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WO2005092929A8 - Esters butyriques d'acide hyaluronique faiblement substitues, procede d'elaboration et utilisation - Google Patents

Esters butyriques d'acide hyaluronique faiblement substitues, procede d'elaboration et utilisation

Info

Publication number
WO2005092929A8
WO2005092929A8 PCT/IB2005/000780 IB2005000780W WO2005092929A8 WO 2005092929 A8 WO2005092929 A8 WO 2005092929A8 IB 2005000780 W IB2005000780 W IB 2005000780W WO 2005092929 A8 WO2005092929 A8 WO 2005092929A8
Authority
WO
WIPO (PCT)
Prior art keywords
hyaluronic acid
esters
substitution
butyric
residues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2005/000780
Other languages
English (en)
Other versions
WO2005092929A1 (fr
Inventor
Danila Coradini
Alberto Perbellini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SINTOFARM SpA
Original Assignee
SINTOFARM SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SINTOFARM SpA filed Critical SINTOFARM SpA
Priority to EP05718276A priority Critical patent/EP1781707A1/fr
Publication of WO2005092929A1 publication Critical patent/WO2005092929A1/fr
Publication of WO2005092929A8 publication Critical patent/WO2005092929A8/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des esters butyriques d'acide hyaluronique dans lesquels les groupes hydroxyle de l'acide hyaluronique sont partiellement estérifiés par des groupes fonctionnels butyriques, caractérisés par un taux de substitution par les groupes fonctionnels butyriques inférieur à 0,1 (nombre de groupes fonctionnels butyriques rapporté au nombre d'unités disaccharide GIcNAc-GIcUA de l'acide hyaluronique). Ces esters faiblement substitués résultent d'un traitement mené en phase homogène dans des conditions anhydres, l'acide hyaluronique étant utilisé sous forme d'un sel d'azote quaternaire. Les esters de l'invention présentent un pouvoir antiproliférant supérieur à celui des esters correspondants plus fortement substitués. Ils sont particulièrement actifs contre les tumeurs primaires et métastatiques, notamment dans le cas de tumeurs primaires d'origine hépatique, ou de métastases hépatiques. Un autre aspect de l'invention concerne des compositions pharmaceutiques dont le principe actif est l'un au moins des esters de l'invention.
PCT/IB2005/000780 2004-03-29 2005-03-25 Esters butyriques d'acide hyaluronique faiblement substitues, procede d'elaboration et utilisation Ceased WO2005092929A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05718276A EP1781707A1 (fr) 2004-03-29 2005-03-25 Esters butyriques d'acide hyaluronique faiblement substitues, procede d'elaboration et utilisation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI20040605 ITMI20040605A1 (it) 2004-03-29 2004-03-29 Esteri butirrici dell'acido ialuronico a basso grado di sostituzione procedimento per la loro preparazione ed uso
ITMI2004A000605 2004-03-29

Publications (2)

Publication Number Publication Date
WO2005092929A1 WO2005092929A1 (fr) 2005-10-06
WO2005092929A8 true WO2005092929A8 (fr) 2006-03-02

Family

ID=34967092

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/000780 Ceased WO2005092929A1 (fr) 2004-03-29 2005-03-25 Esters butyriques d'acide hyaluronique faiblement substitues, procede d'elaboration et utilisation

Country Status (3)

Country Link
EP (1) EP1781707A1 (fr)
IT (1) ITMI20040605A1 (fr)
WO (1) WO2005092929A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1942117A1 (fr) * 2006-12-29 2008-07-09 Sigea S.R.L. Dérivés de polysaccharides acides
ITMI20072237A1 (it) * 2007-11-27 2009-05-28 Sigea Srl Esteri misti butirrico-formico di polisaccaridi acidi, loro preparazione ed uso come dermocosmetici
KR101078302B1 (ko) * 2008-05-29 2011-10-31 (주)프로넥스 약물전달체
ITTO20110428A1 (it) 2011-05-13 2012-11-14 Rottapharm Spa Esteri dell'acido ialuronico, loro preparazione ed uso in dermatologia
CZ2012842A3 (cs) 2012-11-27 2014-08-20 Contipro Biotech S.R.O. Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití
CZ2013914A3 (cs) 2013-11-21 2015-02-25 Contipro Biotech S.R.O. Nanovlákna obsahující fototvrditelný esterový derivát kyseliny hyaluronové nebo její soli, fototvrzená nanovlákna, způsob jejich syntézy, přípravek obsahující fototvrzená nanovlákna a jejich použití
CN103724455B (zh) * 2013-12-11 2016-07-06 四川大学 一种透明质酸衍生物及其水凝胶的制备方法
CZ2014150A3 (cs) 2014-03-11 2015-05-20 Contipro Biotech S.R.O. Konjugáty oligomeru kyseliny hyaluronové nebo její soli, způsob jejich přípravy a použití
CZ2014451A3 (cs) 2014-06-30 2016-01-13 Contipro Pharma A.S. Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití
JP6738337B2 (ja) * 2015-01-13 2020-08-12 シジェア ソシエタ ア レスポンサビリタ リミタータ ヒアルロン酸ナトリウム塩の酪酸エステルの調製のための水中における方法
CZ309295B6 (cs) 2015-03-09 2022-08-10 Contipro A.S. Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití
CZ2015398A3 (cs) 2015-06-15 2017-02-08 Contipro A.S. Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin
CZ306662B6 (cs) 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití
CZ308106B6 (cs) 2016-06-27 2020-01-08 Contipro A.S. Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití
CN116444695B (zh) * 2022-12-27 2024-09-06 山东丰金美业科技有限公司 一种低成本、低分子量乙酰化透明质酸钠的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1286510B1 (it) * 1996-11-29 1998-07-15 Cooperativa Centro Ricerche Po Esteri butirrici ad attivita' antiproliferativa e composizioni farmaceutiche che li contengono

Also Published As

Publication number Publication date
ITMI20040605A1 (it) 2004-06-29
WO2005092929A1 (fr) 2005-10-06
EP1781707A1 (fr) 2007-05-09

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