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WO2005070945A8 - メチシリン耐性黄色ブドウ球菌（ｍｒｓａ）に有効な新規アミノグリコシド系抗生物質 - Google Patents

メチシリン耐性黄色ブドウ球菌（ｍｒｓａ）に有効な新規アミノグリコシド系抗生物質

Info

Publication number
WO2005070945A8
WO2005070945A8 PCT/JP2005/000767 JP2005000767W WO2005070945A8 WO 2005070945 A8 WO2005070945 A8 WO 2005070945A8 JP 2005000767 W JP2005000767 W JP 2005000767W WO 2005070945 A8 WO2005070945 A8 WO 2005070945A8
Authority
WO
WIPO (PCT)
Prior art keywords
mrsa
staphylococcus aureus
effective against
resistant staphylococcus
methicillin resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2005/000767
Other languages
English (en)
French (fr)
Other versions
WO2005070945A1 (ja
Inventor
Nobuto Minowa
Takayuki Usui
Yoshihisa Akiyama
Yukiko Hiraiwa
Toshio Yoneda
Toshifumi Hasegawa
Kazunori Maebashi
Takashi Ida
Kazuko Katsumata
Keiko Otsuka
Daishiro Ikeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Meiji Seika Kaisha Ltd
Original Assignee
Microbial Chemistry Research Foundation
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation, Meiji Seika Kaisha Ltd filed Critical Microbial Chemistry Research Foundation
Priority to JP2005517278A priority Critical patent/JPWO2005070945A1/ja
Priority to EP05703988A priority patent/EP1710248A4/en
Priority to US10/586,853 priority patent/US20070161581A1/en
Publication of WO2005070945A1 publication Critical patent/WO2005070945A1/ja
Publication of WO2005070945A8 publication Critical patent/WO2005070945A8/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PCT/JP2005/000767 2004-01-21 2005-01-21 メチシリン耐性黄色ブドウ球菌（ｍｒｓａ）に有効な新規アミノグリコシド系抗生物質 Ceased WO2005070945A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2005517278A JPWO2005070945A1 (ja) 2004-01-21 2005-01-21 メチシリン耐性黄色ブドウ球菌（ｍｒｓａ）に有効な新規アミノグリコシド系抗生物質
EP05703988A EP1710248A4 (en) 2004-01-21 2005-01-21 NEW AMINOGLYCOSIDE ANTIBIOTICS WITH EFFECT ON METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA)
US10/586,853 US20070161581A1 (en) 2004-01-21 2005-01-21 Novel aminoglycoside antibiotics effective against methicillin resistant staphylococcus auerus (mrsas)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2004013642 2004-01-21
JP2004-013642 2004-01-21

Publications (2)

Publication Number Publication Date
WO2005070945A1 WO2005070945A1 (ja) 2005-08-04
WO2005070945A8 true WO2005070945A8 (ja) 2005-12-15

Family

ID=34805391

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2005/000767 Ceased WO2005070945A1 (ja) 2004-01-21 2005-01-21 メチシリン耐性黄色ブドウ球菌（ｍｒｓａ）に有効な新規アミノグリコシド系抗生物質

Country Status (4)

Country Link
US (1) US20070161581A1 (ja)
EP (1) EP1710248A4 (ja)
JP (1) JPWO2005070945A1 (ja)
WO (1) WO2005070945A1 (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA97245C2 (en) 2006-06-02 2012-01-25 Меиджи Сеика Фарма Ко., Лтд. Aminoglycoside antibiotics
BRPI0819319B8 (pt) 2007-11-21 2021-05-25 Achaogen Inc análogos de aminoglicosídeo antibacteriano
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
KR101070324B1 (ko) * 2009-05-22 2011-10-06 대우제약 주식회사 마크로락틴 에이 및 그 유도체를 유효성분으로 함유하는 항염제 조성물
EP2569324B9 (en) * 2010-05-12 2018-03-28 Rempex Pharmaceuticals, Inc. Aminoglycoside derivatives
KR102133620B1 (ko) * 2013-05-30 2020-07-13 메이지 세이카 파루마 가부시키가이샤 아르베카신 유도체 및 그의 제조 및 이용
EP3344640A4 (en) 2015-09-02 2019-05-01 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
US10786520B2 (en) 2015-09-02 2020-09-29 Eloxx Pharmaceuticals Ltd. Aminoglycoside derivatives and uses thereof in treating genetic disorders
IL295474A (en) 2015-09-02 2022-10-01 Eloxx Pharmaceuticals Ltd Aminoglycoside derivatives and uses thereof in treating genetic disorders
WO2017118967A1 (en) * 2016-01-05 2017-07-13 Technion Research & Development Foundation Limited Aminoglycoside derivatives and uses thereof in treating microbial infections
JP2022514472A (ja) * 2018-12-05 2022-02-14 アジャイルバイオティクス ベー．フェー． 新規抗菌性４，６－二置換２，５－ジデオキシストレプタミンアミノグリコシド系抗生物質の３’’誘導体
CN116462721B (zh) * 2023-04-18 2024-02-02 江南大学 抗菌性氨基糖苷衍生物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH618986A5 (en) * 1974-11-29 1980-08-29 Scherico Ltd Process for the preparation of aminoglycoside antibiotics.
US4000261A (en) * 1974-11-29 1976-12-28 Schering Corporation 5-epi-4,6-di-o-(aminoglycosyl)-2-deoxystreptamines, methods for their manufacture and intermediates useful therein, methods for their use as antibacterial agents and compositions useful therefor
US5488038A (en) * 1992-11-27 1996-01-30 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Dibekacin derivatives and arbekacin derivatives active against resistant bacteria
JP3215759B2 (ja) * 1993-09-09 2001-10-09 財団法人微生物化学研究会 耐性菌に有効な５−置換−２″−アミノ−２″−デオキシアルベカシンとその製造法
JPH07252290A (ja) * 1994-03-11 1995-10-03 Microbial Chem Res Found １−ｎ−（５−アミノ−４−フルオロ−２−ヒドロキシバレリル）カナマイシン類

Also Published As

Publication number Publication date
WO2005070945A1 (ja) 2005-08-04
EP1710248A1 (en) 2006-10-11
US20070161581A1 (en) 2007-07-12
EP1710248A4 (en) 2009-05-27
JPWO2005070945A1 (ja) 2007-09-06

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