WO2004047563A1 - Use of food plants for their hydrogen peroxide destroying activity - Google Patents
Use of food plants for their hydrogen peroxide destroying activity Download PDFInfo
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- WO2004047563A1 WO2004047563A1 PCT/FR2003/003445 FR0303445W WO2004047563A1 WO 2004047563 A1 WO2004047563 A1 WO 2004047563A1 FR 0303445 W FR0303445 W FR 0303445W WO 2004047563 A1 WO2004047563 A1 WO 2004047563A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9717—Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Definitions
- Free radicals hydrogen peroxide are oxidants produced naturally by the body, in the mitochondria. They intervene during phagocytosis; their accumulation is dangerous.
- Such peroxidative systems mainly originate from the intervention of free radicals; such as the superoxide anion O 2 ° which generates hydrogen peroxide H 2 0 2 , leading to hydroxyl radicals which are involved in the lipoperoxidation process.
- reactive oxygen species such as the superoxide anion, hydroxyl radicals and oxygenated water, cause the formation of inflammatory systems, degrading a variety of intra- and extra-cellular molecules.
- antioxidants and protective enzymes can under certain circumstances; for example in the case of a burn, no longer being able to inactivate neutrophils: This is how, for some authors, an increase in the level of hydrogen peroxide and the superoxide radical produced by macrophages, would be the major cause of oxidative stress and the cellular damage that results from it.
- This document relates to a nutritional supplement, intended to increase heavy lipoproteins: HDL and calcium ions, and decrease free radicals and glucose in plasma, characterized in that it comprises green barley, vitamins and an extract Ginkgo Biloba:
- these nutritional supplements include vegetable juices rich in vitamins Example 10 of the description, it describes a mixture of various substances with known antioxidant properties: vitamins + selenium with concentrated juice fruits and vegetables. There is no question of deoxygenation of oxygenated water.
- This document relates to soluble proteins extracted from the bean obtained by a chemical solubilization treatment: So4 (NH4) 2. Even though these proteins destroy hydrogen peroxide, vegetable and fruit extracts do not contain protein.
- RISO P ET AL "Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage?"
- This document relates to tomato juice, characterized by the presence of lycopene, a fat-soluble carotenoid, absent from vegetable and fruit extracts.
- PHAN TOAN-THANG ET AL "Protective effects of curcumin against oxidative damage on skin cells in vitro: Its implication for wound healing.”
- Turmeric which is neither a vegetable; neither a fruit but a spice.
- DATABASE WPI section Ch Week 200149 Derwent Publication Ltd., GB; Class B04, AN 2001-453935 XP002251424
- This document relates to extracts of Paprika sheaths, therefore from a spice as oxygen scavenger of oxygenated water.
- the reaction medium for these activities is lipophilic (oxidation of fat).
- the anti-hydrogen peroxide activity is carried out in a hydrophilic medium.
- the object of the present invention is to produce plant food extracts from vegetables or fruits characterized by their hydrogen antiperoxide activity.
- anti-hydrogen peroxide capacities for 1g of fruit and vegetable extracts, expressed in micrograms of oxygen; The measurements being carried out by potentiometry.
- the subject of the present invention is the production of extracts intended for use as food supplements, but also in cutaneous application in the fields of cosmetics, human and animal dermatology.
- the extracts of vegetables or fruits are obtained by introducing the food plant in water, the whole is brought to a boil, the medium having been mixed. in order to have small particles. The boiling is maintained for an average duration of 30 min. This treatment dissolves the majority of water-soluble substances and deactivates the enzyme systems.
- the water-soluble fraction is separated from the insoluble fraction by filtration (the fat-soluble vitamins are absent from the recovered fraction, since the latter contains only water-soluble substances).
- the water fraction is concentrated by heating to 100 ° C / 110 ° C until a dehydrated product is obtained.
- This extract is ground and reduced to a powder completely soluble in water.
- the extracts of vegetables and fruits after having carried out anti-hydrogen peroxide activity measurements, the extracts of vegetables and fruits, devoid of fat-soluble vitamins (carotenoids, vitamin E), of water-soluble vitamins (vitamin C) will be chosen. ) and enzymes which can be mixed, from those giving the highest results for elimination of this type of active O 2 . In this case, the activity of active oxygen is systematically inhibited. The number of vegetables or fruits capable of being endowed with high anti-hydrogen peroxide properties is thus limited.
- the extracts of vegetables and fruits will be chosen according to their anti-hydrogen peroxide capacities. They will be used as food supplements, in the form of capsules, tablets; capsules, in aqueous solution for example.
