[go: up one dir, main page]

WO2004113365A3 - Inhibiteurs de la tripeptide hepatite c serine protease - Google Patents

Inhibiteurs de la tripeptide hepatite c serine protease Download PDF

Info

Publication number
WO2004113365A3
WO2004113365A3 PCT/US2004/015803 US2004015803W WO2004113365A3 WO 2004113365 A3 WO2004113365 A3 WO 2004113365A3 US 2004015803 W US2004015803 W US 2004015803W WO 2004113365 A3 WO2004113365 A3 WO 2004113365A3
Authority
WO
WIPO (PCT)
Prior art keywords
hepatitis
present
compounds
serine protease
tri
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/015803
Other languages
English (en)
Other versions
WO2004113365A2 (fr
WO2004113365A9 (fr
Inventor
Zhenwei Miao
Ying Sun
Suanne Nakajima
Datong Tang
Zhe Wang
Yat Sun Or
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enanta Pharmaceuticals Inc
Original Assignee
Enanta Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharmaceuticals Inc filed Critical Enanta Pharmaceuticals Inc
Priority claimed from US10/849,107 external-priority patent/US7273851B2/en
Publication of WO2004113365A2 publication Critical patent/WO2004113365A2/fr
Publication of WO2004113365A3 publication Critical patent/WO2004113365A3/fr
Anticipated expiration legal-status Critical
Publication of WO2004113365A9 publication Critical patent/WO2004113365A9/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des composés de formule (I), ou un sel, ester pharmaceutiquement acceptable, ou pro-médicament de ceux-ci, inhibant l'activité de la sérine protéase, en particulier l'activité du virus de l'hépatite C (HCV) NS3-NS4A protéase. En conséquence, les composés selon l'invention interfèrent avec le cycle de vie du virus de l'hépatite C et sont également utilisés comme agents antiviraux. L'invention concerne en outre des compositions pharmaceutiques comprenant les composés précités, pour l'administration à un sujet souffrant d'une infection HCV. L'invention concerne en outre des procédés de traitement d'une infection HCV chez un sujet, par administration d'une composition pharmaceutique comprenant les composés de l'invention.
PCT/US2004/015803 2003-06-05 2004-05-19 Inhibiteurs de la tripeptide hepatite c serine protease Ceased WO2004113365A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45499703A 2003-06-05 2003-06-05
US10/454,997 2003-06-05
US10/849,107 2004-05-19
US10/849,107 US7273851B2 (en) 2003-06-05 2004-05-19 Tri-peptide hepatitis C serine protease inhibitors

Publications (3)

Publication Number Publication Date
WO2004113365A2 WO2004113365A2 (fr) 2004-12-29
WO2004113365A3 true WO2004113365A3 (fr) 2005-07-21
WO2004113365A9 WO2004113365A9 (fr) 2006-03-23

Family

ID=33544050

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/015803 Ceased WO2004113365A2 (fr) 2003-06-05 2004-05-19 Inhibiteurs de la tripeptide hepatite c serine protease

Country Status (1)

