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WO2004085651A3 - Pantolactone hydrolase - Google Patents

Pantolactone hydrolase Download PDF

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Publication number
WO2004085651A3
WO2004085651A3 PCT/EP2004/002902 EP2004002902W WO2004085651A3 WO 2004085651 A3 WO2004085651 A3 WO 2004085651A3 EP 2004002902 W EP2004002902 W EP 2004002902W WO 2004085651 A3 WO2004085651 A3 WO 2004085651A3
Authority
WO
WIPO (PCT)
Prior art keywords
pantolactone
nucleotides sequences
pantolactone hydrolase
hydrolase
hydrolases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/002902
Other languages
French (fr)
Other versions
WO2004085651A2 (en
Inventor
Iqbal Gill
Dahai Guo
Martin Lehmann
Dermot P Moynagh
Rao Hanumantha Valivety
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Priority to GB0516602A priority Critical patent/GB2413329B/en
Priority to JP2006504751A priority patent/JP4571936B2/en
Priority to KR1020057018207A priority patent/KR101156882B1/en
Priority to CN2004800085042A priority patent/CN1768141B/en
Publication of WO2004085651A2 publication Critical patent/WO2004085651A2/en
Publication of WO2004085651A3 publication Critical patent/WO2004085651A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to nucleotides sequences of a gene coding for a pantolactone hydrolase, as well as vectors and host cells containing such nucleotides sequences and pantolactone hydrolases encoded by such nucleotides sequences. Processes for making and using pantolactone hydrolases are also provided.
PCT/EP2004/002902 2003-03-28 2004-03-19 Pantolactone hydrolase Ceased WO2004085651A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB0516602A GB2413329B (en) 2003-03-28 2004-03-19 Novel Enzymes
JP2006504751A JP4571936B2 (en) 2003-03-28 2004-03-19 Pantolactone hydrolase
KR1020057018207A KR101156882B1 (en) 2003-03-28 2004-03-19 Pantolactone hydrolase
CN2004800085042A CN1768141B (en) 2003-03-28 2004-03-19 Pantolactone hydrolase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45922003P 2003-03-28 2003-03-28
US60/459,220 2003-03-28

Publications (2)

Publication Number Publication Date
WO2004085651A2 WO2004085651A2 (en) 2004-10-07
WO2004085651A3 true WO2004085651A3 (en) 2005-01-20

Family

ID=33098294

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/002902 Ceased WO2004085651A2 (en) 2003-03-28 2004-03-19 Pantolactone hydrolase

Country Status (5)

Country Link
JP (1) JP4571936B2 (en)
KR (1) KR101156882B1 (en)
CN (1) CN1768141B (en)
GB (1) GB2413329B (en)
WO (1) WO2004085651A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105669837B (en) * 2015-06-03 2020-01-17 苏州大学 Vascular endothelial cadherin epitopes, antibodies and their applications
CN110358687B (en) * 2018-12-19 2020-12-04 安徽瑞达健康产业有限公司 Gibberellin for producing D-pantolactone hydrolase and application and fermentation method thereof
CN111621541B (en) * 2019-02-27 2025-10-31 广安摩珈生物科技有限公司 Method for resolution of optical isomers using electrodialysis technique
EP3748009A1 (en) * 2019-06-07 2020-12-09 DSM IP Assets B.V. Synthesis of (r)-pantolactone acetate

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011261A1 (en) * 1991-11-25 1993-06-10 Keygene N.V. A novel pcr method with a single primer for nucleic acid analysis
US5411875A (en) * 1991-11-01 1995-05-02 University Of Iowa Research Foundation Method for retrieval of unknown flanking DNA sequence
EP0794251A1 (en) * 1995-09-13 1997-09-10 Fuji Yakuhin Kogyo Kabushiki Kaisha D-pantolactone hydrolase and gene encoding the same
WO2001032890A1 (en) * 1999-10-29 2001-05-10 Basf Aktiengesellschaft L-pantolactone-hydrolase and a method for producing d-pantolactone
US6514706B1 (en) * 1998-10-26 2003-02-04 Christoph Von Kalle Linear amplification mediated PCR (LAM PCR)

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411875A (en) * 1991-11-01 1995-05-02 University Of Iowa Research Foundation Method for retrieval of unknown flanking DNA sequence
WO1993011261A1 (en) * 1991-11-25 1993-06-10 Keygene N.V. A novel pcr method with a single primer for nucleic acid analysis
EP0794251A1 (en) * 1995-09-13 1997-09-10 Fuji Yakuhin Kogyo Kabushiki Kaisha D-pantolactone hydrolase and gene encoding the same
US6514706B1 (en) * 1998-10-26 2003-02-04 Christoph Von Kalle Linear amplification mediated PCR (LAM PCR)
WO2001032890A1 (en) * 1999-10-29 2001-05-10 Basf Aktiengesellschaft L-pantolactone-hydrolase and a method for producing d-pantolactone

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 1 June 2002 (2002-06-01), XP002290406, retrieved from EBI Database accession no. Q8TGG4 *
DATABASE EMBL 15 July 1998 (1998-07-15), XP002290407, retrieved from EBI Database accession no. O34940 *
DATABASE EMBL 16 October 2001 (2001-10-16), XP002290405, retrieved from EBI Database accession no. Q9TTJ5 *
LIU Y-G ET AL: "THERMAL ASYMMETRIC INTERLACED PCR: AUTOMATABLE AMPLIFICATION AND SEQUENCING OF INSERT END FRAGMENTS FROM P1 AND YAC CLONES FOR CHROMOSOME WALKING", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 25, no. 3, 1995, pages 674 - 681, XP008004889, ISSN: 0888-7543 *

Also Published As

Publication number Publication date
JP2006521103A (en) 2006-09-21
GB2413329B (en) 2007-09-19
WO2004085651A2 (en) 2004-10-07
GB2413329A (en) 2005-10-26
CN1768141B (en) 2012-10-10
JP4571936B2 (en) 2010-10-27
CN1768141A (en) 2006-05-03
KR20050119151A (en) 2005-12-20
GB0516602D0 (en) 2005-09-21
KR101156882B1 (en) 2012-07-05

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