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WO2004097034A3 - Diagnostics and therapeutics for diseases associated with human transmembrane serine protease 4 (tmprss4) - Google Patents

Diagnostics and therapeutics for diseases associated with human transmembrane serine protease 4 (tmprss4) Download PDF

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Publication number
WO2004097034A3
WO2004097034A3 PCT/EP2004/004164 EP2004004164W WO2004097034A3 WO 2004097034 A3 WO2004097034 A3 WO 2004097034A3 EP 2004004164 W EP2004004164 W EP 2004004164W WO 2004097034 A3 WO2004097034 A3 WO 2004097034A3
Authority
WO
WIPO (PCT)
Prior art keywords
tmprss4
diseases
therapeutics
diagnostics
serine protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/004164
Other languages
French (fr)
Other versions
WO2004097034A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Stefanie Polej
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of WO2004097034A2 publication Critical patent/WO2004097034A2/en
Publication of WO2004097034A3 publication Critical patent/WO2004097034A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • G01N33/5758—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a human TMPRSS4 which is associated with the cardiovascular disorders, endocrinological diseases, gastroenterological diseases, urological disorders, metabolic dieases, cancer, respiratory diseases and dermatological diseaes. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrinological diseases, gastroenterological diseases, urological disorders, metabolic dieases, cancer, respiratory diseases and dermatological diseaes. The invention also features compounds which bind to and/or activate or inhibit the activity of TMPRSS4 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2004/004164 2003-05-02 2004-04-20 Diagnostics and therapeutics for diseases associated with human transmembrane serine protease 4 (tmprss4) Ceased WO2004097034A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03010004 2003-05-02
EP03010004.4 2003-05-02

Publications (2)

Publication Number Publication Date
WO2004097034A2 WO2004097034A2 (en) 2004-11-11
WO2004097034A3 true WO2004097034A3 (en) 2004-12-16

Family

ID=33395782

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/004164 Ceased WO2004097034A2 (en) 2003-05-02 2004-04-20 Diagnostics and therapeutics for diseases associated with human transmembrane serine protease 4 (tmprss4)

Country Status (1)

Country Link
WO (1) WO2004097034A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100906145B1 (en) 2006-05-30 2009-07-03 한국생명공학연구원 Anticancer agent containing TPMPS4 inhibitor as active ingredient
WO2009143493A2 (en) * 2008-05-22 2009-11-26 Attagene Inc. MODULATORS OF TNFα-DEPENDENT SIGNALING PATHWAYS AND USES THEREOF
KR101039751B1 (en) * 2008-10-16 2011-06-09 한국생명공학연구원 TPMPRS4-specific human antibodies
WO2025199346A1 (en) * 2024-03-20 2025-09-25 Arsenal Biosciences, Inc. Antigen binding proteins that bind tmprss4 and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004953A2 (en) * 2000-07-12 2002-01-17 Agensys, Inc. Novel tumor antigen useful in diagnosis and therapy of bladder, ovary, lung and kidney cancers
WO2002086443A2 (en) * 2001-04-18 2002-10-31 Protein Design Labs, Inc Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002004953A2 (en) * 2000-07-12 2002-01-17 Agensys, Inc. Novel tumor antigen useful in diagnosis and therapy of bladder, ovary, lung and kidney cancers
WO2002086443A2 (en) * 2001-04-18 2002-10-31 Protein Design Labs, Inc Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE OMIM [online] 17 December 2001 (2001-12-17), XP002296467, retrieved from NCBI Database accession no. 606565 *
DATABASE UNIPROT [online] EBI; 16 October 2001 (2001-10-16), XP002296131, Database accession no. Q9NRS4 *
WALLRAPP C ET AL: "A NOVEL TRANSMEMBRANE SERINE PROTEASE (TMPRSS3) OVEREXPRESSED IN PANCREATIC CANCER", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 60, no. 10, 15 May 2000 (2000-05-15), pages 2602 - 2606, XP001018941, ISSN: 0008-5472 *

Also Published As

Publication number Publication date
WO2004097034A2 (en) 2004-11-11

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