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WO2004014295A3 - Tiacumicin production - Google Patents

Tiacumicin production Download PDF

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Publication number
WO2004014295A3
WO2004014295A3 PCT/US2003/021977 US0321977W WO2004014295A3 WO 2004014295 A3 WO2004014295 A3 WO 2004014295A3 US 0321977 W US0321977 W US 0321977W WO 2004014295 A3 WO2004014295 A3 WO 2004014295A3
Authority
WO
WIPO (PCT)
Prior art keywords
tiacumicin
production
produced
nitrogen source
broth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/021977
Other languages
French (fr)
Other versions
WO2004014295A2 (en
Inventor
Youe-Kong Shue
Chi-Jen Frank Du
Ming-His Chiou
Mei-Chiao Wu
Yuan-Ting Chen
Franklin W Okumu
Jonathan James Duffield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Optimer Pharmaceuticals LLC
Original Assignee
Optimer Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2003251902A priority Critical patent/AU2003251902B2/en
Priority to CA2494742A priority patent/CA2494742C/en
Priority to SI200332404T priority patent/SI1539977T1/en
Priority to ES03784766.2T priority patent/ES2527052T3/en
Priority to US10/520,863 priority patent/US7507564B2/en
Priority to EP03784766.2A priority patent/EP1539977B1/en
Priority to DK03784766.2T priority patent/DK1539977T3/en
Priority to JP2004527605A priority patent/JP2005534332A/en
Application filed by Optimer Pharmaceuticals LLC filed Critical Optimer Pharmaceuticals LLC
Publication of WO2004014295A2 publication Critical patent/WO2004014295A2/en
Anticipated expiration legal-status Critical
Publication of WO2004014295A3 publication Critical patent/WO2004014295A3/en
Priority to US11/585,521 priority patent/US20070105791A1/en
Priority to US12/365,230 priority patent/US20100028970A1/en
Priority to US13/494,887 priority patent/US8728796B2/en
Priority to US13/723,881 priority patent/US20140107054A1/en
Priority to US14/281,496 priority patent/US20140296498A1/en
Priority to BE2015C017C priority patent/BE2015C017I2/fr
Priority to FR15C0028C priority patent/FR15C0028I2/en
Priority to HUS1500016C priority patent/HUS1500016I1/en
Priority to CY2015015C priority patent/CY2015015I1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Methods, processes and materials for the production and recovery of Tiacumicins produced by culturing a microorganism belonging to the species Dactylosporangium aurantiacum subspecies hamdenensis having the ability to produce and accumulate one or more Tiacumicin in a nutrient medium comprising a carbon source, a nitrogen source, trace elements such as inorganic salts, and an adsorbent, wherein said nitrogen source comprises fish powder, and wherein said Tiacumicin is produced in a yield greater than about 50 mg/L broth.
PCT/US2003/021977 2002-07-29 2003-07-15 Tiacumicin production Ceased WO2004014295A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
CA2494742A CA2494742C (en) 2002-07-29 2003-07-15 Tiacumicin production
SI200332404T SI1539977T1 (en) 2002-07-29 2003-07-15 Tiacumicin production
ES03784766.2T ES2527052T3 (en) 2002-07-29 2003-07-15 Thiacumycin production
US10/520,863 US7507564B2 (en) 2002-07-29 2003-07-15 Tiacumicin production
EP03784766.2A EP1539977B1 (en) 2002-07-29 2003-07-15 Tiacumicin production
AU2003251902A AU2003251902B2 (en) 2002-07-29 2003-07-15 Tiacumicin production
DK03784766.2T DK1539977T3 (en) 2002-07-29 2003-07-15 PREPARATION OF TIACUMICIN
JP2004527605A JP2005534332A (en) 2002-07-29 2003-07-15 Thiacomycin production
US11/585,521 US20070105791A1 (en) 2002-07-29 2006-10-23 Method of treating clostridium difficile-associated diarrhea
US12/365,230 US20100028970A1 (en) 2002-07-29 2009-02-04 Medium for the Production of Tiacumicin B
US13/494,887 US8728796B2 (en) 2002-07-29 2012-06-12 Tiacumicin production
US13/723,881 US20140107054A1 (en) 2002-07-29 2012-12-21 Method of treating clostridium difficile-associated diarrhea
US14/281,496 US20140296498A1 (en) 2002-07-29 2014-05-19 Tiacumicin Production
BE2015C017C BE2015C017I2 (en) 2002-07-29 2015-03-26
FR15C0028C FR15C0028I2 (en) 2002-07-29 2015-03-27 MANUFACTURE OF TIACUMICIN
HUS1500016C HUS1500016I1 (en) 2002-07-29 2015-03-27 Tiacumicin production
CY2015015C CY2015015I1 (en) 2002-07-29 2015-04-03 PRODUCTION OF THIACOMYCIN

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39995602P 2002-07-29 2002-07-29
US60/399,956 2002-07-29

