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WO2003039469A3 - Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1 - Google Patents

Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1 Download PDF

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Publication number
WO2003039469A3
WO2003039469A3 PCT/US2002/035539 US0235539W WO03039469A3 WO 2003039469 A3 WO2003039469 A3 WO 2003039469A3 US 0235539 W US0235539 W US 0235539W WO 03039469 A3 WO03039469 A3 WO 03039469A3
Authority
WO
WIPO (PCT)
Prior art keywords
heteroaryl derivatives
nociceptin receptor
receptor orl
ligands
superior
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/035539
Other languages
French (fr)
Other versions
WO2003039469A2 (en
Inventor
Deen Tulshian
Ginny D Ho
Fay W Ng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2003541761A priority Critical patent/JP4246066B2/en
Priority to IL16112002A priority patent/IL161120A0/en
Priority to SI200230259T priority patent/SI1442036T1/en
Priority to NZ532088A priority patent/NZ532088A/en
Priority to DE60208724T priority patent/DE60208724T2/en
Priority to HU0402329A priority patent/HUP0402329A2/en
Priority to CA002465871A priority patent/CA2465871C/en
Priority to BR0213907-3A priority patent/BR0213907A/en
Priority to MXPA04004276A priority patent/MXPA04004276A/en
Application filed by Schering Corp filed Critical Schering Corp
Priority to HK04105875.5A priority patent/HK1063019B/en
Priority to EP02802860A priority patent/EP1442036B1/en
Publication of WO2003039469A2 publication Critical patent/WO2003039469A2/en
Publication of WO2003039469A3 publication Critical patent/WO2003039469A3/en
Priority to IL161120A priority patent/IL161120A/en
Anticipated expiration legal-status Critical
Priority to NO20042294A priority patent/NO329026B1/en
Priority to CY20061100498T priority patent/CY1105208T1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Novel compounds of the formula (I), wherein R is optionally substituted heteroaryl or (a); R1 is H or C1-C6 alkyl; and R2 and R3 are -CH3, -OCH3 or halo; or a pharmaceutically acceptable salt or solvate thereof, pharmaceutical compositions therefore, and the use of said compounds in the treatment of pain, anxiety, cough, asthma, depression and alcohol abuse are disclosed.
PCT/US2002/035539 2001-11-07 2002-11-06 Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1 Ceased WO2003039469A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
MXPA04004276A MXPA04004276A (en) 2001-11-07 2002-11-06 Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1.
SI200230259T SI1442036T1 (en) 2001-11-07 2002-11-06 Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1
HK04105875.5A HK1063019B (en) 2001-11-07 2002-11-06 Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1
DE60208724T DE60208724T2 (en) 2001-11-07 2002-11-06 HETEROARYL DERIVATIVES AS BETTER LIGANDS OF THE NOCICEPTIN RECEPTOR ORL-1
HU0402329A HUP0402329A2 (en) 2001-11-07 2002-11-06 Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1 and pharmaceutical compositions containing them
CA002465871A CA2465871C (en) 2001-11-07 2002-11-06 Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1
BR0213907-3A BR0213907A (en) 2001-11-07 2002-11-06 Heteroaryl derivatives as superior ligands for orl-1 nociceptin receptor
JP2003541761A JP4246066B2 (en) 2001-11-07 2002-11-06 Heteroaryl derivatives as excellent ligands for the nociceptin receptor ORL-1
NZ532088A NZ532088A (en) 2001-11-07 2002-11-06 Heteroaryl derivatives as superior ligands for nociceptin receptor ORL-1 to be used in compositions to treat pain, cough and asthma
IL16112002A IL161120A0 (en) 2001-11-07 2002-11-06 Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1
EP02802860A EP1442036B1 (en) 2001-11-07 2002-11-06 Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1
IL161120A IL161120A (en) 2001-11-07 2004-03-28 Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1
NO20042294A NO329026B1 (en) 2001-11-07 2004-06-04 Heteroaryl derivatives, pharmaceutical compositions comprising the compounds and optionally the compounds together with one or more other agents, and the use of the compounds optionally with other agents for the preparation of preparations for the treatment of cough, pain, anxiety, asthma, depression or alcohol abuse.
CY20061100498T CY1105208T1 (en) 2001-11-07 2006-04-07 ETEOPARYL DERIVATIVES AS TOP BINDERS FOR THE NOCICEPTIN ORL-1 RECEPTOR

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33328401P 2001-11-07 2001-11-07
US60/333,284 2001-11-07

Publications (2)

Publication Number Publication Date
WO2003039469A2 WO2003039469A2 (en) 2003-05-15
WO2003039469A3 true WO2003039469A3 (en) 2003-10-16

Family

ID=23302135

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/035539 Ceased WO2003039469A2 (en) 2001-11-07 2002-11-06 Heteroaryl derivatives as superior ligands for nociceptin receptor orl-1

Country Status (26)

