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WO2004011498A3 - Derives de peptide natriuretique de longue duree - Google Patents

Derives de peptide natriuretique de longue duree Download PDF

Info

Publication number
WO2004011498A3
WO2004011498A3 PCT/CA2003/001097 CA0301097W WO2004011498A3 WO 2004011498 A3 WO2004011498 A3 WO 2004011498A3 CA 0301097 W CA0301097 W CA 0301097W WO 2004011498 A3 WO2004011498 A3 WO 2004011498A3
Authority
WO
WIPO (PCT)
Prior art keywords
long lasting
natriuretic peptide
peptide derivatives
peptide
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2003/001097
Other languages
English (en)
Other versions
WO2004011498A2 (fr
Inventor
Dominique P Bridon
Peter Bakis
Julie Carette
France Leclaire
Roger Leger
Martin Robitaille
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ConjuChem Inc
Original Assignee
ConjuChem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP03771007A priority Critical patent/EP1530588A2/fr
Priority to JP2004523679A priority patent/JP2006514607A/ja
Priority to CA002488348A priority patent/CA2488348A1/fr
Priority to US10/471,348 priority patent/US20040266673A1/en
Priority to AU2003246500A priority patent/AU2003246500A1/en
Application filed by ConjuChem Inc filed Critical ConjuChem Inc
Publication of WO2004011498A2 publication Critical patent/WO2004011498A2/fr
Publication of WO2004011498A3 publication Critical patent/WO2004011498A3/fr
Priority to US11/040,810 priority patent/US20050176641A1/en
Anticipated expiration legal-status Critical
Priority to US11/067,556 priority patent/US7601691B2/en
Priority to US11/923,222 priority patent/US7906482B2/en
Priority to US11/926,843 priority patent/US20080199532A1/en
Priority to US12/253,856 priority patent/US20090275506A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des dérivés de peptide natriurétique (NP) de longue durée. Le dérivé NP comprend un peptide NP et une entité réactive couplée au peptide NP. L'entité réactive peut se lier par covalence avec une fonctionnalité sur un composant sanguin. D'une manière plus spécifique, l'invention concerne des dérivés NP ayant une demi-vie in vivo prolongée ainsi qu'une méthode de traitement des maladies et des troubles cardio-vasculaires, tels que l'insuffisance cardiaque globale décompensée aiguë et l'insuffisance cardiaque globale chronique.
PCT/CA2003/001097 1999-05-17 2003-07-29 Derives de peptide natriuretique de longue duree Ceased WO2004011498A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP03771007A EP1530588A2 (fr) 2002-07-31 2003-07-29 Derives de peptide natriuretique de longue duree
JP2004523679A JP2006514607A (ja) 2002-07-31 2003-07-29 長時間持続性ナトリウム排泄増加性ペプチド誘導体
CA002488348A CA2488348A1 (fr) 2002-07-31 2003-07-29 Derives de peptide natriuretique de longue duree
US10/471,348 US20040266673A1 (en) 2002-07-31 2003-07-29 Long lasting natriuretic peptide derivatives
AU2003246500A AU2003246500A1 (en) 2002-07-31 2003-07-29 Long lasting natriuretic peptide derivatives
US11/040,810 US20050176641A1 (en) 2000-05-17 2005-01-21 Long lasting natriuretic peptide derivatives
US11/067,556 US7601691B2 (en) 1999-05-17 2005-02-25 Anti-obesity agents
US11/923,222 US7906482B2 (en) 1999-05-17 2007-10-24 Anti-obesity agents
US11/926,843 US20080199532A1 (en) 1999-05-17 2007-10-29 Long Lasting Natriuretic Peptide Derivatives
US12/253,856 US20090275506A1 (en) 2000-05-17 2008-10-17 Long lasting natriuretic peptide derivatives

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US40041302P 2002-07-31 2002-07-31
US40019902P 2002-07-31 2002-07-31
US60/400,199 2002-07-31
US60/400,413 2002-07-31