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US10/520,863 A-371-Of-International US7507564B2 (en) 2002-07-29 2003-07-15 Tiacumicin production
US10520863 A-371-Of-International 2003-07-15
US11/585,521 Continuation-In-Part US20070105791A1 (en) 2002-07-29 2006-10-23 Method of treating clostridium difficile-associated diarrhea
US12/365,230 Division US20100028970A1 (en) 2002-07-29 2009-02-04 Medium for the Production of Tiacumicin B

Publications (2)

Publication Number Publication Date
WO2004014295A2 WO2004014295A2 (en) 2004-02-19
WO2004014295A3 true WO2004014295A3 (en) 2005-04-14

Family

ID=31715689

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/021977 Ceased WO2004014295A2 (en) 2002-07-29 2003-07-15 Tiacumicin production

Country Status (18)

Country Link
US (4) US7507564B2 (en)
EP (2) EP2860241A1 (en)
JP (3) JP2005534332A (en)
KR (1) KR100972542B1 (en)
CN (1) CN100519757C (en)
AU (1) AU2003251902B2 (en)
BE (1) BE2015C017I2 (en)
CA (1) CA2494742C (en)
CY (1) CY2015015I1 (en)
DK (1) DK1539977T3 (en)
ES (1) ES2527052T3 (en)
FR (1) FR15C0028I2 (en)
HU (1) HUS1500016I1 (en)
LU (1) LU92684I2 (en)
NL (1) NL300727I2 (en)
PT (1) PT1539977E (en)
SI (1) SI1539977T1 (en)
WO (1) WO2004014295A2 (en)

Families Citing this family (42)

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EP2860241A1 (en) * 2002-07-29 2015-04-15 Optimer Pharmaceuticals, Inc. Tiacumicin production
US20070105791A1 (en) * 2002-07-29 2007-05-10 Optimer Pharmaceuticals, Inc. Method of treating clostridium difficile-associated diarrhea
WO2005112990A2 (en) * 2004-05-14 2005-12-01 Optimer Pharmaceuticals, Inc. Treatment of diseases associated with the use of antibiotics
US7906489B2 (en) * 2004-05-14 2011-03-15 Optimer Pharmaceuticals, Inc. 18-membered macrocycles and analogs thereof
US7378508B2 (en) 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
AU2005327308B2 (en) * 2005-01-31 2011-11-10 Merck Sharp & Dohme Llc 18-membered macrocycles and analogs thereof
AU2012200784B2 (en) * 2005-01-31 2013-07-11 Merck Sharp & Dohme Llc 18-membered macrocycles and analogs thereof
JP2009512691A (en) * 2005-10-21 2009-03-26 オプティマー ファーマシューティカルズ，インコーポレーテッド Treatment of Clostridium difficile-related diarrhea
US20080176927A1 (en) * 2007-01-19 2008-07-24 Optimer Pharmaceuticals, Inc. Compositions of stable tiacumicins
KR100891313B1 (en) * 2007-08-17 2009-03-31 (주) 제노텍 Method for producing and extracting tricyclo compounds by providing an adsorbent resin serving as a carrier
TWI326284B (en) * 2007-10-26 2010-06-21 Echem Hightech Co Ltd Derivatives of tiacumicin b as anti-cancer agents
TWI523654B (en) 2007-11-27 2016-03-01 默沙東藥廠 Antibiotic macrocycle compounds and methods of manufacture and use thereof
EP2545023A4 (en) * 2010-02-15 2017-04-12 Abbvie Inc. Process for the preparation of scyllo-inositol
CA2814682C (en) 2010-10-13 2019-01-15 Elan Pharmaceuticals, Inc. Methods of synthesis of scyllitol and related compounds
CN102115757B (en) * 2010-12-14 2015-10-28 中国科学院南海海洋研究所 Platform hooks biological synthesis gene cluster and the application thereof of mycin
ITMI20120559A1 (en) 2012-04-05 2013-10-06 Olon Spa IMPROVED PROCEDURE FOR THE PRODUCTION OF TIACUMICINA B
ITMI20120560A1 (en) * 2012-04-05 2013-10-06 Olon Spa PROCEDURE FOR THE PURIFICATION OF TIACUMICINA B
EA201492059A1 (en) * 2012-05-10 2015-02-27 Тева Фармасьютикал Уоркс Лтд. SOLID FORMS OF FIDAXOMYCINE AND METHODS FOR THEIR RECEPTION
HK1210225A1 (en) * 2012-08-07 2016-04-15 Olon Spa Procedure for the production of tiacumicin b
ITMI20130856A1 (en) * 2013-05-27 2014-11-28 Olon Spa PROCEDURE FOR THE PRODUCTION OF TIACUMICINA B
ITMI20121406A1 (en) * 2012-08-07 2014-02-08 Olon Spa PROCEDURE FOR THE PRODUCTION OF TIACUMICINA B
CN102993251B (en) * 2012-12-17 2016-03-16 苏州纳微科技有限公司 A kind of method of high-efficient liquid phase chromatogram purification TCM B
JO3464B1 (en) 2013-01-15 2020-07-05 Astellas Pharma Europe Ltd Compositions of Tiacumicin Compounds
WO2014174528A2 (en) * 2013-04-23 2014-10-30 Concord Biotech Limited An improved process for the preparation of fidaxomicin
CN103275152B (en) * 2013-05-29 2015-11-18 华北制药集团新药研究开发有限责任公司 A kind of preparation method of high-purity fidaxomicin
CN103275153B (en) * 2013-06-27 2016-03-23 华北制药集团新药研究开发有限责任公司 A kind of preparation method of fidaxomicin crystal
CN104418925B (en) * 2013-09-05 2018-09-28 重庆乾泰生物医药有限公司 A method of preparing high-purity fidaxomicin
CN104513286B (en) * 2013-09-27 2018-08-17 博瑞生物医药（苏州）股份有限公司 A method of isolating and purifying Fei Da meter stars
CN104560766B (en) 2013-10-16 2017-07-28 浙江海正药业股份有限公司 A kind of Actinoplanes bacteria strain and its application
CN104561198B (en) * 2013-10-18 2019-04-12 重庆乾泰生物医药有限公司 A kind of method of fermenting and producing feldamycin
HRP20201363T1 (en) * 2013-12-20 2020-12-25 Xellia Pharmaceuticals Aps TIAKUMICIN PREPARATION PROCESS B
CN104846044B (en) * 2014-02-17 2019-02-01 上海医药工业研究院 A kind of fermentation medium for improving the yield of fidaxomicin
WO2015127955A1 (en) 2014-02-25 2015-09-03 Olon S.P.A. A new polymorph of tiacumicin b and process for preparation thereof
HRP20180668T1 (en) 2014-03-18 2018-06-15 Xellia Pharmaceuticals Aps A NEW POLYMORPH FORM AND A NEW SOLID THIACUMICIN B
CN103880904B (en) * 2014-03-28 2016-08-24 华北制药集团新药研究开发有限责任公司 Feldamycin crystal formation I and preparation method thereof
CN104946708B (en) * 2014-03-28 2018-06-12 上海医药工业研究院 A kind of fermentation medium and fermentation process for producing feldamycin
WO2015169451A1 (en) 2014-05-09 2015-11-12 Astellas Pharma Europe Ltd Treatment regimen tiacumicin compound
CN104098637B (en) * 2014-07-09 2017-01-04 浙江海正药业股份有限公司 A kind of method of purification feldamycin
WO2017005358A1 (en) 2015-07-03 2017-01-12 Astellas Pharma Europe Ltd. Novel dosage regimen tiacumicin compound
IL251499B (en) * 2017-04-02 2019-02-28 Efraty Avi Hydraulic-arm aided closed circuit batch-ro desalination apparatus of low energy and high recovery prospects
CN107236686B (en) * 2017-06-21 2019-10-15 杭州华东医药集团新药研究院有限公司 A kind of cyst fungus citrus finger and its application in regulating the microbial metabolite fidaxomicin
CN114084964B (en) * 2020-08-24 2023-02-24 中国石油化工股份有限公司 Aromatic organic compound wastewater biological treatment accelerant and preparation method and application thereof