- the extracts of vegetables and fruits characterized by their anti-peroxidic action will advantageously be incorporated into preparations intended to be applied to the skin to protect it from aggressive effects of solar radiation or any other aggression triggering an inflammatory oxidative process, by activation of phagocytic cells, producing oxygenated water (wounds, burns, microbial action)
- extracts are introduced to obtain a minimum hydrogen antiperoxide capacity of 100 ⁇ g / O 2 per intake.
- the extracts used in skin applications are introduced at the minimum concentration of 100 ⁇ g / O 2 of anti-hydrogen peroxide capacity per gram of emulsion.
- Anti-peroxide capacity 200 ⁇ g / O 2 -In the form of 200mg tablets
- the invention also relates to a composition
- a composition comprising from 99 to 95% by weight of a base for topical application, characterized in that it comprises from 1 to 15% by weight of a plant extract produced from fruits and vegetables food
- the topical base can consist of an oily phase containing the extract used according to the invention and dispersed in an aqueous phase or of a aqueous phase containing the extract used according to the invention and dispersed in an oily phase.
- the topical base can also consist of the elements necessary for the production of a gel or a lotion and comprising in particular glycerin and a polysorbate.
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Abstract
Description
UTILISATION DE VEGETAUX ALIMENTAIRES POUR LEUR ACTIVITE DESTRUCTRICE DU PEROXYDE D ' HYDROGENE .USE OF FOOD PLANTS FOR THEIR DESTRUCTIVE ACTIVITY OF HYDROGEN PEROXIDE.
II a été largement démontré que les systèmes peroxydatifs tels que l'eau oxygénée et les lipoperoxydes ; conduisent à la formation de molécules toxiques pour l'organisme :It has been widely demonstrated that peroxidative systems such as hydrogen peroxide and lipoperoxides; lead to the formation of molecules toxic to the body:
Radicaux libres ; eau oxygénée sont des oxydants produits naturellement par l'organisme , dans les mitochondries. Ils interviennent au cours de la phagocytose ; leur accumulation est dangereuse.Free radicals ; hydrogen peroxide are oxidants produced naturally by the body, in the mitochondria. They intervene during phagocytosis; their accumulation is dangerous.
De tels systèmes peroxydatifs ont surtout pour origine l'intervention des radicaux libres ; tel l'anion superoxyde O2 ° qui génère l'eau oxygénée H2 02, conduisant à des radicaux hydroxyles qui interviennent dans le processus de lipoperoxydation.Such peroxidative systems mainly originate from the intervention of free radicals; such as the superoxide anion O 2 ° which generates hydrogen peroxide H 2 0 2 , leading to hydroxyl radicals which are involved in the lipoperoxidation process.
Or les espèces réactives d'oxygène comme l'anion superoxyde, les radicaux hydroxyles ainsi que l'eau oxygénée, provoquent la formation de systèmes inflammatoires, en dégradant une variété de molécules intra et extra -cellulaires.However, reactive oxygen species such as the superoxide anion, hydroxyl radicals and oxygenated water, cause the formation of inflammatory systems, degrading a variety of intra- and extra-cellular molecules.
Aussi, la déficience en antioxydants et enzymes protectrices peut dans certaines circonstances ; par exemple dans le cas d'une brûlure, ne plus être en mesure d'inactiver les polynucléaires neutrophiles : C'est ainsi que pour certains auteurs, une augmentation du niveau de l'eau oxygénée et du radical superoxyde produits par les macrophages, serait la cause majeure du stress oxydatif et des dommages cellulaires qui en sont la conséquence.Also, the deficiency in antioxidants and protective enzymes can under certain circumstances; for example in the case of a burn, no longer being able to inactivate neutrophils: This is how, for some authors, an increase in the level of hydrogen peroxide and the superoxide radical produced by macrophages, would be the major cause of oxidative stress and the cellular damage that results from it.
