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WO2004041830A3 - An improved process for the preparation of biotin - Google Patents

An improved process for the preparation of biotin Download PDF

Info

Publication number
WO2004041830A3
WO2004041830A3 PCT/IB2003/004974 IB0304974W WO2004041830A3 WO 2004041830 A3 WO2004041830 A3 WO 2004041830A3 IB 0304974 W IB0304974 W IB 0304974W WO 2004041830 A3 WO2004041830 A3 WO 2004041830A3
Authority
WO
WIPO (PCT)
Prior art keywords
biotin
preparation
improved process
formula
optically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2003/004974
Other languages
French (fr)
Other versions
WO2004041830A2 (en
Inventor
Pandurang Balwant Deshpande
Anil Ganpat Holkar
Sanjay Nivrutti Karale
Wajid Sajjad Jafri
Gautam Kumar Das
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orchid Pharma Ltd
Original Assignee
Orchid Chemicals and Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orchid Chemicals and Pharmaceuticals Ltd filed Critical Orchid Chemicals and Pharmaceuticals Ltd
Priority to AU2003276510A priority Critical patent/AU2003276510A1/en
Publication of WO2004041830A2 publication Critical patent/WO2004041830A2/en
Anticipated expiration legal-status Critical
Publication of WO2004041830A3 publication Critical patent/WO2004041830A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The present invention relates to an improved process for the preparation of optically active (+) biotin of formula (I) in pure form.
PCT/IB2003/004974 2002-11-07 2003-11-06 An improved process for the preparation of biotin Ceased WO2004041830A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003276510A AU2003276510A1 (en) 2002-11-07 2003-11-06 An improved process for the preparation of biotin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN815CH2002 2002-11-07
IN815/MAS/2002 2002-11-07

Publications (2)

Publication Number Publication Date
WO2004041830A2 WO2004041830A2 (en) 2004-05-21
WO2004041830A3 true WO2004041830A3 (en) 2005-05-26

Family

ID=32310093

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2003/004974 Ceased WO2004041830A2 (en) 2002-11-07 2003-11-06 An improved process for the preparation of biotin

Country Status (2)

Country Link
AU (1) AU2003276510A1 (en)
WO (1) WO2004041830A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101195629B (en) * 2006-12-05 2010-05-19 浙江医药股份有限公司新昌制药厂 D-biotin purification process
CN104710437B (en) * 2015-04-04 2017-01-25 富阳科兴生物化工有限公司 Improved method for preparing d-biotin from bisbenzyl biotin by debenzylation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2489238A (en) * 1948-06-08 1949-11-22 Hoffmann La Roche Debenzylation of benzylated imidazolido-thiophane compounds
WO1998043979A1 (en) * 1997-03-27 1998-10-08 Merck Patent Gmbh Method for debenzylation of dibenzyl biotin
DE19962661A1 (en) * 1998-12-24 2000-06-29 Sumitomo Chemical Co Hexahydro-2-oxo-1H-thieno (3,4-d) imidazole-4-pentanoic acid preparation from benzylated analog using inexpensive sulfuric acid, used e.g. as food or feed additive
CN1374312A (en) * 2002-03-27 2002-10-16 复旦大学 Synthetic method of d-biotin

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2489238A (en) * 1948-06-08 1949-11-22 Hoffmann La Roche Debenzylation of benzylated imidazolido-thiophane compounds
WO1998043979A1 (en) * 1997-03-27 1998-10-08 Merck Patent Gmbh Method for debenzylation of dibenzyl biotin
DE19962661A1 (en) * 1998-12-24 2000-06-29 Sumitomo Chemical Co Hexahydro-2-oxo-1H-thieno (3,4-d) imidazole-4-pentanoic acid preparation from benzylated analog using inexpensive sulfuric acid, used e.g. as food or feed additive
CN1374312A (en) * 2002-03-27 2002-10-16 复旦大学 Synthetic method of d-biotin

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEN F-E ET AL: "Synthetic Studies on d-Biotin, Part 6:An Expeditious and Enantiocontrolled Approach to the Total Synthesis of d-Biotin via a Polymer-Supported Chiral Oxazaborolidine-Catalyzed Reduction of meso-Cyclic Imide Strategy", SYNTHESIS 2003 GERMANY, no. 14, 2003, pages 2155 - 2160, XP002278550, ISSN: 0039-7881 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2002, XP002278544, retrieved from STN Database accession no. 140:181254 *
POPSAVIN VELIMIR ET AL: "An efficient synthesis of (+)-oxybiotin from D-arabinose", TETRAHEDRON LETTERS, vol. 43, no. 12, 18 March 2002 (2002-03-18), pages 2281 - 2284, XP002278543, ISSN: 0040-4039 *

Also Published As

Publication number Publication date
AU2003276510A1 (en) 2004-06-07
WO2004041830A2 (en) 2004-05-21

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