[go: up one dir, main page]

WO2004070046A8 - 糖鎖アスパラギン誘導体の製造方法 - Google Patents

糖鎖アスパラギン誘導体の製造方法

Info

Publication number
WO2004070046A8
WO2004070046A8 PCT/JP2004/001048 JP2004001048W WO2004070046A8 WO 2004070046 A8 WO2004070046 A8 WO 2004070046A8 JP 2004001048 W JP2004001048 W JP 2004001048W WO 2004070046 A8 WO2004070046 A8 WO 2004070046A8
Authority
WO
WIPO (PCT)
Prior art keywords
sugar chain
chain asparagine
mixture
asparagine derivative
produce
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2004/001048
Other languages
English (en)
French (fr)
Other versions
WO2004070046A1 (ja
Inventor
Kazuhiro Fukae
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Chemical Co Ltd
Original Assignee
Otsuka Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Chemical Co Ltd filed Critical Otsuka Chemical Co Ltd
Priority to JP2005504829A priority Critical patent/JP4237752B2/ja
Priority to CA2514337A priority patent/CA2514337C/en
Priority to US10/544,212 priority patent/US7955819B2/en
Priority to DK04707645.0T priority patent/DK1591532T3/en
Priority to AU2004209371A priority patent/AU2004209371B2/en
Priority to EP04707645.0A priority patent/EP1591532B1/en
Priority to ES04707645T priority patent/ES2701175T3/es
Publication of WO2004070046A1 publication Critical patent/WO2004070046A1/ja
Anticipated expiration legal-status Critical
Publication of WO2004070046A8 publication Critical patent/WO2004070046A8/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

脱脂卵黄から糖鎖アスパラギン誘導体を製造する方法であって、(a)脱脂卵黄をタンパク質分解酵素により糖鎖ペプチド混合物を製造する工程、(b)糖鎖ペプチド混合物をペプチド分解酵素により糖鎖アスパラギン混合物を製造する工程、(c)糖鎖アスパラギン混合物中の糖鎖アスパラギンに脂溶性の保護基を導入し糖類アスパラギン誘導体混合物を製造する工程、(d)糖鎖アスパラギン誘導体混合物をクロマトグラフィーに供して各糖鎖アスパラギン誘導体を分離する工程、を含む糖鎖アスパラギン誘導体の製造方法。
PCT/JP2004/001048 2003-02-04 2004-02-03 糖鎖アスパラギン誘導体の製造方法 Ceased WO2004070046A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2005504829A JP4237752B2 (ja) 2003-02-04 2004-02-03 糖鎖アスパラギン誘導体の製造方法
CA2514337A CA2514337C (en) 2003-02-04 2004-02-03 Process for producing sugar chain asparagine derivative
US10/544,212 US7955819B2 (en) 2003-02-04 2004-02-03 Process for producing sugar chain asparagine derivative
DK04707645.0T DK1591532T3 (en) 2003-02-04 2004-02-03 PROCEDURE FOR PREPARING ASPARAGIN DERIVATIVES WITH SUGAR CHAIN
AU2004209371A AU2004209371B2 (en) 2003-02-04 2004-02-03 Process for producing sugar chain asparagine derivative
EP04707645.0A EP1591532B1 (en) 2003-02-04 2004-02-03 Process for producing sugar chain asparagine derivative
ES04707645T ES2701175T3 (es) 2003-02-04 2004-02-03 Proceso para producir derivado de asparagina de cadena de azúcar

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003026609 2003-02-04
JP2003-26609 2003-02-04

Publications (2)

Publication Number Publication Date
WO2004070046A1 WO2004070046A1 (ja) 2004-08-19
WO2004070046A8 true WO2004070046A8 (ja) 2005-08-25

Family

ID=32844148

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2004/001048 Ceased WO2004070046A1 (ja) 2003-02-04 2004-02-03 糖鎖アスパラギン誘導体の製造方法

Country Status (14)