Ainsi, par exemple, en cas de déficience d'antioxydants naturels, tel le glutathion réduit, principal antioxygène de l'organisme, il a été constaté, la présence d'eau oxygénée dans l'humeur vitrée, et dans la rétine. (MAUGER T, LANSON L. J. Toxicol. Cutaneous Ocul 1992,44 (4) 369) Que des cellules épithéliales soumises à 2 nM d'eau oxygénée, accusent une chute de glutathion réduit, de plus de 80% (FERRANDELLI J et Col. Neuropatho Exp. Neurol. 1971 60 638) Que l'eau oxygénée induit le stress oxydatif du muscle cardiaque (JANERO D et Col. J. Cell.Physiol : 1991 149 (3) 247)Thus, for example, in case of deficiency of natural antioxidants, such as reduced glutathione, the main antioxidant in the body, it has been found, the presence of hydrogen peroxide in the vitreous humor, and in the retina. (MAUGER T, LANSON LJ Toxicol. Cutaneous Ocul 1992,44 (4) 369) That epithelial cells subjected to 2 nM hydrogen peroxide show a fall in glutathione reduced by more than 80% (FERRANDELLI J and Col. Neuropatho Exp. Neurol. 1971 60 638) That hydrogen peroxide induces the oxidative stress of the heart muscle (JANERO D and Col. J. Cell.Physiol: 1991 149 (3) 247)
Chez le végétal, au stade de dépassement du mûrissement des fruits, on observe une augmentation du peroxyde d'hydrogène, cette maturité pouvant être retardée par inhibition de l'eau oxygénée (PAULS K THOMPSON J-Plant Physiol. 1984 75 1152)In plants, when fruit ripening is over, an increase in hydrogen peroxide is observed, this maturity being able to be delayed by inhibition of hydrogen peroxide (PAULS K THOMPSON J-Plant Physiol. 1984 75 1152)
Chez les fumeurs, l'activité des macrophages augmentant, provoque une production anormalement élevée d'eau oxygénée. Aussi une déficience en catalase ou en peroxydases (enzymes anti-peroxydantes) peut conduire à de graves états pathologiques.In smokers, the activity of macrophages increasing, causes an abnormally high production of oxygenated water. Also a deficiency in catalase or peroxidases (anti-peroxidizing enzymes) can lead to serious medical conditions.
Aujourd'hui, on sait qu'il existe une alimentation oxydative qu'il est impératif de combattre grâce aux propriétés antiradicalaires et antilipoperoxydes des légumes et des fruits, (brevets français N° 97 07273 et N° 99 11752) Quant à la destruction du peroxyde d'hydrogène (H202) en dehors des enzymes spécifiques, et surtout du glutathion, il n'a jamais été décrit jusqu'ici, que des aliments étaient en mesure de le décomposer.Today, we know that there is an oxidative diet that it is imperative to fight thanks to the anti-radical and antilipoperoxid properties of vegetables and fruits, (French patents N ° 97 07273 and N ° 99 11752) As for the destruction of hydrogen peroxide (H 2 0 2 ) apart from specific enzymes, and especially glutathione, it has never been described until now, that food was able to break it down.
1- PCT WO 98/000241- PCT WO 98/00024
Ce document concerne un supplément nutritionnel, destiné à augmenter les lipoprotéines lourdes : HDL et les ions calcium, et diminuer les radicaux libres et le glucose dans le plasma, caractérisé en ce qu'il comporte de l'orge vert, des vitamines et un extrait de Ginkgo Biloba : D'autre part ces compléments nutritionnels comportent des jus de légumes riches en vitamines L'exemple 10 de la description, il décrit un mélange de diverses substances aux propriétés anti-oxydantes connues : vitamines + sélénium avec des concentrés de jus de fruits et de légumes. Il n'est pas question de désoxygénation de l'eau oxygénée. 2-002251421This document relates to a nutritional supplement, intended to increase heavy lipoproteins: HDL and calcium ions, and decrease free radicals and glucose in plasma, characterized in that it comprises green barley, vitamins and an extract Ginkgo Biloba: On the other hand these nutritional supplements include vegetable juices rich in vitamins Example 10 of the description, it describes a mixture of various substances with known antioxidant properties: vitamins + selenium with concentrated juice fruits and vegetables. There is no question of deoxygenation of oxygenated water. 2-002251421
OKADA YOSHINORI ET AL :"Scaving effect of water soluble proteins in broad beans on free radicals and active oxygen species" JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol 46, no. 2, février 1998 (1998- 02), pages 401-406, XP002251421 ISSN: 0021-8561OKADA YOSHINORI ET AL: "Scaving effect of water soluble proteins in broad beans on free radicals and active oxygen species" JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol 46, no. 2, February 1998 (1998-02), pages 401-406, XP002251421 ISSN: 0021-8561
Ce documents concerne des protéines solubles extraites de la fève obtenues par un traitement de solubilisa-ion chimique : So4(NH4)2. Même si ces protéines détruisent l'eau oxygénée, les extraits de légumes et de fruits ne comportent pas de protéine.This document relates to soluble proteins extracted from the bean obtained by a chemical solubilization treatment: So4 (NH4) 2. Even though these proteins destroy hydrogen peroxide, vegetable and fruit extracts do not contain protein.
3- 0022514223- 002251422
RISO P ET AL : " Does tomato consumption effectively increase the résistance of lymphocyte DNA to oxidative damage?"RISO P ET AL: "Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage?"
