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WO2003037920A3 - Especes proteiques botuliniques c3 a deficience enzymatique et leur utilisation pour favoriser la croissance neuronale et la regenerescence neuronale - Google Patents

Especes proteiques botuliniques c3 a deficience enzymatique et leur utilisation pour favoriser la croissance neuronale et la regenerescence neuronale Download PDF

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Publication number
WO2003037920A3
WO2003037920A3 PCT/EP2002/012039 EP0212039W WO03037920A3 WO 2003037920 A3 WO2003037920 A3 WO 2003037920A3 EP 0212039 W EP0212039 W EP 0212039W WO 03037920 A3 WO03037920 A3 WO 03037920A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
peptides
deficient
enzyme
regeneration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2002/012039
Other languages
English (en)
Other versions
WO2003037920A2 (fr
Inventor
Ingo Just
Fred Hofmann
Gudrun Ahnert-Hilger
Gisela Grosse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Charite Universitaetsmedizin Berlin
Original Assignee
Universitatsklinikum Charite Berlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitatsklinikum Charite Berlin filed Critical Universitatsklinikum Charite Berlin
Priority to CA002465371A priority Critical patent/CA2465371A1/fr
Priority to EP02772399A priority patent/EP1444256A2/fr
Priority to US10/493,864 priority patent/US20050255543A1/en
Priority to AU2002337176A priority patent/AU2002337176A1/en
Publication of WO2003037920A2 publication Critical patent/WO2003037920A2/fr
Publication of WO2003037920A3 publication Critical patent/WO2003037920A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des séquences nucléotidiques et leurs protéines et peptides à déficience enzymatique qui régulent la croissance des neurites, notamment la croissance axonale, des agents de reconnaissance, et les utilisations thérapeutiques et diagnostiques desdites protéines et desdits peptides. L'invention concerne également l'utilisation de protéines/dérivés peptidiques C3 inactifs enzymatiques ou à déficience enzymatique dérivés du Clostridium botulinum pour réguler la croissance, l'expansion et/ou la différentiation de neurones et de cellules embryonnaires neuronales ainsi que pour régénérer les neurones. Selon un mode de réalisation spécifique de l'invention, des protéines et des peptides peuvent être utilisés pour favoriser la régénérescence d'axones neuronaux sur de longues distances suite à une lésion de la moëlle épinière. Lesdites protéines et lesdits peptides permettent l'excroissance des neurites, notamment l'excroissance axonale - sans action sur les cellules gliales - dans les tissus de système nerveux in vivo et in vitro. Ils peuvent notamment être utilisés dans le traitement de lésions du système nerveux central et de maladies neurodégénératives.
PCT/EP2002/012039 2001-10-29 2002-10-28 Especes proteiques botuliniques c3 a deficience enzymatique et leur utilisation pour favoriser la croissance neuronale et la regenerescence neuronale Ceased WO2003037920A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002465371A CA2465371A1 (fr) 2001-10-29 2002-10-28 Especes proteiques botuliniques c3 a deficience enzymatique et leur utilisation pour favoriser la croissance neuronale et la regenerescence neuronale
EP02772399A EP1444256A2 (fr) 2001-10-29 2002-10-28 Especes proteiques botuliniques c3 a deficience enzymatique et leur utilisation pour favoriser la croissance neuronale et la regenerescence neuronale
US10/493,864 US20050255543A1 (en) 2001-10-29 2002-10-28 Enzyme-deficient c3 botulinum protein species and their use to promote neuronal growth and neuronal regeneration
AU2002337176A AU2002337176A1 (en) 2001-10-29 2002-10-28 Enzyme-deficient c3 botulinum protein species and their use to promote neuronal growth and neuronal regeneration

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10154685 2001-10-29
DE10154685.8 2001-10-29

Publications (2)

Publication Number Publication Date
WO2003037920A2 WO2003037920A2 (fr) 2003-05-08
WO2003037920A3 true WO2003037920A3 (fr) 2003-12-24

Family

ID=7704917

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/012039 Ceased WO2003037920A2 (fr) 2001-10-29 2002-10-28 Especes proteiques botuliniques c3 a deficience enzymatique et leur utilisation pour favoriser la croissance neuronale et la regenerescence neuronale

Country Status (5)

Country Link
US (1) US20050255543A1 (fr)
EP (1) EP1444256A2 (fr)
AU (1) AU2002337176A1 (fr)
CA (1) CA2465371A1 (fr)
WO (1) WO2003037920A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0506797D0 (en) * 2005-04-04 2005-05-11 Istituto Superiore Di Sanito Treatment of cognitive and learning impairment
EP2236516A1 (fr) 2009-03-31 2010-10-06 Charité-Universitätsmedizin Berlin (Charité) Polypeptides et utilisation associée pour le traitement d'une lésion neuronale traumatique ou dégénérative
WO2017004136A1 (fr) 2015-06-30 2017-01-05 Tela Bio, Inc. Motifs de points à verrouillage de coin
EP3324882B1 (fr) 2015-07-21 2023-10-25 Tela Bio, Inc. Couture de contrôle de souplesse dans des matériaux de substrat
WO2017189772A1 (fr) 2016-04-26 2017-11-02 Tela Bio, Inc. Greffes de réparation de hernie présentant des barrières anti-adhérence
US11590262B2 (en) 2018-03-09 2023-02-28 Tela Bio, Inc. Surgical repair graft
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
EP3934575B1 (fr) 2019-03-08 2025-05-07 Tela Bio, Inc. Textiles médicaux texturés

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
MORIISHI K ET AL: "PURIFICATION AND CHARACTERIZATION OF ADP-RIBOSYLTRANSFERASES EXOENZYME C3 OF CLOSTRIDIUM-BOTULINUM TYPE C AND D STRAINS", JOURNAL OF BACTERIOLOGY, vol. 173, no. 19, 1991, pages 6025 - 6029, XP009009624, ISSN: 0021-9193 *
MORIISHI KOHJI ET AL: "Two different types of ADP-ribosyltransferase C3 from Clostridium botulinum type D lysogenized organisms.", INFECTION AND IMMUNITY, vol. 61, no. 12, 1993, pages 5309 - 5314, XP009009625, ISSN: 0019-9567 *
NEMOTO Y ET AL: "CLOSTRIDIUM-BOTULINUM C3 ADP-RIBOSYLTRANSFERASE GENE CLONING SEQUENCING AND EXPRESSION OF A FUNCTIONAL PROTEIN IN ESCHERICHIA-COLI", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 29, 1991, pages 19312 - 19319, XP001147398, ISSN: 0021-9258 *
POPOFF M ET AL: "DNA SEQUENCE OF EXOENZYME C3 AND ADP RIBOSYLTRANSFERASE ENCODED BY CLOSTRIDIUM-BOTULINUM C AND D PHAGES", NUCLEIC ACIDS RESEARCH, vol. 18, no. 5, 1990, pages 1291, XP001147392, ISSN: 0305-1048 *
POPOFF M R ET AL: "CHARACTERIZATION OF THE C3 GENE OF CLOSTRIDIUM-BOTULINUM TYPES C AND D AND ITS EXPRESSION IN ESCHERICHIA-COLI", INFECTION AND IMMUNITY, vol. 59, no. 10, 1991, pages 3673 - 3679, XP009009712, ISSN: 0019-9567 *

Also Published As

Publication number Publication date
AU2002337176A1 (en) 2003-05-12
CA2465371A1 (fr) 2003-05-08
WO2003037920A2 (fr) 2003-05-08
EP1444256A2 (fr) 2004-08-11
US20050255543A1 (en) 2005-11-17

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