[go: up one dir, main page]

WO2004079367A8 - バイオアレイ - Google Patents

バイオアレイ

Info

Publication number
WO2004079367A8
WO2004079367A8 PCT/JP2004/000247 JP2004000247W WO2004079367A8 WO 2004079367 A8 WO2004079367 A8 WO 2004079367A8 JP 2004000247 W JP2004000247 W JP 2004000247W WO 2004079367 A8 WO2004079367 A8 WO 2004079367A8
Authority
WO
WIPO (PCT)
Prior art keywords
stranded oligonucleotide
double
bonded
bioarray
stranded
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2004/000247
Other languages
English (en)
French (fr)
Other versions
WO2004079367A1 (ja
Inventor
Masayuki Yamamoto
Hozumi Motohashi
Kinuko Ohneda
Motoki Kyo
Yutaka Takarada
Bunsei Kawakami
Yoshihisa Kawamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyobo Co Ltd
Original Assignee
Toyobo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2003007482A external-priority patent/JP4193039B2/ja
Priority claimed from JP2003007469A external-priority patent/JP4189644B2/ja
Priority claimed from JP2003298027A external-priority patent/JP4281108B2/ja
Priority claimed from JP2003333072A external-priority patent/JP4171982B2/ja
Application filed by Toyobo Co Ltd filed Critical Toyobo Co Ltd
Publication of WO2004079367A1 publication Critical patent/WO2004079367A1/ja
Publication of WO2004079367A8 publication Critical patent/WO2004079367A8/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

本発明は、金属基板上に直接的に或いはスペーサーを介して間接的に複数の生体分子(A)を結合させたバイオアレイに関し、特に、金属基板上に複数の二本鎖オリゴヌクレオチドが固定化されたアレイであり、第一の一本鎖オリゴヌクレオチドと第二の一本鎖オリゴヌクレオチドとが全体的あるいは部分的に相補的に結合して二本鎖オリゴヌクレオチドを形成しており、該二本鎖オリゴヌクレオチドにおいて第一の一本鎖オリゴヌクレオチドのみが基板上に結合している二本鎖オリゴヌクレオチドアレイに関する。
PCT/JP2004/000247 2003-01-15 2004-01-15 バイオアレイ Ceased WO2004079367A1 (ja)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP2003-007469 2003-01-15
JP2003-007482 2003-01-15
JP2003007482A JP4193039B2 (ja) 2003-01-15 2003-01-15 二本鎖オリゴヌクレオチドアレイ
JP2003007469A JP4189644B2 (ja) 2003-01-15 2003-01-15 生体分子相互作用測定方法
JP2003-298027 2003-08-21
JP2003298027A JP4281108B2 (ja) 2003-08-21 2003-08-21 バイオチップ
JP2003333072A JP4171982B2 (ja) 2003-09-25 2003-09-25 バイオチップ
JP2003-333072 2003-09-25

Publications (2)

Publication Number Publication Date
WO2004079367A1 WO2004079367A1 (ja) 2004-09-16
WO2004079367A8 true WO2004079367A8 (ja) 2005-01-20

Family

ID=32966627

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2004/000247 Ceased WO2004079367A1 (ja) 2003-01-15 2004-01-15 バイオアレイ

Country Status (2)

