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WO2004002430A3 - Combinations for the treatment of fungal infections - Google Patents

Combinations for the treatment of fungal infections Download PDF

Info

Publication number
WO2004002430A3
WO2004002430A3 PCT/US2003/020737 US0320737W WO2004002430A3 WO 2004002430 A3 WO2004002430 A3 WO 2004002430A3 US 0320737 W US0320737 W US 0320737W WO 2004002430 A3 WO2004002430 A3 WO 2004002430A3
Authority
WO
WIPO (PCT)
Prior art keywords
combinations
treatment
fungal infections
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/020737
Other languages
French (fr)
Other versions
WO2004002430A2 (en
Inventor
Lisa M Johansen
George N Serbedzija
Benjamin A Auspitz
Grant R Zimmermann
Curtis Keith
James M Nichols
Debra A Gaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zalicus Inc
Original Assignee
CombinatoRx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CombinatoRx Inc filed Critical CombinatoRx Inc
Priority to AU2003258983A priority Critical patent/AU2003258983A1/en
Publication of WO2004002430A2 publication Critical patent/WO2004002430A2/en
Publication of WO2004002430A3 publication Critical patent/WO2004002430A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention features a method for treating or preventing fungal growth by contacting fungal cells with (I) an aromatic diamidine or analog thereof or a compound formula (I); and (ii) an aminopyridine, a quaternary ammonium compound, or a compound of formula (II) or (III) simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit fungal growth.
PCT/US2003/020737 2002-06-28 2003-06-30 Combinations for the treatment of fungal infections Ceased WO2004002430A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003258983A AU2003258983A1 (en) 2002-06-28 2003-06-30 Combinations for the treatment of fungal infections

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US39303402P 2002-06-28 2002-06-28
US60/393,034 2002-06-28
US60/393,155 2002-07-02
US39315502P 2002-07-20 2002-07-20

Publications (2)

Publication Number Publication Date
WO2004002430A2 WO2004002430A2 (en) 2004-01-08
WO2004002430A3 true WO2004002430A3 (en) 2004-08-26

Family

ID=30003291

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/020737 Ceased WO2004002430A2 (en) 2002-06-28 2003-06-30 Combinations for the treatment of fungal infections

Country Status (2)

Country Link
AU (1) AU2003258983A1 (en)
WO (1) WO2004002430A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004052391A1 (en) * 2002-12-12 2004-06-24 Takeda Pharmaceutical Company Limited Novel use of edg receptors
US20090298934A1 (en) * 2006-03-27 2009-12-03 Government Of The Us, As Represented By The Secret Diamidine Inhibitors of TDP1
CA2797783A1 (en) 2010-04-30 2011-11-03 University Of Rochester Compounds for anti-fungal treatment
CN102453000B (en) * 2010-10-15 2015-01-14 中国石油化工股份有限公司 Synthetic method of biquaternary ammonium salt
CN101965843B (en) * 2010-10-27 2013-01-23 陕西汤普森生物科技有限公司 Propamidine- and pyrimorph-containing bactericidal composition
WO2022192162A1 (en) * 2021-03-09 2022-09-15 Fox Chase Chemical Diversity Center, Inc. Novel heteroaromatic compounds exhibiting antifungal activity and their method of use
US20250282714A1 (en) * 2022-03-23 2025-09-11 Duke University Compositions for and methods of modulating rna stability

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428051A (en) * 1992-10-13 1995-06-27 University Of North Carolina Methods of combating pneumocystis carinii pneumonia and compounds useful therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428051A (en) * 1992-10-13 1995-06-27 University Of North Carolina Methods of combating pneumocystis carinii pneumonia and compounds useful therefor

Also Published As

Publication number Publication date
WO2004002430A2 (en) 2004-01-08
AU2003258983A8 (en) 2004-01-19
AU2003258983A1 (en) 2004-01-19

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