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WO2005078090A3 - Antisense oligonucleotides for treating unwanted pigmentation of the skin and hair - Google Patents

Antisense oligonucleotides for treating unwanted pigmentation of the skin and hair Download PDF

Info

Publication number
WO2005078090A3
WO2005078090A3 PCT/EP2005/050549 EP2005050549W WO2005078090A3 WO 2005078090 A3 WO2005078090 A3 WO 2005078090A3 EP 2005050549 W EP2005050549 W EP 2005050549W WO 2005078090 A3 WO2005078090 A3 WO 2005078090A3
Authority
WO
WIPO (PCT)
Prior art keywords
hair
skin
antisense oligonucleotides
structures
treating unwanted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2005/050549
Other languages
German (de)
French (fr)
Other versions
WO2005078090A2 (en
Inventor
Claudia Mundt
Stefan Gallinat
Ute Breitenbach
Thomas Blatt
Rainer Wolber
Werner Berens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Priority to EP05707971A priority Critical patent/EP1716236A2/en
Publication of WO2005078090A2 publication Critical patent/WO2005078090A2/en
Publication of WO2005078090A3 publication Critical patent/WO2005078090A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to an oligonucleotide or a physiologically compatible salt thereof, that is able to hybridise with an mRNA or a gene sequence encoding at least one structure contributing to the pigmentation of the skin and/or hair, said structures contributing to: I) the actual melanin synthesis (melanosome structures) and/or to II) the expression of said melanosome structures and/or to III) the transfer of the melanosomes (into the keratinocytes).
PCT/EP2005/050549 2004-02-12 2005-02-08 Antisense oligonucleotides for treating unwanted pigmentation of the skin and hair Ceased WO2005078090A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP05707971A EP1716236A2 (en) 2004-02-12 2005-02-08 Antisense oligonucleotides for treating unwanted pigmentation of the skin and hair

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004007032.6 2004-02-12
DE200410007032 DE102004007032A1 (en) 2004-02-12 2004-02-12 Antisense oligonucleotides hybridizing with mRNA or a gene sequence to code structures inhibiting skin or hair pigmentation act in melanine synthesis, expression of melanosome structures and/or melanosome transfer

Publications (2)

Publication Number Publication Date
WO2005078090A2 WO2005078090A2 (en) 2005-08-25
WO2005078090A3 true WO2005078090A3 (en) 2005-12-01

Family

ID=34801894

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/050549 Ceased WO2005078090A2 (en) 2004-02-12 2005-02-08 Antisense oligonucleotides for treating unwanted pigmentation of the skin and hair

Country Status (3)

Country Link
EP (1) EP1716236A2 (en)
DE (1) DE102004007032A1 (en)
WO (1) WO2005078090A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140296223A1 (en) * 2011-09-01 2014-10-02 The General Hospital Corporation Method for regulating skin pigmentation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014700A1 (en) * 2000-02-11 2004-01-22 Robin Kurfurst Novel oligonucleotides and use of oligonucleotides modulating the expression of enzymes involved in the synthesis of melanic pigments, as depigmentation agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379887B1 (en) * 1998-09-10 2002-04-30 The General Hospital Corporation Gene for inhibiting melanin biosynthesis
TW200718944A (en) * 1999-06-29 2007-05-16 Univ New York Screening methods for compounds that affect melanogenesis
US6327030B1 (en) 1999-08-06 2001-12-04 University Of Florida System, method, and coating for strain analysis
US20020064876A1 (en) * 1999-12-28 2002-05-30 Kyonggeun Yoon Novel gene therapy methods for the treatment of skin disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040014700A1 (en) * 2000-02-11 2004-01-22 Robin Kurfurst Novel oligonucleotides and use of oligonucleotides modulating the expression of enzymes involved in the synthesis of melanic pigments, as depigmentation agents

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AOKI HIROFUMI ET AL: "Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R)", LIFE SCIENCES, vol. 71, no. 18, 20 September 2002 (2002-09-20), pages 2171 - 2179, XP002327571, ISSN: 0024-3205 *
SHIBAHARA SHIGEKI ET AL: "Microphthalmia-associated transcription factor (MITF): Multiplicity in structure, function, and regulation.", JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, vol. 6, no. 1, November 2001 (2001-11-01), pages 99 - 104, XP002327573, ISSN: 1087-0024 *
UDONO TETSUO ET AL: "Structural organization of the human microphthalmia-associated transcription factor gene containing four alternative promoters", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1491, no. 1-3, 25 April 2000 (2000-04-25), pages 205 - 219, XP002327572, ISSN: 0006-3002 *

Also Published As

Publication number Publication date
DE102004007032A1 (en) 2005-08-25
WO2005078090A2 (en) 2005-08-25
EP1716236A2 (en) 2006-11-02

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