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WO2004089904A3 - Preparation of torasemide - Google Patents

Preparation of torasemide Download PDF

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Publication number
WO2004089904A3
WO2004089904A3 PCT/CA2004/000366 CA2004000366W WO2004089904A3 WO 2004089904 A3 WO2004089904 A3 WO 2004089904A3 CA 2004000366 W CA2004000366 W CA 2004000366W WO 2004089904 A3 WO2004089904 A3 WO 2004089904A3
Authority
WO
WIPO (PCT)
Prior art keywords
torasemide
modification
preparation
polymorphic form
stable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2004/000366
Other languages
French (fr)
Other versions
WO2004089904A2 (en
Inventor
Wen-Lung Yeh
Kanjai Khumtaveeporn
David John Mckenzie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torcan Chemical Ltd
Original Assignee
Torcan Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torcan Chemical Ltd filed Critical Torcan Chemical Ltd
Publication of WO2004089904A2 publication Critical patent/WO2004089904A2/en
Publication of WO2004089904A3 publication Critical patent/WO2004089904A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The stable polymorphic form of torasemide, Modification I, is prepared from other, less stable torasemide forms, by forming a solution of the starting polymorphic form of torasemide in water and methanol, stirring for at least 20 hours and then phase separating the solid torasemide modification I from the liquid medium.
PCT/CA2004/000366 2003-04-07 2004-03-12 Preparation of torasemide Ceased WO2004089904A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA2,424,644 2003-04-07
CA 2424644 CA2424644A1 (en) 2003-04-07 2003-04-07 Preparation of torasemide

Publications (2)

Publication Number Publication Date
WO2004089904A2 WO2004089904A2 (en) 2004-10-21
WO2004089904A3 true WO2004089904A3 (en) 2004-12-23

Family

ID=33035026

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2004/000366 Ceased WO2004089904A2 (en) 2003-04-07 2004-03-12 Preparation of torasemide

Country Status (2)

Country Link
CA (1) CA2424644A1 (en)
WO (1) WO2004089904A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102079721B (en) * 2011-01-28 2012-05-09 海南美大制药有限公司 Torasemide compound and preparation method thereof
CN104370805B (en) * 2013-08-13 2016-09-07 天津汉瑞药业有限公司 Torasemide compound
EP3173075B1 (en) 2015-11-27 2018-09-26 ACCUPHARMA Spolka z ograniczona odpowiedzialnoscia Pharmaceutical combination preparation of ace inhibitor and loop diuretic
CN115417810B (en) * 2022-09-22 2023-10-10 南京正科医药股份有限公司 Refining method of torsemide crystal form I

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000020395A1 (en) * 1998-10-02 2000-04-13 Pliva, Farmaceutska Industrija, Dionicko Drustvo New crystal modification iii of torasemide
WO2001010441A1 (en) * 1999-08-11 2001-02-15 Teva Pharmaceutical Industries Ltd. Torsemide polymorphs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000020395A1 (en) * 1998-10-02 2000-04-13 Pliva, Farmaceutska Industrija, Dionicko Drustvo New crystal modification iii of torasemide
WO2001010441A1 (en) * 1999-08-11 2001-02-15 Teva Pharmaceutical Industries Ltd. Torsemide polymorphs

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DUPONT L ET AL: "Structure cristalline et moléculaire d'un diurétique dérivé de l'alkyl-1[(phénylamino-4-pyridyl-3)sulfonyl]-3 urée: la torasémide (C15H20N4SO3)", ACTA CRYSTALLOGRAPHICA. SECTION B, STRUCTURAL CRYSTALLOGRAPHY AND CRYSTAL CHEMISTRY, MUNKSGAARD, COPENHAGEN, DK, vol. B34, no. 4, April 1978 (1978-04-01), pages 1304 - 1310, XP002128455, ISSN: 0567-7408 *
ROLLINGER J M ET AL: "Crystal forms of torasemide: new insights", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 53, no. 1, January 2002 (2002-01-01), pages 75 - 86, XP004331334, ISSN: 0939-6411 *

Also Published As

Publication number Publication date
CA2424644A1 (en) 2004-10-07
WO2004089904A2 (en) 2004-10-21

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