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/471,348 A-371-Of-International US20040266673A1 (en) 1999-05-17 2003-07-29 Long lasting natriuretic peptide derivatives
US11/040,810 Continuation US20050176641A1 (en) 1999-05-17 2005-01-21 Long lasting natriuretic peptide derivatives

Publications (2)

Publication Number Publication Date
WO2004011498A2 WO2004011498A2 (fr) 2004-02-05
WO2004011498A3 true WO2004011498A3 (fr) 2004-06-24

Family

ID=31191354

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2003/001097 Ceased WO2004011498A2 (fr) 1999-05-17 2003-07-29 Derives de peptide natriuretique de longue duree

Country Status (5)

Country Link
EP (1) EP1530588A2 (fr)
JP (2) JP2006514607A (fr)
AU (1) AU2003246500A1 (fr)
CA (1) CA2488348A1 (fr)
WO (1) WO2004011498A2 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7648962B2 (en) 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US7662773B2 (en) 2002-11-26 2010-02-16 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US8071560B2 (en) 2004-02-17 2011-12-06 University Of South Florida Materials and methods for reducing inflammation by inhibition of the atrial natriuretic peptide receptor
US8148114B2 (en) 2004-02-17 2012-04-03 University Of South Florida Materials and methods for treatment of inflammatory and cell proliferation disorders
US8623835B2 (en) 2002-09-06 2014-01-07 University Of South Florida Materials and methods for treatment of respiratory allergic diseases
US9173950B2 (en) 2012-05-17 2015-11-03 Extend Biosciences, Inc. Vitamin D-ghrelin conjugates
US9585934B2 (en) 2014-10-22 2017-03-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
US9616109B2 (en) 2014-10-22 2017-04-11 Extend Biosciences, Inc. Insulin vitamin D conjugates
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
US10184942B2 (en) 2011-03-17 2019-01-22 University Of South Florida Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer
US12233115B2 (en) 2022-09-30 2025-02-25 Extend Biosciences, Inc. Long-acting parathyroid hormone

