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WO2004083185A3 - Phenyl substituted imidazole derivatives - Google Patents

Phenyl substituted imidazole derivatives Download PDF

Info

Publication number
WO2004083185A3
WO2004083185A3 PCT/EP2004/002831 EP2004002831W WO2004083185A3 WO 2004083185 A3 WO2004083185 A3 WO 2004083185A3 EP 2004002831 W EP2004002831 W EP 2004002831W WO 2004083185 A3 WO2004083185 A3 WO 2004083185A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenyl substituted
imidazole derivatives
substituted imidazole
compounds
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2004/002831
Other languages
French (fr)
Other versions
WO2004083185A2 (en
Inventor
Gerard Martin Paul Giblin
Adrian Hall
Xiao Qing Lewell
Neil Derek Miller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of WO2004083185A2 publication Critical patent/WO2004083185A2/en
Publication of WO2004083185A3 publication Critical patent/WO2004083185A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, B, Z, R1, R2a, R2b, Rx, R8, R9, Q, and T are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
PCT/EP2004/002831 2003-03-19 2004-03-17 Phenyl substituted imidazole derivatives Ceased WO2004083185A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0306329.4A GB0306329D0 (en) 2003-03-19 2003-03-19 Compounds
GB0306329.4 2003-03-19

Publications (2)

Publication Number Publication Date
WO2004083185A2 WO2004083185A2 (en) 2004-09-30
WO2004083185A3 true WO2004083185A3 (en) 2004-11-04

Family

ID=9955103

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/002831 Ceased WO2004083185A2 (en) 2003-03-19 2004-03-17 Phenyl substituted imidazole derivatives

Country Status (2)

Country Link
GB (1) GB0306329D0 (en)
WO (1) WO2004083185A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7446222B2 (en) 2002-11-01 2008-11-04 Glaxo Group Limited Phenyl compounds
US7759369B2 (en) 2004-12-23 2010-07-20 Glaxo Group Limited Pyridine compounds for the treatment of prostaglandin mediated diseases

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0323585D0 (en) * 2003-10-08 2003-11-12 Glaxo Group Ltd Compounds
DE602004011966T2 (en) * 2003-10-24 2009-02-12 Glaxo Group Ltd., Greenford heterocyclyl
GB0606876D0 (en) * 2006-04-05 2006-05-17 Glaxo Group Ltd Compounds
WO2010007944A1 (en) 2008-07-17 2010-01-21 旭化成ファーマ株式会社 Nitrogenated bicyclic heterocyclic compound
CN102089303A (en) 2008-07-17 2011-06-08 旭化成制药株式会社 Nitrogenated heterocyclic compound
EP2570125A1 (en) * 2011-09-16 2013-03-20 Almirall, S.A. Ep1 receptor ligands
RS63190B1 (en) 2014-08-04 2022-06-30 Nuevolution As OPTIONALLY FUSIONED PYRIMIDINE DERIVATIVES SUBSTITUTED WITH HETEROCYCLYL USEFUL FOR THE TREATMENT OF INFLAMMATORY, METABOLIC, ONCOLOGICAL AND AUTOIMMUNE DISEASES
AU2020405446A1 (en) 2019-12-20 2022-05-26 Nuevolution A/S Compounds active towards nuclear receptors
US11685727B2 (en) 2019-12-20 2023-06-27 Nuevolution A/S Compounds active towards nuclear receptors
EP4126875A1 (en) 2020-03-31 2023-02-08 Nuevolution A/S Compounds active towards nuclear receptors
MX2022012260A (en) 2020-03-31 2022-11-30 Nuevolution As COMPOUNDS ACTIVE AGAINST NUCLEAR RECEPTORS.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001019814A2 (en) * 1999-09-14 2001-03-22 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
WO2002015902A1 (en) * 2000-08-23 2002-02-28 Merck & Co., Inc. Method of treating or preventing urinary incontinence using prostanoid ep1 receptor antagonists
EP1270559A1 (en) * 2000-03-23 2003-01-02 J. URIACH & CIA. S.A. Novel imidazole derivatives with anti-inflammatory activity
WO2003101959A1 (en) * 2002-05-31 2003-12-11 Glaxo Group Limited Pyrrole compounds for the treatment of prostaglandin mediated diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001019814A2 (en) * 1999-09-14 2001-03-22 Merck Frosst Canada & Co. Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment
EP1270559A1 (en) * 2000-03-23 2003-01-02 J. URIACH & CIA. S.A. Novel imidazole derivatives with anti-inflammatory activity
WO2002015902A1 (en) * 2000-08-23 2002-02-28 Merck & Co., Inc. Method of treating or preventing urinary incontinence using prostanoid ep1 receptor antagonists
WO2003101959A1 (en) * 2002-05-31 2003-12-11 Glaxo Group Limited Pyrrole compounds for the treatment of prostaglandin mediated diseases

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7446222B2 (en) 2002-11-01 2008-11-04 Glaxo Group Limited Phenyl compounds
US7759369B2 (en) 2004-12-23 2010-07-20 Glaxo Group Limited Pyridine compounds for the treatment of prostaglandin mediated diseases

Also Published As

Publication number Publication date
WO2004083185A2 (en) 2004-09-30
GB0306329D0 (en) 2003-04-23

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