perez
Robert Plumb
Christopher Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Waters Investments Ltd
Original Assignee
Waters Investments Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Waters Investments Ltd filed Critical Waters Investments Ltd
Priority to JP2006518777A priority Critical patent/JP4727577B2/en
Priority to DE112004001212.0T priority patent/DE112004001212B4/en
Priority to GB0526547A priority patent/GB2419228B/en
Publication of WO2005009039A2 publication Critical patent/WO2005009039A2/en
Publication of WO2005009039A3 publication Critical patent/WO2005009039A3/en
Priority to US11/315,844 priority patent/US7189964B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D59/00—Separation of different isotopes of the same chemical element
    • B01D59/44—Separation by mass spectrography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8675—Evaluation, i.e. decoding of the signal into analytical information

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Mass intensity values, isotopic ratios and exact mass differences between isotopes may be obtained and analyzed to determine if there are one or more masses of interest. In one implementation, a method will look among the mass intensity values for peaks of interest. The mass intensity values, representative of isotopic signatures, will be compared to a criteria in order to determine which of the masses are of interest. Although the invention is not so limited, examples of such criteria include mass intensity values above a specified threshold, within a certain ratio of another mass intensity value, and/or separation between the masses themselves. Optionally, a tolerance may be applied to the criteria. If masses are found to be of interest, MS/MS can automatically be triggered for one or all of the masses of interest, when an analyzing system such as an LC-MS-MS, GC-MS-MS or MALDI-MS-MS system is used.
PCT/US2004/021248 2003-07-03 2004-07-02 System and method for isotopic signature and mass analysis Ceased WO2005009039A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2006518777A JP4727577B2 (en) 2003-07-03 2004-07-02 Isotope composition and mass spectrometry system and method
DE112004001212.0T DE112004001212B4 (en) 2003-07-03 2004-07-02 Method for the analysis of isotopic signatures and mass analysis
GB0526547A GB2419228B (en) 2003-07-03 2004-07-02 System and method for isotopic signature and mass analysis
US11/315,844 US7189964B2 (en) 2003-07-03 2005-12-22 System and method for isotopic signature and mass analysis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48527803P 2003-07-03 2003-07-03
US60/485,278 2003-07-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/315,844 Continuation US7189964B2 (en) 2003-07-03 2005-12-22 System and method for isotopic signature and mass analysis

Publications (2)

Publication Number Publication Date
WO2005009039A2 WO2005009039A2 (en) 2005-01-27
WO2005009039A3 true WO2005009039A3 (en) 2005-06-23

Family

ID=34079107

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/021248 Ceased WO2005009039A2 (en) 2003-07-03 2004-07-02 System and method for isotopic signature and mass analysis

Country Status (5)

Country Link
US (1) US7189964B2 (en)
JP (1) JP4727577B2 (en)
DE (1) DE112004001212B4 (en)
GB (1) GB2419228B (en)
WO (1) WO2005009039A2 (en)

Families Citing this family (20)