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
ES2307718T3 (es) 2001-02-16 2008-12-01 Conjuchem Biotechnologies Inc. Peptido 2 similar al flucagon (glp-2) de duracion prolongada para el tratamiento de enfermedades y trastornos gastrointestinales.
DK1759001T3 (da) 2004-04-21 2011-08-01 Enobia Pharma Inc Konjugat til tilførsel til knogler og fremgangsmåde til fremstilling deraf ved at målrette proteiner til knoglen
EP1773867B1 (fr) 2004-07-15 2011-01-19 The University Of Queensland Composes proteiniques et leurs utilisations
US8178489B2 (en) * 2005-03-07 2012-05-15 Mondobiotech Ag Formulation for aviptadil
WO2006108686A2 (fr) * 2005-04-14 2006-10-19 Aic Agonistes bnp
US20080227713A1 (en) * 2005-10-03 2008-09-18 Protter Andrew A Oxidized Human Bnp
JP5010913B2 (ja) * 2006-12-31 2012-08-29 寿子 小出 心房利尿ホルモンファミリー分子を活性物質として含有する組織再生製剤また該製剤をもちいる組織再生方法、および心房利尿ホルモンファミリー分子を活性物質として含有する発毛、増毛、育毛剤および皮膚組織修復改善剤また該製剤を用いる発毛、増毛、育毛促進方法および皮膚組織修復改善方法
KR20080098216A (ko) * 2007-05-04 2008-11-07 한미약품 주식회사 캐리어 물질을 이용한 나트륨 배설 펩타이드 약물 결합체
WO2008154226A1 (fr) * 2007-06-06 2008-12-18 Boehringer Ingelheim International Gmbh Protéines de fusion natriurétiques
RU2010103995A (ru) 2007-07-06 2011-08-20 Тератекнолоджиз Инк. (Ca) Бифункциональные слитые белки альфа-меланоцитостимулирующего гормона (альф-msh) и атриального натрийуретического белка (anp) и их применение при гипертонии и остром повреждении почек
DE102010032482A1 (de) 2010-07-28 2012-02-02 Justus-Liebig-Universität Giessen Stoffe zur Beeinflussung der natriuretischen Peptid-Rezeptoren A und B und deren Verwendung
WO2012013597A1 (fr) 2010-07-28 2012-02-02 Justus-Liebig-Universität Giessen Substances et utilisation desdites substances pour influer sur les récepteurs peptidiques natriurétiques
JP6055779B2 (ja) 2010-12-27 2016-12-27 アレクシオン ファーマシューティカルズ， インコーポレイテッド ナトリウム利尿ペプチドを含む組成物およびその使用方法
SG192744A1 (en) * 2011-02-23 2013-09-30 Madeleine Pharmaceuticals Pty Ltd Therapeutic method for treating congestive heart failure
CN102286092B (zh) 2011-09-14 2014-01-01 深圳翰宇药业股份有限公司 利拉鲁肽的固相合成方法
US10052366B2 (en) 2012-05-21 2018-08-21 Alexion Pharmaceuticsl, Inc. Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
WO2016007873A1 (fr) 2014-07-11 2016-01-14 The Regents Of The University Of Michigan Compositions et méthodes de traitement de la craniosynostose
ES3038086T3 (en) 2014-12-05 2025-10-09 Alexion Pharma Inc Treating seizure with recombinant alkaline phosphatase
CA2973883A1 (fr) 2015-01-28 2016-08-04 Alexion Pharmaceuticals, Inc. Methodes de traitement d'un sujet atteint d'une deficience en phosphatase alcaline
EP4014987A3 (fr) * 2015-05-29 2022-07-06 Igisu Co., Ltd. Peptide cyclique et médicament, préparation à usage externe et produit cosmétique contenant tous ledit peptide cyclique
WO2017031114A1 (fr) 2015-08-17 2017-02-23 Alexion Pharmaceuticals, Inc. Fabrication de phosphatases alcalines
WO2017058822A1 (fr) 2015-09-28 2017-04-06 Alexion Pharmaceuticals, Inc. Identification de régimes posologiques efficaces pour une thérapie de l'hypophosphatasie de remplacement de l'enzyme phosphatase alcaline non spécifique à des tissus (tnsalp)
WO2017074466A1 (fr) 2015-10-30 2017-05-04 Alexion Pharmaceuticals, Inc. Méthodes de traitement de la craniosynostose chez un patient
WO2017155569A1 (fr) 2016-03-08 2017-09-14 Alexion Pharmaceuticals, Inc. Méthodes de traitement de l'hypophosphatasie chez l'enfant
MX2018011833A (es) 2016-04-01 2019-02-13 Alexion Pharma Inc Tratamiento para la debilidad muscular con fosfatasas alcalinas.
EP3436020A4 (fr) 2016-04-01 2019-12-25 Alexion Pharmaceuticals, Inc. Méthodes de traitement de l'hypophosphatasie chez les adolescents et les adultes
WO2017214130A1 (fr) 2016-06-06 2017-12-14 Alexion Pharmaceuticals, Inc. Impact du métal sur la production des phosphatases alcalines
WO2018035420A1 (fr) 2016-08-18 2018-02-22 Alexion Pharmaceuticals, Inc. Procédés de traitement de la trachéobronchomalacie
WO2018183720A1 (fr) 2017-03-31 2018-10-04 Alexion Pharmaceuticals, Inc. Méthodes de traitement de l'hypophosphatasie (hpp) chez l'adulte et l'adolescent
EP3773684A1 (fr) 2018-03-30 2021-02-17 Alexion Pharmaceuticals, Inc. Production de glycoprotéines
US12268733B2 (en) 2018-08-10 2025-04-08 Alexion Pharmaceuticals, Inc. Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase
KR20220111693A (ko) 2019-12-09 2022-08-09 알렉시온 파마슈티칼스, 인코포레이티드 알칼리성 포스파타제 폴리펩티드 및 이의 이용 방법
US12083169B2 (en) 2021-02-12 2024-09-10 Alexion Pharmaceuticals, Inc. Alkaline phosphatase polypeptides and methods of use thereof
EP4604986A2 (fr) 2022-10-21 2025-08-27 Eli Lilly and Company Peptides natriurétiques à action prolongée et leurs utilisations
CN116284329B (zh) * 2023-04-28 2023-12-08 成都奥达生物科技有限公司 一种长效利钠肽化合物
CN119529033A (zh) * 2024-12-02 2025-02-28 中山大学 一种用于npr-b靶向的超长效多肽及其在骨骼系统病症中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000069900A2 (fr) * 1999-05-17 2000-11-23 Conjuchem, Inc. Protection de peptides therapeutiques endogenes contre l'activite peptidase par conjugaison de composants sanguins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987002674A1 (fr) * 1985-11-05 1987-05-07 Biotechnology Research Associates, J.V. Analogues de peptides atriaux natriuretiques
JP3042782B2 (ja) * 1985-11-05 2000-05-22 サイオス インコーポレイテッド 心房性ナトリウム尿排泄亢進ペプチド類似化合物
GR1001018B (el) * 1989-05-24 1993-03-31 Abbott Lab Μεθοδος παρασκευης προδρομικων πεπτικων παραγωγων.
CN101289500A (zh) * 1999-05-17 2008-10-22 康久化学生物技术公司 病毒感染的长效融合肽抑制剂
EP1212120A2 (fr) * 1999-09-07 2002-06-12 Conjuchem, Inc. Methodes et compositions comprenants des derives succinimidiques ou maleimidiques d'agents antineoplastiques, destinees a la production d'agents anticancereux a activite prolongee