AMERICAN JOURNAL OF CLINICAL NUTRITION 69 (4) 712-718 1999 DEP.OF FOOD SCI. 1 TECHN., DIV.OF HUMAN NUTR., UNIV.OF MILAN, 20-133 MILAN, 20-133MILAN, ITALIE. E-MAIL NUTR_LAB (A) IMIUCCA.CSI.UNIMI.IT XP 002251422AMERICAN JOURNAL OF CLINICAL NUTRITION 69 (4) 712-718 1999 DEP.OF FOOD SCI. 1 TECHN., DIV.OF HUMAN NUTR., UNIV.OF MILAN, 20-133 MILAN, 20-133MILAN, ITALY. E-MAIL NUTR_LAB (A) IMIUCCA.CSI.UNIMI.IT XP 002251422
4-0022514234-002251423
Ce documents concerne le jus de tomate, caractérisé par la présence de lycopène, caroténoïde liposoluble, absent des extraits de légumes et de fruits.This document relates to tomato juice, characterized by the presence of lycopene, a fat-soluble carotenoid, absent from vegetable and fruit extracts.
4-0022514244-002251424
PHAN TOAN-THANG ET AL : "Protective effects of curcumin against oxidative damage on skin cells in vitro: Its implication for wound healing." Database accession no. PREV200200040617 XP002251423PHAN TOAN-THANG ET AL: "Protective effects of curcumin against oxidative damage on skin cells in vitro: Its implication for wound healing." Database accession no. PREV200200040617 XP002251423
Il s'agit de l'action anti-peroxyde d'hydrogène du Curcuma, qui n'est ni un légume ; ni un fruit mais une épice. DATABASE WPI section Ch, Week 200149 Derwent Publication Ltd., GB ; Class B04, AN 2001-453935 XP002251424It is the anti-hydrogen peroxide action of Turmeric, which is neither a vegetable; neither a fruit but a spice. DATABASE WPI section Ch, Week 200149 Derwent Publication Ltd., GB; Class B04, AN 2001-453935 XP002251424
Concerne l'élimination de l'oxygène de l'eau oxygénée par des essences de plantes.Relates to the removal of oxygen from oxygenated water by plant essences.
DATABASE WPI Section Ch, Week 200206 Derwent Publications Ltd., London GB ; Class B04, AN 2002-044554 XP002251425DATABASE WPI Section Ch, Week 200206 Derwent Publications Ltd., London GB; Class B04, AN 2002-044554 XP002251425
Ce documents concerne des extraits de gaines de Paprika donc d'une épice comme désoxygènant de l'eau oxygénée.This document relates to extracts of Paprika sheaths, therefore from a spice as oxygen scavenger of oxygenated water.
US 5 895 652US 5,895,652
Il n'est pas fait mention d'eau oxygénée.There is no mention of hydrogen peroxide.
EP 1 064 855 A1EP 1 064 855 A1
Il s'agit d'un certain nombre de légumes permettant la prolifération de Bifido Bacterium, d'une action préventive contre l'allergie, d'une diminution du cholestérol. L'eau oxygénée n'est nullement mentionnée dans le texte.It is a number of vegetables allowing the proliferation of Bifido Bacterium, a preventive action against allergy, a decrease in cholesterol. Oxygenated water is not mentioned in the text at all.
II a été observé, ce qui est surprenant, que certains extraits de légumes et fruits alimentaires étaient doués d'une activité destructive du peroxyde d'hydrogène (H202) similaire à celle des enzymes : peroxydases et catalase, conduisant à la formation d'eau et d'oxygène moléculaire.It has been observed, which is surprising, that certain extracts of edible vegetables and fruits were endowed with a destructive activity of hydrogen peroxide (H 2 0 2 ) similar to that of enzymes: peroxidases and catalase, leading to the formation water and molecular oxygen.
Ces extraits végétaux alimentaires ont fait l'objet de travaux mettant en lumière leurs propriétés antiradicalaires et particulièrement leur propriétés antilipoperoxydes. Le milieu réactionnel de ces activités étant lipophile (oxydation des matières grasses). Dans le cadre de l'invention l'activité anti-peroxyde d'hydrogène se réalise en milieu hydrophile. La présente invention a pour objet de réaliser des extraits végétaux alimentaires à partir de légumes ou de fruits caractérisés par leur activité antiperoxyde d'hydrogène.These plant food extracts have been the subject of work highlighting their anti-free radical properties and particularly their anti-lipoperoxid properties. The reaction medium for these activities is lipophilic (oxidation of fat). In the context of the invention, the anti-hydrogen peroxide activity is carried out in a hydrophilic medium. The object of the present invention is to produce plant food extracts from vegetables or fruits characterized by their hydrogen antiperoxide activity.