Country Link
US (1) US6727254B2 (en)
EP (1) EP1442036B1 (en)
JP (2) JP4246066B2 (en)
KR (1) KR100596261B1 (en)
CN (1) CN1252068C (en)
AR (1) AR037211A1 (en)
AT (1) ATE315566T1 (en)
BR (1) BR0213907A (en)
CA (1) CA2465871C (en)
CY (1) CY1105208T1 (en)
DE (1) DE60208724T2 (en)
DK (1) DK1442036T3 (en)
EC (1) ECSP045096A (en)
ES (1) ES2256590T3 (en)
HU (1) HUP0402329A2 (en)
IL (2) IL161120A0 (en)
MX (1) MXPA04004276A (en)
MY (1) MY126268A (en)
NO (1) NO329026B1 (en)
NZ (1) NZ532088A (en)
PE (1) PE20030719A1 (en)
PL (1) PL370269A1 (en)
RU (1) RU2327698C2 (en)
TW (1) TWI317360B (en)
WO (1) WO2003039469A2 (en)
ZA (1) ZA200403404B (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067950A1 (en) * 1998-07-27 2004-04-08 Schering-Plough Corporation High affinity ligands for nociceptin receptor ORL-1
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
US8729107B2 (en) * 2002-12-06 2014-05-20 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
CA2508165C (en) 2002-12-06 2014-05-06 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
WO2005089761A1 (en) * 2004-03-17 2005-09-29 Pfizer Limited Combination for treating inflammatory diseases
JP2008513368A (en) * 2004-09-15 2008-05-01 シェーリング−プラウ・リミテッド Process for preparing substituted 8-azabicyclo [3.2.1] octan-3-ols
DE102005016460A1 (en) 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclic cyclohexane derivatives for the treatment of substance dependence
PE20071159A1 (en) * 2005-10-31 2007-11-30 Schering Corp DERIVATIVES OF TROPANE 3-MONOSUSTITUTED AS LIGANDS OF NOCICEPTIN RECEPTORS
DE102006046745A1 (en) * 2006-09-29 2008-04-03 Grünenthal GmbH Use of spirocyclic cyclohexane-derivative exhibiting an affinity for opioid-receptor and opioid receptor-like-1-receptor, for producing a medicament e.g. for treating diabetic neuropathy, for narcosis or for analgesia during narcosis
CA2730288C (en) * 2008-07-21 2016-09-13 Purdue Pharma L.P. Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof
GB201004311D0 (en) 2010-03-15 2010-04-28 Proximagen Ltd New enzyme inhibitor compounds
GB201115853D0 (en) 2011-09-14 2011-10-26 Proximagen Ltd New enzyme inhibitor compounds
US9724340B2 (en) * 2015-07-31 2017-08-08 Attenua, Inc. Antitussive compositions and methods
WO2025085818A1 (en) * 2023-10-19 2025-04-24 Purdue Pharma L.P. Sunobinop for use in method of treating alcohol use disorder

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001007050A1 (en) * 1999-07-26 2001-02-01 Schering Corporation Nociceptin receptor orl-1 agonists for use in treating cough

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352707A (en) 1992-03-26 1994-10-04 Harbor Branch Oceanographic Institution, Inc. Method for treating airway congestion
TW590268U (en) * 2000-08-08 2004-06-01 Wistron Corp Heat dissipating device

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001007050A1 (en) * 1999-07-26 2001-02-01 Schering Corporation Nociceptin receptor orl-1 agonists for use in treating cough

Also Published As

Publication number Publication date
JP4246066B2 (en) 2009-04-02
ATE315566T1 (en) 2006-02-15
CN1252068C (en) 2006-04-19
DE60208724D1 (en) 2006-04-06
CN1582288A (en) 2005-02-16
KR100596261B1 (en) 2006-06-30
HUP0402329A2 (en) 2005-02-28
RU2004117542A (en) 2006-01-10
PE20030719A1 (en) 2003-08-28
KR20050043725A (en) 2005-05-11
TWI317360B (en) 2009-11-21
IL161120A (en) 2010-11-30
MXPA04004276A (en) 2004-08-11
CY1105208T1 (en) 2010-03-03
DE60208724T2 (en) 2006-11-02
NO20042294L (en) 2004-07-15
JP2009035556A (en) 2009-02-19
NZ532088A (en) 2006-05-26
MY126268A (en) 2006-09-29
ES2256590T3 (en) 2006-07-16
WO2003039469A2 (en) 2003-05-15
AR037211A1 (en) 2004-10-27
PL370269A1 (en) 2005-05-16
ECSP045096A (en) 2004-06-28
EP1442036B1 (en) 2006-01-11
EP1442036A2 (en) 2004-08-04
US20030119847A1 (en) 2003-06-26
NO329026B1 (en) 2010-08-02
CA2465871A1 (en) 2003-05-15
RU2327698C2 (en) 2008-06-27
HK1063019A1 (en) 2004-12-10
CA2465871C (en) 2009-01-20
JP2005508367A (en) 2005-03-31
DK1442036T3 (en) 2006-05-15
IL161120A0 (en) 2004-08-31
BR0213907A (en) 2004-09-28
ZA200403404B (en) 2005-08-15
US6727254B2 (en) 2004-04-27
TW200301765A (en) 2003-07-16

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