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Publication number Priority date Publication date Assignee Title
JP4876253B2 (en) * 2006-10-27 2012-02-15 国立大学法人 東京大学 Protein relative quantification method, program and system
HRP20110610T1 (en) * 2007-04-16 2011-10-31 Momenta Pharmaceuticals Ms methods to evaluate glycans
WO2008137544A1 (en) * 2007-05-02 2008-11-13 Mks Instruments, Inc. Automated model building and model updating
US8494798B2 (en) * 2008-09-02 2013-07-23 Mks Instruments, Inc. Automated model building and batch model building for a manufacturing process, process monitoring, and fault detection
US9069345B2 (en) * 2009-01-23 2015-06-30 Mks Instruments, Inc. Controlling a manufacturing process with a multivariate model
JP5852020B2 (en) 2010-02-23 2016-02-03 ウオーターズ・テクノロジーズ・コーポレイシヨン Online sampling from process sources
JP5502648B2 (en) * 2010-08-06 2014-05-28 株式会社東芝 Method and program for determining brominated flame retardants
US8855804B2 (en) 2010-11-16 2014-10-07 Mks Instruments, Inc. Controlling a discrete-type manufacturing process with a multivariate model
US8725469B2 (en) 2011-03-03 2014-05-13 Mks Instruments, Inc. Optimization of data processing parameters
WO2013144790A1 (en) * 2012-03-29 2013-10-03 Koninklijke Philips N.V. Method and system for filtering gas chromatography-mass spectrometry data
US9541471B2 (en) 2012-04-06 2017-01-10 Mks Instruments, Inc. Multivariate prediction of a batch manufacturing process
US9429939B2 (en) 2012-04-06 2016-08-30 Mks Instruments, Inc. Multivariate monitoring of a batch manufacturing process
GB2514836B (en) * 2013-06-07 2020-04-22 Thermo Fisher Scient Bremen Gmbh Isotopic Pattern Recognition
US9159538B1 (en) * 2014-06-11 2015-10-13 Thermo Finnigan Llc Use of mass spectral difference networks for determining charge state, adduction, neutral loss and polymerization
US10768151B2 (en) * 2014-09-16 2020-09-08 Waters Technologies Corporation Techniques for display and processing of mass spectral data
US20180108521A1 (en) * 2015-03-11 2018-04-19 DH Technologies Development Pte Ltd. Method of Increasing Quality of Tandem Mass Spectra
CN106290616A (en) * 2016-07-29 2017-01-04 云南省烟草农业科学研究院 A kind of tobacco petal metabonomic analysis methods based on gaschromatographic mass spectrometry
CN106018653A (en) * 2016-07-29 2016-10-12 云南省烟草农业科学研究院 Tobacco root metabonomic analysis method based on gas chromatography-mass spectrometry
GB2585258B (en) * 2019-01-30 2022-10-19 Bruker Daltonics Gmbh & Co Kg Mass spectrometric method for determining the presence or absence of a chemical element in an analyte
CN113125589B (en) * 2021-03-17 2022-01-04 广东省农业科学院农业质量标准与监测技术研究所 Application of metabolic analysis technology to identification of duck dung fragrance single tea

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989012312A1 (en) * 1988-06-02 1989-12-14 Regents Of The University Of California Improved surface-induced dissociation for mass spectrometry
US6147344A (en) * 1998-10-15 2000-11-14 Neogenesis, Inc Method for identifying compounds in a chemical mixture

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0863858B1 (en) * 1996-04-08 2004-02-04 Glaxo Group Limited Mass-based encoding and qualitative analysis of combinatorial libraries
US6207861B1 (en) 1998-01-05 2001-03-27 Neogenesis, Inc. Method for producing and screening mass coded combinatorial libraries for drug discovery and target validation
US6428956B1 (en) * 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
US6207561B1 (en) * 1998-09-29 2001-03-27 Texas Instruments Incorporated Selective oxidation methods for metal oxide deposition on metals in capacitor fabrication
JP3756365B2 (en) * 1999-12-02 2006-03-15 株式会社日立製作所 Ion trap mass spectrometry method
US6765200B2 (en) * 2000-02-25 2004-07-20 Hitachi, Ltd. Mass spectrometry and mass spetrometer using the same
JP3894118B2 (en) * 2000-09-20 2007-03-14 株式会社日立製作所 Detection method and detection apparatus using ion trap mass spectrometer
US20020192708A1 (en) * 2000-10-25 2002-12-19 Hanno Steen Detection of modified amino acids by mass spectrometry
US20030001090A1 (en) * 2001-05-24 2003-01-02 Yasmin Ranasinghe Ultra-high throughput system and method for analyzing samples
GB0305796D0 (en) * 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989012312A1 (en) * 1988-06-02 1989-12-14 Regents Of The University Of California Improved surface-induced dissociation for mass spectrometry
US6147344A (en) * 1998-10-15 2000-11-14 Neogenesis, Inc Method for identifying compounds in a chemical mixture

Also Published As

Publication number Publication date
GB2419228A (en) 2006-04-19
US20060169885A1 (en) 2006-08-03
GB2419228B (en) 2008-02-06
WO2005009039A2 (en) 2005-01-27
DE112004001212B4 (en) 2014-07-24
DE112004001212T5 (en) 2006-10-19
US7189964B2 (en) 2007-03-13
JP2007527521A (en) 2007-09-27
GB0526547D0 (en) 2006-02-08
JP4727577B2 (en) 2011-07-20

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