Country Link
WO (1) WO2004113365A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491794B2 (en) 2003-10-14 2009-02-17 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
US8993595B2 (en) 2009-04-08 2015-03-31 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors
US9284307B2 (en) 2009-08-05 2016-03-15 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors
US9353100B2 (en) 2011-02-10 2016-05-31 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
US7176208B2 (en) 2003-04-18 2007-02-13 Enanta Pharmaceuticals, Inc. Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors
WO2005073216A2 (fr) 2004-01-30 2005-08-11 Medivir Ab Inhibiteurs de la serine protease ns-3 du vhc
EP1711515A2 (fr) 2004-02-04 2006-10-18 Vertex Pharmaceuticals Incorporated Inhibiteurs de proteases serines, en particulier de la protease hcv ns3-ns4a
US7323447B2 (en) 2005-02-08 2008-01-29 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7592336B2 (en) * 2005-05-10 2009-09-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7601686B2 (en) 2005-07-11 2009-10-13 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
EP1915378A4 (fr) 2005-08-12 2009-07-22 Boehringer Ingelheim Int Inhibiteurs de polymerase virale
AR055395A1 (es) 2005-08-26 2007-08-22 Vertex Pharma Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
US7772183B2 (en) 2005-10-12 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7741281B2 (en) 2005-11-03 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7816348B2 (en) 2006-02-03 2010-10-19 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
EP2049474B1 (fr) 2006-07-11 2015-11-04 Bristol-Myers Squibb Company Inhibiteurs du virus de l'hépatite c
WO2008008502A1 (fr) 2006-07-13 2008-01-17 Achillion Pharmaceuticals, Inc. 4-amino-4-oxobutanoyl peptides en tant qu'inhibiteurs de la réplication virale
US20090035267A1 (en) * 2007-07-31 2009-02-05 Moore Joel D Acyclic, pyridazinone-derived hepatitis c serine protease inhibitors
US7718612B2 (en) * 2007-08-02 2010-05-18 Enanta Pharmaceuticals, Inc. Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors
CN101674844A (zh) * 2006-08-04 2010-03-17 英安塔制药有限公司 四唑基大环类c型肝炎丝氨酸蛋白酶抑制剂
US20080038225A1 (en) * 2006-08-11 2008-02-14 Ying Sun Triazolyl acyclic hepatitis c serine protease inhibitors
CN101506167A (zh) 2006-08-17 2009-08-12 贝林格尔.英格海姆国际有限公司 病毒聚合酶抑制剂
US8343477B2 (en) 2006-11-01 2013-01-01 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
US7772180B2 (en) 2006-11-09 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7888464B2 (en) 2006-11-16 2011-02-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8003604B2 (en) 2006-11-16 2011-08-23 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7763584B2 (en) 2006-11-16 2010-07-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2125113A2 (fr) 2007-02-26 2009-12-02 Achillion Pharmaceuticals, Inc. Peptides substitués par une amine tertiaire utiles comme inhibiteurs de la réplication du virus de l'hépatite c
MX2009013827A (es) 2007-06-29 2010-03-01 Gilead Sciences Inc Compuestos antivirales.
SG182979A1 (en) 2007-06-29 2012-08-30 Gilead Sciences Inc Antiviral compounds
WO2009018657A1 (fr) 2007-08-03 2009-02-12 Boehringer Ingelheim International Gmbh Inhibiteurs de polymerase virale
EP2190858A4 (fr) 2007-09-24 2013-02-13 Achillion Pharmaceuticals Inc Peptides contenant de l'urée en tant qu'inhibiteurs de la réplication virale
US8383583B2 (en) 2007-10-26 2013-02-26 Enanta Pharmaceuticals, Inc. Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