Country Link
US (1) US20040191815A1 (ja)
WO (1) WO2004079367A1 (ja)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090148346A1 (en) * 2005-10-07 2009-06-11 Canon Kabushiki Kaisha Substrate with binding functional group
EP1790984B1 (en) * 2005-11-25 2013-08-28 FUJIFILM Corporation A method for producing a biosensor having a covalently bound thin polymeric coat
US20090318376A1 (en) * 2006-06-15 2009-12-24 Korea Research Institute Of Bioscience And Biotechnology High Throughput Screening Method of Binding Inhibitor Between caspase3 and XIAP and Binding Inhibitor Screened Thereby
JP2009057549A (ja) * 2007-08-06 2009-03-19 Canon Inc 構造体およびその製造方法
EP2224227B1 (en) * 2008-01-16 2014-09-03 Nippon Telegraph and Telephone Corporation Surface plasmon resonance measuring device, sample cell, and measuring method
EP2267436A4 (en) * 2008-03-26 2011-04-20 Riken SUBSTRATE FOR USE IN IMMOBILIZING SUBSTANCES, SUBSTRATE WITH IMMOBILIZED SUBSTANCE AND ASSAY PROCEDURE
JP2009286968A (ja) * 2008-05-30 2009-12-10 Canon Inc グラフトポリマー含有基体、その製造方法および磁気バイオセンサ
US8792102B2 (en) * 2010-10-28 2014-07-29 General Electric Company Interferometric spectral imaging of a two-dimensional array of samples using surface plasmon resonance
CN103293293B (zh) * 2013-06-24 2015-01-14 浙江大学 用于无标记癌胚抗原检测的电化学免疫传感器的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4379005A (en) * 1979-10-26 1983-04-05 International Business Machines Corporation Semiconductor device fabrication
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5556752A (en) * 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5874165A (en) * 1996-06-03 1999-02-23 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto polymeric subtrates
AU5701198A (en) * 1996-12-13 1998-07-03 Kelsey-Hayes Company Vehicular brake system with vehicle stability management
JPH10267930A (ja) * 1997-03-26 1998-10-09 Masao Karube 表面プラズモン共鳴バイオセンサー用測定チップ及びその製造方法
JPH10267834A (ja) * 1997-03-26 1998-10-09 Dainippon Printing Co Ltd 表面プラズモン共鳴バイオセンサー用測定チップ及びその製造方法
US6326489B1 (en) * 1997-08-05 2001-12-04 Howard Hughes Medical Institute Surface-bound, bimolecular, double-stranded DNA arrays
US6107034A (en) * 1998-03-09 2000-08-22 The Board Of Trustees Of The Leland Stanford Junior University GATA-3 expression in human breast carcinoma
WO2000042222A2 (en) * 1999-01-15 2000-07-20 Gene Logic Inc. Immobilized nucleic acid hybridization reagent and method
US6127129A (en) * 1999-05-04 2000-10-03 Wisconsin Alumni Research Foundation Process to create biomolecule and/or cellular arrays on metal surfaces and product produced thereby
JP3469504B2 (ja) * 1999-06-01 2003-11-25 日立ソフトウエアエンジニアリング株式会社 マイクロアレイチップ及びそのインデックス方法
US6362004B1 (en) * 1999-11-09 2002-03-26 Packard Biochip Technologies, Llc Apparatus and method for using fiducial marks on a microarray substrate
EP1136567A1 (en) * 2000-03-24 2001-09-26 Advanced Array Technologies S.A. Method and kit for the screening, the detection and /or the quantification of transcriptional factors
WO2001086301A1 (en) * 2000-05-11 2001-11-15 Center For Advanced Science And Technology Incubation, Ltd. Polymer composition for forming surface of biosensor
JP3523188B2 (ja) * 2000-12-13 2004-04-26 富士写真フイルム株式会社 プローブ分子が固定された検出具の水性処理液
JP4189123B2 (ja) * 2000-12-28 2008-12-03 株式会社東芝 生体関連物質の検出方法、チップ装置および装置
JP2002333446A (ja) * 2001-05-09 2002-11-22 Fuji Photo Film Co Ltd 生物学的素材チップ

Also Published As

Publication number Publication date
US20040191815A1 (en) 2004-09-30
WO2004079367A1 (ja) 2004-09-16

Similar Documents

Publication Publication Date Title
WO2006125977A3 (en) Hybrid interfering rna
WO2004072238A3 (en) Terminal-phosphate-labeled nucleotides with new linkers
WO2005079397A3 (en) Anti-microrna oligonucleotide molecules
WO2007120208A3 (en) Nanogrid rolling circle dna sequencing
WO2005074467A3 (en) Matrix array nanobiosensor
WO2005120230A3 (en) POSITIONALLY MODIFIED siRNA CONSTRUCTS
WO2004015107A3 (en) Further novel forms of interfering rna molecules
WO2007062664A3 (en) Enzymatic encoding methods for efficient synthesis of large libraries
WO2007100392A3 (en) Enzyme substrate comprising a functional dye and associated technology and methods
WO2006083800A3 (en) Nucleic acid silencing of huntington's disease gene
WO2006078278A3 (en) Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
WO2006073458A8 (en) Oligonucleotides comprising a c5-modified pyrimidine
WO2004079367A8 (ja) バイオアレイ
WO2007051863A3 (en) Method and device for the detection of molecular interactions
WO2009060124A3 (en) Use of oligonucleotides with modified bases in hybridization of nucleic acids
MX2008008261A (es) Intercambio nucleotidico dirigido mejorado con oligonucleotidos modificados por lna.
WO2009045632A3 (en) Nucleic acid based fluorescent sensor for mercury detection
WO2008019254A3 (en) Reagents, methods and systems to suppress pro-inflammatory cytokines
EP2330119A3 (en) Methods for obtaining thermostable enzymes, DNA polymerase I variants from thermus aquaticus having new catalytic activities, methods for obtaining the same, and applications of the same
WO2008001376A3 (en) Detection of analytes in a medium
WO2005030984A3 (en) Method for small volume nucleic acid synthesis
WO2005054270A3 (en) Identification and design of sirna molecules
WO2005040419A8 (en) Oligonucleotide microarray
WO2004044134A3 (en) Phosphorous-linked oligomeric compounds and their use in gene modulation
WO2008048310A3 (en) Bimolecular constructs

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: IN PCT GAZETTE 38/2004 UNDER (81) DELETE "US"; AS A CONSEQUENCE REPLACE "(71) APPLICANT (FOR ALL DESIGNATED STATES EXCEPT US)" BY "(71) APPLICANT" AND REPLACE "(72) INVENTORS; AND (75) INVENTORS/APPLICANTS (FOR US ONLY)" BY "(72) INVENTORS"

122 Ep: pct application non-entry in european phase