Voici quelques exemples des capacités anti-peroxyde d'hydrogène, pour 1g d'extraits de fruits et de légumes, exprimées en microgrammes d'oxygène ; Les mesures étant effectuées par potentiométrie.Here are some examples of the anti-hydrogen peroxide capacities, for 1g of fruit and vegetable extracts, expressed in micrograms of oxygen; The measurements being carried out by potentiometry.
La présente invention a pour objet la réalisation d' extraits destinés à être utilisés comme compléments alimentaires, mais également en application cutanée dans les domaines de la cosmétique, de la dermatologie humaine et animale.The subject of the present invention is the production of extracts intended for use as food supplements, but also in cutaneous application in the fields of cosmetics, human and animal dermatology.
Les extraits de légumes ou de fruits sont obtenus en introduisant le végétal alimentaire dans de l'eau on porte le tout à ébullition, le milieu ayant été mixé afin d'avoir de petites particules. L'ébullition est maintenue pendant une durée moyenne de 30 mn. Ce traitement permet de solubiliser la majorité des substances hydrosolubles et de désactiver les systèmes enzymatiques.The extracts of vegetables or fruits are obtained by introducing the food plant in water, the whole is brought to a boil, the medium having been mixed. in order to have small particles. The boiling is maintained for an average duration of 30 min. This treatment dissolves the majority of water-soluble substances and deactivates the enzyme systems.
On sépare la fraction hydrosoluble de l'insoluble par filtration (les vitamines liposolubles sont absentes de la fraction récupérée, puisque celle-ci ne contient que des substances hydrosolubles).The water-soluble fraction is separated from the insoluble fraction by filtration (the fat-soluble vitamins are absent from the recovered fraction, since the latter contains only water-soluble substances).
La fraction hydrique est concentrée par chauffage à 100° C/110° C jusqu'à obtention d'un produit déshydraté.The water fraction is concentrated by heating to 100 ° C / 110 ° C until a dehydrated product is obtained.
Cet extrait est broyé et réduit en une poudre totalement soluble dans l'eau.This extract is ground and reduced to a powder completely soluble in water.
Les différentes phases de chauffage conduisent à la destruction des vitamines hydrosolubles telles que les vitamines C ou B.The different heating phases lead to the destruction of water-soluble vitamins such as vitamins C or B.
Dans le cadre de l'invention, on choisira après avoir effectué des mesures d'activité anti-peroxydes d'hydrogène, les extraits de légumes et de fruits, dépourones de vitamines liposolubles (caroténoïdes, vitamine E), de vitamines hydrosolubles (vitamine C) et d'enzymes dont on pourra faire des mélanges, à partir de ceux donnant les résultats les plus élevés pour élimination de ce type d'02 actif. Dans ce cas, l'activité de l'oxygène actif est systématiquement inhibée . Le nombre de légumes ou de fruits capables d'être doués de hautes propriétés anti-peroxyde d'hydrogène se trouve ainsi limité.In the context of the invention, after having carried out anti-hydrogen peroxide activity measurements, the extracts of vegetables and fruits, devoid of fat-soluble vitamins (carotenoids, vitamin E), of water-soluble vitamins (vitamin C) will be chosen. ) and enzymes which can be mixed, from those giving the highest results for elimination of this type of active O 2 . In this case, the activity of active oxygen is systematically inhibited. The number of vegetables or fruits capable of being endowed with high anti-hydrogen peroxide properties is thus limited.
Afin de combattre les peroxydes exogènes, plus particulièrement d'origine alimentaire, mais principalement le peroxyde d'hydrogène endogène, les extraits de légumes et de fruits seront choisis en fonction de leurs capacités anti-peroxyde d'hydrogène. Ils seront utilisés comme compléments alimentaires, sous forme de gélules, comprimés; capsules, en solution aqueuse par exemple.In order to combat exogenous peroxides, more particularly of food origin, but mainly endogenous hydrogen peroxide, the extracts of vegetables and fruits will be chosen according to their anti-hydrogen peroxide capacities. They will be used as food supplements, in the form of capsules, tablets; capsules, in aqueous solution for example.