JP2011503201A (ja) 2007-11-14 2011-01-27 エナンタ ファーマシューティカルズ インコーポレイテッド 大環状テトラゾリルｃ型肝炎セリンプロテアーゼ阻害剤
CA2708150A1 (fr) 2007-12-05 2009-06-18 Enanta Pharmaceuticals, Inc. Composes a base de tripeptides fluores inhibant la serine protease du vhc
US8273709B2 (en) 2007-12-14 2012-09-25 Enanta Pharmaceuticals, Inc. Triazole-containing macrocyclic HCV serine protease inhibitors
KR20100098534A (ko) 2007-12-19 2010-09-07 베링거 인겔하임 인터내셔날 게엠베하 바이러스 폴리머라제 억제제
US8202996B2 (en) 2007-12-21 2012-06-19 Bristol-Myers Squibb Company Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
JP5490778B2 (ja) 2008-03-20 2014-05-14 エナンタ ファーマシューティカルズ インコーポレイテッド Ｃ型肝炎ウイルス阻害剤としてのフッ素化大環状化合物
US8163921B2 (en) 2008-04-16 2012-04-24 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7964560B2 (en) 2008-05-29 2011-06-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8044023B2 (en) 2008-05-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8207341B2 (en) 2008-09-04 2012-06-26 Bristol-Myers Squibb Company Process or synthesizing substituted isoquinolines
US8563505B2 (en) 2008-09-29 2013-10-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8044087B2 (en) 2008-09-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
MX2011006244A (es) 2008-12-10 2011-06-27 Achillion Pharmaceuticals Inc Nuevos peptidos de 4-amino-4-oxobutanoilo como inhibidores de replica viral.
US8283310B2 (en) 2008-12-15 2012-10-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
CN102271699A (zh) 2009-01-07 2011-12-07 西尼克斯公司 用于治疗hcv和hiv感染的环孢菌素衍生物
MX2011012155A (es) 2009-05-13 2012-02-28 Enanta Pharm Inc Compuestos macrociclicos como inhibidores del virus de hepatitis c.
EP2618831B1 (fr) 2010-09-21 2016-01-06 Enanta Pharmaceuticals, Inc. Inhibiteurs macroccliques de la sérine protéase du vhc dérivés de la proline
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8691757B2 (en) 2011-06-15 2014-04-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
MA37992B1 (fr) 2012-10-19 2018-09-28 Bristol Myers Squibb Co Composes inhibiteurs de protéase ns3 pour une utilisation dans le traitement de l’infection par le virus de l'hépatite c.
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9334279B2 (en) 2012-11-02 2016-05-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9598433B2 (en) 2012-11-02 2017-03-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9409943B2 (en) 2012-11-05 2016-08-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9580463B2 (en) 2013-03-07 2017-02-28 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
BR112015023343A2 (pt) 2013-03-14 2017-07-18 Achillion Pharmaceuticals Inc método para preparar sovaprevir, método de preparar um composto da fórmula (c), método de preparação do composto f-2, composto, processo, método de preparação de uma forma amorfa pura de sovaprevir, e,forma cristalina de sovaprevir
US9227952B2 (en) 2013-03-15 2016-01-05 Achillion Pharmaceuticals, Inc. Sovaprevir polymorphs and methods of manufacture thereof
US9006423B2 (en) 2013-03-15 2015-04-14 Achillion Pharmaceuticals Inc. Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof
WO2014145600A1 (fr) 2013-03-15 2014-09-18 Achillion Pharmaceuticals, Inc. Polymorphes de sel de sodium d'ach-0142684, composition les comprenant, et leur procédé de fabrication
EP2899207A1 (fr) 2014-01-28 2015-07-29 Amikana.Biologics Nouveau procédé pour tester l'inhibition de la protéase du HCV
JP7164521B2 (ja) * 2016-06-21 2022-11-01 オリオン・オフサルモロジー・エルエルシー 炭素環式プロリンアミド誘導体
KR102595723B1 (ko) * 2016-06-21 2023-10-27 오리온 옵탈몰로지 엘엘씨 헤테로시클릭 프롤린아미드 유도체

