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WO2003100030A3 - Kidney toxicity predictive genes - Google Patents

Kidney toxicity predictive genes Download PDF

Info

Publication number
WO2003100030A3
WO2003100030A3 PCT/US2003/006196 US0306196W WO03100030A3 WO 2003100030 A3 WO2003100030 A3 WO 2003100030A3 US 0306196 W US0306196 W US 0306196W WO 03100030 A3 WO03100030 A3 WO 03100030A3
Authority
WO
WIPO (PCT)
Prior art keywords
kidney toxicity
predictive genes
toxicity predictive
genes
kidney
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2003/006196
Other languages
French (fr)
Other versions
WO2003100030B1 (en
WO2003100030A2 (en
Inventor
Larry Kier
Timothy D Nolan
Usha Sankar
Maher Derbel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phase-1 Molecular Toxicology Inc
Original Assignee
Phase-1 Molecular Toxicology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phase-1 Molecular Toxicology Inc filed Critical Phase-1 Molecular Toxicology Inc
Priority to EP03741753A priority Critical patent/EP1506396A2/en
Priority to AU2003273154A priority patent/AU2003273154A1/en
Priority to CA002477688A priority patent/CA2477688A1/en
Publication of WO2003100030A2 publication Critical patent/WO2003100030A2/en
Anticipated expiration legal-status Critical
Publication of WO2003100030A3 publication Critical patent/WO2003100030A3/en
Publication of WO2003100030B1 publication Critical patent/WO2003100030B1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The invention provides kidney toxicity predictive genes which can be used to predict kidney toxicity in response to one or more agents.
PCT/US2003/006196 2002-02-27 2003-02-27 Kidney toxicity predictive genes Ceased WO2003100030A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP03741753A EP1506396A2 (en) 2002-02-27 2003-02-27 Kidney toxicity predictive genes
AU2003273154A AU2003273154A1 (en) 2002-02-27 2003-02-27 Kidney toxicity predictive genes
CA002477688A CA2477688A1 (en) 2002-02-27 2003-02-27 Kidney toxicity predictive genes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36112802P 2002-02-27 2002-02-27
US60/361,128 2002-02-27

Publications (3)

Publication Number Publication Date
WO2003100030A2 WO2003100030A2 (en) 2003-12-04
WO2003100030A3 true WO2003100030A3 (en) 2004-12-23
WO2003100030B1 WO2003100030B1 (en) 2005-05-06

Family

ID=29584275

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/006196 Ceased WO2003100030A2 (en) 2002-02-27 2003-02-27 Kidney toxicity predictive genes

Country Status (4)

Country Link
EP (1) EP1506396A2 (en)
AU (1) AU2003273154A1 (en)
CA (1) CA2477688A1 (en)
WO (1) WO2003100030A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1392871A4 (en) 2001-05-22 2006-04-19 Gene Logic Inc Molecular toxicology modeling
US7469185B2 (en) 2002-02-04 2008-12-23 Ocimum Biosolutions, Inc. Primary rat hepatocyte toxicity modeling
US7883858B2 (en) 2005-01-27 2011-02-08 Institute For Systems Biology Methods for identifying and monitoring drug side effects
CN116490882A (en) * 2020-09-24 2023-07-25 库瑞科技有限公司 AI laminated chip clinical prediction engine
CN116469463A (en) * 2022-12-28 2023-07-21 北京博奥晶方生物科技有限公司 A drug nephrotoxicity prediction method, device, system and medium

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DEBOUCK ET AL: "DNA microarrays in drug discovery and development", NATURE GENETICS SUPPLEMENT, vol. 21, January 1999 (1999-01-01), pages 48 - 50, XP002928673 *
DOOLEY ET AL: "A method to improve selection of molecular targets by circumventing the ADME pharmacokinetic system utilizing PharmArray DNA microarrays", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 303, 11 April 2003 (2003-04-11), pages 828 - 841, XP002982396 *
GERHOLD ET AL: "Better therapeutics through microarrays", NATURE GENETICS SUPPLEMENT, vol. 32, December 2002 (2002-12-01), pages 547 - 552, XP002982395 *
HUANG ET AL: "Assessment of Cisplatin-induced nephrotoxicity by microarray technology", TOXICOLOGICAL SCIENCES, vol. 63, 2001, pages 196 - 207, XP001096461 *
KRAMER ET AL: "Overview of the application of transcription profiling using selected nephrotoxicants for toxicology assessment", ENVIRONMENTAL HEALTH PERSPECTIVES, vol. 112, no. 4, March 2004 (2004-03-01), pages 460 - 464, XP002982394 *

Also Published As

Publication number Publication date
CA2477688A1 (en) 2003-12-04
WO2003100030B1 (en) 2005-05-06
AU2003273154A1 (en) 2003-12-12
EP1506396A2 (en) 2005-02-16
AU2003273154A8 (en) 2003-12-12
WO2003100030A2 (en) 2003-12-04

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