WO2004072094A3 - Hmgb1 modulator binding domain - Google Patents
Hmgb1 modulator binding domain Download PDFInfo
- Publication number
- WO2004072094A3 WO2004072094A3 PCT/IB2004/000986 IB2004000986W WO2004072094A3 WO 2004072094 A3 WO2004072094 A3 WO 2004072094A3 IB 2004000986 W IB2004000986 W IB 2004000986W WO 2004072094 A3 WO2004072094 A3 WO 2004072094A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- binding domain
- hmgb1
- modulator binding
- modulator
- hmgb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Rehabilitation Therapy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hall/Mr Elements (AREA)
- Metal-Oxide And Bipolar Metal-Oxide Semiconductor Integrated Circuits (AREA)
Abstract
An HMGB 1 modulator binding domain having the structure substantially as presented by the space filling balls in Figure 4 or Figure 11.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04710953A EP1592707A2 (en) | 2003-02-14 | 2004-02-13 | Hmgb1 modulator binding domain |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44731603P | 2003-02-14 | 2003-02-14 | |
| US60/447,316 | 2003-02-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2004072094A2 WO2004072094A2 (en) | 2004-08-26 |
| WO2004072094A3 true WO2004072094A3 (en) | 2005-05-19 |
Family
ID=32869622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2004/000986 Ceased WO2004072094A2 (en) | 2003-02-14 | 2004-02-13 | Hmgb1 modulator binding domain |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP1592707A2 (en) |
| WO (1) | WO2004072094A2 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011235296C1 (en) | 2010-03-29 | 2017-05-04 | Nationwide Children's Hospital, Inc. | Compositions and methods for the removal of biofilms |
| EP2613797B1 (en) | 2010-09-09 | 2015-11-04 | University Of Southern California | Compositions and methods for the removal of biofilms |
| CN102552280A (en) * | 2011-09-09 | 2012-07-11 | 中国科学院生物物理研究所 | Pharmaceutical applications of glycyrrhizic acid or salt and derivative thereof |
| US11274144B2 (en) | 2013-06-13 | 2022-03-15 | Research Institute At Nationwide Children's Hospital | Compositions and methods for the removal of biofilms |
| US9745366B2 (en) | 2013-09-23 | 2017-08-29 | University Of Southern California | Compositions and methods for the prevention of microbial infections |
| US11248040B2 (en) | 2013-09-26 | 2022-02-15 | Trellis Bioscience, Llc | Binding moieties for biofilm remediation |
| US10233234B2 (en) | 2014-01-13 | 2019-03-19 | Trellis Bioscience, Llc | Binding moieties for biofilm remediation |
| AU2016303688B2 (en) | 2015-07-31 | 2023-06-15 | Research Institute At Nationwide Children's Hospital | Peptides and antibodies for the removal of biofilms |
| AU2018236271B2 (en) | 2017-03-15 | 2023-12-21 | Research Institute At Nationwide Children's Hospital | Composition and methods for disruption of bacterial biofilms without accompanying inflammation |
| CN112823038B (en) | 2018-10-05 | 2025-10-03 | 国家儿童医院研究所 | HMGB1 protein derivatives for biofilm removal |
-
2004
- 2004-02-13 WO PCT/IB2004/000986 patent/WO2004072094A2/en not_active Ceased
- 2004-02-13 EP EP04710953A patent/EP1592707A2/en not_active Withdrawn
Non-Patent Citations (5)
| Title |
|---|
| HARDMAN COLIN H ET AL: "Structure of the A-domain of HMG1 and its interaction with DNA as studied by heteronuclear three- and four-dimensional NMR spectroscopy", BIOCHEMISTRY, vol. 34, no. 51, 1995, pages 16596 - 16607, XP002300628, ISSN: 0006-2960 * |
| OKANO MAIKO ET AL: "Biochemical characterization of cholesterol-3-sulfate as the sole effector for the phosphorylation of HMG1 by casein kinase I in vitro", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 281, no. 5, 16 March 2001 (2001-03-16), pages 1325 - 1330, XP002300630, ISSN: 0006-291X * |
| SAKAMOTO RYOKO ET AL: "Inhibitory effect of glycyrrhizin on the phosphorylation and DNA-binding abilities of high mobility group proteins 1 and 2 in vitro", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 24, no. 8, August 2001 (2001-08-01), pages 906 - 911, XP002300629, ISSN: 0918-6158 * |
| THOMAS J O ET AL: "HMG1 and 2, and related 'architectural' DNA-binding proteins", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 26, no. 3, 1 March 2001 (2001-03-01), pages 167 - 174, XP004229458, ISSN: 0968-0004 * |
| YANG HUAN ET AL: "HMGB1 as a cytokine and therapeutic target", JOURNAL OF ENDOTOXIN RESEARCH, CHURCHILL LIVINGSTONE, EDINBURGH, GB, vol. 8, no. 6, 2002, pages 469 - 472, XP009020930, ISSN: 0968-0519 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1592707A2 (en) | 2005-11-09 |
| WO2004072094A2 (en) | 2004-08-26 |
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