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WO2004066183A3 - Microrna - Google Patents

Microrna Download PDF

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Publication number
WO2004066183A3
WO2004066183A3 PCT/IB2004/000620 IB2004000620W WO2004066183A3 WO 2004066183 A3 WO2004066183 A3 WO 2004066183A3 IB 2004000620 W IB2004000620 W IB 2004000620W WO 2004066183 A3 WO2004066183 A3 WO 2004066183A3
Authority
WO
WIPO (PCT)
Prior art keywords
microrna
molecules
mirna
targets
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2004/000620
Other languages
French (fr)
Other versions
WO2004066183A2 (en
Inventor
Stephen Cohen
Julius Brennecke
Robert B Russell
Alexander Stark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Europaisches Laboratorium fuer Molekularbiologie EMBL
Original Assignee
Europaisches Laboratorium fuer Molekularbiologie EMBL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0301459.4A external-priority patent/GB0301459D0/en
Priority claimed from GBGB0317991.8A external-priority patent/GB0317991D0/en
Application filed by Europaisches Laboratorium fuer Molekularbiologie EMBL filed Critical Europaisches Laboratorium fuer Molekularbiologie EMBL
Publication of WO2004066183A2 publication Critical patent/WO2004066183A2/en
Publication of WO2004066183A3 publication Critical patent/WO2004066183A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/10—Nucleic acid folding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/10—Production naturally occurring
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to computational methods of identifying novel microRNA (miRNA) molecules and novel targets for miRNA molecules and the microRNA molecules and targets identified by such methods.
PCT/IB2004/000620 2003-01-22 2004-01-22 Microrna Ceased WO2004066183A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0301459.4 2003-01-22
GBGB0301459.4A GB0301459D0 (en) 2003-01-22 2003-01-22 Microrna
GB0317991.8 2003-07-31
GBGB0317991.8A GB0317991D0 (en) 2003-07-31 2003-07-31 Microrna

Publications (2)

Publication Number Publication Date
WO2004066183A2 WO2004066183A2 (en) 2004-08-05
WO2004066183A3 true WO2004066183A3 (en) 2004-12-02

Family

ID=32773969

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/000620 Ceased WO2004066183A2 (en) 2003-01-22 2004-01-22 Microrna

Country Status (1)

Country Link
WO (1) WO2004066183A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8946177B2 (en) 2004-11-12 2015-02-03 Mima Therapeutics, Inc Methods and compositions involving miRNA and miRNA inhibitor molecules

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2361984A1 (en) 2003-10-09 2011-08-31 E. I. du Pont de Nemours and Company Gene silencing by using modified micro-RNA molecules
WO2005111211A2 (en) 2004-05-14 2005-11-24 Rosetta Genomics Ltd. Micronas and uses thereof
US7795419B2 (en) 2004-05-26 2010-09-14 Rosetta Genomics Ltd. Viral and viral associated miRNAs and uses thereof
AU2005250432B2 (en) 2004-05-28 2011-09-15 Asuragen, Inc. Methods and compositions involving microRNA
AU2005295948A1 (en) 2004-10-12 2006-04-27 The Rockefeller University MicroRNAs
SI2002003T1 (en) 2005-05-27 2016-05-31 Ospedale San Raffaele S.R.L. Gene vector comprising mi-rna
WO2007039454A1 (en) 2005-09-20 2007-04-12 Basf Plant Science Gmbh Methods for controlling gene expression using ta-siran
US8014956B2 (en) 2005-12-30 2011-09-06 Industrial Technology Research Institute MicroRNA precursors
EP2198050A1 (en) 2007-09-14 2010-06-23 Asuragen, INC. Micrornas differentially expressed in cervical cancer and uses thereof
EP2990487A1 (en) 2008-05-08 2016-03-02 Asuragen, INC. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
US9938540B2 (en) 2008-11-12 2018-04-10 Ospedale San Raffaele S.R.L. Gene vector for inducing transgene-specific immune tolerance
US8933051B2 (en) 2010-09-30 2015-01-13 University Of Zurich Treatment of B-cell lymphoma with microRNA
CN105969773A (en) 2011-02-03 2016-09-28 米尔纳医疗股份有限公司 Synthetic mimics of MIR-124
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
WO2013189047A1 (en) * 2012-06-20 2013-12-27 南京大学 Plant microrna identification and application thereof
EP3719129A1 (en) 2014-03-12 2020-10-07 The University of Sydney Rna production in higher plants
WO2015184466A1 (en) * 2014-05-30 2015-12-03 The Trustees Of Columbia University In The City Of New York Methods for altering polypeptide expression
CN109859798B (en) * 2019-01-21 2023-06-23 桂林电子科技大学 Prediction method for interaction of sRNA and target mRNA in bacteria
CN117116361B (en) * 2023-10-25 2024-01-26 江西师范大学 12sRNA secondary structure visualization method based on fixed frame
CN117976033B (en) * 2024-02-01 2024-08-06 西南大学 MicroRNA target prediction method and computer program product

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003065281A1 (en) * 2002-01-29 2003-08-07 Health Research, Inc. Statistical algorithms for folding and target accessibility prediction and design of nucleic acids
WO2004009779A2 (en) * 2002-07-19 2004-01-29 University Of South Carolina Compositions and methods for the modulation of gene expression in plants

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003065281A1 (en) * 2002-01-29 2003-08-07 Health Research, Inc. Statistical algorithms for folding and target accessibility prediction and design of nucleic acids
WO2004009779A2 (en) * 2002-07-19 2004-01-29 University Of South Carolina Compositions and methods for the modulation of gene expression in plants

