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WO2004050180A3 - Method and apparatus for cell and electrical therapy of living tissue - Google Patents

Method and apparatus for cell and electrical therapy of living tissue Download PDF

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Publication number
WO2004050180A3
WO2004050180A3 PCT/US2003/038085 US0338085W WO2004050180A3 WO 2004050180 A3 WO2004050180 A3 WO 2004050180A3 US 0338085 W US0338085 W US 0338085W WO 2004050180 A3 WO2004050180 A3 WO 2004050180A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell
application
electrical therapy
tissue
therapy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/038085
Other languages
French (fr)
Other versions
WO2004050180A2 (en
Inventor
Steven D Girouard
Rodney W Salo
Bruce H Kenknight
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardiac Pacemakers Inc
Original Assignee
Cardiac Pacemakers Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/723,258 external-priority patent/US7627373B2/en
Priority claimed from US10/722,115 external-priority patent/US20040158289A1/en
Application filed by Cardiac Pacemakers Inc filed Critical Cardiac Pacemakers Inc
Priority to AU2003297592A priority Critical patent/AU2003297592A1/en
Priority to JP2004570974A priority patent/JP2006511312A/en
Priority to EP03812469A priority patent/EP1569717A2/en
Publication of WO2004050180A2 publication Critical patent/WO2004050180A2/en
Publication of WO2004050180A3 publication Critical patent/WO2004050180A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/368—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Physiology (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Electrotherapy Devices (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A method for cell and electrical therapy of living tissue including administration of exogenous cells into a region of injured tissue and application of electrical energy. In one application the exogenous cells are conditioned in vitro before their administration into tissue. In one application the combined cell and electrical therapy is applied in vivo to damaged heart tissue. In such applications, minimally invasive procedures are used to apply the cell therapy and the electrical therapy is provided via an implantable pulse generator. In one application an implantable pacemaker is used in the VDD or DDD mode with an atrioventricular delay kept relatively short when compared to the intrinsic atrioventricular delay.
PCT/US2003/038085 2002-11-30 2003-11-26 Method and apparatus for cell and electrical therapy of living tissue Ceased WO2004050180A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2003297592A AU2003297592A1 (en) 2002-11-30 2003-11-26 Method and apparatus for cell and electrical therapy of living tissue
JP2004570974A JP2006511312A (en) 2002-11-30 2003-11-26 Method and apparatus for cell therapy and electrotherapy of biological tissue
EP03812469A EP1569717A2 (en) 2002-11-30 2003-11-26 Method and apparatus for cell and electrical therapy of living tissue

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US42995402P 2002-11-30 2002-11-30
US60/429,954 2002-11-30
US48302803P 2003-06-27 2003-06-27
US60/483,028 2003-06-27
US10/723,258 US7627373B2 (en) 2002-11-30 2003-11-25 Method and apparatus for cell and electrical therapy of living tissue
US10/722,115 2003-11-25
US10/722,115 US20040158289A1 (en) 2002-11-30 2003-11-25 Method and apparatus for cell and electrical therapy of living tissue
US10/723,258 2003-11-25

Publications (2)

Publication Number Publication Date
WO2004050180A2 WO2004050180A2 (en) 2004-06-17
WO2004050180A3 true WO2004050180A3 (en) 2004-11-11

Family

ID=33425557

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/038085 Ceased WO2004050180A2 (en) 2002-11-30 2003-11-26 Method and apparatus for cell and electrical therapy of living tissue

Country Status (4)

Country Link
EP (1) EP1569717A2 (en)
JP (2) JP2006511312A (en)
AU (1) AU2003297592A1 (en)
WO (1) WO2004050180A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8016812B2 (en) 2006-11-03 2011-09-13 Pacesetter, Inc. Techniques for delivery of stem cell and related therapies to treat cardiac conditions
US8761883B2 (en) 2011-08-31 2014-06-24 St. Jude Medical Ab Physiologically adapted cardiac resynchronization therapy

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7627373B2 (en) 2002-11-30 2009-12-01 Cardiac Pacemakers, Inc. Method and apparatus for cell and electrical therapy of living tissue
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US20070003528A1 (en) 2005-06-29 2007-01-04 Paul Consigny Intracoronary device and method of use thereof
JP2009502259A (en) * 2005-07-21 2009-01-29 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク Tandem cardiac pacemaker system
US20070190028A1 (en) * 2006-02-13 2007-08-16 Jihong Qu Method and apparatus for heat or electromagnetic control of gene expression
US8019416B2 (en) * 2006-11-13 2011-09-13 Cardiac Pacemakers, Inc. Reduction of AV delay for treatment of cardiac disease
US8521278B2 (en) 2008-05-08 2013-08-27 Cardiac Pacemakers, Inc. Smart delay for intermittent stress therapy
US10016463B2 (en) 2012-08-01 2018-07-10 United Therapeutics Corporation Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells
IN2015DN00934A (en) 2012-08-01 2015-06-12 United Therapeutics Corp
AU2014205557B2 (en) * 2013-01-09 2017-08-10 United Therapeutics Corporation Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
US10940318B2 (en) * 2014-06-17 2021-03-09 Morton M. Mower Method and apparatus for electrical current therapy of biological tissue
US11571444B2 (en) 2016-10-24 2023-02-07 United Therapeutics Corporation Enhancement of MSC immunomodulatory properties by treprostinil
CN114849060B (en) * 2022-05-07 2023-08-25 江苏省人民医院（南京医科大学第一附属医院） Application of Electrical Stimulation in Regulation of MDK in Organisms
WO2024253157A1 (en) * 2023-06-08 2024-12-12 ヤーマン株式会社 Skin treatment device, beautifying method, and treatment method