Country Link
US (1) US7955819B2 (ja)
EP (2) EP1591532B1 (ja)
JP (1) JP4237752B2 (ja)
KR (1) KR20050095609A (ja)
CN (1) CN100378225C (ja)
AU (1) AU2004209371B2 (ja)
CA (1) CA2514337C (ja)
DK (1) DK1591532T3 (ja)
ES (1) ES2701175T3 (ja)
HU (1) HUE041502T2 (ja)
PT (1) PT1591532T (ja)
TR (1) TR201820053T4 (ja)
TW (1) TWI344819B (ja)
WO (1) WO2004070046A1 (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5004464B2 (ja) * 2005-12-02 2012-08-22 大塚化学株式会社 糖鎖修飾リポソーム
EP2184290B1 (en) 2007-07-31 2015-02-18 Glytech, Inc. Method for producing peptide
CA2727147A1 (en) 2008-06-17 2009-12-23 Otsuka Chemical Co., Ltd. Glycosylated glp-1 peptide
BRPI0917298B8 (pt) 2008-08-19 2021-05-25 Glytech Inc método de produção de glicoproteína e método de rastreamento de glicoproteína
TW201031749A (en) 2009-02-10 2010-09-01 Otsuka Chemical Co Ltd IgG-Fc fragment and method for manufacturing the same
WO2011007747A1 (ja) 2009-07-16 2011-01-20 大塚化学株式会社 糖鎖付加ａｉｌｉｍ細胞外ドメイン及びその製造方法
WO2011027868A1 (ja) * 2009-09-03 2011-03-10 公益財団法人野口研究所 １１糖シアリルオリゴ糖ペプチドの製造方法
CN102666580A (zh) 2009-10-30 2012-09-12 大塚化学株式会社 抗原性glp-1类似物的糖链加成物
JP5285022B2 (ja) * 2010-04-30 2013-09-11 旭化成株式会社 糖ペプチド誘導体及びその製造方法
JP5680576B2 (ja) * 2011-03-03 2015-03-04 旭化成株式会社 １１糖シアリルオリゴ糖アスパラギンの製造方法
BR112013022941B8 (pt) 2011-03-10 2021-02-23 Glytech Inc método para fabricação de glicopeptídeo tendo cadeia de açúcar sialil e método para a fabricação de um derivado de sialilglicoasparagina
BR112014004784A2 (pt) 2011-09-04 2017-03-21 Glytech Inc polipeptídeo glicosilado e composição de drogas contendo referido polipeptídeo
AU2012302637B2 (en) 2011-09-04 2016-09-15 Glytech, Inc. Glycosylated polypeptide and drug composition containing said polypeptide
EP2924053B1 (en) 2012-11-22 2020-11-11 Glytech, Inc. Glycosylated linker, compound containing glycosylated linker moiety and physiologically active substance moiety or salt thereof, and methods for producing said compound or salt thereof
KR102227919B1 (ko) 2012-11-30 2021-03-15 가부시키가이샤 도우사 고가쿠 겐큐쇼 당쇄 부가 링커, 당쇄 부가 링커와 생리 활성 물질을 포함하는 화합물 또는 그 염, 및 그것들의 제조 방법
AU2014245917B2 (en) 2013-03-29 2017-09-28 Glytech, Inc. Polypeptide having sialylated sugar chains attached thereto
EP2980098B1 (en) 2013-03-30 2018-10-03 Glytech, Inc. (sugar chain)-polypeptide complex
CN113121718B (zh) * 2021-05-13 2022-09-23 东南大学 一种迷果芹多糖psgp-2及其制备方法与应用
WO2022255289A1 (ja) 2021-05-31 2022-12-08 Ｋｈネオケム株式会社 糖ぺプチドを製造する方法
JPWO2023157924A1 (ja) * 2022-02-18 2023-08-24

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69530910D1 (de) * 1994-07-15 2003-07-03 Taiyo Kagaku Co Medizinische zusammensetzungen enthaltend ein sialinsäurederivat
JPH0899988A (ja) * 1994-09-29 1996-04-16 Takehiko Yamamoto シアル酸類含有オリゴ糖の製造法
EP2322533A1 (en) * 2001-06-19 2011-05-18 Otsuka Chemical Co., Ltd. Process for producing sugar chain asparagine derivative
AU2002322080A1 (en) * 2001-06-20 2003-01-08 The Brigham And Women's Hospital, Inc. P53 binding protein-related protein in cardiomyopathy