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Also Published As

Publication number Publication date
ES2527052T3 (en) 2015-01-20
CA2494742C (en) 2015-05-12
US20060257981A1 (en) 2006-11-16
CY2015015I1 (en) 2020-05-29
EP2860241A1 (en) 2015-04-15
DK1539977T3 (en) 2014-11-17
US20130123477A1 (en) 2013-05-16
CN100519757C (en) 2009-07-29
US7507564B2 (en) 2009-03-24
HUS1500016I1 (en) 2017-10-30
JP5729919B2 (en) 2015-06-03
JP5907931B2 (en) 2016-04-26
CN1688707A (en) 2005-10-26
CA2494742A1 (en) 2004-02-19
US20100028970A1 (en) 2010-02-04
FR15C0028I2 (en) 2015-11-13
US20140296498A1 (en) 2014-10-02
SI1539977T1 (en) 2015-01-30
EP1539977B1 (en) 2014-10-08
AU2003251902B2 (en) 2008-03-06
WO2004014295A2 (en) 2004-02-19
BE2015C017I2 (en) 2022-09-22
JP2005534332A (en) 2005-11-17
KR100972542B1 (en) 2010-07-28
JP2013208131A (en) 2013-10-10
EP1539977A2 (en) 2005-06-15
JP2010178760A (en) 2010-08-19
KR20050053598A (en) 2005-06-08
AU2003251902A1 (en) 2004-02-25
PT1539977E (en) 2015-01-14
EP1539977A4 (en) 2006-10-11
US8728796B2 (en) 2014-05-20
FR15C0028I1 (en) 2015-05-15
LU92684I2 (en) 2015-11-02
NL300727I2 (en) 2016-05-17

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