Non-Patent Citations (18)

* Cited by examiner, † Cited by third party
Title
AMBROS VICTOR ET AL: "A uniform system for microRNA annotation.", RNA (NEW YORK), vol. 9, no. 3, March 2003 (2003-03-01), pages 277 - 279, XP009032091, ISSN: 1355-8382 *
BRENNECKE J ET AL: "Towards a complete description of the microRNA complement of animal genomes", GENOME BIOLOGY 2003 UNITED KINGDOM, vol. 4, no. 9, 2003, pages 228 - 228.3, XP009032047, ISSN: 1465-6906 *
BRENNECKE JULIUS ET AL: "bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila.", CELL. UNITED STATES 4 APR 2003, vol. 113, no. 1, 4 April 2003 (2003-04-04), pages 25 - 36, XP001181836, ISSN: 0092-8674 *
EDDY S R: "Profile hidden Markov models", METHODS IN ENZYMOLOGY, 1998, XP002194730, Retrieved from the Internet <URL:ftp://ftp.genetics.wustl.edu/pub/eddy/papers/hmmreview-bioinformatics -98.pdf> [retrieved on 20020328] *
ENRIGHT ANTON J ET AL: "MicroRNA targets in Drosophila.", GENOME BIOLOGY 2003, vol. 5, no. 1, 2003, pages 1 - 26, XP002295230, ISSN: 1465-6914 *
GRAD Y ET AL: "Computational and experimental identification of C. elegans microRNAs", MOLECULAR CELL 01 MAY 2003 UNITED STATES, vol. 11, no. 5, 1 May 2003 (2003-05-01), pages 1253 - 1263, XP009032050, ISSN: 1097-2765 *
HIPFNER DAVID R ET AL: "The bantam gene regulates Drosophila growth.", GENETICS. UNITED STATES AUG 2002, vol. 161, no. 4, August 2002 (2002-08-01), pages 1527 - 1537, XP002284380, ISSN: 0016-6731 *
KIRIAKIDOU M ET AL: "A COMBINED COMPUTATIONAL-EXPERIMENTAL APPROACH PREDICTS HUMAN MICRORNA TARGETS", GENES AND DEVELOPMENT, COLD SPRING HARBOR LABORATORY PRESS, NEW YORK, US, vol. 18, no. 10, 15 May 2004 (2004-05-15), pages 1165 - 1178, XP009032049, ISSN: 0890-9369 *
LAGOS-QUINTANA MARIANA ET AL: "Identification of tissue-specific microRNAs from mouse.", CURRENT BIOLOGY: CB. ENGLAND 30 APR 2002, vol. 12, no. 9, 30 April 2002 (2002-04-30), pages 735 - 739, XP002284274, ISSN: 0960-9822 *
LAU N C ET AL: "An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans.", SCIENCE. UNITED STATES 26 OCT 2001, vol. 294, no. 5543, 26 October 2001 (2001-10-26), pages 858 - 862, XP002284276, ISSN: 0036-8075 *
LEE R C ET AL: "An extensive class of small RNAs in Caenorhabditis elegans.", SCIENCE. UNITED STATES 26 OCT 2001, vol. 294, no. 5543, 26 October 2001 (2001-10-26), pages 862 - 864, XP002284273, ISSN: 0036-8075 *
LEWIS BENJAMIN P ET AL: "Prediction of mammalian microRNA targets.", CELL. 26 DEC 2003, vol. 115, no. 7, 26 December 2003 (2003-12-26), pages 787 - 798, XP002295226, ISSN: 0092-8674 *
LIM LEE P ET AL: "Vertebrate microRNA genes.", SCIENCE (WASHINGTON D C), vol. 299, no. 5612, 7 March 2003 (2003-03-07), pages 1540, XP002284278, ISSN: 0036-8075 (ISSN print) *
MOSS ERIC G ET AL: "MicroRNAs: something new under the sun.", CURRENT BIOLOGY: CB. ENGLAND 15 OCT 2002, vol. 12, no. 20, 15 October 2002 (2002-10-15), pages R688 - R690, XP002284275, ISSN: 0960-9822 *
NELSON P ET AL: "The microRNA world: small is mighty", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 28, no. 10, October 2003 (2003-10-01), pages 534 - 540, XP004464445, ISSN: 0968-0004 *
RHOADES MATTHEW W ET AL: "Prediction of plant microRNA targets.", CELL. 23 AUG 2002, vol. 110, no. 4, 23 August 2002 (2002-08-23), pages 513 - 520, XP002295225, ISSN: 0092-8674 *
SERRA M J ET AL: "Predicting thermodynamic properties of RNA.", METHODS IN ENZYMOLOGY. UNITED STATES 1995, vol. 259, 1995, pages 242 - 261, XP009032022, ISSN: 0076-6879 *
STARK A ET AL: "IDENTIFICATION OF DROSOPHILA MICRORNA TARGETS", PLOS BIOLOGY, XX, XX, vol. 1, no. 3, December 2003 (2003-12-01), pages 397, XP009032040, ISSN: 1544-9173 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8946177B2 (en) 2004-11-12 2015-02-03 Mima Therapeutics, Inc Methods and compositions involving miRNA and miRNA inhibitor molecules

Also Published As

Publication number Publication date
WO2004066183A2 (en) 2004-08-05

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