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WO2004073610A3 - Modulateurs des recepteurs des oestrogenes - Google Patents

Modulateurs des recepteurs des oestrogenes Download PDF

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Publication number
WO2004073610A3
WO2004073610A3 PCT/US2004/003678 US2004003678W WO2004073610A3 WO 2004073610 A3 WO2004073610 A3 WO 2004073610A3 US 2004003678 W US2004003678 W US 2004003678W WO 2004073610 A3 WO2004073610 A3 WO 2004073610A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
estrogen
compounds
receptor modulators
estrogen receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2004/003678
Other languages
English (en)
Other versions
WO2004073610A2 (fr
Inventor
Wanying Sun
Lovji D Cama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of WO2004073610A2 publication Critical patent/WO2004073610A2/fr
Publication of WO2004073610A3 publication Critical patent/WO2004073610A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés et leurs dérivés, ainsi que la synthèse et l'utilisation de ceux-ci comme modulateurs des récepteurs des oestrogènes. Ces composés constituent des ligands des récepteurs des oestrogènes, et sont par conséquent utiles pour traiter ou prévenir diverses affections liées au fonctionnement des oestrogènes, qui comprennent : la perte osseuse, les fractures osseuses, l'ostéoporose, les maladies osseuses métastatiques, la maladie de Paget, les parodontopathies, la dégénérescence du cartilage, l'endométriose, le léïomyome utérin, les bouffées de chaleur, des taux accrus de cholestérol LDL, les maladies cardiovasculaires, les troubles de la fonction cognitive, les troubles cérébraux dégénératifs, la resténose, la gynécomastie, la prolifération des cellules du muscle lisse vasculaire, l'obésité, l'incontinence et le cancer.
PCT/US2004/003678 2003-02-13 2004-02-09 Modulateurs des recepteurs des oestrogenes Ceased WO2004073610A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44716303P 2003-02-13 2003-02-13
US60/447,163 2003-02-13

Publications (2)

Publication Number Publication Date
WO2004073610A2 WO2004073610A2 (fr) 2004-09-02
WO2004073610A3 true WO2004073610A3 (fr) 2004-11-25

Family

ID=32908412

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/003678 Ceased WO2004073610A2 (fr) 2003-02-13 2004-02-09 Modulateurs des recepteurs des oestrogenes

Country Status (1)

Country Link
WO (1) WO2004073610A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7354927B2 (en) 2004-09-07 2008-04-08 Wyeth 6H-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents
JP4992091B2 (ja) * 2005-02-17 2012-08-08 ハダシット メディカル リサーチ サービシーズ アンド デベロップメント リミテッド 子宮内膜症を治療するためのビスホスホネート
NL2000351C2 (nl) 2005-12-22 2007-09-11 Pfizer Prod Inc Estrogeen-modulatoren.
CN102675326B (zh) * 2012-04-26 2014-08-20 华东理工大学 3,4-二氢苯并吡喃[3,4-c]吡唑类三环化合物的制备方法
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
CN104592202A (zh) * 2015-01-23 2015-05-06 武汉工程大学 3-乙基-n-甲基-[(n-甲基-n-[(2-吡啶基)氨基甲酰基)苯基]-吡唑-5-甲酰胺及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3624102A (en) * 1969-05-21 1971-11-30 Warner Lambert Co Substituted benzopyranopyrazoles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3624102A (en) * 1969-05-21 1971-11-30 Warner Lambert Co Substituted benzopyranopyrazoles

Also Published As

Publication number Publication date
WO2004073610A2 (fr) 2004-09-02

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