Les extraits de légumes et de fruits caractérisés par leur action anti- peroxydique (H202) seront avantageusement incorporés dans des préparations destinées à être appliquées su la peau pour la protéger des effets agressifs des radiations solaires ou de toute autre agression déclenchant un processus oxydatif inflammatoire, par activation des cellules phagocytaires, productrices d'eau oxygénée (blessures, brûlures, action microbienne)The extracts of vegetables and fruits characterized by their anti-peroxidic action (H 2 0 2 ) will advantageously be incorporated into preparations intended to be applied to the skin to protect it from aggressive effects of solar radiation or any other aggression triggering an inflammatory oxidative process, by activation of phagocytic cells, producing oxygenated water (wounds, burns, microbial action)
C'est ainsi, que pour les compléments alimentaires, on aura recours à titre d'exemple à des extraits tels que ceux de Brocoli, doués d'une forte capacité anti-peroxyde d'hydrogène,tandis que dans le cadre d'applications cutanée, on aura recours par exemple à des extraits comme ceux, de petit pois ou d'endive :Thus, for food supplements, we will use, for example, extracts such as Broccoli, endowed with a strong anti-hydrogen peroxide capacity, while in the context of skin applications , we will use for example extracts like those, of pea or endive:
Il est bien connu, que les radiations solaires sont agressives pour la peau, provoquant l'altération du tissu conjonctif et de ce fait, une activation des polynucléaires neutrophiles, producteurs ; de l'anion superoxyde et d'eau oxygénée. Ceci montre tout l'intérêt d'avoir recours aux extraits de légumes et de fruits dans les préparations cosmétiques contre le vieillissements prématuré de la peau :It is well known that solar radiation is aggressive to the skin, causing damage to the connective tissue and, therefore, activation of the producing neutrophils; superoxide anion and hydrogen peroxide. This shows the value of using vegetable and fruit extracts in cosmetic preparations against premature aging of the skin:
Exemples non limitatifs de compositions contenant des extraits de légumes et de fruits destructeurs du peroxyde d'hydrogène, destinées à la réalisation de compléments alimentaires ou à la l'application cutanée. Pour les compléments alimentaires, on introduit des extraits permettant d'obtenir une capacité antiperoxyde d'hydrogène minimale de 100μg/O2 par prise. Les extraits utilisés en applications cutanée sont introduits à la concentration minimale de 100μg/O2 de capacité anti-peroxyde d'hydrogène par gramme d'émulsion.Non-limiting examples of compositions containing extracts of vegetables and fruits destructive of hydrogen peroxide, intended for the production of food supplements or for skin application. For food supplements, extracts are introduced to obtain a minimum hydrogen antiperoxide capacity of 100 μg / O 2 per intake. The extracts used in skin applications are introduced at the minimum concentration of 100 μg / O 2 of anti-hydrogen peroxide capacity per gram of emulsion.
En Compléments AlimentairesIn Food Supplements
-Sous forme de gélules de 200mg-In the form of 200mg capsules
Extraits de brocoli 42mgBroccoli extracts 42mg
Capacité anti-peroxyde : 200μg/O2 -Sous forme de comprimés de 200mgAnti-peroxide capacity: 200μg / O 2 -In the form of 200mg tablets
Extrait d'endive : 55mg Capacité anti-peroxyde : 200μg/O2 Endive extract: 55mg Anti-peroxide capacity: 200μg / O 2
En Application CutanéeIn Skin Application
1 ) Excipient 95g1) Excipient 95g
Extraits d'endive 5gEndive extracts 5g
(éliminant 3600 μg/02 par g)(eliminating 3600 μg / 0 2 per g)
Soit par g d'émulsion, une capacité destructrice d'oxygène peroxydique de 180μg O2 Either per g of emulsion, a destructive capacity of peroxidic oxygen of 180 μg O 2
2) Excipient 94g Extrait de petit pois 5g2) Excipient 94g Pea extract 5g
(éliminant 3754 μg/02 par g) Extrait de Maïs 7g(eliminating 3754 μg / 0 2 per g) Corn extract 7g
(éliminant 2084 μg 02 par g)(eliminating 2084 μg 0 2 per g)
Soit une capacité destructrice d'oxygène peroxydique de 188μg / 02 et de 146μg/02 par g de crème.Or a destructive capacity of peroxidic oxygen of 188 μg / 0 2 and 146 μg / 0 2 per g of cream.
