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WO2004044190A3 - Zymogen-like protein c polypeptides - Google Patents

Zymogen-like protein c polypeptides Download PDF

Info

Publication number
WO2004044190A3
WO2004044190A3 PCT/DK2003/000775 DK0300775W WO2004044190A3 WO 2004044190 A3 WO2004044190 A3 WO 2004044190A3 DK 0300775 W DK0300775 W DK 0300775W WO 2004044190 A3 WO2004044190 A3 WO 2004044190A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
zymogen
polypeptides
variants
amidolytic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DK2003/000775
Other languages
French (fr)
Other versions
WO2004044190A2 (en
Inventor
Bobby Soni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maxygen ApS
Maxygen Holdings Ltd
Original Assignee
Maxygen ApS
Maxygen Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxygen ApS, Maxygen Holdings Ltd filed Critical Maxygen ApS
Priority to AU2003280316A priority Critical patent/AU2003280316A1/en
Publication of WO2004044190A2 publication Critical patent/WO2004044190A2/en
Publication of WO2004044190A3 publication Critical patent/WO2004044190A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to protein C variants wherein the cleavage site between the light chain and the heavy chain has been removed, in particular by substitution of K156 and/or R157, with the proviso that the substitutions are not K156R and R157K. Such variants have a lowered anticoagulant activity while retaining their amidolytic and anti-inflammatory properties.
PCT/DK2003/000775 2002-11-11 2003-11-11 Zymogen-like protein c polypeptides Ceased WO2004044190A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003280316A AU2003280316A1 (en) 2002-11-11 2003-11-11 Zymogen-like protein c polypeptides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200201732 2002-11-11
DKPA200201732 2002-11-11
US42540302P 2002-11-12 2002-11-12
US60/425,403 2002-11-12

Publications (2)

Publication Number Publication Date
WO2004044190A2 WO2004044190A2 (en) 2004-05-27
WO2004044190A3 true WO2004044190A3 (en) 2004-08-26

Family

ID=32313775

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2003/000775 Ceased WO2004044190A2 (en) 2002-11-11 2003-11-11 Zymogen-like protein c polypeptides

Country Status (2)

Country Link
AU (1) AU2003280316A1 (en)
WO (1) WO2004044190A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023119230A1 (en) 2021-12-22 2023-06-29 L'oreal Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0352651A1 (en) * 1988-07-26 1990-01-31 Hoechst Japan Limited Human protein C mutants and method for preparing the same
WO1991007484A1 (en) * 1989-11-14 1991-05-30 Teijin Limited Protein having activity like that of human protein c and/or activated human protein c
US5516650A (en) * 1985-06-27 1996-05-14 Zymogenetics, Inc. Production of activated protein C
WO2002032461A2 (en) * 2000-10-18 2002-04-25 Maxygen Aps Protein c or activated protein c-like molecules

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516650A (en) * 1985-06-27 1996-05-14 Zymogenetics, Inc. Production of activated protein C
EP0352651A1 (en) * 1988-07-26 1990-01-31 Hoechst Japan Limited Human protein C mutants and method for preparing the same
WO1991007484A1 (en) * 1989-11-14 1991-05-30 Teijin Limited Protein having activity like that of human protein c and/or activated human protein c
WO2002032461A2 (en) * 2000-10-18 2002-04-25 Maxygen Aps Protein c or activated protein c-like molecules

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 199124, Derwent World Patents Index; Class B04, AN 1991-178096, XP002286346 *

Also Published As

Publication number Publication date
AU2003280316A8 (en) 2004-06-03
AU2003280316A1 (en) 2004-06-03
WO2004044190A2 (en) 2004-05-27

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