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5336252A (en) * 1992-06-22 1994-08-09 Cohen Donald M System and method for implanting cardiac electrical leads
WO1998002150A1 (en) * 1996-07-17 1998-01-22 Medtronic, Inc. System for genetically treating cardiac conduction disturbances
WO1998015317A1 (en) * 1996-10-07 1998-04-16 Sulzer Intermedics Inc. Controllable drug injection electrode
WO2000027466A1 (en) * 1998-11-12 2000-05-18 Emed Corporation Electrically mediated angiogenesis
WO2000054661A1 (en) * 1999-03-17 2000-09-21 Angiotrax, Inc. Apparatus and methods for performing percutaneous myocardial revascularization and stimulating angiogenesis using autologous materials
EP1142607A2 (en) * 2000-04-03 2001-10-10 Medtronic, Inc. Dual chamber pacing system having time-adaptive AV delay
US20020032468A1 (en) * 1996-04-30 2002-03-14 Hill Michael R.S. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
WO2002049669A2 (en) * 2000-12-21 2002-06-27 Medtronic, Inc. Electrically responsive promoter system
WO2002070065A2 (en) * 2001-03-05 2002-09-12 Medtronic, Inc. Stimulation for delivery of molecular therapy
US20020124855A1 (en) * 2001-03-12 2002-09-12 Chachques Juan C. Method of providing a dynamic cellular cardiac support
US20020133198A1 (en) * 2001-03-16 2002-09-19 Kramer Andrew P. Automatic selection from multiple cardiac optimization protocols

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5282838A (en) * 1992-06-08 1994-02-01 Cardiac Pacemakers, Inc. Dual chamber cardiac pacemaker employing hysteresis to maximize the number of normally conducted ventricular beats with an optimum A-V delay for paced ventricular beats
US5831008A (en) 1994-08-18 1998-11-03 La Jolla Cancer Research Foundation Retinoblastoma protein-interacting zinc finger proteins

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5336252A (en) * 1992-06-22 1994-08-09 Cohen Donald M System and method for implanting cardiac electrical leads
US20020032468A1 (en) * 1996-04-30 2002-03-14 Hill Michael R.S. Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure
WO1998002150A1 (en) * 1996-07-17 1998-01-22 Medtronic, Inc. System for genetically treating cardiac conduction disturbances
WO1998015317A1 (en) * 1996-10-07 1998-04-16 Sulzer Intermedics Inc. Controllable drug injection electrode
WO2000027466A1 (en) * 1998-11-12 2000-05-18 Emed Corporation Electrically mediated angiogenesis
WO2000054661A1 (en) * 1999-03-17 2000-09-21 Angiotrax, Inc. Apparatus and methods for performing percutaneous myocardial revascularization and stimulating angiogenesis using autologous materials
EP1142607A2 (en) * 2000-04-03 2001-10-10 Medtronic, Inc. Dual chamber pacing system having time-adaptive AV delay
WO2002049669A2 (en) * 2000-12-21 2002-06-27 Medtronic, Inc. Electrically responsive promoter system
WO2002070065A2 (en) * 2001-03-05 2002-09-12 Medtronic, Inc. Stimulation for delivery of molecular therapy
US20020124855A1 (en) * 2001-03-12 2002-09-12 Chachques Juan C. Method of providing a dynamic cellular cardiac support
US20020133198A1 (en) * 2001-03-16 2002-09-19 Kramer Andrew P. Automatic selection from multiple cardiac optimization protocols

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8016812B2 (en) 2006-11-03 2011-09-13 Pacesetter, Inc. Techniques for delivery of stem cell and related therapies to treat cardiac conditions
US8175704B2 (en) 2006-11-03 2012-05-08 Pacesetter, Inc. Techniques for delivery of stem cell and related therapies to treat cardiac conditions
US8761883B2 (en) 2011-08-31 2014-06-24 St. Jude Medical Ab Physiologically adapted cardiac resynchronization therapy

Also Published As

Publication number Publication date
EP1569717A2 (en) 2005-09-07
JP2006511312A (en) 2006-04-06
JP2009178593A (en) 2009-08-13
AU2003297592A1 (en) 2004-06-23
WO2004050180A2 (en) 2004-06-17

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