L'invention vise aussi une composition comprenant de 99 à 95% en poids d' une base pour application topique, caractérisée en ce qu'elle comprend de 1 à 15% en poids d'un extrait végétal produit à partir de fruits et de légumes alimentairesThe invention also relates to a composition comprising from 99 to 95% by weight of a base for topical application, characterized in that it comprises from 1 to 15% by weight of a plant extract produced from fruits and vegetables food
La base topique peut être constituée d'une phase huileuse contenant l'extrait utilisé suivant l'invention et dispersée dans une phase aqueuse ou d'une phase aqueuse contenant l'extrait utilisé suivant l'invention et dispersée dans une phase huileuse. La base topique peut être aussi constituée des éléments nécessaires à la réalisation d'un gel ou d'une lotion et comprenant notamment de la glycérine et un polysorbate. On donne ci-dessus quelques exemples de formulations topiquesThe topical base can consist of an oily phase containing the extract used according to the invention and dispersed in an aqueous phase or of a aqueous phase containing the extract used according to the invention and dispersed in an oily phase. The topical base can also consist of the elements necessary for the production of a gel or a lotion and comprising in particular glycerin and a polysorbate. Some examples of topical formulations are given above
Formule crème eau/huile :Water / oil cream formula:
Phase huileuse :Oily phase:
Methoxy PEG-22 Dodécyl glycol copolymère 5 % Acide stéarique 3 %Methoxy PEG-22 Dodecyl glycol copolymer 5% Stearic acid 3%
Huile paraffinique 10 %Paraffinic oil 10%
Phase aqueuse : Aqua Qs100 %Water phase: Aqua Qs100%
Glycérine 5 %Glycerin 5%
Extrait de pois 1 - 2 %Pea extract 1 - 2%
Conservateur 0,4 % Parfum 0,4 %Preservative 0.4% Perfume 0.4%
Formule crème huile/eau :Oil / water cream formula:
Phase huileuse :Oily phase:
Cetearyl glycosides de son de blé/Cetearyl alcohol 4 % Dimethicone 2 %Cetearyl glycosides of wheat bran / Cetearyl alcohol 4% Dimethicone 2%
Huile de grain de Macadamia Temifolia 8 %Macadamia Temifolia grain oil 8%
Propyl Paraben 0,1 %Propyl Paraben 0.1%
Phase aqueuse : Aqua Qs100 %Water phase: Aqua Qs100%
Glycérine 5 %Glycerin 5%
Extrait d'endives 1 - 2 %Endive extract 1 - 2%
Methyl paraben 0,2 % Parfum 0,4 % Gel :Methyl paraben 0.2% Perfume 0.4% Gel:
Aqua QSP100 %Aqua QSP 100%
Extrait d'endives 1 - 2 %Endive extract 1 - 2%
Glycérine 5 %Glycerin 5%
Chondrus crispus (Carrageenan) 0,5 %Chondrus crispus (Carrageenan) 0.5%
Conservateur 0,5 %Preservative 0.5%
Polysorbate 20 1 ,4 %Polysorbate 20 1.4%
Parfum 0,1 %Perfume 0.1%
Lotion :Lotion:
Aqua QSP100 %Aqua QSP 100%
Extrait d'endives 1 - 2 % Glycérine 5 %Endive extract 1 - 2% Glycerin 5%
Conservateur 0,4 %Preservative 0.4%
Polysorbate 20 1 %Polysorbate 20 1%
Parfum 0,1 % Perfume 0.1%
Claims
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003295049A AU2003295049A1 (en) | 2002-11-22 | 2003-11-21 | Use of food plants for their hydrogen peroxide destroying activity |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0214623A FR2847426B1 (en) | 2002-11-22 | 2002-11-22 | FOOD VEGETABLE ANTI-HYDROGEN PEROXIDE |
| FR02/14623 | 2002-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2004047563A1 true WO2004047563A1 (en) | 2004-06-10 |
Family
ID=32241503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/FR2003/003445 Ceased WO2004047563A1 (en) | 2002-11-22 | 2003-11-21 | Use of food plants for their hydrogen peroxide destroying activity |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2003295049A1 (en) |
| FR (1) | FR2847426B1 (en) |
| WO (1) | WO2004047563A1 (en) |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4702915A (en) * | 1984-11-12 | 1987-10-27 | Innofinance Altalanos Innovacios Penzintezet | Skin regenerating cosmetic composition |
| WO1998000024A1 (en) * | 1996-06-28 | 1998-01-08 | Viva America Marketing, Inc. | Nutritional supplement composition and use |
| US5895652A (en) * | 1996-07-29 | 1999-04-20 | Longevity Institute International | Method of metabolic adjuvanation and cellular repair |
| EP1064855A1 (en) * | 1998-03-19 | 2001-01-03 | Sunstar Inc. | Foods, medical treatments and method relating to effects of promoting the growth of (lactobacillus bifidus), preventing allergy and lowering human cholesterol level |