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000009543A2 (fr) * 1998-08-10 2000-02-24 Boehringer Ingelheim (Canada) Ltd. Tri-peptides inhibiteurs de l'hepatite c
WO2004072243A2 (fr) * 2003-02-07 2004-08-26 Enanta Pharmaceuticals, Inc. Inhibiteurs macrocycliques de la serine protease de l'hepatite c

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122627B2 (en) 1999-07-26 2006-10-17 Bristol-Myers Squibb Company Lactam inhibitors of Hepatitis C virus NS3 protease

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000009543A2 (fr) * 1998-08-10 2000-02-24 Boehringer Ingelheim (Canada) Ltd. Tri-peptides inhibiteurs de l'hepatite c
WO2004072243A2 (fr) * 2003-02-07 2004-08-26 Enanta Pharmaceuticals, Inc. Inhibiteurs macrocycliques de la serine protease de l'hepatite c

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491794B2 (en) 2003-10-14 2009-02-17 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
US8993595B2 (en) 2009-04-08 2015-03-31 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors
US9284307B2 (en) 2009-08-05 2016-03-15 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors
US9353100B2 (en) 2011-02-10 2016-05-31 Idenix Pharmaceuticals Llc Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating HCV infections

Also Published As

Publication number Publication date
WO2004113365A2 (fr) 2004-12-29

Similar Documents

Publication Publication Date Title
WO2004113365A3 (fr) Inhibiteurs de la tripeptide hepatite c serine protease
WO2004093798A3 (fr) Composes macrocycliques de quinoxalinyle inhibant les serine proteases de l'hepatite c
WO2008002924A3 (fr) Inhibiteurs macrocycliques quinoxalinyliques des protéases à sérine du virus de l'hépatite c
WO2005007681A3 (fr) Inhibiteurs de serines proteases, en particulier de la protease ns3-ns4a du vhc
WO2009076173A3 (fr) Composés à base de tripeptides fluorés inhibant la sérine protéase du vhc
WO2009053828A3 (fr) Inhibiteurs p3-hydroxyamino macrocycliques des sérine protéases de l'hépatite c
WO2004072243A3 (fr) Inhibiteurs macrocycliques de la serine protease de l'hepatite c
WO2008022006A3 (fr) Inhibiteurs de protéase du virus de l'hépatite c arylalcoxyle
WO2007143694A3 (fr) Inhibiteurs oximyles macrocycliques de la protéase de l'hépatite c
WO2008021956A3 (fr) Inhibiteurs d'acylamino-hétéroaryle de la protéase du virus de l'hépatite c
WO2005077969A3 (fr) Inhibiteurs de proteases serines, en particulier de la protease hcv ns3-ns4a
WO2008019266A3 (fr) Inhibiteurs de sérine protéase de l'hépatite c dérivés de pyridazinone acycliques
WO2005037860A3 (fr) Inhibiteurs de serine proteases, en particulier la ns3-ns4a protease du hcv
WO2008021871A3 (fr) Inhibiteurs triazolyle acyclique de la sérine protéase de l'hépatite c
WO2008019303A3 (fr) Inhibiteurs de sérine protéases de l'hépatite c macrocycliques de type pyridazinonyle
WO2008021960A3 (fr) Inhibiteurs triazolyle macrocycliques de la sérine protéase de l'hépatite c
TW200510391A (en) Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
WO2009076166A3 (fr) Inhibiteurs oximyles de la sérine protéase de vhc
MX2010005262A (es) Compuestos que contienen quinoxalina como inhibidores del virus de hepatitis c.
WO2008019289A3 (fr) Inhibiteurs de sérine protéases de l'hépatite c macrocycliques de type tétrazolyle
WO2005035525A3 (fr) Inhibiteurs des serines proteases, en particulier de la protease ns3-ns4a du virus de l'hepatite c (vhc)
WO2008021733A3 (fr) Inhibiteurs acycliques tétrazolylés de la sérine protéase de l'hépaptite c
MX2010006209A (es) Derivados de quinoxalinilo.
WO2003087092A3 (fr) Inhibiteurs de la serine protease, notamment de la protease ns3-ns4a du virus de l'hepatite c
MX2010006518A (es) Inhibidores de serina proteasa de hepatitis c de oximil macrociclica.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WSNC Later publication of a supplementary international search report together with a suppl. search report established by non-competent authority
COP Corrected version of pamphlet

Free format text: PUBLISHED INTERNATIONAL SEARCH REPORT (5 PAGES) REPLACED BY CORRECT INTERNATIONAL SEARCH REPORT (5 PAGES)

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 69(1) EPC (EPO FORM 1205A) DATED 08.05.2006

122 Ep: pct application non-entry in european phase