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WO2005065290A3 - Metallization of nucleic acids by metal sols, and uses thereof - Google Patents

Metallization of nucleic acids by metal sols, and uses thereof Download PDF

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Publication number
WO2005065290A3
WO2005065290A3 PCT/US2004/043530 US2004043530W WO2005065290A3 WO 2005065290 A3 WO2005065290 A3 WO 2005065290A3 US 2004043530 W US2004043530 W US 2004043530W WO 2005065290 A3 WO2005065290 A3 WO 2005065290A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecule
metal
metallization
nucleic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/043530
Other languages
French (fr)
Other versions
WO2005065290A2 (en
Inventor
Dennis M Connolly
Charles Deboer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Integrated Nano Technologies LLC
Original Assignee
Integrated Nano Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Integrated Nano Technologies LLC filed Critical Integrated Nano Technologies LLC
Publication of WO2005065290A2 publication Critical patent/WO2005065290A2/en
Publication of WO2005065290A3 publication Critical patent/WO2005065290A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to a method for metallizing a nucleic acid molecule by providing a metal sol, mordanting metal particles from the metal sol on the nucleic acid molecule, and contacting the mordanted nucleic acid molecule with a metal deposition solution to deposit metal on the nucleic acid molecule. A method for detecting a target nucleic acid molecule in a sample employing metallized nucleic acid molecules is also disclosed.
PCT/US2004/043530 2003-12-30 2004-12-22 Metallization of nucleic acids by metal sols, and uses thereof Ceased WO2005065290A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53334203P 2003-12-30 2003-12-30
US60/533,342 2003-12-30

Publications (2)

Publication Number Publication Date
WO2005065290A2 WO2005065290A2 (en) 2005-07-21
WO2005065290A3 true WO2005065290A3 (en) 2005-11-03

Family

ID=34748888

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/043530 Ceased WO2005065290A2 (en) 2003-12-30 2004-12-22 Metallization of nucleic acids by metal sols, and uses thereof

Country Status (1)

Country Link
WO (1) WO2005065290A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999004440A1 (en) * 1997-07-14 1999-01-28 Technion Research And Development Foundation Ltd. Microelectronic components and electronic networks comprising dna
US20030027195A1 (en) * 2001-08-03 2003-02-06 Ford William E. Metallisation of nucleic acids via metal nanoparticles produced ex-situ

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999004440A1 (en) * 1997-07-14 1999-01-28 Technion Research And Development Foundation Ltd. Microelectronic components and electronic networks comprising dna
US20030027195A1 (en) * 2001-08-03 2003-02-06 Ford William E. Metallisation of nucleic acids via metal nanoparticles produced ex-situ

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MBINDYO J.K.N. ET AL, ADV. MATER, vol. 13, no. 4, 19 February 2001 (2001-02-19), pages 249 - 254, XP001004980 *
MIRKIN C.A. ET AL: "A DNA-based method for rationally nanoparicles into macroscopic materials.", NATURE, vol. 382, 15 August 1996 (1996-08-15), pages 607 - 609, XP002113276 *

Also Published As

Publication number Publication date
WO2005065290A2 (en) 2005-07-21

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