| FR2798561A1 (en) * | 1999-09-21 | 2001-03-23 | Jean Morelle | COMPOSITIONS FOR FOOD AND COSMETIC USE, CHARACTERIZED BY THEIR ANTILIPOPEROXIDE PROPERTIES |
| JP2001131046A (en) * | 1999-11-04 | 2001-05-15 | Pola Chem Ind Inc | Hydrogen peroxide eliminant and cosmetic material containing the same |
| WO2001045661A2 (en) * | 1999-12-20 | 2001-06-28 | Cognis France, S.A. | Cosmetic and/or pharmaceutical preparations |
| FR2804318A1 (en) * | 2000-01-31 | 2001-08-03 | Serobiologiques Lab Sa | Cosmetic or pharmaceutical preparation comprises Brassicaaceae extract, especially broccoli extract |
| JP2001253831A (en) * | 2000-03-10 | 2001-09-18 | Yukiyo Iwai | Skin care preparation |
| EP1151744A1 (en) * | 2000-05-05 | 2001-11-07 | Laboratoire Nuxe | Cosmetic and/or dermatologic composition with enhanced stability |
| FR2834718A1 (en) * | 2002-01-15 | 2003-07-18 | Cognis France Sa | ACTIVE COSMETIC AND / OR PHARMACEUTICAL SUBSTANCES |
-
2002
- 2002-11-22 FR FR0214623A patent/FR2847426B1/en not_active Expired - Fee Related
-
2003
- 2003-11-21 WO PCT/FR2003/003445 patent/WO2004047563A1/en not_active Ceased
- 2003-11-21 AU AU2003295049A patent/AU2003295049A1/en not_active Abandoned
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4702915A (en) * | 1984-11-12 | 1987-10-27 | Innofinance Altalanos Innovacios Penzintezet | Skin regenerating cosmetic composition |
| WO1998000024A1 (en) * | 1996-06-28 | 1998-01-08 | Viva America Marketing, Inc. | Nutritional supplement composition and use |
| US5895652A (en) * | 1996-07-29 | 1999-04-20 | Longevity Institute International | Method of metabolic adjuvanation and cellular repair |
| EP1064855A1 (en) * | 1998-03-19 | 2001-01-03 | Sunstar Inc. | Foods, medical treatments and method relating to effects of promoting the growth of (lactobacillus bifidus), preventing allergy and lowering human cholesterol level |
| FR2798561A1 (en) * | 1999-09-21 | 2001-03-23 | Jean Morelle | COMPOSITIONS FOR FOOD AND COSMETIC USE, CHARACTERIZED BY THEIR ANTILIPOPEROXIDE PROPERTIES |
| JP2001131046A (en) * | 1999-11-04 | 2001-05-15 | Pola Chem Ind Inc | Hydrogen peroxide eliminant and cosmetic material containing the same |
| WO2001045661A2 (en) * | 1999-12-20 | 2001-06-28 | Cognis France, S.A. | Cosmetic and/or pharmaceutical preparations |
| FR2804318A1 (en) * | 2000-01-31 | 2001-08-03 | Serobiologiques Lab Sa | Cosmetic or pharmaceutical preparation comprises Brassicaaceae extract, especially broccoli extract |
| JP2001253831A (en) * | 2000-03-10 | 2001-09-18 | Yukiyo Iwai | Skin care preparation |
| EP1151744A1 (en) * | 2000-05-05 | 2001-11-07 | Laboratoire Nuxe | Cosmetic and/or dermatologic composition with enhanced stability |
| FR2834718A1 (en) * | 2002-01-15 | 2003-07-18 | Cognis France Sa | ACTIVE COSMETIC AND / OR PHARMACEUTICAL SUBSTANCES |
Non-Patent Citations (6)
| Title |
|---|
| DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; November 2001 (2001-11-01), PHAN TOAN-THANG ET AL: "Protective effects of curcumin against oxidative damage on skin cells in vitro: Its implication for wound healing.", XP002251423, Database accession no. PREV200200040617 * |
| DATABASE WPI Section Ch Week 200149, Derwent World Patents Index; Class B04, AN 2001-453935, XP002251424 * |
| DATABASE WPI Section Ch Week 200206, Derwent World Patents Index; Class B04, AN 2002-044554, XP002251425 * |
| JOURNAL OF TRAUMA INJURY INFECTION AND CRITICAL CARE, vol. 51, no. 5, November 2001 (2001-11-01), pages 927 - 931, ISSN: 1079-6061 * |
| OKADA YOSHINORI ET AL: "Scavenging effect of water soluble proteins in broad beans on free radicals and active oxygen species.", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 46, no. 2, February 1998 (1998-02-01), pages 401 - 406, XP002251421, ISSN: 0021-8561 * |
| RISO P ET AL: "Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage?", AMERICAN JOURNAL OF CLINICAL NUTRITION 69 (4) 712-718 1999 DEP. OF FOOD SCI. & TECH., DIV. OF HUMAN NUTR., UNIV. OF MILAN, 20-133 MILAN, ITALY. E-MAIL NUTR_LAB(A)IMIUCCA.CSI.UNIMI.IT, XP002251422 * |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2847426A1 (en) | 2004-05-28 |
| AU2003295049A1 (en) | 2004-06-18 |
| FR2847426B1 (en) | 2006-02-24 |
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