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WO2005074389A1 - ビタミンｄ化合物及びそれらの合成中間体の合成方法 - Google Patents

ビタミンｄ化合物及びそれらの合成中間体の合成方法

Info

Publication number
WO2005074389A1
WO2005074389A1 PCT/JP2005/001586 JP2005001586W WO2005074389A1 WO 2005074389 A1 WO2005074389 A1 WO 2005074389A1 JP 2005001586 W JP2005001586 W JP 2005001586W WO 2005074389 A1 WO2005074389 A1 WO 2005074389A1
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
synthesis
vitamin
intermediates
aldehyde
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2005/001586
Other languages
English (en)
French (fr)
Other versions
WO2005074389A3 (ja
WO2005074389A2 (ja
Inventor
Hirotaka Kashiwagi
Yoshiyuki Ono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to US10/588,201 priority Critical patent/US9221753B2/en
Priority to JP2005517719A priority patent/JP4795023B2/ja
Publication of WO2005074389A1 publication Critical patent/WO2005074389A1/ja
Publication of WO2005074389A2 publication Critical patent/WO2005074389A2/ja
Publication of WO2005074389A3 publication Critical patent/WO2005074389A3/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

　本発明の目的は、簡単な操作で低コストにビタミンＤ化合物を合成する方法を提供することである。 　本発明により、（ａ）ケトンまたはアルデヒドと、ウィッティッヒ試薬と、塩基とを混合する工程；または、（ｂ）ケトンまたはアルデヒドとウィッティッヒ試薬とを混合し、得られた混合物に塩基を加える工程；を含む、ビタミンＤ化合物およびその合成中間体の製造方法が提供される。                                                                               
PCT/JP2005/001586 2004-02-03 2005-02-03 ビタミンｄ化合物及びそれらの合成中間体の合成方法 Ceased WO2005074389A2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/588,201 US9221753B2 (en) 2004-02-03 2005-02-03 Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds
JP2005517719A JP4795023B2 (ja) 2004-02-03 2005-02-03 ビタミンｄ化合物及びそれらの合成中間体の合成方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004026291 2004-02-03
JP2004-026291 2004-02-03

Publications (3)

Publication Number Publication Date
WO2005074389A1 true WO2005074389A1 (ja) 2005-08-18
WO2005074389A2 WO2005074389A2 (ja) 2005-08-18
WO2005074389A3 WO2005074389A3 (ja) 2005-10-06

Family

ID=34835841

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/001586 Ceased WO2005074389A2 (ja) 2004-02-03 2005-02-03 ビタミンｄ化合物及びそれらの合成中間体の合成方法

Country Status (3)

Country Link
US (1) US9221753B2 (ja)
JP (1) JP4795023B2 (ja)
WO (1) WO2005074389A2 (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2046737B1 (en) * 2006-04-06 2011-09-07 Wisconsin Alumni Research Foundation 2-methylene-1 alpha,25-dihydroxy-19,21-dinorvitamin d3 analogs and uses thereof
US7648972B2 (en) * 2006-04-06 2010-01-19 Wisconsin Alumni Research Foundation 2-methylene-1α-hydroxy-19,21-dinorvitamin D3 analogs and uses thereof
CN101505725A (zh) * 2006-08-29 2009-08-12 特瓦制药工业有限公司 包含含维生素D的化合物和皮质类固醇化合物的具有低pH相容性的稳定的药理学活性组合物
US20080171728A1 (en) * 2007-01-12 2008-07-17 Quatrx Pharmaceuticals Co. Efficient Process for Preparing Steroids and Vitamin D Derivatives With the Unnatural Configuration at C20 (20 Alpha-Methyl) from Pregnenolone
CN102264751A (zh) * 2008-11-26 2011-11-30 赛特克罗公司 合成维生素d类似物的方法
WO2011002756A2 (en) * 2009-07-01 2011-01-06 Vitamin Derivatives, Inc. Vitamin d compounds and methods for preparing same
US9416102B2 (en) * 2013-01-23 2016-08-16 Wisconsin Alumni Research Foundation (22E)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3 analogs
WO2021107646A1 (ko) * 2019-11-27 2021-06-03 연성정밀화학(주) 막사칼시톨의 제조방법 및 그를 위한 중간체

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
EP0398217B1 (de) * 1989-05-18 1994-01-12 F. Hoffmann-La Roche Ag Dehydrocholecalciferolderivate
PE28297A1 (es) * 1995-01-26 1997-08-20 Hoffmann La Roche Empleo dermatologico de derivados de vitamina d
TR199902639T2 (xx) 1997-04-28 2000-07-21 F.Hoffmann-La Roche Ag Bis C-20 yan zinciri olan D3 vitamini analoglar�.
US6030962A (en) * 1997-04-28 2000-02-29 Synttex (U.S.A.) Inc. Vitamin D3 analogs with bis C-20 side chains
ATE237586T1 (de) 1997-05-02 2003-05-15 Duphar Int Res Verfahren zur herstellung von 16-dehydro vitamin d verbindungen
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln

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