Also Published As

Publication number Publication date
TWI344819B (en) 2011-07-11
DK1591532T3 (en) 2019-01-21
ES2701175T3 (es) 2019-02-21
TR201820053T4 (tr) 2019-01-21
EP1591532B1 (en) 2018-10-31
JP4237752B2 (ja) 2009-03-11
HUE041502T2 (hu) 2019-05-28
TW200420231A (en) 2004-10-16
CN100378225C (zh) 2008-04-02
JPWO2004070046A1 (ja) 2006-05-25
WO2004070046A1 (ja) 2004-08-19
CN1777679A (zh) 2006-05-24
US20060205039A1 (en) 2006-09-14
EP1591532A4 (en) 2011-03-30
EP1591532A1 (en) 2005-11-02
AU2004209371A1 (en) 2004-08-19
CA2514337C (en) 2010-07-13
KR20050095609A (ko) 2005-09-29
CA2514337A1 (en) 2004-08-19
US7955819B2 (en) 2011-06-07
AU2004209371B2 (en) 2008-05-01
PT1591532T (pt) 2019-01-11
EP2626429A1 (en) 2013-08-14

Similar Documents

Publication Publication Date Title
WO2004070046A8 (ja) 糖鎖アスパラギン誘導体の製造方法
AU2002346294A1 (en) Process for producing sugar chain asparagine derivative
WO2003008431A1 (en) Process for producing sugar chain asparagine derivative
AU2001269742A1 (en) Method of treating gastrointestinal diseases associated with species of genus clostridium
EG23230A (en) Plant for producing tyres of different types simultaneously.
EP1520858A4 (en) METHOD FOR PRODUCING A SUGAR PEPTIDE WITH ASPARAGIN SUGAR CHAIN AND THE SUGAR PEPTIDE
AU2003252405A1 (en) Process for producing soy protein
AU2003287210A1 (en) Method for treating emissions
AU2003276296A1 (en) Edible flavor improver, process for its production and use
EP1577397A4 (en) SUGAR CHAIN ASPARAGIN DERIVATIVES, SUGAR CHAIN ASPARAGIN, SUGAR CHAIN, AND METHODS OF PRODUCING THE SAME
AU2002238644A1 (en) Method for extracting, fractionating and purifying polyphenol compounds originating from fresh vegetable culls using a high absorption and elution resin
AU2003200017A1 (en) Oxy-fuel combustion process
WO2005001039A3 (en) Ribozyme-regulated small inhibitory rna (sirna) production and methods of use thereof
EP1608608A4 (en) METHOD FOR EXTRACTING LUTEIN FROM GREEN VEGETABLE MATERIALS
AU2003283635A1 (en) Method of manufacturing a replica, as well as a replica obtained by carrying out a uv light-initiated or thermal curing treatment of a reactive mixture
ZA200405862B (en) Method of changing very large tires.
AU2003211500A1 (en) Split type smokeless roaster
AU2003236292A1 (en) Process for producing canthaxanthin
IL154293A (en) Process for improving appearance of dried fruit, particularly of dates
AP2005003417A0 (en) Method for aquaculture and products obtained by said method.
WO2005004784A3 (fr) Installation comprenant une machine de fabrication de comprimes en particulier a usage therapeutique
AU2003237493A1 (en) Methods for treating diseases or conditions with peptide constructs
AU2003219857A1 (en) Process for treating disease
WO2004078142A3 (en) Compositions and methods for preventing and treating endotoxin-related diseases and conditions
WO2007017277A8 (en) METHOD FOR THE PURIFICATION OF ALPHA-1 PROTEINASE INHIBITOR (a1PI)

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DPEN Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2005504829

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 1020057012948

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2004209371

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2004707645

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10544212

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2514337

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 20048035452

Country of ref document: CN

ENP Entry into the national phase

Ref document number: 2004209371

Country of ref document: AU

Date of ref document: 20040203

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2004209371

Country of ref document: AU

CFP Corrected version of a pamphlet front page

Free format text: UNDER (72, 75) THE TRANSLITERATION IN JAPANESE OF THE NAME OF "FUKAE, KAZUHIRO" CORRECTED

WWP Wipo information: published in national office

Ref document number: 1020057012948

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 2004707645

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 10544212

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 10598251

Country of ref document: US