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WO2004018703A3 - Recombinant chalcomycin polyketide synthase and modifying genes - Google Patents

Recombinant chalcomycin polyketide synthase and modifying genes Download PDF

Info

Publication number
WO2004018703A3
WO2004018703A3 PCT/US2003/026569 US0326569W WO2004018703A3 WO 2004018703 A3 WO2004018703 A3 WO 2004018703A3 US 0326569 W US0326569 W US 0326569W WO 2004018703 A3 WO2004018703 A3 WO 2004018703A3
Authority
WO
WIPO (PCT)
Prior art keywords
chalcomycin
recombinant
polyketide synthase
modifying genes
prepare
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/026569
Other languages
French (fr)
Other versions
WO2004018703A2 (en
Inventor
Leonard Katz
Ralph C Reid
Zhihao Hu
Andreas Schirmer
Shannon L Ward
Christopher Reeves
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kosan Biosciences Inc
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Priority to AU2003260062A priority Critical patent/AU2003260062A1/en
Publication of WO2004018703A2 publication Critical patent/WO2004018703A2/en
Anticipated expiration legal-status Critical
Publication of WO2004018703A3 publication Critical patent/WO2004018703A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Domains of chalcomycin polyketide synthases and modification enzymes and polynucleotides encoding them are provided. Methods to prepare chalcomycin in pharmaceutically useful quantities axe described, as are methods to prepare chalcomycin analogs and other polyketides using the polynucleotides encoding chalcomycin polyketide synthase domains or modifying enzymes.
PCT/US2003/026569 2002-08-21 2003-08-21 Recombinant chalcomycin polyketide synthase and modifying genes Ceased WO2004018703A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003260062A AU2003260062A1 (en) 2002-08-21 2003-08-21 Recombinant chalcomycin polyketide synthase and modifying genes

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US40519402P 2002-08-21 2002-08-21
US60/405,194 2002-08-21
US42099402P 2002-10-24 2002-10-24
US60/420,994 2002-10-24
US49396603P 2003-08-08 2003-08-08
US60/493,966 2003-08-08

Publications (2)

Publication Number Publication Date
WO2004018703A2 WO2004018703A2 (en) 2004-03-04
WO2004018703A3 true WO2004018703A3 (en) 2005-03-17

Family

ID=31950540

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/026569 Ceased WO2004018703A2 (en) 2002-08-21 2003-08-21 Recombinant chalcomycin polyketide synthase and modifying genes

Country Status (2)

Country Link
AU (1) AU2003260062A1 (en)
WO (1) WO2004018703A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065137A (en) * 1959-02-02 1962-11-20 Parke Davis & Co Chalcomycin and its fermentative production
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065137A (en) * 1959-02-02 1962-11-20 Parke Davis & Co Chalcomycin and its fermentative production
US5672491A (en) * 1993-09-20 1997-09-30 The Leland Stanford Junior University Recombinant production of novel polyketides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
REEVES ET AL.: "Production of Hybrid 16-Membered Macrolides by Expressing Combinations of Polyketide Synthase Genes in Engineered Streptomyces fradiae Hosts", CHEMISTRY & BIOLOGY, vol. 11, 2004, pages 1465 - 1472, XP004601880 *

Also Published As

Publication number Publication date
AU2003260062A1 (en) 2004-03-11
WO2004018703A2 (en) 2004-03-04
AU2003260062A8 (en) 2004-03-11

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WO2004018703A3 (en) Recombinant chalcomycin polyketide synthase and modifying genes

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