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000069900A2 (fr) * 1999-05-17 2000-11-23 Conjuchem, Inc. Protection de peptides therapeutiques endogenes contre l'activite peptidase par conjugaison de composants sanguins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LEGER ROGER ET AL: "Synthesis and in vitro analysis of atrial natriuretic peptide-albumin conjugates.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 20, 20 October 2003 (2003-10-20), pages 3571 - 3575, XP001156881, ISSN: 0960-894X *

Cited By (18)

* Cited by examiner, † Cited by third party
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US8623835B2 (en) 2002-09-06 2014-01-07 University Of South Florida Materials and methods for treatment of respiratory allergic diseases
US7662773B2 (en) 2002-11-26 2010-02-16 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US7648962B2 (en) 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US8071560B2 (en) 2004-02-17 2011-12-06 University Of South Florida Materials and methods for reducing inflammation by inhibition of the atrial natriuretic peptide receptor
US8148114B2 (en) 2004-02-17 2012-04-03 University Of South Florida Materials and methods for treatment of inflammatory and cell proliferation disorders
US10184942B2 (en) 2011-03-17 2019-01-22 University Of South Florida Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer
US9884124B2 (en) 2012-05-17 2018-02-06 Extend Biosciences, Inc. Carriers for improved drug delivery
US9173950B2 (en) 2012-05-17 2015-11-03 Extend Biosciences, Inc. Vitamin D-ghrelin conjugates
US9289507B2 (en) 2012-05-17 2016-03-22 Extend Biosciences, Inc. Carriers for improved drug delivery
US9616109B2 (en) 2014-10-22 2017-04-11 Extend Biosciences, Inc. Insulin vitamin D conjugates
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
US9585934B2 (en) 2014-10-22 2017-03-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
US10406202B2 (en) 2014-10-22 2019-09-10 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
US10420819B2 (en) 2014-10-22 2019-09-24 Extend Biosciences, Inc. Insulin vitamin D conjugates
US10702574B2 (en) 2014-10-22 2020-07-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
US11116816B2 (en) 2014-10-22 2021-09-14 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
US12076366B2 (en) 2014-10-22 2024-09-03 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
US12233115B2 (en) 2022-09-30 2025-02-25 Extend Biosciences, Inc. Long-acting parathyroid hormone

Also Published As

Publication number Publication date
WO2004011498A2 (fr) 2004-02-05
AU2003246500A1 (en) 2004-02-16
CA2488348A1 (fr) 2004-02-05
EP1530588A2 (fr) 2005-05-18
JP2010047614A (ja) 2010-03-04
JP2006514607A (ja) 2006-05-11

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